Abstract:
:Kaempferol (Kae), a natural flavonoid, is widely distributed in fruits and vegetables. Previous studies have identified Kae as a possible cancer preventive and therapeutic agent. We found Kae to exhibit potent antiproliferation and anti-migration effects in human bladder cancer EJ cells. Kaempferol robustly induced apoptosis in EJ cells in a dose-dependent manner, as evidenced by increased cleavage of caspase-3. Furthermore, we found Kae-induced apoptosis in EJ cells to be associated with phosphatase and the tensin homolog deleted on the chromosome 10 (PTEN)/PI3K/Akt pathway. Kae significantly increased PTEN and decreased Akt phosphorylation. Kae-induced apoptosis was partially attenuated in PTEN-knockdown cells. Our findings indicate that Kae could be an alternative medicine for bladder cancer, based on a PTEN activation mechanism.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Xie F,Su M,Qiu W,Zhang M,Guo Z,Su B,Liu J,Li X,Zhou Ldoi
10.3390/ijms141121215subject
Has Abstractpub_date
2013-10-24 00:00:00pages
21215-26issue
11issn
1422-0067pii
ijms141121215journal_volume
14pub_type
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