Abstract：
:Ethanol is well known as a teratogenic factor that is capable of inducing a wide range of developmental abnormalities if the developing fetus is exposed to it. Duration and dose are the critical parameters of exposure that affect teratogenic variation to the developing fetus. It is suggested that ethanol interferes with epigenetic processes especially DNA methylation. We aimed to organize all of the available information on the alteration of DNA methylation by ethanol in utero. Thus, we have summarized all published information regarding alcohol-mediated alterations in DNA methylation during gestation. We tried to arrange information in a way that anyone can easily find the alcohol exposure time, doses, sampling time, and major changes in genomic level. Manuscript texts will also represent the correlation between ethanol metabolites and subsequent changes in methylome patterns. We hope that this review will help future researchers to further examine the issues associated with ethanol exposure.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Mandal C,Halder D,Jung KH,Chai YGdoi
10.3390/ijms18071386subject
Has Abstractpub_date
2017-06-28 00:00:00issue
7issn
1422-0067pii
ijms18071386journal_volume
18pub_type
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