Abstract：
:Over 70 different genetic variants with a significant association with rheumatoid arthritis (RA) have been discovered. Anti-citrullination protein antibodies (ACPA)-positive RA variants are more well-defined than their ACPA-negative counterparts. The human leukocyte antigen, HLA-DRB1 locus remains the prime suspect in anti-citrullination protein antibodies (ACPA)-positive RA. Different HLA-DRB1 alleles are linked to RA susceptibility across different ethnicities. With evolving techniques, like genome-wide association studies (GWAS) and single nucleotide polymorphism (SNP) arrays, more non-HLA susceptibility loci have been identified for both types of RA. However, the functional significance of only a handful of these variants is known. Their roles include increasing susceptibility to RA or in determining the speed at which the disease progresses. Additionally, a couple of variations are associated with protection from RA. Defining such clear-cut biological functions can aid in the clinical diagnosis and treatment of RA. Recent research has focused on the implication of microRNAs, with miR-146a widely studied. In addition to disease susceptibility, genetic variations that influence the efficacy and toxicity of anti-RA agents have also been identified. Polymorphisms in the MTHFR gene influence the effectiveness of methotrexate, the first line of therapy in RA. Larger studies are, however, needed to identify potential biomarkers for early disease identification and monitoring disease progression.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chung IM,Ketharnathan S,Thiruvengadam M,Rajakumar Gdoi
10.3390/ijms17060900subject
Has Abstractpub_date
2016-06-08 00:00:00issue
6issn
1422-0067pii
ijms17060900journal_volume
17pub_type
杂志文章,评审abstract：:Ischemia-reperfusion injury (IRI) is a major cause of graft loss and dysfunction in clinical transplantation and organ resection. [...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms19124093
更新日期：2018-12-18 00:00:00
abstract：:Microfluidic flow chambers (MFCs) allow the study of platelet adhesion and thrombus formation under flow, which may be influenced by several variables. We developed a new MFC, with which we tested the effects of different variables on the results of platelet deposition and thrombus formation on a collagen-coated surfa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030750
更新日期：2020-01-23 00:00:00
abstract：:Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DC...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19010042
更新日期：2017-12-23 00:00:00
abstract：:Aromatic isocyanides including isocyanonaphthalene derivatives have been proven to be very effective fluorescent sensors for the quantification of Hg(II) ions in water. Thus, the reaction of 1,5-isocyanoaminonaphthalene (1,5-ICAN), which is one of the most important members of this family, with water and HgCl2 as the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155588
更新日期：2020-08-04 00:00:00
abstract：:Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge in the application of CS NPs was faced during their size-controlled s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246212
更新日期：2019-12-09 00:00:00
abstract：:In this article, we present a method for the enhanced molecular dynamics simulation of protein and DNA systems called potential of mean force (PMF)-enriched sampling. The method uses partitions derived from the potentials of mean force, which we determined from DNA and protein structures in the Protein Data Bank (PDB)...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113405
更新日期：2018-10-30 00:00:00
abstract：:Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and coating. However, the current coating technologies possess several drawbacks, including limited du...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197370
更新日期：2020-10-06 00:00:00
abstract：:It has been hypothesized that genetic variation in base excision repair (BER) might modify colorectal adenoma risk. Thus, we evaluated the influence of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in normal and tumor samples from patients with colorectal cancer. The results indicate a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151017333
更新日期：2014-09-29 00:00:00
abstract：:Cell adhesion ability is one of the components to establish cell organization and shows a great contribution to human body construction consisting of various types of cells mixture to orchestrate tissue specific function. The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and h...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21249732
更新日期：2020-12-20 00:00:00
abstract：:Understanding the kinetics of peptide self-assembly is important because of the involvement of peptide amyloid fibrils in several neurodegenerative diseases. In this paper, we have studied the dissolution kinetics of self-assembled model peptide fibrils after a dilution quench. Due to the low concentrations involved, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207671
更新日期：2020-10-16 00:00:00
abstract：:Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-to-micrometer vesicles released from nearly all cellular types. EVs comprise a mixture of bioactive molecules (e.g., mRNAs, miRNAs, lipids, and proteins) that can be transported to the targeted cells/tissues via the blood or lymph circulation...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145163
更新日期：2020-07-21 00:00:00
abstract：:This study investigated the interaction between eupatorin and bovine serum albumin (BSA) using ultraviolet-visible (UV-vis) absorption, fluorescence, synchronous fluorescence, circular dichroism (CD) spectroscopies, and molecular modeling at pH 7.4. Results of UV-vis and fluorescence spectroscopies illustrated that BS...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140714185
更新日期：2013-07-09 00:00:00
abstract：:Silk sericin (SS) can accelerate cell proliferation and attachment; however, SS can be extracted by various methods, which result in SS exhibiting different physical and biological properties. We found that SS produced from various extraction methods has different molecular weights, zeta potential, particle size and a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11052200
更新日期：2010-05-20 00:00:00
abstract：:Dendrobium officinale is a precious medicinal herb and health food, and its pharmacological actions have been studied and proved. However, the mechanisms by which its active flavonoid glycosides affect epithelial⁻mesenchymal transition (EMT) in hepatocellular carcinoma (HCC) cells, such as HepG2 and Bel-7402 cells, ha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061556
更新日期：2018-05-23 00:00:00
abstract：:Structural alterations of pericytes in microvessels are important features of diabetic retinopathy. Although capillary pericytes had been known not to have α-smooth muscle actin (αSMA), a recent study revealed that a specific fixation method enabled the visualization of αSMA along retinal capillaries. In this study, w...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062158
更新日期：2020-03-20 00:00:00
abstract：:Tea (Camellia sinensis (L.) O. Kuntze), one of the main crops in China, is high in various bioactive compounds including flavonoids, catechins, caffeine, theanine, and other amino acids. C. sinensis is also known as an accumulator of fluoride (F), and the bioactive compounds are affected by F, however, the mechanism r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020237
更新日期：2019-01-09 00:00:00
abstract：:Liquid biopsy-based methods to test biomarkers (e.g., serum proteins and extracellular vesicles) may help to monitor brain tumors. In this proteomics-based study, we aimed to identify a characteristic protein fingerprint associated with central nervous system (CNS) tumors. Overall, 96 human serum samples were obtained...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155359
更新日期：2020-07-28 00:00:00
abstract：:Besides being traditionally used to relieve hepatobiliary disorders, Cynara cardunculus L. has evidenced anticancer potential on triple-negative breast cancer (TNBC). This study highlights the antiproliferative effects of lipophilic extracts from C. cardunculus L. var. altilis (DC) leaves and florets, and of their maj...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010063
更新日期：2016-12-29 00:00:00
abstract：:Absence of effective therapeutic methods for avascular necrosis of femoral head (ANFH) is still perplexing the world's medical community. Bone marrow mesenchymal stem cells (BMSCs) adoptive cell therapy combined with core decompression is a promising modality, which is highly dependent on the cellular activities of BM...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19030734
更新日期：2018-03-05 00:00:00
abstract：:Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17081270
更新日期：2016-08-19 00:00:00
abstract：:The last step in the biosynthesis of flavin adenine dinucleotide (FAD) is considered a target for the design of antimicrobial drugs because it is carried out by two non-homologous proteins in eukaryotic and prokaryotic organisms. Monofunctional FMN: adenylyltransferases (FMNAT) in Eukarya and FMNAT modules of bifuncti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103738
更新日期：2020-05-25 00:00:00
abstract：:Hyperuricemia, or elevated serum urate, causes urate kidney stones and gout and also increases the incidence of many other conditions including renal disease, cardiovascular disease, and metabolic syndrome. As we gain mechanistic insight into how urate contributes to human disease, a clear sex difference has emerged i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124269
更新日期：2020-06-16 00:00:00
abstract：:MicroRNAs are 18-22 nucleotides long, non-coding RNAs that bind transcripts with complementary sequences leading to either mRNA degradation or translational suppression. However, the inherent differences in preferred mode of miRNA regulation among cells of different origin have not been examined. In our previous trans...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010072
更新日期：2016-01-08 00:00:00
abstract：:CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation. In contrast to these pro-tumorigenic functions, CD155 is also a ligand for the activating receptor DNAM-1 expressed on...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030922
更新日期：2020-01-30 00:00:00
abstract：BACKGROUND:On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21093104
更新日期：2020-04-28 00:00:00
abstract：:As p300-mediated RelA/p65 hyperacetylation by signal transducers and activators of transcription 3 (STAT3) is critical for NF-κB activation, in the current study, the apoptotic mechanism of lambertianic acid (LA) was explored in relation to STAT3 phosphorylation and RelA/p65 acetylation in MCF-7, DU145, PC-3, and MDA-...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20122993
更新日期：2019-06-19 00:00:00
abstract：:Chaetomium globosum is frequently isolated in water-damaged buildings and produces two mycotoxins called chaetoglobosins A and C when cultured on building material. In this study, the influence of ambient pH on the growth of C. globosum was examined on an artificial medium. This fungus was capable of growth on potato ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9122357
更新日期：2008-12-01 00:00:00
abstract：:The solvatochromic characteristics of flavone and 7-hydroxyflavone were investigated in neat and binary solvent mixtures. The spectral shifts of these solutes were correlated with the Kamlet and Taft parameters (α, β and π*) using linear solvation energy relationships. The multiparametric analysis indicates that both ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12128895
更新日期：2011-01-01 00:00:00
abstract：:In order to supply new information on the antioxidant function of selected beverages for nutritionists and the general public, total phenolic contents of 51 kinds of herbal and tea infusions made in China were measured by the Folin-Ciocalteu method, and their antioxidant capacities were evaluated using ferric reducing...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12042112
更新日期：2011-01-01 00:00:00
abstract：:Fat deposition, which influences pork production, meat quality and growth efficiency, is an economically important trait in pigs. Numerous studies have demonstrated that stearoyl-CoA desaturase (SCD), a key enzyme that catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, is associated wi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072446
更新日期：2020-04-01 00:00:00
