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Renaissance Distribution for Statistically Failed Experiments.

Abstract：

:Much of the experimental data, especially in life sciences, is considered to be useless if it demonstrates a large standard deviation from the mean value. The Renaissance distribution, as presented in this study, allows one to extract true values from such statistical data with large noise. To obtain proof of the Renaissance distribution, high-throughput synthesis of deep substitutions for a target amino acid sequence was performed, and the known epitope was identified in assay with human serum antibodies. In addition, the Renaissance distribution was shown to approach the epitope affinity maturation by the deep alanine substitution. The Renaissance distribution may have an impact in the development of novel specific drugs.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Popov R,Shankara GK,von Bojničić-Kninski C,Nesterov-Mueller A

doi

10.3390/ijms20133250

subject

Has Abstract

pub_date

2019-07-02 00:00:00

issue

13

issn

1422-0067

pii

ijms20133250

journal_volume

20

pub_type

杂志文章

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