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The association of IFI27 expression and fatigue intensification during localized radiation therapy: implication of a para-inflammatory bystander response.

Abstract：

:The mechanisms behind fatigue intensification during cancer therapy remain elusive. The interferon alpha-inducible protein 27 (IFI27) was the most up-regulated gene based on our previous microarray data in fatigued men with non-metastatic prostate cancer receiving localized external beam radiation therapy (EBRT). The purpose of this study was to confirm the IFI27 up-regulation and determine its association with fatigue intensification during EBRT. Peripheral blood samples and fatigue scores were collected at three time points--prior to EBRT, at midpoint, and at completion of EBRT. Confirmatory quantitative real time polymerase chain reaction (qPCR) and enzyme-linked immunosorbent assay (ELISA) were utilized to verify the microarray results. Subjects were a total of 40 Caucasian men with prostate cancer; 20 scheduled for EBRT (65.6 ± 7.5 years old), and 20 on active surveillance as controls (62.8 ± 6.1 years old). Significant IFI27 expression overtime during EBRT was confirmed by qPCR (p < 0.5), which correlated with fatigue scores during EBRT (R = -0.90, p = 0.006). Alterations in mechanisms associated with immune response and mitochondrial function that explain the up-regulation of IFI27 may provide an understanding of the pathways related to the intensification of fatigue during localized radiation therapy.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Hsiao CP,Araneta M,Wang XM,Saligan LN

doi

10.3390/ijms140816943

subject

Has Abstract

pub_date

2013-08-16 00:00:00

pages

16943-57

issue

8

issn

1422-0067

pii

ijms140816943

journal_volume

14

pub_type

杂志文章

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