Abstract:
:Apocynin, also known as acetovanillone, is a natural organic compound structurally related to vanillin. Apocynin is known to be an inhibitor of NADPH (Nicotinamide adenine dinucleotide phosphate) oxidase activity and is highly effective in suppressing the production of superoxide. The neuroprotective effects of apocynin have been investigated in numerous brain injury settings, such as stroke, traumatic brain injury (TBI), and epilepsy. Our lab has demonstrated that TBI or seizure-induced oxidative injury and neuronal death were reduced by apocynin treatment. Several studies have also demonstrated that neuroblast production is transiently increased in the hippocampus after seizures. Here, we provide evidence confirming the hypothesis that long-term treatment with apocynin may enhance newly generated hippocampal neuronal survival by reduction of superoxide production after seizures. A seizure was induced by pilocarpine [(25 mg/kg intraperitoneal (i.p.)] injection. Apocynin was continuously injected for 4 weeks after seizures (once per day) into the intraperitoneal space. We evaluated neuronal nuclear antigen (NeuN), bromodeoxyuridine (BrdU), and doublecortin (DCX) immunostaining to determine whether treatment with apocynin increased neuronal survival and neurogenesis in the hippocampus after seizures. The present study indicates that long-term treatment of apocynin increased the number of NeuN⁺ and DCX⁺ cells in the hippocampus after seizures. Therefore, this study suggests that apocynin treatment increased neuronal survival and neuroblast production by reduction of hippocampal oxidative injury after seizures.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Lee SH,Choi BY,Kho AR,Jeong JH,Hong DK,Kang DH,Kang BS,Song HK,Choi HC,Suh SWdoi
10.3390/ijms19103087subject
Has Abstractpub_date
2018-10-09 00:00:00issue
10issn
1422-0067pii
ijms19103087journal_volume
19pub_type
杂志文章abstract::Parkinson's disease (PD) is characterized by distinct motor and non-motor symptoms. Sleep disorders are the most frequent and challenging non-motor symptoms in PD patients, and there is growing evidence that they are a consequence of disruptions within the circadian system. PD is characterized by a progressive degener...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19061651
更新日期:2018-06-03 00:00:00
abstract::Glioblastoma is the most common malignant primary brain tumor, and it is one of the causes of cancer fatality in both adult and pediatric populations. Patients with glioblastoma require chemotherapy after surgical resection and radiotherapy. Therefore, chemotherapy constitutes a viable approach for the eradication of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18091945
更新日期:2017-09-11 00:00:00
abstract::α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are assembled of four core subunits and several additional interacting proteins. Cystine-knot AMPA receptor-modulating proteins (CKAMPs) constitute a family of four proteins that influence the trafficking, subcellular localization and function of AM...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20061460
更新日期:2019-03-22 00:00:00
abstract::Lung cancer is the most common cancer worldwide. Disappointingly, despite great effort in encouraging screening or, at least, a close surveillance of high-risk individuals, most of lung cancers are diagnosed when already surgically unresectable because of local advancement or metastasis. In these cases, the treatment ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18071374
更新日期:2017-06-27 00:00:00
abstract::Mg and Mg alloys are becoming more and more of interest for several applications. In the case of biomaterial applications, a special interest exists due to the fact that a predictable degradation should be given. Various investigations were made to characterize and predict the corrosion behavior in vitro and in vivo. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150711456
更新日期:2014-06-26 00:00:00
abstract::Human Ribonuclease 6 is a secreted protein belonging to the ribonuclease A (RNaseA) superfamily, a vertebrate specific family suggested to arise with an ancestral host defense role. Tissue distribution analysis revealed its expression in innate cell types, showing abundance in monocytes and neutrophils. Recent evidenc...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17040552
更新日期:2016-04-13 00:00:00
abstract::Avascular meniscus tears show poor intrinsic regenerative potential. Thus, lesions within this area predispose the patient to developing knee osteoarthritis. Current research focuses on regenerative approaches using growth factors or mesenchymal stem cells (MSCs) to enhance healing capacity within the avascular menisc...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051120
更新日期:2019-03-05 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide. Most patients are diagnosed with advanced disease, limiting their options for treatment. While current treatments are adequate for lower staged disease, available systemic treatments are limited, with marginal benefi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21186757
更新日期:2020-09-15 00:00:00
abstract::Burn-induced heart dysfunction is a key factor for patient mortality. However, the molecular mechanisms are not yet fully elucidated. This study sought to understand whether burn-induced heart dysfunction is associated with cardiac mitochondrial dysfunction and interruption of the PDE5A-cGMP-PKG pathway. Sixty percent...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072350
更新日期:2020-03-28 00:00:00
abstract::Preimplantation horse conceptuses require nutrients and signals from histotroph, the composition of which is regulated by luteal progesterone and conceptus-secreted factors. To distinguish progesterone and conceptus effects we shortened the period of endometrial progesterone-priming by asynchronous embryo transfer. Da...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072562
更新日期:2020-04-07 00:00:00
abstract::Tryptanthrin, a kind of indole quinazoline alkaloid, has been shown to exhibit anti-microbial, anti-inflammation and anti-tumor effects both in vivo and in vitro. However, its biological activity on human chronic myeloid leukemia cell line K562 is not fully understood. In the present study, we investigated the prolife...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12063831
更新日期:2011-01-01 00:00:00
abstract::Antimicrobial peptides have been identified as one of the alternatives to the extensive use of common antibiotics as they show a broad spectrum of activity against human pathogens. Among these is Chionodracine (Cnd), a host-defense peptide isolated from the Antarctic icefish Chionodracohamatus, which belongs to the fa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21041401
更新日期:2020-02-19 00:00:00
abstract::Membrane traffic plays a pivotal role in virulence in the enteric protozoan parasite Entamoeba histolytica. EhRab8A small GTPase is a key regulator of membrane traffic at the endoplasmic reticulum (ER) of this protist and is involved in the transport of plasma membrane proteins. Here we identified the binding proteins...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123831
更新日期:2018-11-30 00:00:00
abstract::Current outcome prediction markers for localized prostate cancer (PCa) are insufficient. The impact of the lipid-modifying Sphingomyelin Phosphodiesterase Acid Like 3B (SMPDL3B) in PCa is unknown. Two cohorts of patients with PCa who underwent radical prostatectomy (n = 40, n = 56) and benign prostate hyperplasia (BPH...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124373
更新日期:2020-06-19 00:00:00
abstract::Octamer-binding transcription factor 4 (Oct4) is a member of POU (Pit-Oct-Unc) transcription factor family Class V that plays a crucial role in maintaining the pluripotency and self-renewal of stem cells. Though it has been deeply investigated in mammals, its lower vertebrate homologue, especially in the marine fish, ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18010231
更新日期:2017-01-23 00:00:00
abstract::Cancers can cause some proteins to be aberrantly excreted or released in the urine, which can be used as biomarkers. To screen for potential biomarkers for endometrial cancer (ECa), the urinary proteins from patients who were newly diagnosed with early stage ECa and untreated controls were separated using two-dimensio...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13089489
更新日期:2012-01-01 00:00:00
abstract::Coffee is a popular drink consumed all over the world. Besides its long-recognized stimulant effect, it has important nutritional and health effects. However, the type of bean processing modifies the composition of brewed coffee and possibly its bioactivity. In this study, extracts obtained from green and roasted bean...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113407
更新日期:2018-10-31 00:00:00
abstract::Globally, chickpea production is severely affected by salinity stress. Understanding the genetic basis for salinity tolerance is important to develop salinity tolerant chickpeas. A recombinant inbred line (RIL) population developed using parental lines ICCV 10 (salt-tolerant) and DCP 92-3 (salt-sensitive) was screened...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21145058
更新日期:2020-07-17 00:00:00
abstract::SAASoti is a unique fluorescent protein (FP) that combines properties of green-to-red photoconversion and reversible photoswitching (in its green state), without any amino acid substitutions in the wild type gene. In the present work, we investigated its ability to photoswitch between fluorescent red ('on') and dark (...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20143399
更新日期:2019-07-11 00:00:00
abstract::The maturation of iPSC-derived cardiomyocytes is still a critical point for their application in cardiovascular research as well as for their clinical use. Although multiple differentiation protocols have been established, researchers failed to generate fully mature cardiomyocytes in vitro possessing identical phenoty...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082819
更新日期:2020-04-17 00:00:00
abstract::Escherichia coli (E. coli) F18 is the main pathogen responsible for post-weaning diarrhea (PWD) in piglets. Resistance to E. coli F18 depends on the expression of the cognate receptors in the intestinal epithelial cells. However, the molecular mechanism of E. coli F18 resistance in weaned piglets remains unclear. Here...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113301
更新日期:2018-10-24 00:00:00
abstract::Interleukin-1β (IL-1β) is a prominent pro-inflammatory cytokine that is implicated in a variety of autoimmune diseases and plays an important role in host defense against infections. IL-1β activity increases with its increasing binding capacity to IL-1 receptors (IL-1Rs). Thus, numerous studies have tar...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19071835
更新日期:2018-06-22 00:00:00
abstract::Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I metabotropic Glu receptors (mGluR1, mGluR5) produced abnormal Glu releas...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184552
更新日期:2019-09-13 00:00:00
abstract::Tear stability decreases with increasing age and the same signs of instability are exacerbated with dry eye. Meibum lipid compositional changes with age provide insights into the biomolecules responsible for tear film instability. Meibum was collected from 69 normal donors ranging in age from 0.6 to 68 years of age. I...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18091862
更新日期:2017-08-28 00:00:00
abstract::The DNA excision repair protein ERCC-1-DNA repair endonuclease XPF (ERCC1-XPF) is a heterodimeric endonuclease essential for the nucleotide excision repair (NER) DNA repair pathway. Although its activity is required to maintain genome integrity in healthy cells, ERCC1-XPF can counteract the effect of DNA-damaging ther...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051328
更新日期:2018-04-30 00:00:00
abstract::Busulfan is an alkylating agent routinely used in conditioning regimens prior to allogeneic hematopoietic cell transplantation (HCT) for various nonmalignant disorders, including inborn errors of metabolism. The combination of model-based dosing and therapeutic drug monitoring (TDM) of busulfan pharmacokinetics (PK) t...
journal_title:International journal of molecular sciences
pub_type:
doi:10.3390/ijms21165634
更新日期:2020-08-06 00:00:00
abstract::Nonylphenol polyethoxylates (NPnEOs), a major class of nonionic surfactants, can easily enter into aquatic environments through various pathways due to their wide applications, which leads to the extensive existence of their relative stable metabolites, namely nonylphenol (NP) and mono- to tri-ethoxylates. This study ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15011255
更新日期:2014-01-17 00:00:00
abstract::Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis. Ir...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20010095
更新日期:2018-12-27 00:00:00
abstract::The synaptic cleft has been vastly investigated in the last decades, leading to a novel and fascinating model of the functional and structural modifications linked to synaptic transmission and brain processing. The classic neurocentric model encompassing the neuronal pre- and post-synaptic terminals partly explains th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21041539
更新日期:2020-02-24 00:00:00
abstract::Bruton's tyrosine kinase (BTK) is an attractive target for treating patients with B cell malignancies and autoimmune diseases. Many BTK inhibitors have been identified; however, like other kinase inhibitors, they lack diversity in their core structures. Therefore, it is important to secure a novel scaffold that occupi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21217919
更新日期:2020-10-25 00:00:00