Abstract：
:Idiopathic osteoporosis and nephrolithiasis are formidable health problems showing a progressive increase in their incidence and prevalence in the last decades. These temporal trends were observed in both pediatric and adult populations worldwide. Epidemiological and experimental studies indicate that both disorders show several common pathogenic environmental and genetic factors. In this review, we analyzed the clinical characteristics common to the two disorders and the state-of-the-art knowledge regarding the genetic predisposition and the environmental factors recognized as triggers in adult and pediatric ages. As a result of this work, we propose to consider idiopathic nephrolithiasis and osteoporosis as two possible expressions of a unique clinical syndrome. Accordingly, the clinical approach to both disorders should be modified in order to program an efficient primary and secondary prevention strategy.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Rendina D,De Filippo G,Iannuzzo G,Abate V,Strazzullo P,Falchetti Adoi
10.3390/ijms21218183subject
Has Abstractpub_date
2020-10-31 00:00:00issue
21issn
1422-0067pii
ijms21218183journal_volume
21pub_type
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