Abstract：
:Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria, such as Shigella, Listeria, enteroinvasive E. coli and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithelial cells and causes bacillary dysentery. Invasion of Shigella into intestinal epithelial cells requires extensive remodeling of the actin cytoskeleton with the aid of pathogenic effector proteins injected into the host cell by the activity of the type III secretion system. These so-called Shigella invasins, including IpaA, IpaC, IpgB1, IpgB2 and IpgD, modulate the actin-regulatory system in a concerted manner to guarantee efficient entry of the bacteria into host cells.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Lee JH,Park H,Park YHdoi
10.3390/ijms151018253subject
Has Abstractpub_date
2014-10-10 00:00:00pages
18253-66issue
10issn
1422-0067pii
ijms151018253journal_volume
15pub_type
杂志文章,评审abstract：:Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a re...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030690
更新日期：2020-01-21 00:00:00
abstract：:Enteroaggregative Escherichia coli (EAEC) is an emerging pathogen frequently associated with acute diarrhea in children and travelers to endemic regions. EAEC was found the most prevalent bacterial diarrheal pathogen from hospitalized Bolivian children less than five years of age with acute diarrhea from 2007 to 2010....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249543
更新日期：2020-12-15 00:00:00
abstract：:Obesity is a multifactorial disease that can lead to other health issues. Glucagon-like peptide-1(GLP-1), as one of the satiety signal, has been linked with appetite suppression and weight loss. Due to the limitations of GLP-1 and its analogues, alternative treatments such as herbal therapies have become popular. The ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082854
更新日期：2020-04-19 00:00:00
abstract：:Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit bacterial proliferation by sequestering trace minerals (mainly iron, but also zinc and manganese). This strategy, selected by evolution, r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21062145
更新日期：2020-03-20 00:00:00
abstract：:Immunomodulation is increasingly being recognised as a part of mental diseases. Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). An analysis of plasma samples from patients with a major depressive episode ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246172
更新日期：2019-12-06 00:00:00
abstract：:Genetic analysis of plants relies on high yields of pure DNA. For the strawberry tree (Arbutus unedo) this represents a great challenge since leaves can accumulate large amounts of polysaccharides, polyphenols and secondary metabolites, which co-purify with DNA. For this specie, standard protocols do not produce effic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12064156
更新日期：2011-01-01 00:00:00
abstract：:Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase gene (GBA1). Besides causing GD, GBA1 mutations constitute the main genetic risk factor for developing Parkinson's disease. The molecular basis of neurological manifestations in GD remain elusive. Ho...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093268
更新日期：2020-05-05 00:00:00
abstract：:Aging is an inevitable and gradually progressive process affecting all organs and systems. The musculoskeletal system makes no exception, elderly exhibit an increased risk of sarcopenia (low muscle mass),dynapenia (declining muscle strength), and subsequent disability. Whereas in recent years the subject of skeletal m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21020592
更新日期：2020-01-16 00:00:00
abstract：:Since 2003, several loss-of-function mutations in the HCN4 gene, which encodes the HCN4 protein, have been associated with sinus node dysfunction. In human sinoatrial node (SAN), HCN4 is the most abundant of the four isoforms of the HCN family. Tetramers of HCN subunits constitute the ion channels that conduct the hyp...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16023071
更新日期：2015-01-29 00:00:00
abstract：:The mouse model of Alzheimer's disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their behavioral and amyloidosis phenotypes. In this study, we further characterize the role of MT-1 by crossing Mt1-overexpressing mice with Tg2576 mice (APPTgMT). ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020251
更新日期：2017-01-26 00:00:00
abstract：:Cardamom is a popular spice that has been commonly used in cuisines for flavor since ancient times. It has copious health benefits such as improving digestion, stimulating metabolism, and exhibits antioxidant and anti-inflammatory effects. The current study investigated the effect of cardamom on hemodynamic, biochemic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126040
更新日期：2015-11-17 00:00:00
abstract：:Mineralization of hydrogel biomaterials with calcium phosphate (CaP) is considered advantageous for bone regeneration. Mineralization can be both induced by the enzyme alkaline phosphatase (ALP) and promoted by calcium-binding biomolecules, such as plant-derived polyphenols. In this study, ALP-loaded gellan gum (GG) h...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072315
更新日期：2020-03-27 00:00:00
abstract：:Articular cartilage is compressed with joint-loading and weight-bearing stresses, followed by a bulging of the tissue during times of off-loading. This loading and off-loading causes changes in water content, and thus alterations in osmotic pressure. Another unique characteristic of articular cartilage is that it has ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051507
更新日期：2018-05-18 00:00:00
abstract：:The voltage-dependent anion channel (VDAC), a highly conserved major mitochondrial outer membrane protein, plays crucial roles in energy metabolism and metabolite transport. However, knowledge about the roles of the VDAC family in plants is limited. In this study, we investigated the expression pattern of VDAC1 in Ara...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14010701
更新日期：2013-01-04 00:00:00
abstract：:The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20071576
更新日期：2019-03-29 00:00:00
abstract：:Selectively targeted nanoscale drug delivery systems have recently emerged as promising intravenously therapeutic option for most chronic joint diseases. Here, a newly synthetized dodecapeptide (GE11)-polylactide-co-glycolide (PLGA)-based conjugate was used to prepare smart nanoparticles (NPs) intended for intra-artic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082304
更新日期：2018-08-06 00:00:00
abstract：:tRNA and some other non-coding RNA genes are transcribed by RNA polymerase III (pol III), due to the presence of intragenic promoter, consisting of boxes A and B spaced by 30-40 bp. Such pol III promoters, called type 2, are also intrinsic to Short Interspersed Elements (SINEs). The contribution of 5'-flanking sequenc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103706
更新日期：2020-05-25 00:00:00
abstract：:Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these biological responses, GTPases activity is regulated by guanine nucleotide exchange factors (GEFs), GTP...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176312
更新日期：2020-08-31 00:00:00
abstract：:Metallothioneins (MTs) are multifunctional proteins occurring throughout the animal kingdom. While the expression and transcriptional regulation of MTs is well-studied in vertebrates, the mechanism of MT activation is still unknown for most invertebrates. Therefore, we examined wMT-2 gene regulation and expression pat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061113
更新日期：2017-05-24 00:00:00
abstract：:Globally, chickpea production is severely affected by salinity stress. Understanding the genetic basis for salinity tolerance is important to develop salinity tolerant chickpeas. A recombinant inbred line (RIL) population developed using parental lines ICCV 10 (salt-tolerant) and DCP 92-3 (salt-sensitive) was screened...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145058
更新日期：2020-07-17 00:00:00
abstract：:Lysin-motif receptor-like kinase PsK1 is involved in symbiosis initiation and the maintenance of infection thread (IT) growth and bacterial release in pea. We verified PsK1 specificity in relation to the Nod factor structure using k1 and rhizobial mutants. Inoculation with nodO and nodE nodO mutants significantly redu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071624
更新日期：2019-04-01 00:00:00
abstract：:The normal cellular isoform of prion protein, designated PrPC, is constitutively converted to the abnormally folded, amyloidogenic isoform, PrPSc, in prion diseases, which include Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals. PrPC is a membrane glycoprotein consisting...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176233
更新日期：2020-08-28 00:00:00
abstract：:Glucokinase (GCK) is the rate-limiting enzyme of liver glucose metabolism. Through protein-protein interactions, glucokinase regulatory protein (GCKR) post-transcriptionally regulates GCK function in the liver, and causes its nuclear localization. However the role of GCK in regulating GCKR localization is unknown. In ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047377
更新日期：2015-04-02 00:00:00
abstract：:We previously reported that oral formulations containing indomethacin nanoparticles (IND-NPs) showed high bioavailability, and, consequently, improved therapeutic effects and reduced injury to the small intestine. However, the pathway for the transintestinal penetration of nanoparticles remained unclear. Thus, in this...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030476
更新日期：2019-01-22 00:00:00
abstract：:Shellfish allergy affects 2% of the world's population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfis...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010032
更新日期：2020-12-22 00:00:00
abstract：:Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030585
更新日期：2019-01-30 00:00:00
abstract：:This study aimed to explore the effect of L-arginine on lipopolysaccharide (LPS)-induced inflammatory response and oxidative stress in IPEC-2 cells. We found that the expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), cluster of differentiation 14 (CD14), nuclear factor-kap...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071800
更新日期：2019-04-11 00:00:00
abstract：:Fetuin-A is the protein product of the AHSG gene in humans. It is mainly synthesized by the liver in adult humans and is secreted into the blood where its concentration can vary from a low of ~0.2 mg/mL to a high of ~0.8 mg/mL. Presently, it is considered to be a multifunctional protein that plays important roles in d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19082211
更新日期：2018-07-29 00:00:00
abstract：:Wound healing is an important process in the human body to protect against external threats. A dysregulation at any stage of the wound healing process may result in the development of various intractable ulcers or excessive scar formation. Numerous factors such as growth factors, cytokines, and chemokines are involved...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228435
更新日期：2020-11-10 00:00:00
abstract：:Papillary thyroid cancer (PTC) is the most common tumor subtype of thyroid cancer. However, not all PTCs are responsive to current surgical and radioiodine treatment. The well-established clinical prognostic factors include tumor size, lymph node/distal metastasis, and extrathyroidal invasion. The RET/PTC-RAS-BRAF lin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18030636
更新日期：2017-03-15 00:00:00
