Abstract：
:Superoxide dismutase (SOD) has attracted considerable attention on treatment of reactive oxygen species (ROS)-related disorders. We previously conjugated Cu/Zn SOD to O-quaternary chitosan derivatives (O-HTCC) to yield a polymer-enzyme conjugate O-HTCC-SOD that demonstrated superior therapeutic effect to native SOD. The present study demonstrated that O-HTCC-SOD had wider pH activity range, better thermal stability, excellent long-term stability for storage, as well as unique reinstatement of activity exposure to proteolytic degradation that was helpful for longer half-life in vivo. O-HTCC-SOD exerted significant anti-inflammatory effects on lipopolysaccharides (LPS)-stimulated mouse peritoneal macrophages by down-regulating production of pro-inflammatory cytokines and intracellular ROS. O-HTCC-SOD significantly attenuated dextran sodium (DSS)-induced colitis in mice as observed by the colitis severity, neutrophil infiltration and histopathological damage, whereas native SOD failed to do so. In conclusion, conjugation of O-HTCC conferred SOD with better stability and enhanced therapeutic potential, offering a promising option in treatment of inflammatory bowel disease.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zhao N,Feng Z,Shao M,Cao J,Wang F,Liu Cdoi
10.3390/ijms18061121subject
Has Abstractpub_date
2017-05-24 00:00:00issue
6issn
1422-0067pii
ijms18061121journal_volume
18pub_type
杂志文章abstract：:Perillaldehyde (PAE), an essential oil in Perilla plants, serves as a safe flavor ingredient in foods, and shows an effectively antifungal activity. Reactive oxygen species (ROS) accumulation in Aspergillus flavus plays a critical role in initiating a metacaspase-dependent apoptosis. However, the reason for ROS accumu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-02-23 00:00:00
abstract：:The circadian transcriptional network is based on a competition between transcriptional activator and repressor complexes regulating the rhythmic expression of clock-controlled genes. We show here that the MYC-associated factor X, MAX, plays a repressive role in this network and operates through a MYC-independent bind...
journal_title：International journal of molecular sciences
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abstract：UNLABELLED:Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However, gastrointestinal (GI) complications, particularly diarrhea, are frequently observed as a side effect following MPA therapy. We recently reported that MPA altered the tight junction (TJ)-mediated barrier func...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17040597
更新日期：2016-04-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-08-27 00:00:00
abstract：:In the present study, we investigated the signal transduction of mutants of the eel follicle-stimulating hormone receptor (eelFSHR). Specifically, we examined the constitutively activating mutant D540G in the third intracellular loop, and four inactivating mutants (A193V, N195I, R546C, and A548V). To directly assess f...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-09-25 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-08-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-12-30 00:00:00
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更新日期：2020-04-22 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms160818252
更新日期：2015-08-06 00:00:00
abstract：:Powdery mildew caused by Blumeria graminis f. sp. hordei (Bgh) is one of the most serious diseases in barley. The numerous barley varieties across China provide valuable genetic resources to screen the resistant germplasm and to discover the primary genes of resistance to powdery mildew. In this study, Chinese barley ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-12-24 00:00:00
abstract：:Major depressive disorder (MDD) represents a serious health problem estimated to affect 350 million people globally. Importantly, MDD has repeatedly emerged as an etiological or prognostic factor in cardiovascular disease (CVD) development, including vascular pathology. Several linking pathomechanisms between MDD and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-03-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-08-31 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124253
更新日期：2020-06-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21144907
更新日期：2020-07-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092582
更新日期：2018-08-30 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-09-19 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2016-01-26 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-04-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析
doi：10.3390/ijms20020257
更新日期：2019-01-10 00:00:00
abstract：:The market success of any rice cultivar is exceedingly dependent on its grain appearance, as well as its grain yield, which define its demand by consumers as well as growers. The present study was undertaken to explore the contribution of nine major genes, qPE9~1, GW2, SLG7, GW5, GS3, GS7, GW8, GS5, and GS2, in regula...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-09-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246315
更新日期：2019-12-14 00:00:00
abstract：:In eukaryotes, DNA is compacted into a complex structure known as chromatin. The unravelling of DNA is a crucial step in DNA repair, replication, transcription and recombination as this allows access to DNA for these processes. Failure to package DNA into the nucleosome, the individual unit of chromatin, can lead to g...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
abstract：:n/a. ...
journal_title：International journal of molecular sciences
pub_type： 已发布勘误
doi：10.3390/ijms18010178
更新日期：2017-01-17 00:00:00
abstract：BACKGROUND:Growth failure and delayed puberty are well known features of children and adolescents with inflammatory bowel disease (IBD), in addition to the chronic course of the disease. Urinary metabonomics was applied in order to better understand metabolic changes between healthy and IBD children. METHODS:21 Pediat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17081310
更新日期：2016-08-11 00:00:00
abstract：:Before utilization in biomedical diagnosis, therapeutic treatment, and biotechnology, the diverse variety of peptides and proteins must be preliminarily purified and thoroughly characterized. The recombinant DNA technology and heterologous protein expression have helped simplify the isolation of targeted polypeptides ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030928
更新日期：2020-01-31 00:00:00
abstract：:RNAi technology has significant potential as a future therapeutic and could theoretically be used to knock down disease-specific RNAs. However, due to frequent off-target effects, low efficiency, and limited accessibility of nuclear transcripts, the clinical application of the technology remains challenging. In this s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21238904
更新日期：2020-11-24 00:00:00
