当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength.

Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength.

Abstract：

:Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development. Serum samples (n = 408) from young overweight subjects (n = 143) were collected during a lifestyle intervention study. Anthropometric parameters, along with leptin, IGF1 and IGF1R-aAb concentrations, were analyzed, and the subjects were categorized into positive or negative for IGF1R-aAb. Eleven out of 143 subjects (7.7%) were positive for IGF1R-aAb. Identified IGF1R-aAb were molecularly characterized and showed antagonistic activity in vitro impairing IGF1-mediated IGF1R activation. Mean body weight, height or age were similar between IGF1R-aAb-positive and -negative subjects, but IGF1 concentrations differed. Jumping ability, as well as right and left handgrip strengths, were lower in the IGF1R-aAb-positive as compared to the IGF1R-aAb-negative subjects. We conclude that natural IGF1R-aAb are detectable in apparently healthy subjects and are capable of antagonizing IGF1-dependent IGF1R activation. Moreover, the presence of IGF1R-aAb is associated with poor physical strength. Although the causality of this association is unclear, the data imply a potential influence of IGF1R autoimmunity on muscle development.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Schwiebert C,Kühnen P,Becker NP,Welsink T,Keller T,Minich WB,Wiegand S,Schomburg L

doi

10.3390/ijms21020463

subject

Has Abstract

pub_date

2020-01-11 00:00:00

issue

2

issn

1422-0067

pii

ijms21020463

journal_volume

21

pub_type

临床试验,杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Interactions between Host PPARs and Gut Microbiota in Health and Disease.

    abstract：:The human gastrointestinal tract is inhabited by many types of microbiota, including bacteria, viruses, and fungi. Dysregulations of their microenvironment are associated with various health problems, not only limited to gastrointestinal disorders, such as inflammatory bowel disease, but to impacts beyond the intestin...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20020387

    authors： Hasan AU,Rahman A,Kobori H

    更新日期：2019-01-17 00:00:00

  • Safety Profile of TiO₂-Based Photocatalytic Nanofabrics for Indoor Formaldehyde Degradation.

    abstract：:Anatase TiO₂ nanoparticles (TNPs) are synthesized using the sol-gel method and loaded onto the surface of polyester-cotton (65/35) fabrics. The nanofabrics degrade formaldehyde at an efficiency of 77% in eight hours with visible light irradiation or 97% with UV light. The loaded TNPs display very little release from n...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms161126055

    authors： Cui G,Xin Y,Jiang X,Dong M,Li J,Wang P,Zhai S,Dong Y,Jia J,Yan B

    更新日期：2015-11-19 00:00:00

  • Tanshinone IIA Inhibits Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Modulation of STAT3-CCL2 Signaling.

    abstract：:Tanshinone IIA (Tan-IIA) is an extract from the widely used traditional Chinese medicine (TCM) Danshen (Salvia miltiorrhiza), and has been found to attenuate the proliferation of bladder cancer (BCa) cells (The IC50 were: 5637, 2.6 μg/mL; BFTC, 2 μg/mL; T24, 2.7 μg/mL, respectively.). However, the mechanism of the eff...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18081616

    authors： Huang SY,Chang SF,Liao KF,Chiu SC

    更新日期：2017-07-25 00:00:00

  • Atrazine affects phosphoprotein and protein expression in MCF-10A human breast epithelial cells.

    abstract：:Atrazine, a member of the 2-chloro-s-triazine family of herbicides, is the most widely used pesticide in the world and often detected in agriculture watersheds. Although it was generally considered as an endocrine disruptor, posing a potential threat to human health, the molecular mechanisms of atrazine effects remain...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms151017806

    authors： Huang P,Yang J,Song Q

    更新日期：2014-10-01 00:00:00

  • Expression and Localization of BDNF/TrkB System in the Zebrafish Inner Ear.

    abstract：:Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is involved in multiple and fundamental functions of the central and peripheral nervous systems including sensory organs. Despite recent advances in knowledge on the functional significance of BDNF and TrkB in the regulation of the acoustic...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21165787

    authors： Germanà A,Guerrera MC,Laurà R,Levanti M,Aragona M,Mhalhel K,Germanà G,Montalbano G,Abbate F

    更新日期：2020-08-12 00:00:00

  • Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype.

    abstract：:The forced swim stress test (FST) is widely used for screening pharmacological or non-pharmacological strategies with potential antidepressant activities. Recent data have suggested that repeated FST for five consecutive days (i.e., 5d-RFSS) could be used to generate a robust depressive-like phenotype in mice. However...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020937

    authors： Bullich S,Delcourte S,Haddjeri N,Guiard BP

    更新日期：2021-01-19 00:00:00

  • In vitro cytotoxicity of fluorescent silica nanoparticles hybridized with aggregation-induced emission luminogens for living cell imaging.

    abstract：:Fluorescent silica nanoparticles (FSNPs) can provide high-intensity and photostable fluorescent signals as a probe for biomedical analysis. In this study, FSNPs hybridized with aggregation-induced emission (AIE) luminogens (namely FSNP-SD) were successfully fabricated by a surfactant-free sol-gel method. The FSNP-SD w...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14011080

    authors： Xia Y,Li M,Peng T,Zhang W,Xiong J,Hu Q,Song Z,Zheng Q

    更新日期：2013-01-07 00:00:00

  • Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189.

    abstract：:We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50-60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron loss. Because microgl...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms16010758

    authors： Reiner A,Heldt SA,Presley CS,Guley NH,Elberger AJ,Deng Y,D'Surney L,Rogers JT,Ferrell J,Bu W,Del Mar N,Honig MG,Gurley SN,Moore BM 2nd

    更新日期：2014-12-31 00:00:00

  • Preparation and Characterization of Whey Protein Isolate-DIM Nanoparticles.

    abstract：:3,3'-Diindolylmethane (DIM) is a bioactive compound found in Cruciferous vegetables that possesses health benefits such as antioxidant, anticancer, and anti-inflammatory effects. However, hydrophobicity and photolabile limit its pharmaceutical applications. This study aims to prepare and characterize DIM-encapsulated ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20163917

    authors： Khan A,Wang C,Sun X,Killpartrick A,Guo M

    更新日期：2019-08-12 00:00:00

  • The Multiplicity of Infection-Dependent Effects of Recombinant Adenovirus Carrying HGF Gene on the Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells.

    abstract：:Absence of effective therapeutic methods for avascular necrosis of femoral head (ANFH) is still perplexing the world's medical community. Bone marrow mesenchymal stem cells (BMSCs) adoptive cell therapy combined with core decompression is a promising modality, which is highly dependent on the cellular activities of BM...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19030734

    authors： Wen Q,Zhang S,Du X,Wang R,Li Y,Liu H,Hu S,Zhou C,Zhou X,Ma L

    更新日期：2018-03-05 00:00:00

  • Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats.

    abstract：:Parkinson's disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration. Evidence suggests that mitochondrial dysfunction may be linked to PD through a variety of different pathways, including free-radical generation and dysfunction of the mitochondrial Complex I activity. In ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13078722

    authors： Lin TK,Cheng CH,Chen SD,Liou CW,Huang CR,Chuang YC

    更新日期：2012-01-01 00:00:00

  • Secretome of Adipose Tissue-Derived Stem Cells (ASCs) as a Novel Trend in Chronic Non-Healing Wounds: An Overview of Experimental In Vitro and In Vivo Studies and Methodological Variables.

    abstract：:Wound healing is a complex process with a linear development that involves many actors in a multistep timeline commonly divided into four stages: Hemostasis, inflammation, proliferation, and remodeling. Chronic non-healing wounds fail to progress beyond the inflammatory phase, thus precluding the next steps and, ultim...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20153721

    authors： Lombardi F,Palumbo P,Augello FR,Cifone MG,Cinque B,Giuliani M

    更新日期：2019-07-30 00:00:00

  • Redox Components: Key Regulators of Epigenetic Modifications in Plants.

    abstract：:Epigenetic modifications including DNA methylation, histone modifications, and chromatin remodeling are crucial regulators of chromatin architecture and gene expression in plants. Their dynamics are significantly influenced by oxidants, such as reactive oxygen species (ROS) and nitric oxide (NO), and antioxidants, lik...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21041419

    authors： R M SK,Wang Y,Zhang X,Cheng H,Sun L,He S,Hao F

    更新日期：2020-02-19 00:00:00

  • Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.

    abstract：:Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms22020727

    authors： Song X,Traub B,Shi J,Kornmann M

    更新日期：2021-01-13 00:00:00

  • Integrated RNA-Seq Analysis and Meta-QTLs Mapping Provide Insights into Cold Stress Response in Rice Seedling Roots.

    abstract：:Rice (Oryza sativa L.) is a widely cultivated food crop around the world, especially in Asia. However, rice seedlings often suffer from cold stress, which affects their growth and yield. Here, RNA-seq analysis and Meta-QTLs mapping were performed to understand the molecular mechanisms underlying cold tolerance in the ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21134615

    authors： Kong W,Zhang C,Qiang Y,Zhong H,Zhao G,Li Y

    更新日期：2020-06-29 00:00:00

  • Hepatic Stellate Cells Enhance Liver Cancer Progression by Inducing Myeloid-Derived Suppressor Cells through Interleukin-6 Signaling.

    abstract：:The tumor microenvironment, which consists of fibroblasts, smooth muscle cells, endothelial cells, immune cells, epithelial cells, and extracellular matrices, plays a crucial role in tumor progression. Hepatic stellate cells (HSCs), a class of unique liver stromal cells, participate in immunomodulatory activities by i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20205079

    authors： Hsieh CC,Hung CH,Chiang M,Tsai YC,He JT

    更新日期：2019-10-13 00:00:00

  • Degenerated Cones in Cultured Human Retinas Can Successfully Be Optogenetically Reactivated.

    abstract：:Biblical references aside, restoring vision to the blind has proven to be a major technical challenge. In recent years, considerable advances have been made towards this end, especially when retinal degeneration underlies the vision loss such as occurs with retinitis pigmentosa. Under these conditions, optogenetic the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21020522

    authors： Kamar S,Howlett MHC,Klooster J,Graaff W,Csikós T,Rabelink MJWE,Hoeben RC,Kamermans M

    更新日期：2020-01-14 00:00:00

  • Domain Organization in Plant Blue-Light Receptor Phototropin2 of Arabidopsis thaliana Studied by Small-Angle X-ray Scattering.

    abstract：:Phototropin2 (phot2) is a blue-light (BL) receptor protein that regulates the BL-dependent activities of plants for efficient photosynthesis. Phot2 is composed of two light-oxygen-voltage sensing domains (LOV1 and LOV2) to absorb BL, and a kinase domain. Photo-activated LOV domains, especially LOV2, play a major role ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186638

    authors： Nakasako M,Oide M,Takayama Y,Oroguchi T,Okajima K

    更新日期：2020-09-10 00:00:00

  • Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis.

    abstract：:Tauroursodeoxycholic acid (TUDCA) is a US FDA-approved hydrophilic bile acid for the treatment of chronic cholestatic liver disease. In the present study, we investigate the effects of TUDCA on the proliferation and differentiation of osteoblasts and its therapeutic effect on a mice model of osteoporosis. Following tr...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21124274

    authors： Ahn TK,Kim KT,Joshi HP,Park KH,Kyung JW,Choi UY,Sohn S,Sheen SH,Shin DE,Lee SH,Han IB

    更新日期：2020-06-16 00:00:00

  • Bioinformatics Approaches for Fetal DNA Fraction Estimation in Noninvasive Prenatal Testing.

    abstract：:The discovery of cell-free fetal DNA molecules in plasma of pregnant women has created a paradigm shift in noninvasive prenatal testing (NIPT). Circulating cell-free DNA in maternal plasma has been increasingly recognized as an important proxy to detect fetal abnormalities in a noninvasive manner. A variety of approac...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18020453

    authors： Peng XL,Jiang P

    更新日期：2017-02-20 00:00:00

  • Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer.

    abstract：:Iron is an essential element for the growth and proliferation of cells. Cellular iron uptake, storage, utilization and export are tightly regulated to maintain iron homeostasis. However, cellular iron metabolism pathways are disturbed in most cancer cells. To maintain rapid growth and proliferation, cancer cells acqui...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19051545

    authors： Zhou L,Zhao B,Zhang L,Wang S,Dong D,Lv H,Shang P

    更新日期：2018-05-22 00:00:00

  • Potential Molecular Pathways Related to Pulmonary Artery Aneurysm Development: Lessons to Learn from the Aorta.

    abstract：:Pulmonary arterial hypertension (PAH) is a rare disease caused by pulmonary vascular remodeling. Current vasodilator treatments have substantially improved patients' survival. This improved survival has led to the appearance of complications related to conditions previously underdiagnosed or even ignored, such as pulm...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21072509

    authors： Nuche J,Palomino-Doza J,Ynsaurriaga FA,Delgado JF,Ibáñez B,Oliver E,Escribano Subías P

    更新日期：2020-04-04 00:00:00

  • ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1.

    abstract：:Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeting and translocation of APE1/Ref-1 in HEK293T cells with enhanced ace...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20133178

    authors： Lee YR,Joo HK,Lee EO,Cho HS,Choi S,Kim CS,Jeon BH

    更新日期：2019-06-28 00:00:00

  • The inhibitory effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activities of mushroom tyrosinase.

    abstract：:In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12063998

    authors： Sato K,Toriyama M

    更新日期：2011-01-01 00:00:00

  • Protein Corona Gold Nanoparticles Fingerprinting Reveals a Profile of Blood Coagulation Proteins in the Serum of HER2-Overexpressing Breast Cancer Patients.

    abstract：:Breast cancer (BC) is a molecularly heterogeneous disease that encompasses five major molecular subtypes (luminal A (LA), luminal B HER2 negative (LB-), luminal B HER2 positive (LB+), HER2 positive (HER2+) and triple negative breast cancer (TNBC)). BC treatment mainly depends on the identification of the specific subt...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21228449

    authors： Chantada-Vázquez MDP,Castro López A,García-Vence M,Acea-Nebril B,Bravo SB,Núñez C

    更新日期：2020-11-10 00:00:00

  • L-Dopa-Decarboxylase (DDC) Is a Positive Prognosticator for Breast Cancer Patients and Epinephrine Regulates Breast Cancer Cell (MCF7 and T47D) Growth In Vitro According to Their Different Expression of Gi- Protein- Coupled Receptors.

    abstract：:A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system. Catecholamines themselves are synthesized by the L-dopa decarboxylase (DDC). The aim of our study...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21249565

    authors： Tremmel E,Kuhn C,Kaltofen T,Vilsmaier T,Mayr D,Mahner S,Ditsch N,Jeschke U,Vattai A

    更新日期：2020-12-15 00:00:00

  • Markers of Angiogenesis, Lymphangiogenesis, and Epithelial-Mesenchymal Transition (Plasticity) in CIN and Early Invasive Carcinoma of the Cervix: Exploring Putative Molecular Mechanisms Involved in Early Tumor Invasion.

    abstract：:The establishment of a proangiogenic phenotype and epithelial-to-mesenchymal transition (EMT) are considered as critical events that promote the induction of invasive growth in epithelial tumors, and stimulation of lymphangiogenesis is believed to confer the capacity for early dissemination to cancer cells. Recent res...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186515

    authors： Kurmyshkina O,Kovchur P,Schegoleva L,Volkova T

    更新日期：2020-09-06 00:00:00

  • Synthesis and properties of poly(L-lactide)-b-poly (L-phenylalanine) hybrid copolymers.

    abstract：:Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(l-lactide-b-l-phenylalanine) copolymers with various...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms150813247

    authors： Planellas M,Puiggalí J

    更新日期：2014-07-29 00:00:00

  • Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy.

    abstract：:A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable batho...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms15058091

    authors： Cui BC,Yoon I,Li JZ,Lee WK,Shim YK

    更新日期：2014-05-08 00:00:00

  • Association between toll-like receptor 4 expression and neural stem cell proliferation in the hippocampus following traumatic brain injury in mice.

    abstract：:Whether or how neural stem cells (NSCs) respond to toll-like receptor 4 (TLR4) in an inflammatory environment caused by traumatic brain injury (TBI) has not been understood. In the present study, association between TLR4 expression and NSCs proliferation in the hippocampus was investigated in a mouse model of TBI usin...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms150712651

    authors： Ye Y,Xu H,Zhang X,Li Z,Jia Y,He X,Huang JH

    更新日期：2014-07-17 00:00:00