Abstract：
:Autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are chronic inflammatory disorders of unknown etiology characterized by a wide range of abnormalities of the immune system that may compromise the function of several organs, such as kidney, heart, joints, brain and skin. Corticosteroids (CCS), synthetic and biologic immunosuppressive agents have demonstrated the capacity to improve the course of autoimmune diseases. However, a significant number of patients do not respond or develop resistance to these therapies over time. P-glycoprotein (P-gp) is a transmembrane protein that pumps several drugs out of the cell, including CCS and immunosuppressants; thus, its over-expression or hyper-function has been proposed as a possible mechanism of drug resistance in patients with autoimmune disorders. Recently, different authors have demonstrated that P-gp inhibitors, such as cyclosporine A (CsA) and its analogue Tacrolimus, are able to reduce P-gp expression and or function in SLE, RA and PsA patients. These observations suggest that P-gp antagonists could be adopted to revert drug resistance and improve disease outcome. The complex inter-relationship among drug resistance, P-gp expression and autoimmunity still remains elusive.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Picchianti-Diamanti A,Rosado MM,Scarsella M,Laganà B,D'Amelio Rdoi
10.3390/ijms15034965subject
Has Abstractpub_date
2014-03-20 00:00:00pages
4965-76issue
3issn
1422-0067pii
ijms15034965journal_volume
15pub_type
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journal_title：International journal of molecular sciences
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abstract：:Several cellular insults can result in sperm DNA fragmentation either on one or both DNA strands. Oxidative damage, premature interruption of the apoptotic process and defects in DNA compaction during spermatogenesis are the main mechanisms that cause DNA breaks in sperm. The two-tailed Comet assay is the only techniq...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2015-11-24 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2011-01-01 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2016-09-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-08-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-07-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-05-25 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-01-21 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-08-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-01-23 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-11-28 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-06-20 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-10-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2014-08-21 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-01-30 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-02-13 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-08-10 00:00:00
abstract：:Aegilops geniculata Roth has been used as a donor of disease-resistance genes, to enrich the gene pool for wheat (Triticum aestivum) improvement through distant hybridization. In this study, the wheat-Ae. geniculata alien disomic substitution line W16998 was obtained from the BC1F8 progeny of a cross between the commo...
journal_title：International journal of molecular sciences
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更新日期：2020-03-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-02-07 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-11-03 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms150813247
更新日期：2014-07-29 00:00:00
