当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Spirulina maxima Extract Ameliorates Learning and Memory Impairments via Inhibiting GSK-3β Phosphorylation Induced by Intracerebroventricular Injection of Amyloid-β 1-42 in Mice.

Spirulina maxima Extract Ameliorates Learning and Memory Impairments via Inhibiting GSK-3β Phosphorylation Induced by Intracerebroventricular Injection of Amyloid-β 1-42 in Mice.

Abstract：

:Spirulina maxima, a microalga containing high levels of protein and many polyphenols, including chlorophyll a and C-phycocyanin, has antioxidant and anti-inflammatory therapeutic effects. However, the mechanisms where by Spirulina maxima ameliorates cognitive disorders induced by amyloid-β 1-42 (Aβ1-42) are not fully understood. In this study, we investigated whether a 70% ethanol extract of Spirulina maxima (SM70EE) ameliorated cognitive impairments induced by an intracerebroventricular injection of Aβ1-42 in mice. SM70EE increased the step-through latency time in the passive avoidance test and decreased the escape latency time in the Morris water maze test in Aβ1-42-injected mice. SM70EE reduced hippocampal Aβ1-42 levels and inhibited amyloid precursor protein processing-associated factors in Aβ1-42-injected mice. Additionally, acetylcholinesterase activity was suppressed by SM70EE in Aβ1-42-injected mice. Hippocampal glutathione levels were examined to determine the effects of SM70EE on oxidative stress in Aβ1-42-injected mice. SM70EE increased the levels of glutathione and its associated factors that were reduced in Aβ1-42-injected mice. SM70EE also promoted activation of the brain-derived neurotrophic factor/phosphatidylinositol-3 kinase/serine/threonine protein kinase signaling pathway and inhibited glycogen synthase kinase-3β phosphorylation. These findings suggested that SM70EE ameliorated Aβ1-42-induced cognitive impairments by inhibiting the increased phosphorylation of glycogen synthase kinase-3β caused by intracerebroventricular injection of Aβ1-42 in mice.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Koh EJ,Kim KJ,Song JH,Choi J,Lee HY,Kang DH,Heo HJ,Lee BY

doi

10.3390/ijms18112401

subject

Has Abstract

pub_date

2017-11-13 00:00:00

issue

11

issn

1422-0067

pii

ijms18112401

journal_volume

18

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model.

    abstract：:Axitinib is an orally available inhibitor of tyrosine kinases, with high specificity for vascular endothelial growth factor receptors (VEGFRs) 1, 2, and 3. It is approved for the treatment of advanced renal cell carcinoma and is in phase II clinical trials for recurrent glioblastoma (GBM). GBM is a brain tumor peculia...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041490

    authors： Merolle M,Mongiardi MP,Piras M,Levi A,Falchetti ML

    更新日期：2020-02-21 00:00:00

  • Mesotheliomas in Genetically Engineered Mice Unravel Mechanism of Mesothelial Carcinogenesis.

    abstract：:Malignant mesothelioma (MM), a rare and severe cancer, mainly caused as a result of past-asbestos exposure, is presently a public health concern. Current molecular studies aim to improve the outcome of the disease, providing efficient therapies based on the principles of precision medicine. To model the molecular prof...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19082191

    authors： Jean D,Jaurand MC

    更新日期：2018-07-27 00:00:00

  • Novel Allergen Discovery through Comprehensive De Novo Transcriptomic Analyses of Five Shrimp Species.

    abstract：:Shellfish allergy affects 2% of the world's population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfis...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010032

    authors： Karnaneedi S,Huerlimann R,Johnston EB,Nugraha R,Ruethers T,Taki AC,Kamath SD,Wade NM,Jerry DR,Lopata AL

    更新日期：2020-12-22 00:00:00

  • Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways.

    abstract：:Salidroside (Sal) is an active ingredient that is isolated from Rhodiola rosea, which has been reported to have anti-inflammatory activities and a renal protective effect. However, the role of Sal on renal fibrosis has not yet been elucidated. Here, the purpose of the current study is to test the protective effects of...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20051103

    authors： Li R,Guo Y,Zhang Y,Zhang X,Zhu L,Yan T

    更新日期：2019-03-04 00:00:00

  • Transcriptome Analysis Reveals the Mechanism of Fluoride Treatment Affecting Biochemical Components in Camellia sinensis.

    abstract：:Tea (Camellia sinensis (L.) O. Kuntze), one of the main crops in China, is high in various bioactive compounds including flavonoids, catechins, caffeine, theanine, and other amino acids. C. sinensis is also known as an accumulator of fluoride (F), and the bioactive compounds are affected by F, however, the mechanism r...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20020237

    authors： Zhu J,Pan J,Nong S,Ma Y,Xing A,Zhu X,Wen B,Fang W,Wang Y

    更新日期：2019-01-09 00:00:00

  • Alpha-Synuclein RNA Expression is Increased in Major Depression.

    abstract：:Alpha-synuclein (SNCA) is a small membrane protein that plays an important role in neuro-psychiatric diseases. It is best known for its abnormal subcellular aggregation in Lewy bodies that serves as a hallmark of Parkinson's disease (PD). Due to the high comorbidity of PD with depression, we investigated the role of S...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20082029

    authors： Rotter A,Lenz B,Pitsch R,Richter-Schmidinger T,Kornhuber J,Rhein C

    更新日期：2019-04-25 00:00:00

  • Synthesis of 8-Aryl-O-methylcyanidins and Their Usage for Dye-Sensitized Solar Cell Devices.

    abstract：:Anthocyanins as natural pigments are colorful and environmentally compatible dyes for dye-sensitized solar cells (DSSCs). To increase the efficiency, we designed and synthesized unnatural O-methylflavonols and O-methylcyanidins that possess an aryl group at the 8-position. We synthesized per-O-methylquercetin from que...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18020427

    authors： Kimura Y,Oyama KI,Murata Y,Wakamiya A,Yoshida K

    更新日期：2017-02-16 00:00:00

  • Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection.

    abstract：:Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus. It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investiga...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21176245

    authors： Diot A,Dyon-Tafani V,Bergot M,Tasse J,Martins-Simões P,Josse J,Valour F,Laurent F

    更新日期：2020-08-28 00:00:00

  • LHCSR Expression under HSP70/RBCS2 Promoter as a Strategy to Increase Productivity in Microalgae.

    abstract：:Microalgae are unicellular photosynthetic organisms considered as potential alternative sources for biomass, biofuels or high value products. However, limited biomass productivity is commonly experienced in their cultivating system despite their high potential. One of the reasons for this limitation is the high therma...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19010155

    authors： Perozeni F,Stella GR,Ballottari M

    更新日期：2018-01-05 00:00:00

  • Optimization of a WGA-Free Molecular Tagging-Based NGS Protocol for CTCs Mutational Profiling.

    abstract：:Molecular characterization of Circulating Tumor Cells (CTCs) is still challenging, despite attempts to minimize the drawbacks of Whole Genome Amplification (WGA). In this paper, we propose a Next-Generation Sequencing (NGS) optimized protocol based on molecular tagging technology, in order to detect CTCs mutations whi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21124364

    authors： De Luca G,Cardinali B,Del Mastro L,Lastraioli S,Carli F,Ferrarini M,Calin GA,Garuti A,Mazzitelli C,Zupo S,Dono M

    更新日期：2020-06-19 00:00:00

  • Conversion of Isocyanide to Amine in The Presence of Water and Hg(II) Ions: Kinetics and Mechanism as Detected by Fluorescence Spectroscopy and Mass Spectrometry.

    abstract：:Aromatic isocyanides including isocyanonaphthalene derivatives have been proven to be very effective fluorescent sensors for the quantification of Hg(II) ions in water. Thus, the reaction of 1,5-isocyanoaminonaphthalene (1,5-ICAN), which is one of the most important members of this family, with water and HgCl2 as the ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21155588

    authors： Adamoczky A,Nagy L,Nagy M,Zsuga M,Kéki S

    更新日期：2020-08-04 00:00:00

  • Impact of serum chemerin levels on liver functional reserves and platelet counts in patients with hepatocellular carcinoma.

    abstract：:Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver functional reserves i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms150711294

    authors： Imai K,Takai K,Hanai T,Shiraki M,Suzuki Y,Hayashi H,Naiki T,Nishigaki Y,Tomita E,Shimizu M,Moriwaki H

    更新日期：2014-06-25 00:00:00

  • Bioactive Phytochemicals from Wild Arbutus unedo L. Berries from Different Locations in Portugal: Quantification of Lipophilic Components.

    abstract：:The lipophilic composition of wild Arbutus unedo L. berries, collected from six locations in Penacova (center of Portugal), as well as some general chemical parameters, namely total soluble solids, pH, titratable acidity, total phenolic content and antioxidant activity was studied in detail to better understand its po...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160614194

    authors： Fonseca DF,Salvador ÂC,Santos SA,Vilela C,Freire CS,Silvestre AJ,Rocha SM

    更新日期：2015-06-23 00:00:00

  • Intrathecal Injection in A Rat Model: A Potential Route to Deliver Human Wharton's Jelly-Derived Mesenchymal Stem Cells into the Brain.

    abstract：:Mesenchymal stem cells (MSCs) are considered as promising therapeutic agents for neurodegenerative disorders because they can reduce underlying pathology and also repair damaged tissues. Regarding the delivery of MSCs into the brain, intravenous and intra-arterial routes may be less feasible than intraparenchymal and ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041272

    authors： Kim H,Na DL,Lee NK,Kim AR,Lee S,Jang H

    更新日期：2020-02-13 00:00:00

  • Variations in Physiology and Multiple Bioactive Constituents under Salt Stress Provide Insight into the Quality Evaluation of Apocyni Veneti Folium.

    abstract：:As one of the major abiotic stresses, salinity stress may affect the physiology and biochemical components of Apocynum venetum L. To systematically evaluate the quality of Apocyni Veneti Folium (AVF) from the perspective of physiological and the wide variety of bioactive components response to various concentrations o...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19103042

    authors： Chen C,Wang C,Liu Z,Liu X,Zou L,Shi J,Chen S,Chen J,Tan M

    更新日期：2018-10-05 00:00:00

  • Calcium ions regulate K⁺ uptake into brain mitochondria: the evidence for a novel potassium channel.

    abstract：:The mitochondrial response to changes of cytosolic calcium concentration has a strong impact on neuronal cell metabolism and viability. We observed that Ca(2+) additions to isolated rat brain mitochondria induced in potassium ion containing media a mitochondrial membrane potential depolarization and an accompanying in...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms10031104

    authors： Skalska J,Bednarczyk P,Piwońska M,Kulawiak B,Wilczynski G,Dołowy K,Kudin AP,Kunz WS,Szewczyk A

    更新日期：2009-03-01 00:00:00

  • Insight in Adhesion Protein Sialylation and Microgravity Dependent Cell Adhesion-An Omics Network Approach.

    abstract：:The adhesion behavior of human tissue cells changes in vitro, when gravity forces affecting these cells are modified. To understand the mechanisms underlying these changes, proteins involved in cell-cell or cell-extracellular matrix adhesion, their expression, accumulation, localization, and posttranslational modifica...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051749

    authors： Bauer TJ,Gombocz E,Wehland M,Bauer J,Infanger M,Grimm D

    更新日期：2020-03-04 00:00:00

  • De Novo Assembly, Annotation, and Characterization of Root Transcriptomes of Three Caladium Cultivars with a Focus on Necrotrophic Pathogen Resistance/Defense-Related Genes.

    abstract：:Roots are vital to plant survival and crop yield, yet few efforts have been made to characterize the expressed genes in the roots of non-model plants (root transcriptomes). This study was conducted to sequence, assemble, annotate, and characterize the root transcriptomes of three caladium cultivars (Caladium × hortula...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18040712

    authors： Cao Z,Deng Z

    更新日期：2017-03-27 00:00:00

  • Dietary polyphenols in prevention and treatment of prostate cancer.

    abstract：:Prostate cancer is the most prevalent disease affecting males in many Western countries, with an estimated 29,480 deaths in 2014 in the US alone. Incidence rates for prostate cancer deaths have been decreasing since the early 1990s in men of all races/ethnicities, though they remain about 60% higher in African America...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms16023350

    authors： Lall RK,Syed DN,Adhami VM,Khan MI,Mukhtar H

    更新日期：2015-02-03 00:00:00

  • Toxic Effects of the Major Components of Diesel Exhaust in Human Alveolar Basal Epithelial Cells (A549).

    abstract：:We investigated the toxicity of benzo[a]pyrene (B[a]P), 1-nitropyrene (1-NP) and 3-nitrobenzanthrone (3-NBA) in A549 cells. Cells were treated for 4 h and 24 h with: B[a]P (0.1 and 1 μM), 1-NP (1 and 10 μM) and 3-NBA (0.5 and 5 μM). Bulky DNA adducts, lipid peroxidation, DNA and protein oxidation and mRNA expression o...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17091393

    authors： Rossner P,Strapacova S,Stolcpartova J,Schmuczerova J,Milcova A,Neca J,Vlkova V,Brzicova T,Machala M,Topinka J

    更新日期：2016-08-26 00:00:00

  • Polysaccharides from the Edible Mushroom Agaricus bitorquis (Quél.) Sacc. Chaidam Show Anti-hypoxia Activities in Pulmonary Artery Smooth Muscle Cells.

    abstract：:Three kinds of new water-soluble polysaccharides (FA, FB and FC) were isolated from wild mushroom Agaricus bitorquis (Quél.) Sacc. Chaidam by the classical method "water extraction and alcohol precipitation" and purified by column chromatography. The Mw of FA, FB and FC ranged from 5690 Da to 38,340 Da. The three poly...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20030637

    authors： Jiao Y,Kuang H,Wu J,Chen Q

    更新日期：2019-02-01 00:00:00

  • Effects of OsCDPK1 on the Structure and Physicochemical Properties of Starch in Developing Rice Seeds.

    abstract：:Overexpression of a constitutively active truncated form of OsCDPK1 (OEtr) in rice produced smaller seeds, but a double-stranded RNA gene-silenced form of OsCDPK1 (Ri) yielded larger seeds, suggesting that OsCDPK1 plays a functional role in rice seed development. In the study presented here, we propose a model in whic...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19103247

    authors： Jiang JZ,Kuo CH,Chen BH,Chen MK,Lin CS,Ho SL

    更新日期：2018-10-19 00:00:00

  • Ca2+/Calmodulin-Dependent AtSR1/CAMTA3 Plays Critical Roles in Balancing Plant Growth and Immunity.

    abstract：:During plant-pathogen interactions, plants have to relocate their resources including energy to defend invading organisms; as a result, plant growth and development are usually reduced. Arabidopsis signal responsive1 (AtSR1) has been documented as a negative regulator of plant immune responses and could serve as a pos...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19061764

    authors： Yuan P,Du L,Poovaiah BW

    更新日期：2018-06-14 00:00:00

  • Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors.

    abstract：:The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence. Therefore, ClpP is considered as a potential drug target in Gram-positive and Gram-negative bacteria. In this study, we utiliz...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20112686

    authors： Sassetti E,Durante Cruz C,Tammela P,Winterhalter M,Augustyns K,Gribbon P,Windshügel B

    更新日期：2019-05-31 00:00:00

  • Development of 101 gene-based single nucleotide polymorphism markers in sea cucumber, Apostichopus japonicus.

    abstract：:Single nucleotide polymorphisms (SNPs) are currently the marker of choice in a variety of genetic studies. Using the high resolution melting (HRM) genotyping approach, 101 gene-based SNP markers were developed for Apostichopus japonicus, a sea cucumber species with economic significance for the aquaculture industry in...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13067080

    authors： Du H,Bao Z,Yan J,Tian M,Mu X,Wang S,Lu W

    更新日期：2012-01-01 00:00:00

  • Polyvinyl Butyral (PVB) Nanofiber/Nanoparticle-Covered Yarns for Antibacterial Textile Surfaces.

    abstract：:In this study, nanoparticle-incorporated nanofiber-covered yarns were prepared using a custom-made needle-free electrospinning system. The ultimate goal of this work was to prepare functional nanofibrous surfaces with antibacterial properties and realize high-speed production. As antibacterial agents, we used various ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20174317

    authors： Yalcinkaya F,Komarek M

    更新日期：2019-09-03 00:00:00

  • MiRNAs in the Peri-Implantation Period: Contribution to Embryo-Maternal Communication in Pigs.

    abstract：:MicroRNAs (miRNAs) constitute a large family of noncoding RNAs, approximately 22 nucleotides long, which function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathophysiological processes in animals. To date, the regulatory roles of...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21062229

    authors： Kaczmarek MM,Najmula J,Guzewska MM,Przygrodzka E

    更新日期：2020-03-23 00:00:00

  • Polymer Stabilized Cholesteric Liquid Crystal Siloxane for Temperature-Responsive Photonic Coatings.

    abstract：:Temperature-responsive photonic coatings are appealing for a variety of applications, including smart windows. However, the fabrication of such reflective polymer coatings remains a challenge. In this work, we report the development of a temperature-responsive, infrared-reflective coating consisting of a polymer-stabi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051803

    authors： Zhang W,Lub J,Schenning APHJ,Zhou G,de Haan LT

    更新日期：2020-03-06 00:00:00

  • Special Issue of International Journal of Molecular Sciences (IJMS) "Purinergic P2 Receptors: Structure and Function".

    abstract：:This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 receptors[...]. ...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms22010383

    authors： Zemkova H

    更新日期：2020-12-31 00:00:00

  • Targeted Therapy in Melanoma and Mechanisms of Resistance.

    abstract：:The common mutation BRAFV600 in primary melanomas activates the mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway and the introduction of proto-oncogene B-Raf (BRAF) and mitogen-activated protein kinase kinase (MEK) inhibitors (BRAFi and MEKi) was a breakthrough in the treatment...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21134576

    authors： Czarnecka AM,Bartnik E,Fiedorowicz M,Rutkowski P

    更新日期：2020-06-27 00:00:00