Current Biomedical Use of Copper Chelation Therapy.


:Copper is an essential microelement that plays an important role in a wide variety of biological processes. Copper concentration has to be finely regulated, as any imbalance in its homeostasis can induce abnormalities. In particular, excess copper plays an important role in the etiopathogenesis of the genetic disease Wilson's syndrome, in neurological and neurodegenerative pathologies such as Alzheimer's and Parkinson's diseases, in idiopathic pulmonary fibrosis, in diabetes, and in several forms of cancer. Copper chelating agents are among the most promising tools to keep copper concentration at physiological levels. In this review, we focus on the most relevant compounds experimentally and clinically evaluated for their ability to counteract copper homeostasis deregulation. In particular, we provide a general overview of the main disorders characterized by a pathological increase in copper levels, summarizing the principal copper chelating therapies adopted in clinical trials.


Int J Mol Sci


Baldari S,Di Rocco G,Toietta G




Has Abstract


2020-02-06 00:00:00










  • Naturally Prefabricated Marine Biomaterials: Isolation and Applications of Flat Chitinous 3D Scaffolds from Ianthella labyrinthus (Demospongiae: Verongiida).

    abstract::Marine sponges remain representative of a unique source of renewable biological materials. The demosponges of the family Ianthellidae possess chitin-based skeletons with high biomimetic potential. These three-dimensional (3D) constructs can potentially be used in tissue engineering and regenerative medicine. In this s...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Schubert M,Binnewerg B,Voronkina A,Muzychka L,Wysokowski M,Petrenko I,Kovalchuk V,Tsurkan M,Martinovic R,Bechmann N,Ivanenko VN,Fursov A,Smolii OB,Fromont J,Joseph Y,Bornstein SR,Giovine M,Erpenbeck D,Guan K,Ehrlich

    更新日期:2019-10-15 00:00:00

  • Effect of PHRs and PCPs on Microalgal Growth, Metabolism and Microalgae-Based Bioremediation Processes: A Review.

    abstract::In this review, the effect of pharmaceuticals (PHRs) and personal care products (PCPs) on microalgal growth and metabolism is reported. Concentrations of various PHRs and PCPs that cause inhibition and toxicity to growths of different microalgal strains are summarized and compared. The effect of PHRs and PCPs on micro...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Miazek K,Brozek-Pluska B

    更新日期:2019-05-20 00:00:00

  • Brassinosteroid Signaling in Plant⁻Microbe Interactions.

    abstract::As sessile organisms, plants are frequently exposed to different stress conditions caused by either biotic or abiotic factors. Understanding the mechanisms that underlie plant interaction with the biotic and abiotic environments is fundamental to both plant biotechnology and sustainable agriculture. Brassinosteroids (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Yu MH,Zhao ZZ,He JX

    更新日期:2018-12-17 00:00:00

  • Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells.

    abstract::Breast cancer is a common malignancy threatening women's health around the world. Despite improved treatments for different subtypes of breast tumors that have been put forward, there still exists a poor therapeutic response and prognosis. Magnetic fields, as a non-invasive therapy, have shown anti-tumor effects in vi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Xu A,Wang Q,Lin T

    更新日期:2020-04-22 00:00:00

  • Ruthenium(III) Complexes of Heterocyclic Tridentate (ONN) Schiff Base: Synthesis, Characterization and its Biological Properties as an Antiradical and Antiproliferative Agent.

    abstract::The current work reports the synthesis, spectroscopic studies, antiradical and antiproliferative properties of four ruthenium(III) complexes of heterocyclic tridentate Schiff base bearing a simple 2',4'-dihydroxyacetophenone functionality and ethylenediamine as the bridging ligand with RCHO moiety. The reaction of the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ejidike IP,Ajibade PA

    更新日期:2016-01-04 00:00:00

  • The Role of miRNAs in Virus-Mediated Oncogenesis.

    abstract::To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Vojtechova Z,Tachezy R

    更新日期:2018-04-17 00:00:00

  • Activity of laccase immobilized on TiO2-montmorillonite complexes.

    abstract::The TiO2-montmorillonite (TiO2-MMT) complex was prepared by blending TiO2 sol and MMT with certain ratio, and its properties as an enzyme immobilization support were investigated. The pristine MMT and TiO2-MMT calcined at 800 °C (TiO2-MMT800) were used for comparison to better understand the immobilization mechanism. ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang Q,Peng L,Li G,Zhang P,Li D,Huang F,Wei Q

    更新日期:2013-06-14 00:00:00

  • Chromosome Missegregation in Single Human Oocytes Is Related to the Age and Gene Expression Profile.

    abstract::The growing trend for women to postpone childbearing has resulted in a dramatic increase in the incidence of aneuploid pregnancies. Despite the importance to human reproductive health, the events precipitating female age-related meiotic errors are poorly understood. To gain new insight into the molecular basis of age-...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Barone S,Sarogni P,Valli R,Pallotta MM,Silvia G,Frattini A,Khan AW,Rapalini E,Parri C,Musio A

    更新日期:2020-03-12 00:00:00

  • Neonatal HDL Counteracts Placental Vascular Inflammation via S1P-S1PR1 Axis.

    abstract::Placental inflammation and dysfunction during pregnancy are associated with short- and long-term adverse outcomes for the offspring. However, the mechanisms of vascular protection at the feto-placental interface are still poorly investigated. The high-density lipoprotein (HDL) associated sphingosine-1-phosphate (S1P) ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Del Gaudio I,Hendrix S,Christoffersen C,Wadsack C

    更新日期:2020-01-25 00:00:00

  • In Search for the Membrane Regulators of Archaea.

    abstract::Membrane regulators such as sterols and hopanoids play a major role in the physiological and physicochemical adaptation of the different plasmic membranes in Eukarya and Bacteria. They are key to the functionalization and the spatialization of the membrane, and therefore indispensable for the cell cycle. No archaeon h...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Salvador-Castell M,Tourte M,Oger PM

    更新日期:2019-09-09 00:00:00

  • Suppression of Brown Adipocyte Autophagy Improves Energy Metabolism by Regulating Mitochondrial Turnover.

    abstract::The high abundance of mitochondria and the expression of mitochondrial uncoupling protein 1 (UCP1) confer upon brown adipose tissue (BAT) the unique capacity to convert chemical energy into heat at the expense of ATP synthesis. It was long believed that BAT is present only in infants, and so, it was not considered as ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kim D,Kim JH,Kang YH,Kim JS,Yun SC,Kang SW,Song Y

    更新日期:2019-07-18 00:00:00

  • Mitochondrial Dysfunction Mediated by Poly(ADP-Ribose) Polymerase-1 Activation Contributes to Hippocampal Neuronal Damage Following Status Epilepticus.

    abstract::Mitochondrial dysfunction plays a central role in the neuropathology associated with status epilepticus (SE) and is implicated in the development of epilepsy. While excitotoxic mechanisms are well-known mediators affecting mitochondrial health following SE, whether hyperactivation of poly(ADP-ribose) polymerase-1 (PAR...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lai YC,Baker JS,Donti T,Graham BH,Craigen WJ,Anderson AE

    更新日期:2017-07-12 00:00:00

  • Genetic Analysis for Fruit Phenolics Content, Flesh Color, and Browning Related Traits in Eggplant (Solanum melongena).

    abstract::Eggplant varieties rich in bioactive chlorogenic acid along with less browning are preferred by consumers. Therefore, genetics of fruit phenolics, fruit flesh colour, and browning related traits were studied in the genotypes of eggplant, comprising of nine cultivated varieties and one accession of eggplant's primary g...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kaushik P

    更新日期:2019-06-19 00:00:00

  • The miRacle in Pancreatic Cancer by miRNAs: Tiny Angels or Devils in Disease Progression.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with increasing incidence and high mortality. Surgical resection is the only potentially curative treatment of patients with PDAC. Because of the late presentation of the disease, about 20 percent of patients are candidates for this treatment. The ave...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Hawa Z,Haque I,Ghosh A,Banerjee S,Harris L,Banerjee SK

    更新日期:2016-05-26 00:00:00

  • TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly.

    abstract::Yeast proteins Ntr1, Ntr2 and Prp43 function in spliceosome disassembly. An Ntr1-Ntr2 protein complex recruits Prp43 to allow the removal of the lariat-intron in late-stage RNA splicing activity. Based on amino-acid sequence similarities across species, TFIP11 and mDEAH9/Dhx15 have been identified as homologues of yea...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wen X,Tannukit S,Paine ML

    更新日期:2008-11-01 00:00:00

  • Biofunctional constituents from Liriodendron tulipifera with antioxidants and anti-melanogenic properties.

    abstract::From the stems of Liriodendron tulipifera, seventeen known compounds have been extracted, isolated and purified. By using spectroscopic analysis, the structures of these pure constituents were determined as three lignans, four steroids and ten benzenoids. Identified compounds were screened for antioxidant abilities u...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Li WJ,Lin YC,Wu PF,Wen ZH,Liu PL,Chen CY,Wang HM

    更新日期:2013-01-15 00:00:00

  • Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities.

    abstract::Right ventricular failure (RVF) remains the leading cause of death in pulmonary arterial hypertension (PAH). We investigated the transcriptomic signature of RVF in hemodynamically well-phenotyped monocrotaline (MCT)-treated, male, Sprague-Dawley rats with severe PAH and decompensated RVF (increased right ventricular (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Potus F,Hindmarch CCT,Dunham-Snary KJ,Stafford J,Archer SL

    更新日期:2018-09-12 00:00:00

  • Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers.

    abstract::Immunomodulation is increasingly being recognised as a part of mental diseases. Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). An analysis of plasma samples from patients with a major depressive episode ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bhandage AK,Cunningham JL,Jin Z,Shen Q,Bongiovanni S,Korol SV,Syk M,Kamali-Moghaddam M,Ekselius L,Birnir B

    更新日期:2019-12-06 00:00:00

  • Comparative Transcriptome Analysis Provides Novel Insight into Morphologic and Metabolic Changes in the Fat Body during Silkworm Metamorphosis.

    abstract::The fat body plays key roles in energy storage and utilization as well as biosynthetic and metabolic activities in insects. During metamorphosis from larva to pupa, the fat body undergoes dramatic changes in morphology and metabolic processes. However, the genetic basis underlying these changes has not been completely...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Peng J,Li Z,Yang Y,Wang P,Zhou X,Zhao T,Guo M,Meng M,Zhang T,Qian W,Xia Q,Cheng D,Zhao P

    更新日期:2018-11-09 00:00:00

  • The Origin of Skin Dendritic Cell Network and Its Role in Psoriasis.

    abstract::Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DC...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Kim TG,Kim SH,Lee MG

    更新日期:2017-12-23 00:00:00

  • Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes.

    abstract::The spleen plays an important role in coordinating both adaptive and innate immune responses. Here, the transcriptional response to T. gondii infection in the murine spleen was characterized concerning inflammasome sensors (two different models: seven days after oral or four weeks after intraperitoneal infection). Add...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Znalesniak EB,Fu T,Salm F,Händel U,Hoffmann W

    更新日期:2017-06-10 00:00:00

  • Proteomic analysis of embryogenesis and the acquisition of seed dormancy in Norway maple (Acer platanoides L.).

    abstract::The proteome of zygotic embryos of Acer platanoides L. was analyzed via high-resolution 2D-SDS-PAGE and MS/MS in order to: (1) identify significant physiological processes associated with embryo development; and (2) identify changes in the proteome of the embryo associated with the acquisition of seed dormancy. Sevent...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Staszak AM,Pawłowski TA

    更新日期:2014-06-17 00:00:00

  • BRAF Controls the Effects of Metformin on Neuroblast Cell Divisions in C. elegans.

    abstract::Metformin has demonstrated substantial potential for use in cancer treatments. Liver kinase B (LKB)-AMP-activated protein kinase (AMPK) and mTOR are reported to be the main targets of metformin in relation to its ability to prevent cancer cell proliferation. However, the role of metformin in the control of neoplastic ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Qu Z,Ji S,Zheng S

    更新日期:2020-12-26 00:00:00

  • MiRNA-Target Interaction Reveals Cell-Specific Post-Transcriptional Regulation in Mammalian Cell Lines.

    abstract::MicroRNAs are 18-22 nucleotides long, non-coding RNAs that bind transcripts with complementary sequences leading to either mRNA degradation or translational suppression. However, the inherent differences in preferred mode of miRNA regulation among cells of different origin have not been examined. In our previous trans...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kulkarni V,Naqvi AR,Uttamani JR,Nares S

    更新日期:2016-01-08 00:00:00

  • In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein Extracts.

    abstract::Bovine immunoglobulin G (bIgG) was previously shown to enhance innate immune responses to toll-like receptor (TLR) stimulation, via induction of trained immunity. In this study, we investigated whether minimally processed dairy streams with high levels of whey proteins as potential infant nutrition ingredients could a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hellinga AH,Tsallis T,Eshuis T,Triantis V,Ulfman LH,Neerven RJJV

    更新日期:2020-11-28 00:00:00

  • New Cav1.2 Channelopathy with High-Functioning Autism, Affective Disorder, Severe Dental Enamel Defects, a Short QT Interval, and a Novel CACNA1C Loss-Of-Function Mutation.

    abstract::Complex neuropsychiatric-cardiac syndromes can be genetically determined. For the first time, the authors present a syndromal form of short QT syndrome in a 34-year-old German male patient with extracardiac features with predominant psychiatric manifestation, namely a severe form of secondary high-functioning autism s...

    journal_title:International journal of molecular sciences



    authors: Endres D,Decher N,Röhr I,Vowinkel K,Domschke K,Komlosi K,Tzschach A,Gläser B,Schiele MA,Runge K,Süß P,Schuchardt F,Nickel K,Stallmeyer B,Rinné S,Schulze-Bahr E,Tebartz van Elst L

    更新日期:2020-11-15 00:00:00

  • Signalling Pathways Implicated in Alzheimer's Disease Neurodegeneration in Individuals with and without Down Syndrome.

    abstract::Down syndrome (DS), the most common cause of intellectual disability of genetic origin, is characterized by alterations in central nervous system morphology and function that appear from early prenatal stages. However, by the fourth decade of life, all individuals with DS develop neuropathology identical to that found...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Martínez-Cué C,Rueda N

    更新日期:2020-09-20 00:00:00

  • 1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione Induces G1 Cell Cycle Arrest and Autophagy in HeLa Cervical Cancer Cells.

    abstract::The natural agent, 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione (HMDB), has been reported to have growth inhibitory effects on several human cancer cells. However, the role of HMDB in cervical cancer remains unclear. Herein, we found that HMDB dose- and time-dependently inhibited growth of HeLa cervical canc...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Tsai JH,Hsu LS,Huang HC,Lin CL,Pan MH,Hong HM,Chen WJ

    更新日期:2016-08-05 00:00:00

  • Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients.

    abstract::We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression. This study investigates if specific AR phosphorylation sites have differing roles in the progression of hormone naïve prostate cancer (HNPC) to castrate resis...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: McCall P,Adams CE,Willder JM,Bennett L,Qayyum T,Orange C,Underwood MA,Edwards J

    更新日期:2013-08-13 00:00:00

  • Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice.

    abstract::Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks. After two weeks of HE administration, all mice...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chiu CH,Chyau CC,Chen CC,Lee LY,Chen WP,Liu JL,Lin WH,Mong MC

    更新日期:2018-01-24 00:00:00