Abstract：
:Single nucleotide polymorphisms (SNPs) are currently the marker of choice in a variety of genetic studies. Using the high resolution melting (HRM) genotyping approach, 101 gene-based SNP markers were developed for Apostichopus japonicus, a sea cucumber species with economic significance for the aquaculture industry in East Asian countries. HRM analysis revealed that all the loci showed polymorphisms when evaluated using 40 A. japonicus individuals collected from a natural population. The minor allele frequency ranged from 0.035 to 0.489. The observed and expected heterozygosities ranged from 0.050 to 0.833 and 0.073 to 0.907, respectively. Thirteen loci were found to depart significantly from Hardy-Weinberg equilibrium (HWE) after Bonferroni corrections. Significant linkage disequilibrium (LD) was detected in one pair of markers. These SNP markers are expected to be useful for future quantitative trait loci (QTL) analysis, and to facilitate marker-assisted selection (MAS) in A. japonicus.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Du H,Bao Z,Yan J,Tian M,Mu X,Wang S,Lu Wdoi
10.3390/ijms13067080subject
Has Abstractpub_date
2012-01-01 00:00:00pages
7080-97issue
6issn
1422-0067pii
ijms-13-07080journal_volume
13pub_type
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