当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Biochemical properties and possible roles of ectophosphatase activities in fungi.

Biochemical properties and possible roles of ectophosphatase activities in fungi.

Abstract：

:Ectophosphatases are surface membrane-bound proteins whose active sites face the extracellular medium. These enzymes have been reported in several microorganisms including a large number of medically relevant fungal species. An effective technique for identifying ectophosphatases is performing phosphatase activity assays using living intact cells. Biochemical characterization of these activities has shown their differential modulation by classical phosphatase inhibitors, divalent metals and pH range. The physiological roles of ectophosphatases are not well established; however, it has been suggested that these enzymes play important roles in nutrition, proliferation, differentiation, adhesion, virulence and infection. Adhesion to host cells is the first step in establishing a fungal infection and ectophosphatases may be one of the first parasite proteins that come into contact with the host cells. Several results indicate that ectophosphatase activities increase the capacity of fungi to adhere to the host cells. In this context, the present review provides an overview of recent discoveries related to the occurrence and possible roles of ectophosphatase activities in fungal cells.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Freitas-Mesquita AL,Meyer-Fernandes JR

doi

10.3390/ijms15022289

subject

Has Abstract

pub_date

2014-02-06 00:00:00

pages

2289-304

issue

2

issn

1422-0067

pii

ijms15022289

journal_volume

15

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Conformational analysis of thioether musks using density functional theory.

    abstract：:A conformational analysis of nine macrocyclic thioether musks has been carried out using molecular mechanics (MMFF), density functional theory (DFT) using both B3LYP and M06 functionals, as well as Hartree-Fock and post-Hartree-Fock (MP2) ab initio methods. 6-Thia-, 10-thia- and 4-methyl-5-thia-14-tetradecananolide, 4...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms10083488

    authors： Setzer WN

    更新日期：2009-08-04 00:00:00

  • Sustained Exposure of Substance P Causes Tendinopathy.

    abstract：:Recently, neuromediators such as substance P (SP) have been found to be important factors in tendon homeostasis. Some studies have found SP to be the cause of inflammation and tendinopathy, whereas others have determined it to be a critical component of tendon healing. As demonstrated by these conflicting findings, th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21228633

    authors： Oh SY,Kim DK,Han SH,Lee HH,Jeong Y,Baek M,Kim H,Ahn W,Lee S

    更新日期：2020-11-16 00:00:00

  • Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma.

    abstract：:This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. We used 3-bromopyruvate (3-BP), a HK-II inhibitor to target HK-II. T...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20061292

    authors： Yoo JJ,Yu SJ,Na J,Kim K,Cho YY,Lee YB,Cho EJ,Lee JH,Kim YJ,Youn H,Yoon JH

    更新日期：2019-03-14 00:00:00

  • NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells.

    abstract：:The stromal vascular cell fraction (SVF) of visceral and subcutaneous adipose tissue (VAT and SAT) has increasingly come into focus in stem cell research, since these compartments represent a rich source of multipotent adipose-derived stem cells (ASCs). ASCs exhibit a self-renewal potential and differentiation capacit...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18061107

    authors： Pitrone M,Pizzolanti G,Tomasello L,Coppola A,Morini L,Pantuso G,Ficarella R,Guarnotta V,Perrini S,Giorgino F,Giordano C

    更新日期：2017-05-23 00:00:00

  • Hydroxyapatite Formation on Self-Assembling Peptides with Differing Secondary Structures and Their Selective Adsorption for Proteins.

    abstract：:Self-assembling peptides have been employed as biotemplates for biomineralization, as the morphologies and sizes of the inorganic materials can be easily controlled. We synthesized two types of highly ordered self-assembling peptides with different secondary structures and investigated the effects of secondary structu...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184650

    authors： Kojima S,Nakamura H,Lee S,Nagata F,Kato K

    更新日期：2019-09-19 00:00:00

  • Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research.

    abstract：:Growing evidence supports a role of vitamin D (VD) in reproductive health. Vitamin D receptor (VDR) is expressed in the ovary, endometrium, and myometrium. The biological actions of VD in fertility and reproductive tissues have been investigated but mainly using animal models. Conversely, the molecular data addressing...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19082320

    authors： Cermisoni GC,Alteri A,Corti L,Rabellotti E,Papaleo E,Viganò P,Sanchez AM

    更新日期：2018-08-08 00:00:00

  • The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases.

    abstract：:The treatment of memory impairments associated with the central nervous system diseases remains an unmet medical need with social and economic implications. Here we show, that a multi-target ligand of aminergic G protein-coupled receptors with antipsychotic activity in vivo (D2AAK1) stimulates neuron growth and surviv...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21228849

    authors： Koszła O,Sołek P,Woźniak S,Kędzierska E,Wróbel TM,Kondej M,Archała A,Stępnicki P,Biała G,Matosiuk D,Kaczor AA

    更新日期：2020-11-23 00:00:00

  • HDAC-Linked "Proliferative" miRNA Expression Pattern in Pancreatic Neuroendocrine Tumors.

    abstract：:Epigenetic factors are essentially involved in carcinogenesis, tumor promotion, and chemoresistance. Two epigenetic key players are miRNAs and histone deacetylases (HDACs). As previously shown by own theoretical databank analysis, the crosstalk between miRNAs and HDACs is relevant in different human chronic diseases a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19092781

    authors： Klieser E,Urbas R,Swierczynski S,Stättner S,Primavesi F,Jäger T,Mayr C,Kiesslich T,Fazio PD,Helm K,Neureiter D

    更新日期：2018-09-15 00:00:00

  • Melatonin Non-Linearly Modulates Bull Spermatozoa Motility and Physiology in Capacitating and Non-Capacitating Conditions.

    abstract：:Bull spermatozoa physiology may be modulated by melatonin. We washed ejaculated spermatozoa free of melatonin and incubated them (4 h, 38 °C) with 0-pM, 1-pM, 100-pM, 10-nM and 1-µM melatonin in TALP-HEPES (non-capacitating) and TALP-HEPES-heparin (capacitating). This range of concentrations encompassed the effects me...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21082701

    authors： Fernández-Alegre E,Álvarez-Fernández I,Domínguez JC,Casao A,Martínez-Pastor F

    更新日期：2020-04-13 00:00:00

  • Translational Regenerative Therapies for Chronic Spinal Cord Injury.

    abstract：:Spinal cord injury is a chronic and debilitating neurological condition that is currently being managed symptomatically with no real therapeutic strategies available. Even though there is no consensus on the best time to start interventions, the chronic phase is definitely the most stable target in order to determine ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19061776

    authors： Dalamagkas K,Tsintou M,Seifalian A,Seifalian AM

    更新日期：2018-06-15 00:00:00

  • Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats.

    abstract：:The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy. Here, we analyzed the Kir4.1 expressional changes in Leucine-Rich Glioma-Inactivated 1 (Lgi1) mutant rats, which ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20051013

    authors： Kinboshi M,Shimizu S,Mashimo T,Serikawa T,Ito H,Ikeda A,Takahashi R,Ohno Y

    更新日期：2019-02-26 00:00:00

  • Deleterious Effect of Advanced CKD on Glyoxalase System Activity not Limited to Diabetes Aetiology.

    abstract：:Methylglyoxal production is increased in diabetes. Methylglyoxal is efficiently detoxified by enzyme glyoxalase 1 (GLO1). The aim was to study the effect of diabetic and CKD milieu on (a) GLO1 gene expression in peripheral blood mononuclear cells; (b) GLO1 protein levels in whole blood; and (c) GLO1 activity in RBCs i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19051517

    authors： Pácal L,Chalásová K,Pleskačová A,Řehořová J,Tomandl J,Kaňková K

    更新日期：2018-05-18 00:00:00

  • Diatom-Derived Polyunsaturated Aldehydes Activate Similar Cell Death Genes in Two Different Systems: Sea Urchin Embryos and Human Cells.

    abstract：:Programmed cell death, such as apoptosis and autophagy, are key processes that are activated early on during development, leading to remodelling in embryos and homeostasis in adult organisms. Genomic conservation of death factors has been largely investigated in the animal and plant kingdoms. In this study, we analyse...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21155201

    authors： Galasso C,Celentano S,Costantini M,D'Aniello S,Ianora A,Sansone C,Romano G

    更新日期：2020-07-22 00:00:00

  • Antioxidant-induced stress.

    abstract：:Antioxidants are among the most popular health-protecting products, sold worldwide without prescription. Indeed, there are many reports showing the benefits of antioxidants but only a few questioning the possible harmful effects of these "drugs". The normal balance between antioxidants and free radicals in the body is...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms13022091

    authors： Villanueva C,Kross RD

    更新日期：2012-01-01 00:00:00

  • Royal Jelly Abrogates Cadmium-Induced Oxidative Challenge in Mouse Testes: Involvement of the Nrf2 Pathway.

    abstract：:The current study examined the efficacy of royal jelly (RJ) against cadmium chloride (CdCl₂)-induced testicular dysfunction. A total of 28 Swiss male mice were allocated into four groups (n = 7), and are listed as follows: (1) the control group, who was intraperitoneally injected with physiological saline (0.9% NaCl) ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19123979

    authors： Almeer RS,Soliman D,Kassab RB,AlBasher GI,Alarifi S,Alkahtani S,Ali D,Metwally D,Abdel Moneim AE

    更新日期：2018-12-10 00:00:00

  • Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability.

    abstract：:Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity phosphatases (DUSPs) dephosphorylate many key signaling molecules, including MAPKs, leading to the regulation of duration, magnitude, or...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20112668

    authors： Chen HF,Chuang HC,Tan TH

    更新日期：2019-05-30 00:00:00

  • In Silico Finding of Key Interaction Mediated α3β4 and α7 Nicotinic Acetylcholine Receptor Ligand Selectivity of Quinuclidine-Triazole Chemotype.

    abstract：:The selective binding of six (S)-quinuclidine-triazoles and their (R)-enantiomers to nicotinic acetylcholine receptor (nAChR) subtypes α3β4 and α7, respectively, were analyzed by in silico docking to provide the insight into the molecular basis for the observed stereospecific subtype discrimination. Homology modeling ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21176189

    authors： Arunrungvichian K,Chongruchiroj S,Sarasamkan J,Schüürmann G,Brust P,Vajragupta O

    更新日期：2020-08-27 00:00:00

  • Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk.

    abstract：:Although our understanding of psychotic disorders has advanced substantially in the past few decades, very little has changed in the standard of care for these illnesses since the development of atypical anti-psychotics in the 1990s. Here, we integrate new insights into the pathophysiology with the increasing interest...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18030651

    authors： Barron H,Hafizi S,Andreazza AC,Mizrahi R

    更新日期：2017-03-17 00:00:00

  • Myosin Binding Protein-C Forms Amyloid-Like Aggregates In Vitro.

    abstract：:This work investigated in vitro aggregation and amyloid properties of skeletal myosin binding protein-C (sMyBP-C) interacting in vivo with proteins of thick and thin filaments in the sarcomeric A-disc. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) found a rapid (5-10 min) formation of large...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020731

    authors： Bobyleva LG,Shumeyko SA,Yakupova EI,Surin AK,Galzitskaya OV,Kihara H,Timchenko AA,Timchenko MA,Penkov NV,Nikulin AD,Suvorina MY,Molochkov NV,Lobanov MY,Fadeev RS,Vikhlyantsev IM,Bobylev AG

    更新日期：2021-01-13 00:00:00

  • Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins by JQ1 Unravels a Novel Epigenetic Modulation to Control Lipid Homeostasis.

    abstract：:The homeostatic control of lipid metabolism is essential for many fundamental physiological processes. A deep understanding of its regulatory mechanisms is pivotal to unravel prospective physiopathological factors and to identify novel molecular targets that could be employed to design promising therapies in the manag...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041297

    authors： Tonini C,Colardo M,Colella B,Di Bartolomeo S,Berardinelli F,Caretti G,Pallottini V,Segatto M

    更新日期：2020-02-14 00:00:00

  • OsMKK3, a Stress-Responsive Protein Kinase, Positively Regulates Rice Resistance to Nilaparvata lugens via Phytohormone Dynamics.

    abstract：:Plants undergo several but very precise molecular, physiological, and biochemical modulations in response to biotic stresses. Mitogen-activated protein kinase (MAPK) cascades orchestrate multiple cellular processes including plant growth and development as well as plant responses against abiotic and biotic stresses. H...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20123023

    authors： Zhou S,Chen M,Zhang Y,Gao Q,Noman A,Wang Q,Li H,Chen L,Zhou P,Lu J,Lou Y

    更新日期：2019-06-20 00:00:00

  • Comparison of Dietary Oils with Different Polyunsaturated Fatty Acid n-3 and n-6 Content in the Rat Model of Cutaneous Wound Healing.

    abstract：:Dietary supplementation with polyunsaturated fatty acids (PUFA) n-3 can affect cutaneous wound healing; however, recent findings demonstrate the variable extent of their influence on the quality of healing. Here, we compare the effect of several dietary oils, containing different levels of PUFA n-3 and PUFA n-6, on wo...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21217911

    authors： Komprda T,Sladek Z,Sevcikova Z,Svehlova V,Wijacki J,Guran R,Do T,Lackova Z,Polanska H,Vrlikova L,Popelkova V,Michalek P,Zitka O,Buchtova M

    更新日期：2020-10-24 00:00:00

  • Proteomic Differences in Feline Fibrosarcomas Grown Using Doxorubicin-Sensitive and -Resistant Cell Lines in the Chick Embryo Model.

    abstract：:Proteomic analyses are rapid and powerful tools that are used to increase the understanding of cancer pathogenesis, discover cancer biomarkers and predictive markers, and select and monitor novel targets for cancer therapy. Feline injection-site sarcomas (FISS) are aggressive skin tumours with high recurrence rates, d...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19020576

    authors： Zabielska-Koczywąs K,Michalak K,Wojtalewicz A,Winiarczyk M,Adaszek Ł,Winiarczyk S,Lechowski R

    更新日期：2018-02-14 00:00:00

  • Lipopolysaccharide-Preconditioned Periodontal Ligament Stem Cells Induce M1 Polarization of Macrophages through Extracellular Vesicles.

    abstract：:Periodontitis is a common disease characterized by chronic inflammation and tissue destruction of gums. Human periodontal ligament stem cells (PDLSCs), derived from the periodontium, have stem cell properties similar to those of mesenchymal stem cells. PDLSCs possess not only the potential to differentiate into other ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19123843

    authors： Kang H,Lee MJ,Park SJ,Lee MS

    更新日期：2018-12-03 00:00:00

  • Terminal Phase Components of the Clotting Cascade in Patients with End-Stage Renal Disease Undergoing Hemodiafiltration or Hemodialysis Treatment.

    abstract：:Hemostasis disorder in patients with end-stage renal disease (ESRD) is frequently associated with bleeding diathesis but it may also manifest in thrombotic complications. Analysis of individual coagulation and fibrinolytic factors may shed light on the background of this paradox situation. Here we explored components ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21228426

    authors： Pénzes K,Hurják B,Katona É,Becs G,Balla J,Muszbek L

    更新日期：2020-11-10 00:00:00

  • Mechanisms of Tumor-Lymphatic Interactions in Invasive Breast and Prostate Carcinoma.

    abstract：:During the last few years, diverse studies have shown that tumors can actively interact with the lymphatic system and promote metastases development. In order to examine the molecular mechanisms involved in this interaction, we co-cultured tumor and lymphatic endothelial cells (LEC) and subsequently analyzed the molec...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21020602

    authors： Oliveira-Ferrer L,Milde-Langosch K,Eylmann K,Rossberg M,Müller V,Schmalfeldt B,Witzel I,Wellbrock J,Fiedler W

    更新日期：2020-01-17 00:00:00

  • Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation.

    abstract：:Prenatal smoke exposure (PreSE) is a risk factor for nicotine dependence, which is further enhanced by postnatal smoke exposure (PostSE). One susceptibility gene to nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine in the liver. Higher CYP2A6 activity is...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010164

    authors： Lkhagvadorj K,Zeng Z,Meyer KF,Verweij LP,Kooistra W,Reinders-Luinge M,Dijkhuizen HW,de Graaf IAM,Plösch T,Hylkema MN

    更新日期：2020-12-26 00:00:00

  • Real-Time 3D Imaging and Inhibition Analysis of Various Amyloid Aggregations Using Quantum Dots.

    abstract：:Amyloidosis refers to aggregates of protein that accumulate and are deposited as amyloid fibrils into plaques. When these are detected in organs, they are the main hallmark of Alzheimer's disease, Parkinson's disease, and other related diseases. Recent medical advances have shown that many precursors and proteins can ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21061978

    authors： Lin X,Galaqin N,Tainaka R,Shimamori K,Kuragano M,Noguchi TQP,Tokuraku K

    更新日期：2020-03-13 00:00:00

  • Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling.

    abstract：:Colorectal cancer (CRC) is a highly prevailing cancer and the fourth leading cause of cancer mortality worldwide. Aberrant expression of antiapoptotic BCL-2 family proteins is closely linked to neoplastic progression and chemoresistance. Obatoclax is a clinically developed drug, which binds antiapoptotic BCL-2, BCL-xL...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051773

    authors： Or CR,Huang CW,Chang CC,Lai YC,Chen YJ,Chang CC

    更新日期：2020-03-05 00:00:00

  • Parent-of-Origin Effects in 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome.

    abstract：:To identify whether parent-of-origin effects (POE) of the 15q11.2 BP1-BP2 microdeletion are associated with differences in clinical features in individuals inheriting the deletion, we collected 71 individuals reported with phenotypic data and known inheritance from a clinical cohort, a research cohort, the DECIPHER da...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20061459

    authors： Davis KW,Serrano M,Loddo S,Robinson C,Alesi V,Dallapiccola B,Novelli A,Butler MG

    更新日期：2019-03-22 00:00:00