Abstract：
:The circadian transcriptional network is based on a competition between transcriptional activator and repressor complexes regulating the rhythmic expression of clock-controlled genes. We show here that the MYC-associated factor X, MAX, plays a repressive role in this network and operates through a MYC-independent binding to E-box-containing regulatory regions within the promoters of circadian BMAL1 targets. We further show that this "clock" function of MAX is required for maintaining a proper circadian rhythm and that MAX and BMAL1 contribute to two temporally alternating transcriptional complexes on clock-regulated promoters. We also identified MAX network transcriptional repressor, MNT, as a fundamental partner of MAX-mediated circadian regulation. Collectively, our data indicate that MAX regulates clock gene expression and contributes to keeping the balance between positive and negative elements of the molecular clock machinery.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Blaževitš O,Bolshette N,Vecchio D,Guijarro A,Croci O,Campaner S,Grimaldi Bdoi
10.3390/ijms21072294subject
Has Abstractpub_date
2020-03-26 00:00:00issue
7issn
1422-0067pii
ijms21072294journal_volume
21pub_type
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