Abstract：
:For patients with end-stage renal disease requiring hemodialysis, their vascular access is both their lifeline and their Achilles heel. Despite being recommended as primary vascular access, the arteriovenous fistula (AVF) shows sub-optimal results, with about 50% of patients needing a revision during the year following creation. After the AVF is created, the venous wall must adapt to new environment. While hemodynamic changes are responsible for the adaptation of the extracellular matrix and activation of the endothelium, surgical dissection and mobilization of the vein disrupt the vasa vasorum, causing wall ischemia and oxidative stress. As a consequence, migration and proliferation of vascular cells participate in venous wall thickening by a mechanism of neointimal hyperplasia (NH). When aggressive, NH causes stenosis and AVF dysfunction. In this review we show how hypoxia, metabolism, and flow parameters are intricate mechanisms responsible for the development of NH and stenosis during AVF maturation.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sadaghianloo N,Contenti J,Dardik A,Mazure NMdoi
10.3390/ijms20215387subject
Has Abstractpub_date
2019-10-29 00:00:00issue
21issn
1422-0067pii
ijms20215387journal_volume
20pub_type
杂志文章,评审abstract：:Besides being traditionally used to relieve hepatobiliary disorders, Cynara cardunculus L. has evidenced anticancer potential on triple-negative breast cancer (TNBC). This study highlights the antiproliferative effects of lipophilic extracts from C. cardunculus L. var. altilis (DC) leaves and florets, and of their maj...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010063
更新日期：2016-12-29 00:00:00
abstract：:The emergence of multidrug-resistant bacteria is a major global health concern. The search for new therapies has brought bacteriophages into the spotlight, and new phages are being described as possible therapeutic agents. Among the bacteria that are most extensively resistant to current antibiotics is Klebsiella pneu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093160
更新日期：2020-04-30 00:00:00
abstract：:Streptococcus pneumoniae can cause diseases such as pneumonia. Broad-spectrum antibiotic therapy for Streptococcus pneumoniae is increasingly limited due to the emergence of drug-resistant strains. The development of novel drugs is still currently of focus. Abundant polyphenols have been demonstrated to have antivirus...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21031003
更新日期：2020-02-03 00:00:00
abstract：:The (1)H-NMR shifts of the imidazolium protons of some novel dimeric ionic liquids were examined in various deuterated solvents. Interactions between the solvent and the imidazolium salt of butyl substituted ionic liquids were observed to give higher chemical shifts than methyl substitution. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9071207
更新日期：2008-06-01 00:00:00
abstract：:The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the acti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20030728
更新日期：2019-02-08 00:00:00
abstract：:Perillafrutescen is used as traditional food and medicine in East Asia. Its seeds contain high levels of α-linolenic acid (ALA), which is important for health, but is scarce in our daily meals. Previous reports on RNA-seq of perilla seed had identified fatty acid (FA) and triacylglycerol (TAG) synthesis genes, but the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112433
更新日期：2017-11-16 00:00:00
abstract：:The effective dose of irradiation to control pest mites in quarantine has been studied extensively, but the molecular mechanisms underlying the effects of the irradiation on mites are largely unknown. In this study, exposure to 400 Gy of γ rays had significant (p < 0.05) effects on the adult survival, fecundity and eg...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126004
更新日期：2015-11-11 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a major cause of stroke, with high mortality and morbidity. There is no effective pharmacological therapy for ICH. Previous studies have indicated that CXCR4 antagonists reduced microglia activation, attenuated infiltration of T cells, and improved functional recovery in ischemic stro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197085
更新日期：2020-09-25 00:00:00
abstract：:Mammalian aquaporins (AQPs) are transmembrane channels expressed in a large variety of cells and tissues throughout the body. They are known as water channels, but they also facilitate the transport of small solutes, gasses, and monovalent cations. To date, 13 different AQPs, encoded by the genes AQP0-AQP12, have been...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20082039
更新日期：2019-04-25 00:00:00
abstract：:Esophageal adenocarcinoma (EAC) is a highly lethal cancer type with an overall poor survival rate. Twenty to thirty percent of EAC overexpress the human epidermal growth factor receptor 2 (Her2), a transmembrane receptor tyrosine kinase promoting cell growth and proliferation. Patients with Her2 overexpressing breast ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103069
更新日期：2018-10-08 00:00:00
abstract：:Carbonic anhydrase is a ubiquitous metalloenzyme that catalyzes the reversible interconversion of CO2/HCO3-. Equilibrium of these species is maintained by the action of carbonic anhydrase. Recent advances in magnetic resonance spectroscopy have allowed, for the first time, in vivo characterization of carbonic anhydras...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21072442
更新日期：2020-04-01 00:00:00
abstract：:The phylum Thermotogae is composed of a single class (Thermotogae), 4 orders (Thermotogales, Kosmotogales, Petrotogales, Mesoaciditogales), 5 families (Thermatogaceae, Fervidobacteriaceae, Kosmotogaceae, Petrotogaceae, Mesoaciditogaceae), and 13 genera. They have been isolated from extremely hot environments whose cha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010341
更新日期：2020-12-30 00:00:00
abstract：:A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation has been recently proposed. However, little is known about TSPO-activated pathways underlying the modulation of reactive microglia. In the present work, the TSPO activation was explored in an in vitro human primary microglia model ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184467
更新日期：2019-09-10 00:00:00
abstract：:Inflammation and transforming growth factor-β1 (TGF-β1) contribute to the development of peritoneal fibrosis (PF), which is associated with peritoneal dialysis (PD). Astragalus membranaceus (Astragalus) has anti-inflammatory and anti-fibrotic effects in many diseases. The goal of this study was to determine the anti-f...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150712959
更新日期：2014-07-22 00:00:00
abstract：:Even though advancement in medicine has contributed to the control of many diseases to date, cancer therapy continues to pose several challenges. Hepatocellular carcinoma (HCC) etiology is multifactorial. Recently, non-alcoholic fatty liver disease (NAFLD) has been considered as an important risk factor of HCC. NAFLD ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21175999
更新日期：2020-08-20 00:00:00
abstract：:Forty mice were randomly divided into four groups on the basis of the diet to be fed as follows: 5% (low) fat diet (T1: LF); 20% (high) fat diet (T2: HF); 20% fat containing 1% conjugated linoleic acid (CLA) (T3: HFC); and 20% fat containing 1% CLA with 0.5% biopolymers (T4: HFCB). The high-fat with CLA diet groups (H...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14046848
更新日期：2013-03-26 00:00:00
abstract：:To investigate the effect of pollination on the fruit quality of 'Dangshan Su' pear, 'Dangshan Su' was fertilized by the pollen of 'Wonhwang' (Pyrus pyrifolia Nakai.) (DW) and 'Jingbaili' (Pyrus ussuriensis Maxim.) (DJ). The analysis of primary metabolites was achieved through untargeted metabolomics, and the quantita...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082273
更新日期：2018-08-02 00:00:00
abstract：:Stress-associated proteins (SAPs) are novel A20/AN1 zinc finger domain-containing proteins that are now favorable targets to improve abiotic stress tolerance in plants. However, the SAP gene family and their biological functions have not been identified in the important fruit crop apple (Malus × domestica Borkh.). We ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092478
更新日期：2018-08-21 00:00:00
abstract：:In the last decade, a wide range of avian influenza viruses (AIVs) have infected various mammalian hosts and continuously threaten both human and animal health. It is a result of overcoming the inter-species barrier which is mostly associated with gene reassortment and accumulation of mutations in their gene segments....
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18122706
更新日期：2017-12-13 00:00:00
abstract：:Human cytomegalovirus (HCMV) is ubiquitously prevalent. HCMV infection is typically asymptomatic and controlled by the immune system in healthy individuals, yet HCMV can be severely pathogenic for the fetus during pregnancy and in immunocompromised persons, such as transplant recipients or HIV infected patients. HCMV ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20153626
更新日期：2019-07-24 00:00:00
abstract：:The first algorithm for Emulsion Stability Simulations (ESS) was presented at the V Conferencia Iberoamericana sobre Equilibrio de Fases y Diseño de Procesos [Luis, J.; García-Sucre, M.; Urbina-Villalba, G. Brownian Dynamics Simulation of Emulsion Stability In: Equifase 99. Libro de Actas, 1(st) Ed., Tojo J., Arce, A....
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms10030761
更新日期：2009-03-01 00:00:00
abstract：:Administration of oxygen is one of the most common interventions in medicine. Previous research showed that differential regulated proteins could be linked to hyperoxia-associated signaling cascades in different tissues. However, it still remains unclear which signaling pathways are activated by hyperoxia. The present...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071960
更新日期：2018-07-04 00:00:00
abstract：:Microwave-assisted depolymerization of black-liquor lignin in formic acid was studied, concentrating on the yield of liquid fractions as bio-oil 1 (mainly aromatic monomers) and bio-oil 2 (mainly aromatic oligomers) and the distribution of the specific compositions. Bio-oil 1 (9.69%) and bio-oil 2 (54.39%) achieved th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102082
更新日期：2017-10-01 00:00:00
abstract：:Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, detrimental cardiac remodeling, and cardiac fibrosis occurring after the injury. This study aimed at discovering the role of the anti-aging protein α-klotho (KL), whic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062186
更新日期：2020-03-22 00:00:00
abstract：:Laser-driven accelerators allow to generate ultrashort (from femto- to picoseconds) high peak dose-rate (up to tens of GGy/s) accelerated particle beams. However, the radiobiological effects of ultrashort pulsed irradiation are still poorly studied. The aim of this work was to compare the formation and elimination of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249488
更新日期：2020-12-14 00:00:00
abstract：:Hybrid peptides integrating different functional domains of peptides have many advantages, such as remarkable antimicrobial activity, lower hemolysis and ideal cell selectivity, compared with natural antimicrobial peptides. FV7 (FRIRVRV-NH₂), a consensus amphiphilic sequence was identified as being analogous to host d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020339
更新日期：2017-02-06 00:00:00
abstract：:In 1993, Rosen and collaborators discovered that the gene encoding SOD1 has mutations in amyotrophic lateral sclerosis (ALS) patients; moreover, these mutations are found in the exon regions, suggesting that their toxic effects are the consequence of protein dysfunction with an increase of oxidative stress. While a cl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19051345
更新日期：2018-05-03 00:00:00
abstract：:Haemophilus parasuis (H. parasuis) can cause Glässer’s disease in pigs. However, the molecular mechanism of the inflammation response induced by H. parasuis remains unclear. The high-mobility group box 1 (HMGB1) protein is related to the pathogenesis of various infectious pathogens, but little is known abou...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051307
更新日期：2018-04-27 00:00:00
abstract：:The edible and medicinal perennial herb Aster scaber is known to have anticancer, antioxidant, and immunomodulatory properties. However, the biological effects of its polysaccharides are not well understood. Here, we aimed to extract novel polysaccharides with enhanced biological properties from Aster scaber using enz...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092839
更新日期：2018-09-19 00:00:00
abstract：:Resistance to conventional chemotherapeutic agents, a typical feature of cholangiocarcinoma, prevents the efficacy of the therapeutic arsenal usually used to combat malignancy in humans. Mechanisms of chemoresistance by neoplastic cholangiocytes include evasion of drug-induced apoptosis mediated by autocrine and parac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18010149
更新日期：2017-01-13 00:00:00
