Abstract：
:Hepatic diseases, like viral hepatitis, autoimmune hepatitis, hereditary hemochromatosis, non-alcoholic fatty liver disease (NAFLD) and Wilson's disease, play an important role in the development of liver cirrhosis and, hence, hepatocellular carcinoma. In this review, the current treatment options and the molecular mechanisms of action of the drugs are summarized. Unfortunately, the treatment options for most of these hepatic diseases are limited. Since hepatitis B (HBV) and C (HCV) infections are the most common causes of liver cirrhosis and hepatocellular carcinoma, they are the focus of the development of new drugs. The current treatment of choice for HBV/HCV infection is an interferon-based combination therapy with oral antiviral drugs, like nucleos(t)ide analogues, which is associated with improving the therapeutic success and also preventing the development of resistances. Currently, two new protease inhibitors for HCV treatment are expected (deleobuvir, faldaprevir) and together with the promising drug, daclatasvir (NS5A-inhibitor, currently in clinical trials), adequate therapy is to be expected in due course (circumventing the requirement of interferon with its side-effects), while in contrast, efficient HBV therapeutics are still lacking. In this respect, entry inhibitors, like Myrcludex B, the lead substance of the first entry inhibitor for HBV/HDV (hepatitis D) infection, provide immense potential. The pharmacokinetics and the mechanism of action of Myrcludex B are described in detail.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Uhl P,Fricker G,Haberkorn U,Mier Wdoi
10.3390/ijms15057500subject
Has Abstractpub_date
2014-04-30 00:00:00pages
7500-12issue
5issn
1422-0067pii
ijms15057500journal_volume
15pub_type
杂志文章,评审abstract：:Atrazine, a member of the 2-chloro-s-triazine family of herbicides, is the most widely used pesticide in the world and often detected in agriculture watersheds. Although it was generally considered as an endocrine disruptor, posing a potential threat to human health, the molecular mechanisms of atrazine effects remain...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151017806
更新日期：2014-10-01 00:00:00
abstract：:The fms-like tyrosine kinase 3 (Flt3) is a cell surface receptor that is expressed by various hematopoietic progenitor cells (HPC) and Flt3-activating mutations are commonly present in acute myeloid and lymphoid leukemias. These findings underscore the importance of Flt3 to steady-state and malignant hematopoiesis. In...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18051037
更新日期：2017-05-12 00:00:00
abstract：:This study was conducted to monitor the macrophage infiltration of atopic dermatitis (AD)-like skin lesions and to evaluate the effects of anti-AD therapeutic agents in immunocompetent mice via optical reporter-gene-based molecular imaging. The enhanced firefly luciferase (effluc)-expressing macrophage cell line (Raw2...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176205
更新日期：2020-08-27 00:00:00
abstract：:High-dose human recombinant erythropoietin (rEPO) is a promising potential neuroprotective treatment in preterm and full-term neonates with hypoxic-ischemic encephalopathy (HIE). There are limited data on the pharmacokinetics of high-dose rEPO in neonates. We examined the effects of body weight, gestation age, global ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093042
更新日期：2020-04-25 00:00:00
abstract：:Various sulfonamide derivatives are intensively studied as anticancer agents owing to their inhibitory activity against human tumor-associated carbonic anhydrase isoforms. In this work, different synthetic procedures for the series of 1,3,5-triazinyl-aminobenzenesulfonamide conjugates with amino acids, possessing pola...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103661
更新日期：2020-05-22 00:00:00
abstract：:Alterations to the programmed cell death protein-1 (PD-1) pathway were previously shown to be involved in a poorer prognosis for patients with proliferative glomerulonephritis (PGN). Here, we investigated the association between several infectious agents and the expression of PD-1 and its ligand (PD-L1) on T and B lym...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218001
更新日期：2020-10-27 00:00:00
abstract：:Lonicera japonica Thunb. is a widely used medicinal plant and is rich in a variety of active ingredients. Flavonoids are one of the important components in L. japonica and their content is an important indicator for evaluating the quality of this herb. To study the regulation of flavonoid biosynthesis in L. japonica, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184494
更新日期：2019-09-11 00:00:00
abstract：:The insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2) is an oncogenic protein known to be overexpressed in different tumor types. Pancreatic cancer is a very lethal cancer that requires early diagnosis and new treatment options. The aim of our study was to investigate the role of IMP2 in the init...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133204
更新日期：2019-06-29 00:00:00
abstract：:Molecular motors are microtubule-based proteins which contribute to many cell functions, such as intracellular transportation and cell division. The details of the nature of the mutual interactions between motors and microtubules still needs to be extensively explored. However, electrostatic interaction is known as on...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21144935
更新日期：2020-07-13 00:00:00
abstract：:Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects, however, remain unclear. The inhibitory effects of these antidepre...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18112483
更新日期：2017-11-21 00:00:00
abstract：:Octamer-binding transcription factor 4 (Oct4) is a member of POU (Pit-Oct-Unc) transcription factor family Class V that plays a crucial role in maintaining the pluripotency and self-renewal of stem cells. Though it has been deeply investigated in mammals, its lower vertebrate homologue, especially in the marine fish, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010231
更新日期：2017-01-23 00:00:00
abstract：:Increasing evidence implicates mitochondrial dysfunction in the etiology of Parkinson's disease (PD). Mitochondrial DNA (mtDNA) mutations are considered a possible cause and this mechanism might be shared with the aging process and with other age-related neurodegenerative disorders such as Alzheimer's disease (AD). We...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051758
更新日期：2020-03-04 00:00:00
abstract：:Tyrosinase (TYR) is a metalloenzyme classified as a type-3 copper protein, which is involved in the synthesis of melanin through a catalytic process beginning with the conversion of the amino acid l-Tyrosine (l-Tyr) to l-3,4-dihydroxyphenylalanine (l-DOPA). It plays an important role in the mechanism of melanogenesis ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134783
更新日期：2020-07-06 00:00:00
abstract：:Background: Chronic skin wounds are a growing financial burden for healthcare providers, causing discomfort/immobility to patients. Whilst animal chronic wound models have been developed to allow for mechanistic studies and to develop/test potential therapies, such systems are not good representations of the human chr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041001
更新日期：2018-03-27 00:00:00
abstract：:Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a promising target for developing novel anticancer drugs. A combined molecular docking, structure-based pharmacophore modeling and three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12128713
更新日期：2011-01-01 00:00:00
abstract：:tRNA and some other non-coding RNA genes are transcribed by RNA polymerase III (pol III), due to the presence of intragenic promoter, consisting of boxes A and B spaced by 30-40 bp. Such pol III promoters, called type 2, are also intrinsic to Short Interspersed Elements (SINEs). The contribution of 5'-flanking sequenc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103706
更新日期：2020-05-25 00:00:00
abstract：BACKGROUND:Endothelial progenitor cells (EPCs) were indicated in vascular repair, angiogenesis of ischemic organs, and inhibition of formation of initial hyperplasia. Differentiation of endothelial cells (ECs) from human induced pluripotent stem cells (hiPSC)-derived endothelial cells (hiPSC-ECs) provides an unlimited ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20143536
更新日期：2019-07-19 00:00:00
abstract：:Cover crops are key determinants of the ecological stability and sustainability of continuous cropping soils. However, their agro-ecological role in differentially reshaping the microbiome structure and functioning under a degraded agroecosystem remains poorly investigated. Therefore, structural and metabolic changes ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20112619
更新日期：2019-05-28 00:00:00
abstract：:Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, which are widely used in the production of industrial and consumer surfactants. The aim of the present study was to evaluate the effect of NP on the antioxidant capacity and cognitive ability of mice. NP was given orally by gavages at doses of 0...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12010114
更新日期：2010-12-30 00:00:00
abstract：:Docking-i.e., interaction of a small molecule (ligand) with a proteic structure (receptor)-represents the ground of drug action mechanism of the vast majority of bioactive chemicals. Ligand and receptor accommodate their geometry and energy, within this interaction, in the benefit of receptor-ligand complex. In an ind...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071377
更新日期：2017-06-27 00:00:00
abstract：:In this study, drug nanocarriers were designed using linear copolymers with different contents of cholinium-based ionic liquid units, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMAMA/Cl: 25, 50, and 75 mol%). The amphiphilicity of the copolymers was evaluated on the basis of their critical micelle con...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010284
更新日期：2020-12-30 00:00:00
abstract：:The translocator protein (TSPO), located at the outer mitochondrial membrane (OMM), serves multiple functions and contributes to numerous processes, including cholesterol import, mitochondrial metabolism, apoptosis, cell proliferation, Ca2+ signaling, oxidative stress, and inflammation. TSPO forms a complex with the v...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20133348
更新日期：2019-07-08 00:00:00
abstract：:The medicinal herbal plant has been commonly used for prevention and intervention of disease and health promotions worldwide. Brazilein is a bioactive compound extracted from Caesalpinia sappan Linn. Several studies have showed that brazilein exhibited the immune suppressive effect and anti-oxidative function. However...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126048
更新日期：2015-11-18 00:00:00
abstract：:Kidney-yang deficiency syndrome (KYDS) is a metabolic disease caused by a neuro-endocrine disorder. The You-gui pill (YGP) is a classic traditional Chinese medicine (TCM) formula for the treatment of KYDS and has been widely used to warm and recuperate KYDS clinically for hundreds of years in China. However, it is unk...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153655
更新日期：2019-07-26 00:00:00
abstract：:Different concentrations of asafoetida extract were added to the medium of Pleurotus ferulic and the effects of the extract on growth of P. ferulic mycelium and fruiting bodies was observed. As the amount of asafoetida extract additive was increased, the growth of Pleurotus mycelium was faster, the time formation of b...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11010041
更新日期：2009-12-29 00:00:00
abstract：:NAC (NAM, ATAF1/2, and CUC2) transcription factors play important roles in many biological processes, and mainly bind to the NACRS with core sequences "CACG" or "CATGTG" to regulate gene expression. However, whether NAC proteins can bind to other motifs without these core sequences remains unknown. In this study, we e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103271
更新日期：2018-10-21 00:00:00
abstract：:Soil is a complex matrix where biotic and abiotic components establish a still unclear network involving bacteria, fungi, archaea, protists, protozoa, and roots that are in constant communication with each other. Understanding these interactions has recently focused on metagenomics, metatranscriptomics and less on met...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228455
更新日期：2020-11-11 00:00:00
abstract：:The abnormal deposition of calcium within renal parenchyma, termed nephrocalcinosis, frequently occurs as a result of impaired renal calcium handling. It is closely associated with renal stone formation (nephrolithiasis) as elevated urinary calcium levels (hypercalciuria) are a key common pathological feature underlyi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21010369
更新日期：2020-01-06 00:00:00
abstract：:Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms141019867
更新日期：2013-10-01 00:00:00
abstract：:The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18040787
更新日期：2017-04-07 00:00:00
