Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN.

Abstract:

:Kaempferol (Kae), a natural flavonoid, is widely distributed in fruits and vegetables. Previous studies have identified Kae as a possible cancer preventive and therapeutic agent. We found Kae to exhibit potent antiproliferation and anti-migration effects in human bladder cancer EJ cells. Kaempferol robustly induced apoptosis in EJ cells in a dose-dependent manner, as evidenced by increased cleavage of caspase-3. Furthermore, we found Kae-induced apoptosis in EJ cells to be associated with phosphatase and the tensin homolog deleted on the chromosome 10 (PTEN)/PI3K/Akt pathway. Kae significantly increased PTEN and decreased Akt phosphorylation. Kae-induced apoptosis was partially attenuated in PTEN-knockdown cells. Our findings indicate that Kae could be an alternative medicine for bladder cancer, based on a PTEN activation mechanism.

journal_name

Int J Mol Sci

authors

Xie F,Su M,Qiu W,Zhang M,Guo Z,Su B,Liu J,Li X,Zhou L

doi

10.3390/ijms141121215

subject

Has Abstract

pub_date

2013-10-24 00:00:00

pages

21215-26

issue

11

issn

1422-0067

pii

ijms141121215

journal_volume

14

pub_type

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