Abstract：
:Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes. Lack of these modifications increases the level of missense errors and affects codon decoding rate, contributing to protein aggregation with deleterious consequences to the cell. Recent works show that tRNA hypomodification and tRNA-modifying-enzyme deregulation occur in several diseases where proteostasis is affected, namely, neurodegenerative and metabolic diseases. In this review, we discuss the recent findings that correlate aberrant tRNA modification with proteostasis imbalances, in particular in neurological and metabolic disorders, and highlight the association between tRNAs, their modifying enzymes, translational decoding, and disease onset.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Pereira M,Francisco S,Varanda AS,Santos M,Santos MAS,Soares ARdoi
10.3390/ijms19123738subject
Has Abstractpub_date
2018-11-24 00:00:00issue
12issn
1422-0067pii
ijms19123738journal_volume
19pub_type
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