Abstract：
:Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose tissue. Obesity is considered a chronic low-grade inflammatory state and the liver has been recognized as being an "immunological organ". The complex role of the immune system in the pathogenesis of NASH is currently raising great interest, also in view of the possible therapeutic potential of immunotherapy in NASH. This review focuses on the disturbances of the cells constituting the innate and adaptive immune system in the liver and in adipose tissue.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Vonghia L,Michielsen P,Francque Sdoi
10.3390/ijms141019867subject
Has Abstractpub_date
2013-10-01 00:00:00pages
19867-90issue
10issn
1422-0067pii
ijms141019867journal_volume
14pub_type
杂志文章,评审abstract：:Nonylphenol polyethoxylates (NPnEOs), a major class of nonionic surfactants, can easily enter into aquatic environments through various pathways due to their wide applications, which leads to the extensive existence of their relative stable metabolites, namely nonylphenol (NP) and mono- to tri-ethoxylates. This study ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15011255
更新日期：2014-01-17 00:00:00
abstract：:A split plot 3 by 4 experiment was designed to characterize the relationship between production of gluthatione (GSH), oxidized gluthatione (GSSG), total flavonoid, anthocyanin, ascorbic acid and antioxidant activities (FRAP and DPPH) in three varieties of Labisia pumila Blume, namely the varieties alata, pumila and la...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13010393
更新日期：2012-01-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) are promising therapeutic agents for treating antibiotic-resistant bacterial infections. Previous studies showed that magainin 2 (isolated from African clawed fogs Xenopus laevis) has antimicrobial activity against gram-positive and gram-negative bacteria. The present study was conducted ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103041
更新日期：2018-10-05 00:00:00
abstract：:Chemerin, a novel adipokine, has been associated with metabolic, inflammatory, and atherosclerotic diseases. We aimed to determine the genetic basis of chemerin levels by conducting a genome-wide association study (GWAS) and to investigate the role of RARRES2 polymorphisms and circulating chemerin levels in the long-t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051174
更新日期：2019-03-07 00:00:00
abstract：:We show that, under in vitro conditions, the vulnerability of astroglia to hypoxia is reflected by alterations in endothelin (ET)-1 release and capacity of erythropoietin (EPO) to regulate ET-1 levels. Exposure of cells to 24 h hypoxia did not induce changes in ET-1 release, while 48-72 h hypoxia resulted in increase ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15022858
更新日期：2014-02-19 00:00:00
abstract：:Microfluidic flow chambers (MFCs) allow the study of platelet adhesion and thrombus formation under flow, which may be influenced by several variables. We developed a new MFC, with which we tested the effects of different variables on the results of platelet deposition and thrombus formation on a collagen-coated surfa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030750
更新日期：2020-01-23 00:00:00
abstract：:Plants are able to synthesize all essential metabolites from minerals, water, and light to complete their life cycle. This plasticity comes at a high energy cost, and therefore, plants need to tightly allocate resources in order to control their economy. Being sessile, plants can only adapt to fluctuating environmenta...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21082771
更新日期：2020-04-16 00:00:00
abstract：:In the present study, IL-1β cDNA was identified and analyzed from largemouth bass (Micropterus salmoides). Full length IL-1β mRNA was obtained using Rapid Amplification of cDNA Ends (RACE), which contains 78 bp 3'-UTR, a 455 bp 5'-UTR, and an open reading frame (ORF) of 702 bp coding for 233 amino acid residues. The m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101670
更新日期：2016-10-01 00:00:00
abstract：:The transition from pregnancy to lactation is characterized by a progressive decrease in insulin sensitivity. Propionate increases with dietary fiber consumption and has been shown to improve insulin sensitivity. Recent studies suggest that plasma odd-chain fatty acids [OCFAs; pentadecanoic acid (C15:0) and heptadecan...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020635
更新日期：2020-01-18 00:00:00
abstract：:Type 2 innate lymphoid cells (ILC2s) and their adaptive counterpart type 2 T helper (TH2) cells respond to interleukin-33 (IL-33) by producing IL-5, which is a crucial cytokine for eosinophil development in the bone marrow. The aim of this study was to determine if bone marrow ILC2s, TH cells, and eosinophils are loca...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113751
更新日期：2020-05-26 00:00:00
abstract：:A tight junction (TJ) makes a physical barrier in the epidermal cells of skin. Ultraviolet (UV) light may disrupt the TJ barrier, but the mechanism has not been well clarified. Weak UVB (5 mJ/cm2) caused mislocalization of claudin-1 (CLDN1), a component of the TJ strand, and disruption of TJ barrier in human keratinoc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197138
更新日期：2020-09-27 00:00:00
abstract：:The recent emergence of antibiotic-resistant bacteria requires the development of new antibiotics or new agents capable of enhancing antibiotic activity. Lysozyme degrades bacterial cell wall without involving antibiotic resistance and has become a new antibacterial strategy. However, direct use of native, active prot...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051635
更新日期：2020-02-27 00:00:00
abstract：:Metal compounds such as arsenic, cadmium, chromium, cobalt, lead, mercury, and nickel are classified as carcinogens affecting human health through occupational and environmental exposure. However, the underlying mechanisms involved in tumor formation are not well clarified. Interference of metal homeostasis may result...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms12129576
更新日期：2011-01-01 00:00:00
abstract：:Double-spikes Phalaenopsis orchids have greater market value than those with single-spike. In this study, a gene designated as Spike Activator 1 (SPK1), which encodes a basic helix-loop-helix (bHLH) transcription factor, was isolated and characterized from Phalaenopsis aphrodite (moth orchid). SPK1 was highly expresse...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215406
更新日期：2019-10-30 00:00:00
abstract：:Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained virologic response; however, the HCC risk remains elevated in cured patients, especially those with advanced liver disease. Long-term HCV inf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21093057
更新日期：2020-04-26 00:00:00
abstract：:A common problem in the immunodetection of structurally close compounds is understanding the regularities of immune recognition, and elucidating the basic structural elements that provide it. Correct identification of these elements would allow for select immunogens to obtain antibodies with either wide specificity to...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020265
更新日期：2019-01-11 00:00:00
abstract：:Hepatic disorders have been increasing in recent years because of high carbohydrate diets. Hepatocytes depend mainly on the basal autophagy to maintain hepatic glucose/lipid homeostasis in mammals. However, the regulatory mechanisms of autophagy in hepatic energy metabolism are still unknown in fish species. According...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041533
更新日期：2020-02-24 00:00:00
abstract：:The reliability of reverse transcription-quantitative PCR (RT-qPCR) results in gene expression studies depends on the approaches used to account for non-biological variations. In order to find a proper normalization strategy for the study of genes related to growth hormone signaling in skeletal muscle of growing mice,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18051060
更新日期：2017-05-16 00:00:00
abstract：:Auxin plays crucial roles in multiple developmental processes, such as embryogenesis, organogenesis, cell determination and division, as well as tropic responses. These processes are finely coordinated by the auxin, which requires the polar distribution of auxin within tissues and cells. The intercellular directionali...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092759
更新日期：2018-09-14 00:00:00
abstract：:Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription factors, and physical activity. However, whether skeletal phenotype can be oriented or not during early embryonic stages has never been investigated. Here, we report that pyruvate as the only source of carb...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197203
更新日期：2020-09-29 00:00:00
abstract：:Interleukin-18 (IL-18) is a multi-functional immuno-mediator in the development and progression of many types of infectious and inflammatory diseases. In this study, we evaluated the contribution of IL-18 genotypes to renal cell carcinoma (RCC) in Taiwan via the genotyping of IL-18 -656 (A/C), -607 (A/C), and -137 (G/...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071563
更新日期：2019-03-28 00:00:00
abstract：:Triazophos is a widely used organophosphorous insecticide that has potentially adverse effects to organisms. In the present study, a high-affinity single-chain variable fragment (scFv) antibody with specific lambda light chain was developed for residue monitoring. First, the specific variable regions were correctly am...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17060823
更新日期：2016-06-07 00:00:00
abstract：:Integrins are important regulators of cell survival, proliferation, adhesion and migration. Once activated, integrins establish a regulated link between the extracellular matrix and the cytoskeleton. Integrins have well-established functions in cancer, such as in controlling cell survival by engagement of many specifi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18010189
更新日期：2017-01-18 00:00:00
abstract：:Hypoxia, a common factor ruling the microenvironment composition, leads to tumor progression. In this hypoxic context, cytokines and cells cooperate to favor cancer development and metastasis. Tumor hypoxia is heterogeneously distributed. Oxygen gradients depend on the vicinity, functionality of blood vessels, and oxy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21249492
更新日期：2020-12-14 00:00:00
abstract：:Proteins regulate many cellular functions and analyzing the presence and abundance of proteins in biological samples are central focuses in proteomics. The discovery and validation of biomarkers, pathways, and drug targets for various diseases can be accomplished using mass spectrometry-based proteomics. However, with...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16023537
更新日期：2015-02-05 00:00:00
abstract：:B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19071928
更新日期：2018-06-30 00:00:00
abstract：:Transient Receptor Potential (TRP) channels are a family of ion channels whose members are distributed among all kinds of animals, from invertebrates to vertebrates. The importance of these molecules is exemplified by the variety of physiological roles they play. Perhaps, the most extensively studied member of this fa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21113837
更新日期：2020-05-28 00:00:00
abstract：:Cancer represents a group of heterogeneous diseases characterized by uncontrolledgrowth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a significantrole in the development of nanodrugs, nanodevices, drug delivery systems and nanocarriers. Someof the major issues in the treatment of cance...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19103264
更新日期：2018-10-20 00:00:00
abstract：:One of the most striking features occurring in the root-knot nematode Meloidogyne incognita induced galls is the reorganization of the vascular tissues. During the interaction of the model tree species Populus and M. incognita, a pronounced xylem proliferation was previously described in mature galls. To better charac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020406
更新日期：2020-01-09 00:00:00
abstract：:Melatonin has long been recognized as a positive signaling molecule and potent antioxidant in plants, which alleviates damage caused by adverse conditions such as salt, cold, and heat stress. In this study, we found a paradoxical role for melatonin in abiotic stress responses. Suppression of the serotonin N-acetyltran...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205173
更新日期：2019-10-18 00:00:00
