Abstract:
:It has been confirmed that alternatively activated macrophages (M2) participate in tissue remodeling and fibrosis occurrence, but the effect of M2 on peritoneal fibrosis related to peritoneal dialysis (PD) hasn't been elucidated. This study was therefore conducted to assess the association between M2 and peritoneal fibrosis related to PD. In this study, peritoneal fibrosis was induced by intraperitoneal (i.p.) injection of Lactate-4.25% dialysate (100 mL/kg) to C57BL/6J mice for 28 days, and liposome-encapsulated clodronate (LC, the specific scavenger of macrophages) was used to treat the peritoneal fibrosis mice model by i.p. injection at day 18 and day 21. All animals were sacrificed at day 29. Parietal peritonea were stained with Masson's trichrome, and the expression of type I collagen (Col-I), fibronectin, mannose receptor (CD206), transforming growth factor beta (TGF-β), chemokine receptor 7 (CCR7), chitinase 3-like 3 (Ym-1) and arginase-1 (Arg-1) was determined by Western blotting, immunofluorescence and quantitative real-time PCR. Our results revealed that peritoneal thickness, Col-I, fibronectin, CD206, TGF-β, Ym-1 and Arg-1 were upregulated in the peritoneal fibrosis mice model, and all of these indexes were downregulated in those treated with LC. Additionally, there was no difference in the level of CCR7 between the model and treatment group. Our study indicated that peritoneal M2 played an important role in the process of peritoneal fibrosis related to PD and might be a potential target for intervention therapy of peritoneal fibrosis.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wang J,Jiang ZP,Su N,Fan JJ,Ruan YP,Peng WX,Li YF,Yu XQdoi
10.3390/ijms140510369subject
Has Abstractpub_date
2013-05-17 00:00:00pages
10369-82issue
5issn
1422-0067pii
ijms140510369journal_volume
14pub_type
杂志文章abstract::This study explored the inhibiting effect and mechanism of myricanol on lung adenocarcinoma A549 xenografts in nude mice. Forty nude mice with subcutaneous A549 xenografts were randomly divided into five groups: high-dose myricanol (40 mg/kg body weight) group; middle-dose myricanol (20 mg/kg body weight) group; low-d...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16022717
更新日期:2015-01-26 00:00:00
abstract::There is evidence that spaceflight poses acute and late risks to the central nervous system. To explore possible mechanisms, the proteomic changes following spaceflight in mouse brain were characterized. Space Shuttle Atlantis (STS-135) was launched from the Kennedy Space Center (KSC) on a 13-day mission. Within 3⁻5 h...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20010007
更新日期:2018-12-20 00:00:00
abstract::High-density genetic linkage maps of crop species are particularly useful in detecting qualitative and quantitative trait loci for important agronomic traits and in improving the power of classical approaches to identify candidate genes. The aim of this study was to develop a high-density genetic linkage map in a duru...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18061329
更新日期:2017-06-21 00:00:00
abstract::Autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are chronic inflammatory disorders of unknown etiology characterized by a wide range of abnormalities of the immune system that may compromise the function of several organs, such as kidney, heart, j...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms15034965
更新日期:2014-03-20 00:00:00
abstract::We have originally reported that colony-forming units granulocyte/macrophage (CFU-GM) formation is an in vitro feature of chronic myelomonocytic leukemia (CMML) and a strong predictor for short survival. Elucidation of the molecular basis underlying this in vitro phenomenon could be helpful to define molecular feature...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176057
更新日期:2020-08-22 00:00:00
abstract::Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulatio...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19030670
更新日期:2018-02-27 00:00:00
abstract::Administration of antioxidants and anti-inflammatory agents is an effective strategy for preventing ultraviolet (UV) irradiation-induced skin damage. Artocarpus communis possesses several pharmacological activities, such as antioxidant, anticancer and anti-inflammation. However, the photoprotective activity of methan...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14023860
更新日期:2013-02-12 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is often diagnosed at a late stage and may be malignantly transformed from oral leukoplakia (OL). This study aimed to identify potential plasma microRNAs (miRNAs) for the early detection of oral cancer. Plasma from normal, OL, and OSCC patients were evaluated. Small RNA sequencing w...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19030758
更新日期:2018-03-07 00:00:00
abstract::This work investigated in vitro aggregation and amyloid properties of skeletal myosin binding protein-C (sMyBP-C) interacting in vivo with proteins of thick and thin filaments in the sarcomeric A-disc. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) found a rapid (5-10 min) formation of large...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020731
更新日期:2021-01-13 00:00:00
abstract::The paper studies the combined effects of beta-emitting radionuclide tritium and Humic Substances (HS) on the marine unicellular microorganism-luminous bacteria-under conditions of low-dose radiation exposures (<0.04 Gy). Tritium was used as a component of tritiated water. Bacterial luminescence intensity was consider...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186783
更新日期:2020-09-16 00:00:00
abstract::Protein phosphatase 5 (PP5) is a unique member of serine/threonine phosphatases which has been recognized in regulation of diverse cellular processes. A cDNA fragment encoding PP5 (EcPP5) was cloned and characterized from the cantharidin-producing blister beetle, E. chinensis. EcPP5 contains an open reading frame of 1...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141224501
更新日期:2013-12-16 00:00:00
abstract::Reduced low-density lipoprotein (LDL) cholesterol level is a characteristic feature of dyslipidemia in chronic hepatitis C virus (HCV) infection. However, abnormality in serum triglyceride (TG) has not been fully investigated. To clarify the impact of HCV genotype 1b (G1b) infection and advanced fibrosis on serum TG p...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160920576
更新日期:2015-08-31 00:00:00
abstract::Esterification of starch was carried out to expand the usefulness of starch for a myriad of industrial applications. Lipase B from Candida antarctica, immobilized on macroporous acrylic resin (Novozym 435), was used for starch esterification in two reaction systems: micro-solvent system and solvent-free system. The es...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13067226
更新日期:2012-01-01 00:00:00
abstract::Facioscapulohumeral muscular dystrophy (FSHD) is a disabling inherited muscular disorder characterized by asymmetric, progressive muscle weakness and degeneration. Patients display widely variable disease onset and severity, and sometimes present with extra-muscular symptoms. There is a consensus that FSHD is caused b...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21030729
更新日期:2020-01-22 00:00:00
abstract::Evidence suggests that high-density lipoprotein (HDL) components distinct from cholesterol, such as sphingosine-1-phosphate (S1P), may account for the anti-atherothrombotic effects attributed to this lipoprotein. The current method for the determination of plasma levels of S1P as well as levels associated with HDL par...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18081800
更新日期:2017-08-18 00:00:00
abstract::Caspase-8 was originally identified as a central player of programmed cell death triggered by death receptor stimulation. In that context, its activity is tightly regulated through several mechanisms, with the best established being the expression of FLICE-like inhibitory protein (FLIP) family proteins and the Src-dep...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19123798
更新日期:2018-11-29 00:00:00
abstract::Juglone, a major naphthalenedione component of walnut trees, has long been used in traditional medicine as an antimicrobial and antitumor agent. Nonetheless, its impact on oocyte and preimplantation embryo development has not been entirely clarified. Using the bovine model, we sought to elucidate the impact of juglone...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010168
更新日期:2020-12-26 00:00:00
abstract::At a resting sarcomere length of approximately 2.2 µm bony fish muscles put into rigor in the presence of BDM (2,3-butanedione monoxime) to reduce rigor tension generation show the normal arrangement of myosin head interactions with actin filaments as monitored by low-angle X-ray diffraction. However, if the muscles a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19072091
更新日期:2018-07-18 00:00:00
abstract::The Chinese white pine beetle Dendroctonus armandi Tsai and Li, is arguably the most destructive forest insect in the Qinling Mountains in Northern China. Little is known about the structure of the bacterial communities associated with D. armandi even though this wood-boring insect plays important roles in ecosystem a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141021006
更新日期:2013-10-18 00:00:00
abstract::The TiO2-montmorillonite (TiO2-MMT) complex was prepared by blending TiO2 sol and MMT with certain ratio, and its properties as an enzyme immobilization support were investigated. The pristine MMT and TiO2-MMT calcined at 800 °C (TiO2-MMT800) were used for comparison to better understand the immobilization mechanism. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140612520
更新日期:2013-06-14 00:00:00
abstract::The mechanisms behind fatigue intensification during cancer therapy remain elusive. The interferon alpha-inducible protein 27 (IFI27) was the most up-regulated gene based on our previous microarray data in fatigued men with non-metastatic prostate cancer receiving localized external beam radiation therapy (EBRT). The ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140816943
更新日期:2013-08-16 00:00:00
abstract::The analgesic effect of venlafaxine (VLX), which is a selective serotonin and noradrenaline reuptake inhibitor (SNRI), has been observed on oxaliplatin-induced neuropathic pain in mice. Significant allodynia was shown after oxaliplatin treatment (6 mg/kg, i.p.); acetone and von Frey hair tests were used to assess cold...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20071652
更新日期:2019-04-03 00:00:00
abstract::Recent studies have identified cyclic GMP-AMP synthase (cGAS) as an important target for treating autoimmune diseases, and several inhibitors of human cGAS (hcGAS) and their structures in complexation with hcGAS have been reported. However, the mechanisms via which these inhibitors interact with hcGAS are not complete...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031164
更新日期:2021-01-25 00:00:00
abstract::Due to a typesetting error during layout, several references were incorrectly listed in [...]. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,已发布勘误
doi:10.3390/ijms20112651
更新日期:2019-05-29 00:00:00
abstract::Shellfish allergy affects 2% of the world's population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfis...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010032
更新日期:2020-12-22 00:00:00
abstract::Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new os...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms11010354
更新日期:2010-01-25 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC), a major histologic type of esophageal cancer, is one of the frequent causes of cancer-related death worldwide. Picropodophyllotoxin (PPT) is the main component of Podophyllum hexandrum root with antitumor activity via apoptosis-mediated mechanisms in several cancer cells. How...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21134640
更新日期:2020-06-30 00:00:00
abstract::Paired box gene 3 (Pax3) and cAMP responsive element-binding protein (CREB) directly interact with the cis-acting elements on the promoter of microphthalmia-associated transcription factor isoform M (MITF-M) for transcriptional activation in the melanogenic process. Tyrosinase (Tyro) is a target gene of MITF-M, and fu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249631
更新日期:2020-12-17 00:00:00
abstract::Ischemic stroke is a leading cause of human death in present times. Two phases of pathological impact occur during an ischemic stroke, namely, ischemia and reperfusion. Both periods include individual characteristic effects on cell injury and apoptosis. Moreover, these conditions can cause severe cell defects and harm...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246168
更新日期:2019-12-06 00:00:00
abstract::Pulmonary hypertension (PH) complicates bronchopulmonary dysplasia (BPD) in 25% of infants. Superoxide dismutase 2 (SOD2) is an endogenous mitochondrial antioxidant, and overexpression protects against acute lung injury in adult mice. Little is known about SOD2 in neonatal lung disease and PH. C57Bl/6 mice and isogeni...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16036373
更新日期:2015-03-19 00:00:00