当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis.

Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis.

Abstract：

:Tauroursodeoxycholic acid (TUDCA) is a US FDA-approved hydrophilic bile acid for the treatment of chronic cholestatic liver disease. In the present study, we investigate the effects of TUDCA on the proliferation and differentiation of osteoblasts and its therapeutic effect on a mice model of osteoporosis. Following treatment with different concentrations of TUDCA, cell viability, differentiation, and mineralization were measured. Three-month-old female C57BL/6 mice were randomly divided into three groups (n = 8 mice per group): (i) normal mice as the control group, (ii) ovariectomy (OVX) group (receiving phosphate-buffered saline (PBS) treatment every other day for 4 weeks), and (iii) OVX group with TUDCA (receiving TUDCA treatment every other day for 4 weeks starting 6 weeks after OVX). At 11 weeks post-surgery, serum levels of procollagen type I N-terminal propeptides (PINP) and type I collagen crosslinked C-telopeptides (CTX) were measured, and all mice were sacrificed to examine the distal femur by micro-computed tomography (CT) scans and histology. TUDCA (100 nM, 1 µM) significantly increased the proliferation and viability of osteoblasts and osteoblast differentiation and mineralization when used in vitro. Furthermore, TUDCA neutralized the detrimental effects of methylprednisolone (methylprednisolone-induced osteoblast apoptosis). In the TUDCA treatment group the PINP level was higher and the CTX level was lower, but these levels were not significantly different compared to the PBS treatment group. Micro-CT and histology showed that the TUDCA treatment group preserved more trabecular structures in the distal femur compared to the PBS treatment group. In addition, the TUDCA treatment group increased the percentage bone volume with respect to the total bone volume, bone mineral density, and mice distal femur trabeculae compared with the PBS treatment group. Taken together, our findings suggest that TUDCA may provide a favorable effect on bones and could be used for the prevention and treatment of osteoporosis.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Ahn TK,Kim KT,Joshi HP,Park KH,Kyung JW,Choi UY,Sohn S,Sheen SH,Shin DE,Lee SH,Han IB

doi

10.3390/ijms21124274

subject

Has Abstract

pub_date

2020-06-16 00:00:00

issue

12

issn

1422-0067

pii

ijms21124274

journal_volume

21

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • De Novo Sequencing and Analysis of the Safflower Transcriptome to Discover Putative Genes Associated with Safflor Yellow in Carthamus tinctorius L.

    abstract：:Safflower (Carthamus tinctorius L.), an important traditional Chinese medicine, is cultured widely for its pharmacological effects, but little is known regarding the genes related to the metabolic regulation of the safflower's yellow pigment. To investigate genes related to safflor yellow biosynthesis, 454 pyrosequenc...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms161025657

    authors： Liu X,Dong Y,Yao N,Zhang Y,Wang N,Cui X,Li X,Wang Y,Wang F,Yang J,Guan L,Du L,Li H,Li X

    更新日期：2015-10-26 00:00:00

  • Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia.

    abstract：:Kinase drug discovery represents an active area of therapeutic research, with previous pharmaceutical success improving patient outcomes across a wide variety of human diseases. In pancreatic ductal adenocarcinoma (PDAC), innovative pharmaceutical strategies such as kinase targeting have been unable to appreciably inc...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21228823

    authors： Creeden JF,Alganem K,Imami AS,Henkel ND,Brunicardi FC,Liu SH,Shukla R,Tomar T,Naji F,McCullumsmith RE

    更新日期：2020-11-21 00:00:00

  • Detection of Bacterial Pathogens from Broncho-Alveolar Lavage by Next-Generation Sequencing.

    abstract：:The applications of whole-metagenome shotgun sequencing (WMGS) in routine clinical analysis are still limited. A combination of a DNA extraction procedure, sequencing, and bioinformatics tools is essential for the removal of human DNA and for improving bacterial species identification in a timely manner. We tackled th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18092011

    authors： Leo S,Gaïa N,Ruppé E,Emonet S,Girard M,Lazarevic V,Schrenzel J

    更新日期：2017-09-20 00:00:00

  • DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.

    abstract：:DNA damage-regulated autophagy modulator protein 1 (DRAM1), a multi-pass membrane lysosomal protein, is reportedly a tumor protein p53 (TP53) target gene involved in autophagy. During cerebral ischemia/reperfusion (I/R) injury, DRAM1 protein expression is increased, and autophagy is activated. However, the functional ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms151019253

    authors： Yu M,Jiang Y,Feng Q,Ouyang Y,Gan J

    更新日期：2014-10-23 00:00:00

  • Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases.

    abstract：:The molecular pathology of diseases seen from the mitochondrial axis has become more complex with the progression of research. A variety of factors, including the failure of mitochondrial dynamics and quality control, have made it extremely difficult to narrow down drug discovery targets. We have identified MITOL (mit...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21113781

    authors： Shiiba I,Takeda K,Nagashima S,Yanagi S

    更新日期：2020-05-27 00:00:00

  • Beyond PSA: The Role of Prostate Health Index (phi).

    abstract：BACKGROUND:Widespread use of prostate specific antigen (PSA) in screening procedures allowed early identification of an increasing number of prostate cancers (PCas), mainly including indolent cancer. Availability of different therapeutic strategies which have a very different impact on the patient's quality of life sug...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21041184

    authors： Ferro M,De Cobelli O,Lucarelli G,Porreca A,Busetto GM,Cantiello F,Damiano R,Autorino R,Musi G,Vartolomei MD,Muto M,Terracciano D

    更新日期：2020-02-11 00:00:00

  • Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair.

    abstract：:Meniscal injuries, particularly in the avascular zone, have a low propensity for healing and are associated with the development of osteoarthritis. Current meniscal repair techniques are limited to specific tear types and have significant risk for failure. In previous work, we demonstrated the ability of meniscus-deri...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21010044

    authors： Lyons LP,Hidalgo Perea S,Weinberg JB,Wittstein JR,McNulty AL

    更新日期：2019-12-19 00:00:00

  • Expression of Sox2 and Oct4 and their clinical significance in human non-small-cell lung cancer.

    abstract：:Sox2 and Oct4 are transcription factors with the characteristics of regulating self-renewal and differentiation of embryonic stem cell. The aim of this study was to detect the expression of Sox2 and Oct4 and analyze their clinical significance in human non-small-cell lung cancer (NSCLC). Expression of Sox2 and Oct4 we...

    journal_title：International journal of molecular sciences

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.3390/ijms13067663

    authors： Li X,Wang J,Xu Z,Ahmad A,Li E,Wang Y,Qin S,Wang Q

    更新日期：2012-01-01 00:00:00

  • Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms.

    abstract：:Diabetes mellitus (DM) is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18092002

    authors： Heckler K,Kroll J

    更新日期：2017-09-19 00:00:00

  • Molecular and Hormonal Aspects of Drought-Triggered Flower Shedding in Yellow Lupine.

    abstract：:The drought is a crucial environmental factor that determines yielding of many crop species, e.g., Fabaceae, which are a source of valuable proteins for food and feed. Herein, we focused on the events accompanying drought-induced activation of flower abscission zone (AZ)-the structure responsible for flower detachment...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20153731

    authors： Wilmowicz E,Kućko A,Burchardt S,Przywieczerski T

    更新日期：2019-07-31 00:00:00

  • Fragments of gD Protein as Inhibitors of BTLA/HVEM Complex Formation-Design, Synthesis, and Cellular Studies.

    abstract：:One of the major current trends in cancer immunotherapy is the blockade of immune checkpoint proteins that negatively regulate the immune response. This has been achieved through antibodies blocking PD-1/PD-L1 and CTLA-4/CD80/CD86 interactions. Such antibodies have revolutionized oncological therapy and shown a new wa...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21228876

    authors： Kuncewicz K,Battin C,Sieradzan A,Karczyńska A,Orlikowska M,Wardowska A,Pikuła M,Steinberger P,Rodziewicz-Motowidło S,Spodzieja M

    更新日期：2020-11-23 00:00:00

  • Interstitial Flow Recapitulates Gemcitabine Chemoresistance in A 3D Microfluidic Pancreatic Ductal Adenocarcinoma Model by Induction of Multidrug Resistance Proteins.

    abstract：:Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers due to a high chemoresistance and poor vascularization, which results in an ineffective systemic therapy. PDAC is characterized by a high intratumoral pressure, which is not captured by current 2D and 3D in vitro models. Here, we demonstrated a ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184647

    authors： Kramer B,Haan L,Vermeer M,Olivier T,Hankemeier T,Vulto P,Joore J,Lanz HL

    更新日期：2019-09-19 00:00:00

  • Autocrine TGF-β in Cancer: Review of the Literature and Caveats in Experimental Analysis.

    abstract：:Autocrine signaling is defined as the production and secretion of an extracellular mediator by a cell followed by the binding of that mediator to receptors on the same cell to initiate signaling. Autocrine stimulation often operates in autocrine loops, a type of interaction, in which a cell produces a mediator, for wh...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms22020977

    authors： Ungefroren H

    更新日期：2021-01-19 00:00:00

  • Fluorescence Lifetime and Intensity of Thioflavin T as Reporters of Different Fibrillation Stages: Insights Obtained from Fluorescence Up-Conversion and Particle Size Distribution Measurements.

    abstract：:Thioflavin T (ThT) assay is extensively used for studying fibrillation kinetics in vitro. However, the differences in the time course of ThT fluorescence intensity and lifetime and other physical parameters of the system, such as particle size distribution, raise questions about the correct interpretation of the aggre...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21176169

    authors： Rovnyagina NR,Budylin GS,Vainer YG,Tikhonova TN,Vasin SL,Yakovlev AA,Kompanets VO,Chekalin SV,Priezzhev AV,Shirshin EA

    更新日期：2020-08-26 00:00:00

  • Neuroprotection by Neurotropin through Crosstalk of Neurotrophic and Innate Immune Receptors in PC12 Cells.

    abstract：:Infected or damaged tissues release multiple "alert" molecules such as alarmins and damage-associated molecular patterns (DAMPs) that are recognized by innate immune receptors, and induce tissue inflammation, regeneration, and repair. Recently, an extract from inflamed rabbit skin inoculated with vaccinia virus (Neuro...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186456

    authors： Fukuda Y,Nakajima K,Mutoh T

    更新日期：2020-09-04 00:00:00

  • Dynamics of Plant Metabolism during Cold Acclimation.

    abstract：:Plants have evolved strategies to tightly regulate metabolism during acclimation to a changing environment. Low temperature significantly constrains distribution, growth and yield of many temperate plant species. Exposing plants to low but non-freezing temperature induces a multigenic processes termed cold acclimation...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20215411

    authors： Fürtauer L,Weiszmann J,Weckwerth W,Nägele T

    更新日期：2019-10-30 00:00:00

  • Ovarian Cancer Immunotherapy: Turning up the Heat.

    abstract：:Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological malignancies. Despite surgery and chemotherapy, 5-years survival rates have improved only modestly over the past few decades remaining at 45% for advanced stages. Therefore, novel therapies are urgently needed. The presence of tumor-infi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20122927

    authors： Ghisoni E,Imbimbo M,Zimmermann S,Valabrega G

    更新日期：2019-06-15 00:00:00

  • Immune Checkpoint Inhibitors in Esophageal Cancers: are we Finally Finding the Right Path in the Mist?

    abstract：:Esophageal cancer remains a challenging disease due to limited treatment options and poor prognosis. In recent years, immune checkpoint inhibitors (ICI) have been proven to be safe and effective in the treatment of highly lethal malignancies, such as non-small cell lung cancer and melanoma. Recent clinical trials also...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21051658

    authors： Vivaldi C,Catanese S,Massa V,Pecora I,Salani F,Santi S,Lencioni M,Vasile E,Falcone A,Fornaro L

    更新日期：2020-02-28 00:00:00

  • Effect of Clotting Duration and Temperature on BDNF Measurement in Human Serum.

    abstract：:Brain-derived neurothrophic factor (BDNF) is a neurotrophin expressed in different tissues and cells, including neurons, endothelial cells, leukocytes, megakaryocytes and platelets. Modifications of BDNF in plasma and/or in serum are associated with neurodegenerative and psychiatric disorders, cardiovascular diseases,...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18091987

    authors： Amadio P,Sandrini L,Ieraci A,Tremoli E,Barbieri SS

    更新日期：2017-09-15 00:00:00

  • Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A1 and A2A Receptors.

    abstract：:Acute or chronic administration of guanosine (GUO) induces anxiolytic-like effects, for which the adenosine (ADO) system involvement has been postulated yet without a direct experimental evidence. Thus, we aimed to investigate whether adenosine receptors (ARs) are involved in the GUO-mediated anxiolytic-like effect, e...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21239281

    authors： Frinchi M,Verdi V,Plescia F,Ciruela F,Grillo M,Garozzo R,Condorelli DF,Di Iorio P,Caciagli F,Ciccarelli R,Belluardo N,Di Liberto V,Mudò G

    更新日期：2020-12-05 00:00:00

  • Comparative Proteomic Analysis of Wild-Type Physcomitrella Patens and an OPDA-Deficient Physcomitrella Patens Mutant with Disrupted PpAOS1 and PpAOS2 Genes after Wounding.

    abstract：:Wounding is a serious environmental stress in plants. Oxylipins such as jasmonic acid play an important role in defense against wounding. Mechanisms to adapt to wounding have been investigated in vascular plants; however, those mechanisms in nonvascular plants remain elusive. To examine the response to wounding in Phy...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041417

    authors： Luo W,Komatsu S,Abe T,Matsuura H,Takahashi K

    更新日期：2020-02-19 00:00:00

  • Identification of tillering node proteins differentially accumulated in barley recombinant inbred lines with different juvenile growth habits.

    abstract：:Barley (Hordeum vulgare L.) is an important cereal crop grown for both the feed and malting industries. The allelic dwarfing gene sdw1/denso has been used throughout the world to develop commercial barley varieties. Proteomic analysis offers a new approach to identify a broad spectrum of genes that are expressed in th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms130810410

    authors： Kuczyńska A,Kosmala A,Surma M,Adamski T

    更新日期：2012-01-01 00:00:00

  • Chiral Ionic Liquids: Structural Diversity, Properties and Applications in Selected Separation Techniques.

    abstract：:Ionic liquids (ILs) are chemical compounds composed of ions with melting points below 100 °C exhibiting a design feature. ILs are commonly used as the so-called green solvents, reagents or highly efficient catalysts in varied chemical processes. The huge application potential of ionic liquids (IL) justifies the growin...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21124253

    authors： Flieger J,Feder-Kubis J,Tatarczak-Michalewska M

    更新日期：2020-06-15 00:00:00

  • Anti-Epileptogenic Effects of Antiepileptic Drugs.

    abstract：:Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as o...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21072340

    authors： Miziak B,Konarzewska A,Ułamek-Kozioł M,Dudra-Jastrzębska M,Pluta R,Czuczwar SJ

    更新日期：2020-03-28 00:00:00

  • Myosin Binding Protein-C Forms Amyloid-Like Aggregates In Vitro.

    abstract：:This work investigated in vitro aggregation and amyloid properties of skeletal myosin binding protein-C (sMyBP-C) interacting in vivo with proteins of thick and thin filaments in the sarcomeric A-disc. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) found a rapid (5-10 min) formation of large...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020731

    authors： Bobyleva LG,Shumeyko SA,Yakupova EI,Surin AK,Galzitskaya OV,Kihara H,Timchenko AA,Timchenko MA,Penkov NV,Nikulin AD,Suvorina MY,Molochkov NV,Lobanov MY,Fadeev RS,Vikhlyantsev IM,Bobylev AG

    更新日期：2021-01-13 00:00:00

  • Bacterial growth kinetics under a novel flexible methacrylate dressing serving as a drug delivery vehicle for antiseptics.

    abstract：:A flexible methacrylate powder dressing (Altrazeal®) transforms into a wound contour conforming matrix once in contact with wound exudate. We hypothesised that it may also serve as a drug delivery vehicle for antiseptics. The antimicrobial efficacy and influence on bacterial growth kinetics in combination with three a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms140510582

    authors： Forstner C,Leitgeb J,Schuster R,Dosch V,Kramer A,Cutting KF,Leaper DJ,Assadian O

    更新日期：2013-05-21 00:00:00

  • Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity.

    abstract：:Human cytomegalovirus (HCMV) is an opportunistic pathogen causing disease mainly in immunocompromised patients or after congenital infection. HCMV infection of the respiratory tract leads to pneumonitis in the immunocompromised host, which is often associated with a bad clinical course. The related mouse cytomegalovir...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20163865

    authors： Fonseca Brito L,Brune W,Stahl FR

    更新日期：2019-08-08 00:00:00

  • Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats.

    abstract：:Windup, a progressive increase in spinal response to repetitive stimulations of nociceptive peripheral fibers, is a useful model to study central sensitization to pain. Windup is expressed by neurons in both the dorsal and ventral horn of the spinal cord. In juvenile rats, it has been demonstrated both in vivo and in ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20246146

    authors： Aby F,Bouali-Benazzouz R,Landry M,Fossat P

    更新日期：2019-12-05 00:00:00

  • Effect of Nanoencapsulated Vitamin B1 Derivative on Inhibition of Both Mycelial Growth and Spore Germination of Fusarium oxysporum f. sp. raphani.

    abstract：:Nanoencapsulation of thiamine dilauryl sulfate (TDS), a vitamin B1 derivative, was proved to effectively inhibit the spore germination of Fusarium oxysporum f. sp. raphani (F. oxysporum), as well as mycelial growth. The average diameter of nanoparticles was measured as 136 nm by being encapsulated with an edible encap...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14024283

    authors： Cho JS,Seo YC,Yim TB,Lee HY

    更新日期：2013-02-21 00:00:00

  • G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technology.

    abstract：:Studying multidimensional signaling of G protein-coupled receptors (GPCRs) in search of new and better treatments requires flexible, reliable and sensitive assays in high throughput screening (HTS) formats. Today, more than half of the detection techniques used in HTS are based on fluorescence, because of the high sen...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms15022554

    authors： Nørskov-Lauritsen L,Thomsen AR,Bräuner-Osborne H

    更新日期：2014-02-13 00:00:00