Abstract：
:Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO₃ (CaCO₃:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO₃:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO₃:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO₃:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO₃:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H & E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO₂ generation by CaCO₃:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Yang CC,Wang WY,Lin FH,Hou CHdoi
10.3390/ijms20051148subject
Has Abstractpub_date
2019-03-06 00:00:00issue
5issn
1422-0067pii
ijms20051148journal_volume
20pub_type
杂志文章abstract：:Acute liver failure (ALF) leads to neurological symptoms defined as hepatic encephalopathy (HE). Although accumulation of ammonia and neuroinflammation are generally accepted as main contributors to HE pathomechanism, a buildup of bile acids (BA) in the blood is a frequent component of liver injury in HE patients. Rec...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207750
更新日期：2020-10-20 00:00:00
abstract：:Fisetin is found in many fruits and plants such as grapes and onions, and exerts anti-inflammatory, anti-proliferative, and anticancer activity. However, whether fisetin regulates melanogenesis has been rarely studied. Therefore, we evaluated the effects of fisetin on melanogenesis in B16F10 melanoma cell and zebrafis...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010312
更新日期：2020-01-02 00:00:00
abstract：:The quaternary transition between the relaxed (R) and tense (T) states of heme-binding proteins is a textbook example for the allosteric structural transition. Homodimeric hemoglobin (HbI) from Scapharca inaequivalvis is a useful model system for investigating the allosteric behavior because of the relatively simple q...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19113633
更新日期：2018-11-18 00:00:00
abstract：:Peptide Nucleic Acids (PNAs) are synthetic mimics of natural oligonucleotides, which bind complementary DNA/RNA strands with high sequence specificity. They display numerous advantages, but in vivo applications are still rare. One of the main drawbacks of PNAs application is the poor cellular uptake that could be over...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205127
更新日期：2019-10-16 00:00:00
abstract：:Understanding the composition and structure of the acquired enamel pellicle (AEP) has been a major goal in oral biology. Our lab has conducted studies on the composition of AEP formed on permanent enamel. The exhaustive exploration has provided a comprehensive identification of more than 100 proteins from AEP formed o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14010920
更新日期：2013-01-07 00:00:00
abstract：:Levodopa (LD) is used to increase dopamine level for treating Parkinson's disease. The major metabolism of LD to produce dopamine is decarboxylation. In order to understand the metabolism of LD; the electronic structure of levodopa was investigated at the Density Functional DFT/B3LYP level of theory using the 6-311+G*...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13044321
更新日期：2012-01-01 00:00:00
abstract：:The presence of lysine (Lys) or arginine (Arg) and tryptophan (Trp) are important for the antimicrobial effects of cationic peptides. Therefore, we designed and synthesized a series of antimicrobial peptides with various numbers of Lys (or Arg) and Trp repeats [(KW and RW)(n)-NH(2), where n equals 2, 3, 4, or 5]. Anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131115042
更新日期：2012-11-15 00:00:00
abstract：:The glucocorticoid receptor (GR) is a transcription factor, which interacts with DNA and other cofactors to regulate gene transcription. Binding to other partners in the cell nucleus alters the diffusion properties of GR. Raster image correlation spectroscopy (RICS) was applied to quantitatively characterize the diffu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18091855
更新日期：2017-08-25 00:00:00
abstract：:The establishment of a proangiogenic phenotype and epithelial-to-mesenchymal transition (EMT) are considered as critical events that promote the induction of invasive growth in epithelial tumors, and stimulation of lymphangiogenesis is believed to confer the capacity for early dissemination to cancer cells. Recent res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186515
更新日期：2020-09-06 00:00:00
abstract：:There is strong association between inflammatory processes and their main metabolic mediators, such as leptin, adiponectin secretion, and low/high-density lipoproteins, with the cancer risk and aggressive behavior of solid tumors. In this scenario, cancer cells (CCs) and cancer stem cells (CSCs) have important roles. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20102466
更新日期：2019-05-18 00:00:00
abstract：:The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression for structure, function and metabolism of skeletal muscle is clear when observ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20174318
更新日期：2019-09-03 00:00:00
abstract：:Cadmium at environmental concentrations is a risk factor for many diseases, including cardiovascular and neurodegenerative diseases, in which macrophages play an important role. The aim of this study was to evaluate the effects of cadmium at low environmental (nanomolar) concentrations on apoptotic processes in THP-1(...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160921410
更新日期：2015-09-07 00:00:00
abstract：:Yeonsan Ogye is a rare Korean domestic chicken breed whose entire body, including feathers and skin, has a unique black coloring. Although some protein-coding genes related to this unique feature have been examined, non-coding elements have not been widely investigated. Thus, we evaluated coding and non-coding transcr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082359
更新日期：2018-08-10 00:00:00
abstract：:Demands for safe depigmentation compounds are constantly increasing in the pharmaceutical and cosmetic industry, since the numerous relevant compounds reported to date have shown undesirable side effects or low anti-melanogenic effects. In this study, we reported three novel inhibitors of tyrosinase, which is the key ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093144
更新日期：2020-04-29 00:00:00
abstract：:Osteosarcoma (OS) is the most common type of primary bone tumor. Currently, there are limited treatment options for metastatic OS. Alpha-ketoglutarate (AKG), i.e., a multifunctional intermediate of the Krebs cycle, is one of the central metabolic regulators of tumor fate and plays an important role in cancerogenesis a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249406
更新日期：2020-12-10 00:00:00
abstract：:Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-bas...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197355
更新日期：2020-10-05 00:00:00
abstract：:Community-acquired pneumonia (CAP) places a considerable burden on society. A substantial number of pediatric and adult CAP cases are due to Streptococcus pneumoniae, but fortunately there are effective vaccines available that have a significant impact on CAP-related medical, social, and economic problems. The main ai...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18010030
更新日期：2016-12-25 00:00:00
abstract：:The estrogen receptor (ER) signaling regulates numerous physiological processes mainly through activation of gene transcription (genomic pathways). Caveolin1 (CAV1) is a membrane-resident protein that behaves as platform to enable different signaling molecules and receptors for membrane-initiated pathways. CAV1 direct...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21175989
更新日期：2020-08-20 00:00:00
abstract：:microRNA-143(miR-143) is a well-known tumor suppressive microRNA that exhibits anti-tumoral function by targeting KRAS signaling pathways in various malignancies. We hypothesized that miR-143 suppresses breast cancer progression by targeting KRAS and its effector molecules. We further hypothesized that high expression...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093213
更新日期：2020-05-01 00:00:00
abstract：:In plants, microRNAs have been indicated to control various developmental processes, including somatic embryogenesis (SE), which is triggered in the in vitro cultured somatic cells of plants. Although a transcriptomic analysis has indicated that numerous MIRNAs are differentially expressed in the SE of different plant...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205221
更新日期：2019-10-21 00:00:00
abstract：:This paper presents the results obtained after studying the thermal stability and decomposition kinetics of perindopril erbumine as a pure active pharmaceutical ingredient as well as a solid pharmaceutical formulation containing the same active pharmaceutical ingredient (API). Since no data were found in the literatur...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010164
更新日期：2017-01-15 00:00:00
abstract：:Platelets (PLT) are the second most abundant cell type in human blood and exert various immune-regulatory functions under both physiological and pathological conditions. In fact, immune cell regulation via platelets has been demonstrated in several studies within the past decade. However, the exact mechanisms behind T...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207507
更新日期：2020-10-12 00:00:00
abstract：:It has been confirmed that alternatively activated macrophages (M2) participate in tissue remodeling and fibrosis occurrence, but the effect of M2 on peritoneal fibrosis related to peritoneal dialysis (PD) hasn't been elucidated. This study was therefore conducted to assess the association between M2 and peritoneal fi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140510369
更新日期：2013-05-17 00:00:00
abstract：:The effects of thyroid hormone disrupting chemicals (THDCs) on eye development of zebrafish were investigated. We expected THDC exposure to cause transcriptional changes of vision-related genes, which find their phenotypic anchoring in eye malformations and dysfunction, as observed in our previous studies. Zebrafish w...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071543
更新日期：2019-03-27 00:00:00
abstract：:We have extracted an extensive collection of recurrent structural motifs (RSMs), which consist of sequentially non-contiguous structural motifs (4-6 residues), each of which appears with very similar conformation in three or more mutually unrelated protein structures. We find that the proteins in our set are covered t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14047795
更新日期：2013-04-10 00:00:00
abstract：:Glucose variability (GV) has been recognized recently as a promoter of complications and therapeutic targets in diabetes. The aim of this study was to reconstruct and analyze gene networks related to GV in diabetes and its complications. For network analysis, we used the ANDSystem that provides automatic network recon...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228691
更新日期：2020-11-18 00:00:00
abstract：:Silk sericin (SS) can accelerate cell proliferation and attachment; however, SS can be extracted by various methods, which result in SS exhibiting different physical and biological properties. We found that SS produced from various extraction methods has different molecular weights, zeta potential, particle size and a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11052200
更新日期：2010-05-20 00:00:00
abstract：:In the absence of visible mucosal damage, it is hypothesized that the esophageal mucosal barrier is functionally impaired in patients with non-erosive reflux disease (NERD). The aim of the present study was to perform an exploratory analysis of the mucosal barrier in NERD compared to erosive esophagitis (EE) and contr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18051091
更新日期：2017-05-19 00:00:00
abstract：:EAAC1 is important in modulating brain ischemic tolerance. Mice lacking EAAC1 exhibit increased susceptibility to neuronal oxidative stress in mice after transient cerebral ischemia. EAAC1 was first described as a glutamate transporter but later recognized to also function as a cysteine transporter in neurons. EAAC1-m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151119444
更新日期：2014-10-27 00:00:00
abstract：:Short-term abiotic stress treatment before harvest can enhance the quality of horticultural crops cultivated in controlled environments. Here, we investigated the effects of combined chilling and UV-A treatment on the accumulation of phenolic compounds in kale (Brassica oleracea var. acephala). Five-week-old plants we...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194950
更新日期：2019-10-08 00:00:00
