Abstract:
:Melanocytes in the skin play an indispensable role in the pigmentation of skin and its appendages. It is well known that the embryonic origin of melanocytes is neural crest cells. In adult skin, functional melanocytes are continuously repopulated by the differentiation of melanocyte stem cells (McSCs) residing in the epidermis of the skin. Many preceding studies have led to significant discoveries regarding the cellular and molecular characteristics of this unique stem cell population. The alteration of McSCs has been also implicated in several skin abnormalities and disease conditions. To date, our knowledge of McSCs largely comes from studying the stem cell niche of mouse hair follicles. Suggested by several anatomical differences between mouse and human skin, there could be distinct features associated with mouse and human McSCs as well as their niches in the skin. Recent advances in human pluripotent stem cell (hPSC) research have provided us with useful tools to potentially acquire a substantial amount of human McSCs and functional melanocytes for research and regenerative medicine applications. This review highlights recent studies and progress involved in understanding the development of cutaneous melanocytes and the regulation of McSCs.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Mull AN,Zolekar A,Wang YCdoi
10.3390/ijms161226207subject
Has Abstractpub_date
2015-12-21 00:00:00pages
30458-69issue
12issn
1422-0067pii
ijms161226207journal_volume
16pub_type
杂志文章,评审abstract::Chronic immune response to bone implant may lead to delayed healing and its failure. Thus, newly developed biomaterials should be characterized by high biocompatibility. Moreover, it is well known that macrophages play a crucial role in the controlling of biomaterial-induced inflammatory response. Immune cells synthes...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031109
更新日期:2021-01-23 00:00:00
abstract::Sulfur (S) is an essential element for all forms of life. It is involved in numerous essential processes because S is considered as the primary source of one of the essential amino acids, methionine, which plays an important role in biological events. For the control and regulation of sulfate in a metabolic network th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072572
更新日期:2020-04-07 00:00:00
abstract::Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Sil...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21113745
更新日期:2020-05-26 00:00:00
abstract::A three-dimensional (3D) representative volume element (RVE) model was developed for analyzing effective mechanical behavior of fiber-reinforced ceramic matrix composites with imperfect interfaces. In the model, the fiber is assumed to be perfectly elastic until its tensile strength, and the ceramic material is modele...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151223389
更新日期:2014-12-16 00:00:00
abstract::In 1937, Sir H. A Krebs first published the Citric Acid Cycle, a unidirectional cycle with carboxylic acids. The original concept of the Citric Acid Cycle from Krebs' 1953 Nobel Prize lecture illustrates the unidirectional degradation of lactic acid to water, carbon dioxide and hydrogen. Here, we add the heart lactate...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22020604
更新日期:2021-01-09 00:00:00
abstract::Matrix metalloproteinases (MMPs) are enzymes involved in periodontal tissue destruction. Hemagglutinin B (HagB) from the periodontal pathogen Porphyromonas gingivalis induces an elevated MMP response in dendritic cells, but responses from cultures of single-cell types do not reflect the local tissue environment. The o...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123923
更新日期:2018-12-07 00:00:00
abstract::Glucose variability (GV) has been recognized recently as a promoter of complications and therapeutic targets in diabetes. The aim of this study was to reconstruct and analyze gene networks related to GV in diabetes and its complications. For network analysis, we used the ANDSystem that provides automatic network recon...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228691
更新日期:2020-11-18 00:00:00
abstract::The removal of damaged or superfluous organelles from the cytosol by selective autophagy is required to maintain organelle function, quality control and overall cellular homeostasis. Precisely how substrate selectivity is achieved, and how individual substrates are degraded during selective autophagy in response to bo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21020578
更新日期:2020-01-16 00:00:00
abstract::Much of the experimental data, especially in life sciences, is considered to be useless if it demonstrates a large standard deviation from the mean value. The Renaissance distribution, as presented in this study, allows one to extract true values from such statistical data with large noise. To obtain proof of the Rena...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20133250
更新日期:2019-07-02 00:00:00
abstract::Calcific aortic valve disease (CAVD) is the result of maladaptive fibrocalcific processes leading to a progressive thickening and stiffening of aortic valve (AV) leaflets. CAVD is the most common cause of aortic stenosis (AS). At present, there is no effective pharmacotherapy in reducing CAVD progression; when CAVD be...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21238917
更新日期:2020-11-24 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is a dangerous pathogen resistant to β-lactam antibiotics. Due to its resistance, it is difficult to manage the infections caused by this strain. We examined this issue in terms of observation of the growth properties and ability to form biofilms in sensitive S. aureu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161024656
更新日期:2015-10-16 00:00:00
abstract::The author wishes to make a change to the published paper [1].[...]. ...
journal_title:International journal of molecular sciences
pub_type: 已发布勘误
doi:10.3390/ijms17091572
更新日期:2016-09-19 00:00:00
abstract::Borneol and menthol are terpenes that are widely used as penetration enhancers in transdermal drug delivery. To explore their penetration-enhancement effects on hydrophilic drugs, 5-fluorouracil (5-FU) was selected as a model drug. An approach that combined in vitro permeation studies and coarse-grained molecular dyna...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122747
更新日期:2017-12-18 00:00:00
abstract::In order to use cyanobacteria for the biological production of hydrogen, it is important to thoroughly study the function and the regulation of the hydrogen-production machine in order to better understand its role in the global cell metabolism and identify bottlenecks limiting H2 production. Most of the recent advanc...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms151119938
更新日期:2014-10-31 00:00:00
abstract::Integrins are important regulators of cell survival, proliferation, adhesion and migration. Once activated, integrins establish a regulated link between the extracellular matrix and the cytoskeleton. Integrins have well-established functions in cancer, such as in controlling cell survival by engagement of many specifi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18010189
更新日期:2017-01-18 00:00:00
abstract::Burkholderia cenocepacia is an important opportunistic pathogen in cystic fibrosis (CF) patients, and has also been isolated from natural environments. In previous work, we explored the virulence and pathogenic potential of environmental B. cenocepacia strains and demonstrated that they do not differ from clinical str...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18112417
更新日期:2017-11-14 00:00:00
abstract::In healthy individuals, the healing of soft tissues such as skin after pathological insult or post injury follows a relatively predictable and defined series of cell and molecular processes to restore tissue architecture and function(s). Healing progresses through the phases of hemostasis, inflammation, proliferation,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21031015
更新日期:2020-02-04 00:00:00
abstract::Metabolic stability is an important parameter to be optimized during the complex process of designing new active compounds. Tuning this parameter with the simultaneous maintenance of a desired compound's activity is not an easy task due to the extreme complexity of metabolic pathways in living organisms. In this study...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041040
更新日期:2018-03-30 00:00:00
abstract::Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsiste...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,meta分析
doi:10.3390/ijms20205088
更新日期:2019-10-14 00:00:00
abstract::Compared to other mammalian species, porcine oocytes and embryos are characterized by large amounts of lipids stored mainly in the form of droplets in the cytoplasm. The amount and the morphology of lipid droplets (LD) change throughout the preimplantation development, however, relatively little is known about express...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186488
更新日期:2020-09-05 00:00:00
abstract::Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10). All isolated compounds were evaluated for their inhibitory ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18112479
更新日期:2017-11-21 00:00:00
abstract::This study reports the effect of Spilanthes acmella Murr. extracts on phenylephrine-induced contraction of rat thoracic aorta as well as their antioxidant activity. Results show that the extracts exert maximal vasorelaxations in a dose-dependent manner, but their effects are less than acetylcholine-induced nitric oxid...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms9122724
更新日期:2008-12-01 00:00:00
abstract::An economical and environmentally friendly whey protein fractionation process was developed using supercritical carbon dioxide (sCO(2)) as an acid to produce enriched fractions of α-lactalbumin (α-LA) and β-lactoglobulin (β-LG) from a commercial whey protein isolate (WPI) containing 20% α-LA and 55% β-LG, through sele...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13010240
更新日期:2012-01-01 00:00:00
abstract::Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure. Introduction of combination chemotherapy in the 1970s, however, dramatically increased overall survival rates from 20% to approximately 70%. Unfortunat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21186885
更新日期:2020-09-19 00:00:00
abstract::Sequence-defined recombinant antibodies (rAbs) have emerged as alternatives to hybridoma-secreted monoclonal antibodies (mAbs) for performing immunoassays. However, the polyploidy nature of hybridomas often leads to the coexistence of aberrant or non-specific functional variable region (VR) gene transcripts, which com...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186857
更新日期:2020-09-18 00:00:00
abstract::Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria, such as Shigella, Listeria, enteroinvasive E. coli and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms151018253
更新日期:2014-10-10 00:00:00
abstract::Thioflavin T (ThT) assay is extensively used for studying fibrillation kinetics in vitro. However, the differences in the time course of ThT fluorescence intensity and lifetime and other physical parameters of the system, such as particle size distribution, raise questions about the correct interpretation of the aggre...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176169
更新日期:2020-08-26 00:00:00
abstract::A large percentage of primary sensory neurons in the trigeminal ganglia (TG) contain neuropeptides such as tachykinins or calcitonin gene-related peptide. Neuropeptides released from the central terminals of primary afferents sensitize the secondary nociceptive neurons in the trigeminal nucleus caudalis (TNC), but als...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082938
更新日期:2020-04-22 00:00:00
abstract::In patients with aortic stenosis (AS), a novel staging classification of extra-valvular left and right heart damage with prognostic relevance was introduced in 2017. The aim of the study was to evaluate the biomarkers of cardiovascular tissue remodelling in relation to this novel staging classification. Patients were ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21114174
更新日期:2020-06-11 00:00:00
abstract::Acute lung injury is characterized by the infiltration of neutrophils into lungs and the subsequent impairment of lung function. Here we explored the role of TDAG8 in lung injury induced by lipopolysaccharide (LPS) administrated intratracheally. In this model, cytokines and chemokines released from resident macrophage...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161226145
更新日期:2015-12-04 00:00:00