当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Knockdown of snail sensitizes pancreatic cancer cells to chemotherapeutic agents and irradiation.

Knockdown of snail sensitizes pancreatic cancer cells to chemotherapeutic agents and irradiation.

Abstract：

:The prognosis of patients with pancreatic cancer remains poor; only patients with small tumors and complete resection have a chance of a complete cure. Pancreatic cancer responds poorly to conventional therapies, including chemotherapy and irradiation. Snail is a transcription factor that has been associated with anti-apoptotic and chemoresistant properties in pancreatic cancer cells. In this study, we investigated whether knockdown of Snail suppresses growth of and/or sensitizes pancreatic cancer cells to chemotherapeutic agents and irradiation through induction of apoptosis. An adeno-associated virus vector was used to deliver Snail siRNA and knockdown Snail expression in untreated pancreatic cancer cells and in pancreatic cancer cells treated with chemotherapeutic agents or γ-irradiation. Our data indicate that our adeno-associated virus vector can efficiently deliver Snail siRNA into PANC-1 cells both in vitro and in vivo, resulting in the knockdown of Snail expression at the mRNA and protein levels. We further show that knockdown of Snail expression results in potent growth suppression of pancreatic cancer cells and suppresses xenograft tumor growth in vivo through induction of apoptosis. Finally, knockdown of Snail expression significantly sensitizes pancreatic cancer cells to chemotherapeutic agents and γ-irradiation through induction of apoptosis. In conclusion, our findings indicate that Snail is an important modulator of therapeutic responses of pancreatic cancer cells and is potentially useful as a sensitizer in pancreatic cancer therapy.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Zhang K,Jiao X,Liu X,Zhang B,Wang J,Wang Q,Tao Y,Zhang D

doi

10.3390/ijms11124891

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

4891-2

issue

12

issn

1422-0067

pii

ijms-11-04891

journal_volume

11

pub_type

杂志文章,收录出版

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Optimization of the preparation of fish protein anti-obesity hydrolysates using response surface methodology.

    abstract：:The enzymatic condition for producing the anti-obesity hydrolysates from fish water-soluble protein was optimized with the aid of response surface methodology, which also derived a statistical model for experimental validation. Compared with neutral protease, papain and protamex, the porcine pancreas lipase inhibitory...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14023124

    authors： Liu L,Wang Y,Peng C,Wang J

    更新日期：2013-02-01 00:00:00

  • Bevacizumab or PARP-Inhibitors Maintenance Therapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis.

    abstract：INTRODUCTION:Targeted agents such as bevacizumab (BEV) or poly (ADP-ribose) polymerase inhibitors (PARPi) which have been added as concomitant or maintenance therapies have been shown to improve progression-free survival (PFS) in patients with platinum-sensitive recurrent ovarian cancer (PS rOC). In the absence of dire...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21113805

    authors： Bartoletti M,Pelizzari G,Gerratana L,Bortot L,Lombardi D,Nicoloso M,Scalone S,Giorda G,Baldassarre G,Sorio R,Puglisi F

    更新日期：2020-05-27 00:00:00

  • The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep.

    abstract：:High-dose human recombinant erythropoietin (rEPO) is a promising potential neuroprotective treatment in preterm and full-term neonates with hypoxic-ischemic encephalopathy (HIE). There are limited data on the pharmacokinetics of high-dose rEPO in neonates. We examined the effects of body weight, gestation age, global ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21093042

    authors： Dhillon SK,Wassink G,Lear CA,Davidson JO,Holford NHG,Gunn AJ,Bennet L

    更新日期：2020-04-25 00:00:00

  • Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells.

    abstract：:Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment is characterized by acidosis and hypoxia due to tumor heterogeneity, aerobic glycolysis (the "War...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18020278

    authors： Dong L,Krewson EA,Yang LV

    更新日期：2017-01-27 00:00:00

  • Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1.

    abstract：:Epithelial cell adhesion molecule (EpCAM) is overexpressed in 55%-75% of ovarian carcinomas (OC). EpCAM might be used as a target for a treatment of disseminated OC. Designed ankyrin repeats protein (DARPin) Ec1 is a small (18 kDa) protein, which binds to EpCAM with subnanomolar affinity. We tested a hypothesis that E...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21093310

    authors： Vorobyeva A,Konovalova E,Xu T,Schulga A,Altai M,Garousi J,Rinne SS,Orlova A,Tolmachev V,Deyev S

    更新日期：2020-05-07 00:00:00

  • Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?

    abstract：:Idiopathic osteoporosis and nephrolithiasis are formidable health problems showing a progressive increase in their incidence and prevalence in the last decades. These temporal trends were observed in both pediatric and adult populations worldwide. Epidemiological and experimental studies indicate that both disorders s...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21218183

    authors： Rendina D,De Filippo G,Iannuzzo G,Abate V,Strazzullo P,Falchetti A

    更新日期：2020-10-31 00:00:00

  • Designer Biopolymers: Self-Assembling Proteins and Nucleic Acids.

    abstract：:Nature has evolved sequence-controlled polymers such as DNA and proteins over its long history [...]. ...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms21093276

    authors： Sugawara-Narutaki A,Kamiya Y

    更新日期：2020-05-06 00:00:00

  • Mechanistic and Kinetic Study on Self-/Cross- Condensation of PCTA/DT Formation Mechanisms from Three Types of Radicals of 2,4-Dichlorothiophenol.

    abstract：:Chlorothiophenols (CTPs) are known to be key and direct precursors of polychlorinated thianthrene/dibenzothiophenes (PCTA/DTs). Self/cross-coupling of the chlorothiophenoxy radicals (CTPRs), sulfydryl-substituted phenyl radicals and thiophenoxyl diradicals evolving from CTPs are initial and important steps for PCTA/DT...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20112623

    authors： Wang H,Zuo C,Zheng S,Sun Y,Xu F,Zhang Q

    更新日期：2019-05-28 00:00:00

  • Glycosylation in Indolent, Significant and Aggressive Prostate Cancer by Automated High-Throughput N-Glycan Profiling.

    abstract：:The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression pat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21239233

    authors： Gilgunn S,Murphy K,Stöckmann H,Conroy PJ,Murphy TB,Watson RW,O'Kennedy RJ,Rudd PM,Saldova R

    更新日期：2020-12-03 00:00:00

  • Wound Dressing Selection Is Critical to Enhance Platelet-Rich Fibrin Activities in Wound Care.

    abstract：:The use of platelet-rich fibrin (PRF) is investigated in ulcer management because it provides a healing milieu rich in growth factors and cytokines. Although crucial, the relevance of secondary dressings is under-researched and no data support the use of any particular dressing in preference to another. We assessed th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21020624

    authors： Del Amo C,Perez-Valle A,Perez-Zabala E,Perez-Del-Pecho K,Larrazabal A,Basterretxea A,Bully P,Andia I

    更新日期：2020-01-17 00:00:00

  • Computer-Aided Estimation of Biological Activity Profiles of Drug-Like Compounds Taking into Account Their Metabolism in Human Body.

    abstract：:Most pharmaceutical substances interact with several or even many molecular targets in the organism, determining the complex profiles of their biological activity. Moreover, due to biotransformation in the human body, they form one or several metabolites with different biological activity profiles. Therefore, the deve...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21207492

    authors： Filimonov DA,Rudik AV,Dmitriev AV,Poroikov VV

    更新日期：2020-10-11 00:00:00

  • Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata.

    abstract：:The stingless bee, Melipona fasciculata Smith (Apidae, Meliponini), is a native species from Brazil. Their products have high biotechnological potential, however there are no studies about the biological activities of pollen collected by M. fasciculata. In this context, the present study investigated the chemical comp...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184512

    authors： Lopes AJO,Vasconcelos CC,Pereira FAN,Silva RHM,Queiroz PFDS,Fernandes CV,Garcia JBS,Ramos RM,Rocha CQD,Lima STJRM,Cartágenes MDSS,Ribeiro MNS

    更新日期：2019-09-12 00:00:00

  • Energy-Dependent Endocytosis is Involved in the Absorption of Indomethacin Nanoparticles in the Small Intestine.

    abstract：:We previously reported that oral formulations containing indomethacin nanoparticles (IND-NPs) showed high bioavailability, and, consequently, improved therapeutic effects and reduced injury to the small intestine. However, the pathway for the transintestinal penetration of nanoparticles remained unclear. Thus, in this...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20030476

    authors： Ishii M,Fukuoka Y,Deguchi S,Otake H,Tanino T,Nagai N

    更新日期：2019-01-22 00:00:00

  • Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.

    abstract：:Neurodegenerative disorders affect around one billion people worldwide. They can arise from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer's and Parkinson's diseases. A progressive neurodegenerative...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20030719

    authors： Van Bulck M,Sierra-Magro A,Alarcon-Gil J,Perez-Castillo A,Morales-Garcia JA

    更新日期：2019-02-08 00:00:00

  • Special Issue of International Journal of Molecular Sciences (IJMS) "Purinergic P2 Receptors: Structure and Function".

    abstract：:This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 receptors[...]. ...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms22010383

    authors： Zemkova H

    更新日期：2020-12-31 00:00:00

  • Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons.

    abstract：:Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21134781

    authors： Melfi R,Cancemi P,Chiavetta R,Barra V,Lentini L,Di Leonardo A

    更新日期：2020-07-06 00:00:00

  • Growth and mycotoxin production by Chaetomium globosum is favored in a neutral pH.

    abstract：:Chaetomium globosum is frequently isolated in water-damaged buildings and produces two mycotoxins called chaetoglobosins A and C when cultured on building material. In this study, the influence of ambient pH on the growth of C. globosum was examined on an artificial medium. This fungus was capable of growth on potato ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms9122357

    authors： Fogle MR,Douglas DR,Jumper CA,Straus DC

    更新日期：2008-12-01 00:00:00

  • Differentiation of Adsorptive and Viscous Effects of Dietary Fibres on Bile Acid Release by Means of In Vitro Digestion and Dialysis.

    abstract：:To explain the cholesterol-reducing effects of dietary fibres, one of the major mechanisms proposed is the reduced reabsorption of bile acids in the ileum. The interaction of dietary fibres with bile acids is associated with their viscous or adsorptive effects. Since these fibre characteristics are difficult to invest...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19082193

    authors： Naumann S,Schweiggert-Weisz U,Bader-Mittermaier S,Haller D,Eisner P

    更新日期：2018-07-27 00:00:00

  • Cardiotonic Steroids-A Possible Link Between High-Salt Diet and Organ Damage.

    abstract：:High dietary salt intake has been listed among the top ten risk factors for disability-adjusted life years. We discuss the role of endogenous cardiotonic steroids in mediating the dietary salt-induced hypertension and organ damage. ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20030590

    authors： Paczula A,Wiecek A,Piecha G

    更新日期：2019-01-30 00:00:00

  • Redox Components: Key Regulators of Epigenetic Modifications in Plants.

    abstract：:Epigenetic modifications including DNA methylation, histone modifications, and chromatin remodeling are crucial regulators of chromatin architecture and gene expression in plants. Their dynamics are significantly influenced by oxidants, such as reactive oxygen species (ROS) and nitric oxide (NO), and antioxidants, lik...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21041419

    authors： R M SK,Wang Y,Zhang X,Cheng H,Sun L,He S,Hao F

    更新日期：2020-02-19 00:00:00

  • Anabolic Therapies in Osteoporosis and Bone Regeneration.

    abstract：:Osteoporosis represents the most common bone disease worldwide and results in a significantly increased fracture risk. Extrinsic and intrinsic factors implicated in the development of osteoporosis are also associated with delayed fracture healing and impaired bone regeneration. Based on a steadily increasing life expe...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20010083

    authors： Russow G,Jahn D,Appelt J,Märdian S,Tsitsilonis S,Keller J

    更新日期：2018-12-26 00:00:00

  • Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity.

    abstract：:Photodynamic therapy (PDT) of the thoracic cavity can be performed in conjunction with surgery to treat cancers of the lung and its pleura. However, illumination of the cavity results in tissue exposure to a broad range of fluence rates. In a murine model of intrathoracic PDT, we studied the efficacy of 2-(1-hexyloxye...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17010101

    authors： Grossman CE,Carter SL,Czupryna J,Wang L,Putt ME,Busch TM

    更新日期：2016-01-14 00:00:00

  • Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?

    abstract：:Therapeutic drug monitoring is routinely performed to maintain optimal tacrolimus concentrations in kidney transplant recipients. Nonetheless, toxicity and rejection still occur within an acceptable concentration-range. To have a better understanding of the relationship between tacrolimus dose, tacrolimus concentratio...

    journal_title：International journal of molecular sciences

    pub_type： 临床试验,杂志文章

    doi：10.3390/ijms20194710

    authors： In 't Veld AE,Grievink HW,Saghari M,Stuurman FE,de Kam ML,de Vries APJ,de Winter BCM,Burggraaf J,Cohen AF,Moerland M

    更新日期：2019-09-23 00:00:00

  • Iron Metabolism in Cancer.

    abstract：:Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis. Ir...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20010095

    authors： Wang Y,Yu L,Ding J,Chen Y

    更新日期：2018-12-27 00:00:00

  • Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis.

    abstract：:NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21155378

    authors： Haque E,Karim MR,Salam Teeli A,Śmiech M,Leszczynski P,Winiarczyk D,Parvanov ED,Atanasov AG,Taniguchi H

    更新日期：2020-07-29 00:00:00

  • Molecular motors and apical CFTR traffic in epithelia.

    abstract：:Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement o...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms14059628

    authors： Kravtsov DV,Ameen NA

    更新日期：2013-05-03 00:00:00

  • SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis.

    abstract：:The solute carrier (SLC) family-38 of transporters has eleven members known to transport amino acids, with glutamine being a common substrate for ten of them, with SLC38A9 being the exception. In this study, we examine the subcellular localization of SNAT10 in several independent immortalized cell lines and stem cell-...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20246265

    authors： Tripathi R,Hosseini K,Arapi V,Fredriksson R,Bagchi S

    更新日期：2019-12-12 00:00:00

  • Growth Hormone Deficiency Following Traumatic Brain Injury.

    abstract：:Traumatic brain injury (TBI) is fairly common and annually affects millions of people worldwide. Post traumatic hypopituitarism (PTHP) has been increasingly recognized as an important and prevalent clinical entity. Growth hormone deficiency (GHD) is the most common pituitary hormone deficit in long-term survivors of T...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20133323

    authors： Kgosidialwa O,Hakami O,Muhammad Zia-Ul-Hussnain H,Agha A

    更新日期：2019-07-06 00:00:00

  • Growth suppression of colorectal cancer by plant-derived multiple mAb CO17-1A × BR55 via inhibition of ERK1/2 phosphorylation.

    abstract：:We have generated the transgenic Tabaco plants expressing multiple monoclonal antibody (mAb) CO7-1A × BR55 by cross-pollinating with mAb CO17-1A and mAb BR55. We have demonstrated the anti-cancer effect of plant-derived multiple mAb CO17-1A × BR55. We find that co-treatment of colorectal mAbs (anti-epithelial cellular...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms151121105

    authors： Kwak DH,Moussavou G,Lee JH,Heo SY,Ko K,Hwang KA,Jekal SJ,Choo YK

    更新日期：2014-11-14 00:00:00

  • Targeting Cancer Stem Cells to Overcome Chemoresistance.

    abstract：:Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant to most anti-cancer treatments and could be preferential targets to reverse this resistance, either targeting stemness pathways or cancer stem ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19124036

    authors： Nunes T,Hamdan D,Leboeuf C,El Bouchtaoui M,Gapihan G,Nguyen TT,Meles S,Angeli E,Ratajczak P,Lu H,Di Benedetto M,Bousquet G,Janin A

    更新日期：2018-12-13 00:00:00