Abstract：
:MicroRNAs (miRNAs) are single-stranded, endogenous RNA molecules that play a significant role in the regulation of gene expression as well as cell development, differentiation, and function. Recent data suggest that these small molecules are responsible for the regulation of immune responses. Therefore, they may act as potent modulators of the immune system and play an important role in the development of several autoimmune diseases. Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by venous and/or arterial thromboses and/or recurrent fetal losses in the presence of antiphospholipid antibodies (aPLs). Several lines of evidence suggest that like other autoimmune disorders, miRNAs are deeply involved in the pathogenesis of APS, interacting with the function of innate and adaptive immune responses. In this review, we characterize miRNAs in the light of having a functional role in the immune system and autoimmune responses focusing on APS. In addition, we also discuss miRNAs as potential biomarkers and target molecules in treating APS.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kotyla PJ,Islam MAdoi
10.3390/ijms21062076subject
Has Abstractpub_date
2020-03-18 00:00:00issue
6issn
1422-0067pii
ijms21062076journal_volume
21pub_type
杂志文章,评审abstract：:Overexpression of a constitutively active truncated form of OsCDPK1 (OEtr) in rice produced smaller seeds, but a double-stranded RNA gene-silenced form of OsCDPK1 (Ri) yielded larger seeds, suggesting that OsCDPK1 plays a functional role in rice seed development. In the study presented here, we propose a model in whic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103247
更新日期：2018-10-19 00:00:00
abstract：:Articular cartilage (AC) is an avascular tissue composed of scattered chondrocytes embedded in a dense extracellular matrix, in which nourishment takes place via the synovial fluid at the surface. AC has a limited intrinsic healing capacity, and thus mainly surgical techniques have been used to relieve pain and improv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218249
更新日期：2020-11-04 00:00:00
abstract：:Pseudomonas aeruginosa and Staphylococcus aureus are two major pathogens involved in a large variety of infections. Their co-occurrence in the same site of infection has been frequently reported and is linked to enhanced virulence and difficulty of treatment. Herein, the antimicrobial and antibiofilm activities of an ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20143604
更新日期：2019-07-23 00:00:00
abstract：BACKGROUND:Patients with breast cancer-the deadliest cancer among women-are at constant risk of developing metastasis. Oxidative stress and hypoxia are common feature of tumor cells that can proliferate even in a resultant metabolic acidosis. Despite the low extracellular pH, intracellular pH of tumor cells remains rel...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040170
更新日期：2017-03-23 00:00:00
abstract：:Fresh produce is often a source of enterohaemorrhagic Escherichia coli (EHEC) outbreaks. Fimbriae are extracellular structures involved in cell-to-cell attachment and surface colonisation. F9 (Fml) fimbriae have been shown to be expressed at temperatures lower than 37 °C, implying a function beyond the mammalian host....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249720
更新日期：2020-12-19 00:00:00
abstract：:Of the multiple sources of reactive oxygen species (ROS) in the blood vessel, NADPH oxidases are the primary source. Whereas several studies have implicated NADPH oxidases in the initiation of atherosclerosis, their roles in disease progression are incompletely understood. Our objective was to determine the potential ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140817017
更新日期：2013-08-19 00:00:00
abstract：:Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(l-lactide-b-l-phenylalanine) copolymers with various...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150813247
更新日期：2014-07-29 00:00:00
abstract：:Pancreatic cancer (PC) is a highly lethal malignancy due to the cancer routinely being diagnosed late and having a limited response to chemotherapy. Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic malignant tumor, representing more than 85% of all pancreatic cancers. In the present study,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124473
更新日期：2020-06-23 00:00:00
abstract：:The largest group of deubiquitinases-ubiquitin-specific proteases (UBPs)-perform extensive and significant roles in plants, including the regulation of development and stress responses. A comprehensive analysis of UBP genes has been performed in Arabidopsis thaliana, but no systematic study has been conducted in moso ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174309
更新日期：2019-09-03 00:00:00
abstract：:In the last decade, the development of radiogenomics research has produced a significant amount of papers describing relations between imaging features and several molecular 'omic signatures arising from next-generation sequencing technology and their potential role in the integrated diagnostic field. The most vulnera...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20236033
更新日期：2019-11-29 00:00:00
abstract：:Although most cancer types have been viewed as immunologically silent until recently, it has become increasingly clear that the immune system plays key roles in the course of tumor development. Remarkable progress towards understanding cancer immunogenicity and tumor-immune system interactions has revealed important i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17071030
更新日期：2016-06-29 00:00:00
abstract：:Quorum sensing is an intercellular form of communication that bacteria use to coordinate group behaviors such as biofilm formation and the production of antibiotics and virulence factors. The term quorum sensing was originally coined to describe the mechanism underlying the onset of luminescence production in cultures...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140816386
更新日期：2013-08-07 00:00:00
abstract：:The retromer is a multiprotein complex conserved from yeast to humans, which is involved in intracellular protein trafficking and protein recycling. Selection of cargo proteins transported by the retromer depends on the core retromer subunit composed of the three vacuolar protein sorting (VPS) proteins, namely VPS26, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020362
更新日期：2019-01-16 00:00:00
abstract：:Photodynamic diagnosis (PDD) can improve diagnostic accuracy by using PDD agents such as 5-aminolevulinic acid (ALA). However, the weakness and photobleaching of fluorescence of PDD agents may lead to insufficient fluorescence visibility for the detection of cancer during resection operations. We focused on the "fluor...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153698
更新日期：2019-07-28 00:00:00
abstract：:Understanding disease pathology often does not require an overall proteomic analysis of clinical samples but rather the analysis of different, often rare, subpopulations of cells in a heterogeneous mixture of cell types. For the isolation of pre-specified cellular subtypes, fluorescence activated cell sorting (FACS) i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186557
更新日期：2020-09-08 00:00:00
abstract：:The recent emergence of antibiotic-resistant bacteria requires the development of new antibiotics or new agents capable of enhancing antibiotic activity. Lysozyme degrades bacterial cell wall without involving antibiotic resistance and has become a new antibacterial strategy. However, direct use of native, active prot...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051635
更新日期：2020-02-27 00:00:00
abstract：:Ion channels included in the family of Connexins (Cx) help to control cell proliferation and differentiation of neuronal progenitors. Here we explored the role of Connexin 50 (Cx50) in cell fate modulation of adult spinal cord derived neural precursors located in the ependymal canal (epSPC). epSPC from non-injured ani...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161125981
更新日期：2015-11-06 00:00:00
abstract：:The Cpi-17 (ppp1r14) gene family is an evolutionarily conserved, vertebrate specific group of protein phosphatase 1 (PP1) inhibitors. When phosphorylated, Cpi-17 is a potent inhibitor of myosin phosphatase (MP), a holoenzyme complex of the regulatory subunit Mypt1 and the catalytic subunit PP1. Myosin phosphatase deph...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165709
更新日期：2020-08-09 00:00:00
abstract：:: Mitochondrial respiratory chain supercomplexes (RCS), particularly, the respirasome, which contains complexes I, III, and IV, have been suggested to participate in facilitating electron transport, reducing the production of reactive oxygen species (ROS), and maintaining the structural integrity of individual electro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051555
更新日期：2020-02-25 00:00:00
abstract：:The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010120
更新日期：2020-12-24 00:00:00
abstract：:In contrast to the well-studied effect of auxin on the plasma membrane K+ channel activity, little is known about the role of this hormone in regulating the vacuolar K+ channels. Here, the patch-clamp technique was used to investigate the effect of auxin (IAA) on the fast-activating vacuolar (FV) channels. It was foun...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21144876
更新日期：2020-07-10 00:00:00
abstract：:(Pro)renin receptor ((P)RR) is a multi-functional molecule that is related to both the renin-angiotensin system (RAS) and vacuolar H⁺-ATPase (v-ATPase), an ATP-dependent multi-subunit proton pump. Soluble (P)RR (s(P)RR), which consists of the extracellular domain of (P)RR, is present in blood and urine. Elevated plasm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18061313
更新日期：2017-06-20 00:00:00
abstract：:Inflammation is the body's response to injury or infection. As early as 2000 years ago, the Roman encyclopaedist Aulus Cornelius Celsus recognised four cardinal signs of this response-redness, heat, swelling and pain; a fifth sign is loss of function.[...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms18112415
更新日期：2017-11-14 00:00:00
abstract：:Derivatives of 3,4-hydroxypyridinones have been extensively studied for in vivo Fe3+ sequestration. Deferiprone, a 1,2-dimethyl-3,4-hydroxypyridinone, is now routinely used for clinical treatment of iron overload disease. Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe3+ at very low iron concentration...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18010116
更新日期：2017-01-08 00:00:00
abstract：:Calcium-dependent protein kinase (CDPK or CPK) and CDPK-related kinase (CRK) play an important role in plant growth, development, and adaptation to environmental stresses. However, their gene families had been yet inadequately investigated in Medicago truncatula. In this study, six MtCRK genes were computationally ide...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031044
更新日期：2021-01-21 00:00:00
abstract：:Subcutaneous adipose tissue is a loose connective tissue specializing in the regulation of energy storage and metabolization. In domesticated pigs (Sus scrofa), the temporal development of subcutaneous adipose tissue is critical for meat production. However, the regulation of adipose tissue development remains unclear...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123892
更新日期：2018-12-05 00:00:00
abstract：:TCDD-inducible poly-ADP-ribose polymerase (TIPARP) is an aryl hydrocarbon receptor (AHR) target gene that functions as part of a negative feedback loop to repress AHR activity. Tiparp-/- mice exhibit increased sensitivity to the toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), including lethal wast...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092312
更新日期：2019-05-10 00:00:00
abstract：:In vivo inoculation of cells such as tumor cells and induced pluripotent stem (iPS)/embryonic stem (ES) cells into immunocompromised mice has been considered as a powerful technique to evaluate their potential to proliferate or differentiate into various cell types originating from three germ cell layers. Subcutaneous...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18081678
更新日期：2017-08-02 00:00:00
abstract：:Centrosome aberrations have been implicated in the development and progression of breast cancer. Our previous worked show that centrosomal protein 70 (Cep70) regulates breast cancer growth and metastasis. However, it remains elusive whether Cep70 is implicated in the sensitivity of the anti-microtubule drug paclitaxel...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061267
更新日期：2017-06-20 00:00:00
abstract：:The concentration of five soil heavy metals (Pb, Co, Cr, Cu, Hg) was measured in forty sampling sites in central Transylvania, Romania, regions known as centres of pollution due to the chemical and metallurgical activities. The soil samples were collected from locations where the ground is not sliding and the probabil...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9040434
更新日期：2008-04-01 00:00:00
