Abstract：
:Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the treatment of various diseases. However, only a few of these ligands are clinically used. Recently, more detailed structural information for cannabinoid receptors was revealed thanks to the powerfulness of cryo-electron microscopy, which now can accelerate structure-based drug discovery. At the same time, novel peptide-type cannabinoids from animal sources have arrived at the scene, with their potential in vivo therapeutic effects in relation to cannabinoid receptors. From a natural products perspective, it is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, including voltage- and ligand-gated ion channels, G protein-coupled receptors such as CB1 and CB2, with astonishing affinity and selectivity. Therefore, it is believed that discovering novel cannabinoids starting from studying the biodiversity of the species living on planet earth is an uncharted territory.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
An D,Peigneur S,Hendrickx LA,Tytgat Jdoi
10.3390/ijms21145064subject
Has Abstractpub_date
2020-07-17 00:00:00issue
14issn
1422-0067pii
ijms21145064journal_volume
21pub_type
杂志文章,评审abstract：:Metallothioneins have been viewed as modulators in a number of biological regulations regarding cancerous development; however, the function of metallothionein 3 (MT3) in bladder cancer is unexplored. We determined the regulatory mechanisms and potential function of MT3 in bladder carcinoma cells. Real-Time Reverse Tr...
journal_title：International journal of molecular sciences
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更新日期：2019-04-15 00:00:00
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更新日期：2020-10-02 00:00:00
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更新日期：2020-11-24 00:00:00
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更新日期：2018-11-21 00:00:00
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pub_type： 杂志文章,评审
doi：10.3390/ijms21020592
更新日期：2020-01-16 00:00:00
