Abstract:
:Following the epidemics of obesity due to the consumption of high-calorie diet and sedentary lifestyle, nonalcoholic fatty liver disease (NAFLD) is now the leading cause of liver disease in Western countries. NAFLD is epidemiologically associated with metabolic syndrome and insulin resistance, and in susceptible individuals it may progress to cirrhosis and hepatocellular carcinoma. Genetic factors play a key role in NAFLD predisposition by interacting with nutritional and other environmental factors. To date, there is no drug therapy for the treatment of NAFLD, and the main clinical recommendation is lifestyle modification. In the last years, nutrigenomics is promoting an increased understanding of how nutrition affects the switch from health to disease by altering the expression of an individual's genetic makeup. The present review tries to summarize the most recent data evidencing how the interactions between nutrients and genetic factors can influence NAFLD development. The final goal should be to develop tools to quantify these complex interactions. The definition of a "nutrigenomic risk score" for each individual may represent a novel therapeutic approach for the management of NAFLD patients.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Dongiovanni P,Valenti Ldoi
10.3390/ijms18071534subject
Has Abstractpub_date
2017-07-16 00:00:00issue
7issn
1422-0067pii
ijms18071534journal_volume
18pub_type
杂志文章,评审abstract::The aim of this study was to investigate the chemical composition of acetone extracts of the lichens Toninia candida and Usnea barbata and in vitro antioxidant, antimicrobial, and anticancer activities of these extracts together with some of their major metabolites. The chemical composition of T. candida and U. barbat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms131114707
更新日期:2012-11-12 00:00:00
abstract::Inflammasomes are components of the innate immune response that have recently emerged as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain, leucine-rich-containing (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is a complex platform involved in the activation of caspa...
journal_title:International journal of molecular sciences
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abstract::The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes ...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms18091921
更新日期:2017-09-07 00:00:00
abstract::Activation of the mineralocorticoid receptor (MR) in the heart is considered to be a cardiovascular risk factor. MR activation leads to heart hypertrophy and arrhythmia. In ventricular cardiomyocytes, aldosterone induces a profound remodeling of ion channel expression, in particular, an increase in the expression and ...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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abstract::A new anticancer ligustrazine derivative, 3β-hydroxyolea-12-en-28-oic acid- 3,5,6-trimethylpyrazin-2-methylester (T-OA, C38H58O3N2), was previously reported. It was synthesized via conjugating hepatoprotective and anticancer ingredients of traditional Chinese medicine. We found that T-OA exerted its anticancer activit...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2018-01-04 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2014-02-06 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21207672
更新日期:2020-10-16 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms14010547
更新日期:2012-12-27 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19103217
更新日期:2018-10-18 00:00:00
abstract::Chorea acanthocytosis (ChAc), an ultra-rare devastating neurodegenerative disease, is caused by mutations in the VPS13A gene, which encodes for the protein chorein. Affected patients suffer from chorea, orofacial dyskinesia, epilepsy, parkinsonism as well as peripheral neuropathy. Although medium spinal neurons of the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051797
更新日期:2020-03-05 00:00:00
abstract::Fresh produce is often a source of enterohaemorrhagic Escherichia coli (EHEC) outbreaks. Fimbriae are extracellular structures involved in cell-to-cell attachment and surface colonisation. F9 (Fml) fimbriae have been shown to be expressed at temperatures lower than 37 °C, implying a function beyond the mammalian host....
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249720
更新日期:2020-12-19 00:00:00
abstract::Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the b...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20246196
更新日期:2019-12-08 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms18010108
更新日期:2017-01-06 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21145044
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21155350
更新日期:2020-07-28 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms22020807
更新日期:2021-01-15 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051307
更新日期:2018-04-27 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21041255
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abstract::Bradysia odoriphaga (Diptera: Sciaridae) is the most important pest of Chinese chive. Insecticides are used widely and frequently to control B. odoriphaga in China. However, the performance of the insecticides chlorpyrifos and clothianidin in controlling the Chinese chive maggot is quite different. Using next generati...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms18112445
更新日期:2017-11-17 00:00:00
abstract::The activating leukocyte immunoglobulin-like receptors (LILRAs) play an important role in innate immunity. However, most of the LILRA members have not been characterized in avian species including chickens. The present study is the first attempt at cloning, structural analysis and functional characterization of two LI...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19092710
更新日期:2018-09-11 00:00:00
abstract::Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge on placental stem cells have revealed that human amniotic epithelial stem cells ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21207730
更新日期:2020-10-19 00:00:00
abstract::The prognosis of patients with pancreatic cancer remains poor; only patients with small tumors and complete resection have a chance of a complete cure. Pancreatic cancer responds poorly to conventional therapies, including chemotherapy and irradiation. Snail is a transcription factor that has been associated with anti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,收录出版
doi:10.3390/ijms11124891
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160511369
更新日期:2015-05-18 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051275
更新日期:2018-04-24 00:00:00