Abstract：
:Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a multimodal approach that leverages publicly available independent genome-wide expression datasets. CSMD1-related genes were found and analyzed to examine the clinical significance of CSMD1 inactivation in the HNSCC cohort of publicly available databases. We analyzed the frequency of somatic mutations, clinicopathologic characteristics, association with immunotherapy-related gene signatures, and the pathways of gene signatures. We found 363 CSMD1-related genes. The prognosis of the CSMD1-inactivated subgroup was poor. FBXW7, HLA-A, MED1, NOTCH2, NOTCH3, and TP53 had higher mutation rates in the CSMD1-inactivated subgroups. The Interferon-gamma score and immune signature score were elevated in CSMD1-inactivated subgroups. We identified several CSMD1-related pathways, such as the phosphatidylinositol signaling system and inositol phosphate metabolism. Our study using three large and independent datasets suggests that CSMD1-related gene signatures are associated with the prognosis of HNSCC patients.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Jung AR,Eun YG,Lee YC,Noh JK,Kwon KHdoi
10.3390/ijms19123996subject
Has Abstractpub_date
2018-12-12 00:00:00issue
12issn
1422-0067pii
ijms19123996journal_volume
19pub_type
杂志文章abstract：:Antimicrobial lipids such as fatty acids and monoglycerides are promising antibacterial agents that destabilize bacterial cell membranes, causing a wide range of direct and indirect inhibitory effects. The goal of this review is to introduce the latest experimental approaches for characterizing how antimicrobial lipid...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19041114
更新日期：2018-04-08 00:00:00
abstract：:Clipping of recombinant proteins is a major issue in animal cell cultures. A recombinant Fc-fusion protein, VEGFR1(D1-D3)-Fc expressed in CHOK1SV GS-KO cells was observed to be undergoing clippings in lab scale cultures. Partial cleaving of expressed protein initiated early on in cell culture and was observed to incre...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2013-11-01 00:00:00
abstract：:Acute myeloid leukemia (AML) is caused by malignant transformation of hematopoietic stem or progenitor cells and displays the most frequent acute leukemia in adults. Although some patients can be cured with high dose chemotherapy and allogeneic hematopoietic stem cell transplantation, the majority still succumbs to ch...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
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更新日期：2020-06-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-06-04 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-11-20 00:00:00
abstract：:Environmental issues pose huge threats to public health, particularly the damage caused by fine particulate matter (PM2.5). However, the mechanisms of injury require further investigation and medical materials that can protect the lungs from PM2.5 are needed. We have found that Colla corii asini, a traditional Chinese...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20010055
更新日期：2018-12-23 00:00:00
abstract：:An increased flux of potassium ions into the mitochondrial matrix through the ATP-sensitive potassium channel (mitoKATP) has been shown to provide protection against ischemia-reperfusion injury. Recently, it was proposed that the mitochondrial-targeted isoform of the renal outer medullary potassium channel (ROMK) prot...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215323
更新日期：2019-10-25 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms21030786
更新日期：2020-01-25 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010469
更新日期：2021-01-05 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041110
更新日期：2018-04-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020376
更新日期：2020-01-07 00:00:00
abstract：INTRODUCTION:Targeted agents such as bevacizumab (BEV) or poly (ADP-ribose) polymerase inhibitors (PARPi) which have been added as concomitant or maintenance therapies have been shown to improve progression-free survival (PFS) in patients with platinum-sensitive recurrent ovarian cancer (PS rOC). In the absence of dire...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113805
更新日期：2020-05-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040712
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-12-05 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14023395
更新日期：2013-02-06 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2015-06-03 00:00:00
abstract：:Psoralea corylifolia L., (P. corylifolia), which is used for treating vitiligo in clinic, shows inhibitory and activating effects on tyrosinase, a rate-limiting enzyme of melanogenesis. This study aimed to determine the active ingredients in the ethenal extracts of P. corylifolia on tyrosinase activity. The spectrum-e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113439
更新日期：2018-11-02 00:00:00
abstract：:A previous report showed that both Pyruvatedecarboxylase (PDC) genes were significantly upregulated in kiwifruit after waterlogging treatment using Illumina sequencing technology, and that the kiwifruit AdPDC1 gene was required during waterlogging, but might not be required during other environmental stresses. Here, t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112377
更新日期：2017-11-09 00:00:00
abstract：OBJECTIVE:To evaluate in a systematic review and meta-analysis model the effect of statin therapy on carotid plaque echogenicity assessed by ultrasound. METHODS:We have systematically searched electronic databases (PubMed, MEDLINE, EMBASE and Cochrane Center Register) up to April, 2015, for studies evaluating the effe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析,评审
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更新日期：2015-05-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041095
更新日期：2018-04-06 00:00:00
abstract：:A thrombotic occlusion of the vessel fed by ruptured coronary atherosclerotic plaque may result in unstable angina, myocardial infarction or death, whereas embolization from a plaque in carotid arteries may result in transient ischemic attack or stroke. The atherosclerotic plaque prone to such clinical events is terme...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160510121
更新日期：2015-05-05 00:00:00
