当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection.

Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection.

Abstract：

:Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing drug resistance, there is a critical need to develop new drugs and vaccines to control Leishmania infection. Over the past few years, proteomics has become an important tool to understand the underlying biology of Leishmania parasites and host interaction. The large-scale study of proteins, both in parasites and within the host in response to infection, can accelerate the discovery of new therapeutic targets. By studying the proteomes of host cells and tissues infected with Leishmania, as well as changes in protein profiles among promastigotes and amastigotes, scientists hope to better understand the biology involved in the parasite survival and the host-parasite interaction. This review demonstrates the feasibility of proteomics as an approach to identify new proteins involved in Leishmania differentiation and intracellular survival.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Veras PS,Bezerra de Menezes JP

doi

10.3390/ijms17081270

subject

Has Abstract

pub_date

2016-08-19 00:00:00

issue

8

issn

1422-0067

pii

ijms17081270

journal_volume

17

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • The Salicylic Acid-Mediated Release of Plant Volatiles Affects the Host Choice of Bemisia tabaci.

    abstract：:The whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) causes serious crop losses worldwide by transmitting viruses. We have previously shown that salicylic acid (SA)-related plant defenses directly affect whiteflies. In this study, we applied exogenous SA to tomato plants in order to investigate the interac...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17071048

    authors： Shi X,Chen G,Tian L,Peng Z,Xie W,Wu Q,Wang S,Zhou X,Zhang Y

    更新日期：2016-06-30 00:00:00

  • Develop a High-Throughput Screening Method to Identify C-P4H1 (Collagen Prolyl 4-Hydroxylase 1) Inhibitors from FDA-Approved Chemicals.

    abstract：:Collagen prolyl 4-hydroxylase 1 (C-P4H1) is an α-ketoglutarate (α-KG)-dependent dioxygenase that catalyzes 4-hydroxylation of proline on collagen. C-P4H1-induced prolyl hydroxylation is required for proper collagen deposition and cancer metastasis. Therefore, targeting C-P4H1 is considered a potential therapeutic stra...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186613

    authors： Wang S,Lee KH,Araujo NV,Zhan CG,Rangnekar VM,Xu R

    更新日期：2020-09-10 00:00:00

  • Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons.

    abstract：:The demise of retinal ganglion cells (RGCs) is characteristic of diseases of the retina such as glaucoma and diabetic or ischemic retinopathies. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein that mediates neuroprotection and inhibition of angiogenesis in the retina. We have studied exp...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010369

    authors： Bürger S,Meng J,Zwanzig A,Beck M,Pankonin M,Wiedemann P,Eichler W,Unterlauft JD

    更新日期：2020-12-31 00:00:00

  • Metabolic Features of Multiple Myeloma.

    abstract：:Cancer is known for its cellular changes contributing to tumour growth and cell proliferation. As part of these changes, metabolic rearrangements are identified in several cancers, including multiple myeloma (MM), which is a condition whereby malignant plasma cells accumulate in the bone marrow (BM). These metabolic c...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19041200

    authors： El Arfani C,De Veirman K,Maes K,De Bruyne E,Menu E

    更新日期：2018-04-14 00:00:00

  • In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins.

    abstract：:Phosphodiesterases (PDEs) are essential enzymes for the regulation of pathways mediated by cyclic adenosine monophosphate (cAMP). Secondary plant compounds like anthocyanins (ACs) can inhibit PDE activity and, consequently, may be beneficial for lipid metabolism. This study investigated 18 AC-rich juice extracts and p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186934

    authors： Göttel C,Niesen S,Daub V,Werle T,Bakuradze T,Winterhalter P,Richling E

    更新日期：2020-09-21 00:00:00

  • Multi-step usage of in vivo models during rational drug design and discovery.

    abstract：:In this article we propose a systematic development method for rational drug design while reviewing paradigms in industry, emerging techniques and technologies in the field. Although the process of drug development today has been accelerated by emergence of computational methodologies, it is a herculean challenge requ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms12042262

    authors： Williams CH,Hong CC

    更新日期：2011-01-01 00:00:00

  • Impact of serum chemerin levels on liver functional reserves and platelet counts in patients with hepatocellular carcinoma.

    abstract：:Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver functional reserves i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms150711294

    authors： Imai K,Takai K,Hanai T,Shiraki M,Suzuki Y,Hayashi H,Naiki T,Nishigaki Y,Tomita E,Shimizu M,Moriwaki H

    更新日期：2014-06-25 00:00:00

  • Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis.

    abstract：:Obesity is a multifaceted pathophysiological condition that has been associated with lipid accumulation, adipocyte dysfunction, impaired mitochondrial biogenesis and an altered metabolic profile. Redox imbalance and excessive release of inflammatory mediators have been intricately linked in obesity-associated phenotyp...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21010087

    authors： Pratt R,Lakhani HV,Zehra M,Desauguste R,Pillai SS,Sodhi K

    更新日期：2019-12-21 00:00:00

  • Functional Recovery of a GCDH Variant Associated to Severe Deflavinylation-Molecular Insights into Potential Beneficial Effects of Riboflavin Supplementation in Glutaric Aciduria-Type I Patients.

    abstract：:Riboflavin is the biological precursor of two important flavin cofactors-flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN)-that are critical prosthetic groups in several redox enzymes. While dietary supplementation with riboflavin is a recognized support therapy in several inborn errors of metabolism, ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197063

    authors： Ribeiro JV,Gomes CM,Henriques BJ

    更新日期：2020-09-25 00:00:00

  • Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene.

    abstract：:Gastrointestinal stromal tumors (GIST) carrying the D842V activating mutation in the platelet-derived growth factor receptor alpha (PDGFRA) gene are a very rare subgroup of GIST (about 10%) known to be resistant to conventional tyrosine kinase inhibitors (TKIs) and to show an indolent behavior. In this study, we perfo...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19030732

    authors： Indio V,Astolfi A,Tarantino G,Urbini M,Patterson J,Nannini M,Saponara M,Gatto L,Santini D,do Valle IF,Castellani G,Remondini D,Fiorentino M,von Mehren M,Brandi G,Biasco G,Heinrich MC,Pantaleo MA

    更新日期：2018-03-04 00:00:00

  • Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells.

    abstract：:The aim of this study is to elucidate the detailed mechanism of endoplasmic reticulum (ER) stress-induced auditory cell death based on the function of the initiator caspases and molecular complex of necroptosis. Here, we demonstrated that ER stress initiates not only caspase-9-dependent intrinsic apoptosis along with ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20235896

    authors： Kishino A,Hayashi K,Maeda M,Jike T,Hidai C,Nomura Y,Oshima T

    更新日期：2019-11-24 00:00:00

  • Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids.

    abstract：:Mammalian target of rapamycin (mTOR), which is now referred to as mechanistic target of rapamycin, integrates many signals, including those from growth factors, energy status, stress, and amino acids, to regulate cell growth and proliferation, protein synthesis, protein degradation, and other physiological and biochem...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms151120753

    authors： Zheng X,Liang Y,He Q,Yao R,Bao W,Bao L,Wang Y,Wang Z

    更新日期：2014-11-13 00:00:00

  • Unveiling the Actual Functions of Awns in Grasses: From Yield Potential to Quality Traits.

    abstract：:Awns, which are either bristles or hair-like outgrowths of lemmas in the florets, are one of the typical morphological characteristics of grass species. These stiff structures contribute to grain dispersal and burial and fend off animal predators. However, their phenotypic and genetic associations with traits deciding...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21207593

    authors： Ntakirutimana F,Xie W

    更新日期：2020-10-14 00:00:00

  • Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2.

    abstract：:Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in immature osteoblasts, and is down-regulated in mature osteoblast...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20071694

    authors： Komori T

    更新日期：2019-04-04 00:00:00

  • Insight in Adhesion Protein Sialylation and Microgravity Dependent Cell Adhesion-An Omics Network Approach.

    abstract：:The adhesion behavior of human tissue cells changes in vitro, when gravity forces affecting these cells are modified. To understand the mechanisms underlying these changes, proteins involved in cell-cell or cell-extracellular matrix adhesion, their expression, accumulation, localization, and posttranslational modifica...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051749

    authors： Bauer TJ,Gombocz E,Wehland M,Bauer J,Infanger M,Grimm D

    更新日期：2020-03-04 00:00:00

  • Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15+ Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma.

    abstract：:Squamous cell carcinoma (SCC) is the second commonest type of skin cancer, and SCCs make up about 90% of head and neck cancers (HNSCCs). HNSCCs harbor two frequent molecular alterations, namely, gain-of-function alterations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and loss-of-...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186585

    authors： Chen SMY,Li B,Nicklawsky AG,Krinsky AL,Brunetti T,Woolaver RA,Wang X,Chen Z,Young CD,Gao D,Wang XJ,Wang JH

    更新日期：2020-09-09 00:00:00

  • Pulmonary Hypertension Phenotypes in Systemic Sclerosis: The Right Diagnosis for the Right Treatment.

    abstract：:Systemic sclerosis is an auto-immune disease characterized by skin involvement that often affects multiple organ systems. Pulmonary hypertension is a common finding that can significantly impact prognosis. Molecular pathophysiological mechanisms underlying pulmonary hypertension in systemic sclerosis can be extremely ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21124430

    authors： Attanasio U,Cuomo A,Pirozzi F,Loffredo S,Abete P,Petretta M,Marone G,Bonaduce D,De Paulis A,Rossi FW,Tocchetti CG,Mercurio V

    更新日期：2020-06-22 00:00:00

  • Reviewing ligand-based rational drug design: the search for an ATP synthase inhibitor.

    abstract：:Following major advances in the field of medicinal chemistry, novel drugs can now be designed systematically, instead of relying on old trial and error approaches. Current drug design strategies can be classified as being either ligand- or structure-based depending on the design process. In this paper, by describing t...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms12085304

    authors： Lee CH,Huang HC,Juan HF

    更新日期：2011-01-01 00:00:00

  • Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT7 Receptor.

    abstract：:Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT) plays an important role in mitochondrial biogenesis in cortical neur...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21249629

    authors： Tempio A,Niso M,Laera L,Trisolini L,Favia M,Ciranna L,Marzulli D,Petrosillo G,Pierri CL,Lacivita E,Leopoldo M

    更新日期：2020-12-17 00:00:00

  • Expression analysis of four peroxiredoxin genes from Tamarix hispida in response to different abiotic stresses and Exogenous Abscisic Acid (ABA).

    abstract：:Peroxiredoxins (Prxs) are a recently discovered family of antioxidant enzymes that catalyze the reduction of peroxides and alkyl peroxides. In this study, four Prx genes (named as ThPrxII, ThPrxIIE, ThPrxIIF, and Th2CysPrx) were cloned from Tamarix hispida. Their expression profiles in response to stimulus of NaCl, Na...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13033751

    authors： Gao C,Zhang K,Yang G,Wang Y

    更新日期：2012-01-01 00:00:00

  • The Role of BRAF in Metastatic Colorectal Carcinoma-Past, Present, and Future.

    abstract：:With a global incidence of 1.8 million cases, colorectal cancer represents one of the most common cancers worldwide. Despite impressive improvements in treatment efficacy through cytotoxic and biological agents, the cancer-related death burden of metastatic colorectal cancer (mCRC) is still high. mCRC is not a genetic...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21239001

    authors： Djanani A,Eller S,Öfner D,Troppmair J,Maglione M

    更新日期：2020-11-26 00:00:00

  • Role of Tricellular Tight Junction Protein Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Cancer Cells.

    abstract：:Maintaining a robust epithelial barrier requires the accumulation of tight junction proteins, LSR/angulin-1 and tricellulin, at the tricellular contacts. Alterations in the localization of these proteins temporarily cause epithelial barrier dysfunction, which is closely associated with not only physiological different...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20143555

    authors： Kohno T,Konno T,Kojima T

    更新日期：2019-07-20 00:00:00

  • The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective.

    abstract：:Vascular calcification (VC) is an important complication among patients of advanced age, those with chronic kidney disease, and those with diabetes mellitus. The pathophysiology of VC encompasses passive occurrence of physico-chemical calcium deposition, active cellular secretion of osteoid matrix upon exposure to met...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21030980

    authors： Hou YC,Lu CL,Yuan TH,Liao MT,Chao CT,Lu KC

    更新日期：2020-02-01 00:00:00

  • Induction of Oxidative Stress and Mitochondrial Dysfunction by Juglone Affects the Development of Bovine Oocytes.

    abstract：:Juglone, a major naphthalenedione component of walnut trees, has long been used in traditional medicine as an antimicrobial and antitumor agent. Nonetheless, its impact on oocyte and preimplantation embryo development has not been entirely clarified. Using the bovine model, we sought to elucidate the impact of juglone...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010168

    authors： Mesalam AA,El-Sheikh M,Joo MD,Khalil AAK,Mesalam A,Ahn MJ,Kong IK

    更新日期：2020-12-26 00:00:00

  • Bioactive Phytochemicals from Wild Arbutus unedo L. Berries from Different Locations in Portugal: Quantification of Lipophilic Components.

    abstract：:The lipophilic composition of wild Arbutus unedo L. berries, collected from six locations in Penacova (center of Portugal), as well as some general chemical parameters, namely total soluble solids, pH, titratable acidity, total phenolic content and antioxidant activity was studied in detail to better understand its po...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160614194

    authors： Fonseca DF,Salvador ÂC,Santos SA,Vilela C,Freire CS,Silvestre AJ,Rocha SM

    更新日期：2015-06-23 00:00:00

  • SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line.

    abstract：:As most chemotherapeutic drugs are ineffective in the treatment of chondrosarcoma, we studied the expression pattern and function of SOX9, the master transcription factor for chondrogenesis, in chondrosarcoma, to understand the basic molecular principles needed for engineering new targeted therapies. Our study shows a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21207627

    authors： Stöckl S,Lindner G,Li S,Schuster P,Haferkamp S,Wagner F,Prodinger PM,Multhoff G,Boxberg M,Hillmann A,Bauer RJ,Grässel S

    更新日期：2020-10-15 00:00:00

  • Chemoprevention of Colorectal Cancer by Dietary Compounds.

    abstract：:Colorectal cancer is one of the leading causes of death, and the third most diagnosed type of cancer, worldwide. It is most common amongst men and women over 50 years old. Risk factors include smoking, alcohol, diet, physical inactivity, genetics, alterations in gut microbiota, and associated pathologies (diabetes, ob...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19123787

    authors： Costea T,Hudiță A,Ciolac OA,Gălățeanu B,Ginghină O,Costache M,Ganea C,Mocanu MM

    更新日期：2018-11-28 00:00:00

  • LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression.

    abstract：:Type I collagen is the most abundant structural protein in all vertebrates, but its constitutive rate of synthesis is low due to long half-life of the protein (60-70 days). However, several hundred fold increased production of type I collagen is often seen in reparative or reactive fibrosis. The mechanism which is res...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17030419

    authors： Zhang Y,Stefanovic B

    更新日期：2016-03-22 00:00:00

  • Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.

    abstract：:Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evalu...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051566

    authors： Piro MC,Ventura A,Smirnov A,Saggini A,Lena AM,Mauriello A,Bianchi L,Melino G,Candi E

    更新日期：2020-02-25 00:00:00

  • OsMKK3, a Stress-Responsive Protein Kinase, Positively Regulates Rice Resistance to Nilaparvata lugens via Phytohormone Dynamics.

    abstract：:Plants undergo several but very precise molecular, physiological, and biochemical modulations in response to biotic stresses. Mitogen-activated protein kinase (MAPK) cascades orchestrate multiple cellular processes including plant growth and development as well as plant responses against abiotic and biotic stresses. H...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20123023

    authors： Zhou S,Chen M,Zhang Y,Gao Q,Noman A,Wang Q,Li H,Chen L,Zhou P,Lu J,Lou Y

    更新日期：2019-06-20 00:00:00