Eicosanoids in Skin Wound Healing.

abstract：:With age, our cognitive skills and abilities decline. Maybe starting as an annoyance, this decline can become a major impediment to normal daily life. Recent research shows that the neurodegenerative disorders responsible for age associated cognitive dysfunction are mechanistically linked to the state of the microvasc...

journal_title：International journal of molecular sciences

authors： Costea L,Mészáros Á,Bauer H,Bauer HC,Traweger A,Wilhelm I,Farkas AE,Krizbai IA

更新日期：2019-11-03 00:00:00

abstract：:The estrogen receptor (ER) signaling regulates numerous physiological processes mainly through activation of gene transcription (genomic pathways). Caveolin1 (CAV1) is a membrane-resident protein that behaves as platform to enable different signaling molecules and receptors for membrane-initiated pathways. CAV1 direct...

journal_title：International journal of molecular sciences

authors： Romano A,Feola A,Porcellini A,Gigantino V,Di Bonito M,Di Mauro A,Caggiano R,Faraonio R,Zuchegna C

更新日期：2020-08-20 00:00:00

abstract：:Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investiga...

journal_title：International journal of molecular sciences

authors： Ibeawuchi C,Schmidt H,Voss R,Titze U,Abbas M,Neumann J,Eltze E,Hoogland AM,Jenster G,Brandt B,Semjonow A

更新日期：2013-06-03 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crucial biological processes, which converts them into high potential contenders in the ongoing search for effective therapeutic strategies. However, extracellular RNAs are unstable and rapidly degraded, reducing the poss...

journal_title：International journal of molecular sciences

authors： Del Pozo-Acebo L,Hazas MLL,Tomé-Carneiro J,Gil-Cabrerizo P,San-Cristobal R,Busto R,García-Ruiz A,Dávalos A

更新日期：2021-01-22 00:00:00

abstract：:Deubiquitinases (DUBs) play a critical role in ubiquitin-directed signaling by catalytically removing the ubiquitin from substrate proteins. Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes. USP15 har...

journal_title：International journal of molecular sciences

authors： Chou CK,Chang YT,Korinek M,Chen YT,Yang YT,Leu S,Lin IL,Tang CJ,Chiu CC

更新日期：2017-02-24 00:00:00

abstract：:Unfolded protein response (UPR) is a cytoprotective mechanism that alleviates the protein-folding burden in eukaryotic organisms. Moderate activation of UPR is required for maintaining endoplasmic reticulum (ER) homeostasis and profoundly contributes to tumorigenesis. Defects in UPR signaling are implicated in the att...

journal_title：International journal of molecular sciences

authors： Chou CK,Liu W,Hong YJ,Dahms HU,Chiu CH,Chang WT,Chien CM,Yen CH,Cheng YB,Chiu CC

更新日期：2018-06-21 00:00:00

abstract：:Uterine fibroids are the most common gynecologic benign tumors. Studies supporting a strong pregnancy-related growth of leiomyomas generally claimed a crucial role of sex steroid hormones. However, sex steroids are unlikely the unique actors involved as estrogen and progesterone achieve a pick serum concentration in t...

journal_title：International journal of molecular sciences

authors： Sarais V,Cermisoni GC,Schimberni M,Alteri A,Papaleo E,Somigliana E,Vigano' P

更新日期：2017-09-20 00:00:00

abstract：:Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders. Fetal 5-HT levels can be influenced by several gestational factors, such as maternal genotype, diet, stress, medication, and immune activation. In this review, addressing both human and animal studies, we discuss how these gesta...

journal_title：International journal of molecular sciences

authors： Hanswijk SI,Spoelder M,Shan L,Verheij MMM,Muilwijk OG,Li W,Liu C,Kolk SM,Homberg JR

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:Gastritis is a prevalent disease and commonly classified into autoimmune (A), bacterial (B), and chemical (C) type gastritis. While the former two subtypes are associated with an increased risk of developing gastric intestinal adenocarcinoma, the latter subtype is not. In this study, we evaluated the capabil...

journal_title：International journal of molecular sciences

authors： Steinbuss G,Kriegsmann K,Kriegsmann M

更新日期：2020-09-11 00:00:00

abstract：:The activation of extracellular signal-regulated kinases (ERK) leads to a number of cellular changes associated with the development of long-term memory. Using cultured cortical neurons, we previously showed that the n-hexane extract prepared from the peels of Citrus grandis (Kawachi bankan) induces the activation of ...

journal_title：International journal of molecular sciences

authors： Furukawa Y,Watanabe S,Okuyama S,Nakajima M

更新日期：2012-01-01 00:00:00

abstract：:Sepsis is a severe and multifactorial disease with a high mortality rate. It represents a strong inflammatory response to an infection and is associated with vascular inflammation and oxidative/nitrosative stress. Here, we studied the underlying time responses in the widely used lipopolysaccharide (LPS)-induced endoto...

journal_title：International journal of molecular sciences

authors： Steven S,Dib M,Roohani S,Kashani F,Münzel T,Daiber A

更新日期：2017-10-18 00:00:00

abstract：:Metabolic stability is an important parameter to be optimized during the complex process of designing new active compounds. Tuning this parameter with the simultaneous maintenance of a desired compound's activity is not an easy task due to the extreme complexity of metabolic pathways in living organisms. In this study...

journal_title：International journal of molecular sciences

authors： Podlewska S,Kafel R

更新日期：2018-03-30 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) typically migrates and metastasizes. Interleukin-6 (IL-6) is a multifunctional cytokine associated with disease status and cancer outcomes. The effect of IL-6 on human OSCC cells, however, is unknown. Here, we showed that IL-6 increased cell migration and Intercellular adhesion mole...

journal_title：International journal of molecular sciences

authors： Chuang JY,Huang YL,Yen WL,Chiang IP,Tsai MH,Tang CH

更新日期：2014-01-06 00:00:00

abstract：:Free fatty acids (FFAs) are cytotoxic to pancreatic islet β-cells and play a crucial role in the diabetes disease process. A recent study revealed a down-regulation of transcription factor 2 (TCF2) levels during FFA-mediated cytotoxicity in pancreatic β-cells. However, its function during this process and the underlyi...

journal_title：International journal of molecular sciences

authors： Quan X,Zhang L,Li Y,Liang C

更新日期：2014-07-30 00:00:00

abstract：:Postmenopausal females display a chronic inflammatory phenotype with higher levels of circulating pro-inflammatory cytokines. Furthermore, the inflammatory response to injury may be altered under estrogen-deficiency, because it was shown previously that estrogen-deficient mice displayed increased levels of the inflamm...

journal_title：International journal of molecular sciences

authors： Fischer V,Kalbitz M,Müller-Graf F,Gebhard F,Ignatius A,Liedert A,Haffner-Luntzer M

更新日期：2018-07-16 00:00:00

abstract：:A bacterial strain EMS with the capability of degrading microcystins (MCs) was isolated from Lake Taihu, China. The bacterium was tentatively identified as a Stenotrophomonas sp. The bacterium could completely consume MC-LR and MC-RR within 24 hours at a concentration of 0.7 microg/mL and 1.7 microg/mL, respectively. ...

journal_title：International journal of molecular sciences

authors： Chen J,Hu LB,Zhou W,Yan SH,Yang JD,Xue YF,Shi ZQ

更新日期：2010-03-02 00:00:00

abstract：:The genus of Termitomyces purchased from the market has been identified as Termitomyces eurrhizus using the Internal Transcribed Spacer (ITS) method. An α-galactosidase from T. eurrhizus (TEG), a monomeric protein with a molecular mass of 72 kDa, was purified 146 fold by employing ion exchange chromatography and gel f...

journal_title：International journal of molecular sciences

authors： Zhang W,Du F,Wang L,Zhao L,Wang H,Ng TB

更新日期：2015-12-08 00:00:00

abstract：:A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting. The aim of the present meta-analysis was to estimate the overall association between risk of CAD and eNOS 4b/a pol...

journal_title：International journal of molecular sciences

authors： Yang Y,Du K,Liu Z,Lu X

更新日期：2014-05-07 00:00:00

abstract：:B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescenc...

journal_title：International journal of molecular sciences

authors： Borrás C,Mas-Bargues C,Román-Domínguez A,Sanz-Ros J,Gimeno-Mallench L,Inglés M,Gambini J,Viña J

更新日期：2020-01-09 00:00:00

abstract：:MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been impli...

journal_title：International journal of molecular sciences

authors： Tang J,Ahmad A,Sarkar FH

更新日期：2012-10-18 00:00:00

abstract：:Asia-Pacific NMR (APNMR) has been an important scientific event in the region, engaging a large number of NMR scientists from academia and industries [...]. ...

journal_title：International journal of molecular sciences

authors： Bhattacharjya S,Yang D,Yoon HS

更新日期：2020-06-22 00:00:00

abstract：:The At-Hook Motif Nuclear Localized Protein (AHL) gene family encodes embryophyte-specific nuclear proteins with DNA binding activity. They modulate gene expression and affect various developmental processes in plants. We identify AHL18 (At3G60870) as a developmental modulator of root system architecture and growth. A...

journal_title：International journal of molecular sciences

authors： Širl M,Šnajdrová T,Gutiérrez-Alanís D,Dubrovsky JG,Vielle-Calzada JP,Kulich I,Soukup A

更新日期：2020-03-10 00:00:00

abstract：UNLABELLED:Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However, gastrointestinal (GI) complications, particularly diarrhea, are frequently observed as a side effect following MPA therapy. We recently reported that MPA altered the tight junction (TJ)-mediated barrier func...

journal_title：International journal of molecular sciences

authors： Khan N,Lenz C,Binder L,Pantakani DV,Asif AR

更新日期：2016-04-20 00:00:00

abstract：:Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a promising target for developing novel anticancer drugs. A combined molecular docking, structure-based pharmacophore modeling and three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on ...

journal_title：International journal of molecular sciences

authors： Lu S,Liu HC,Chen YD,Yuan HL,Sun SL,Gao YP,Yang P,Zhang L,Lu T

更新日期：2011-01-01 00:00:00

abstract：:Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones are intensively investigated because of a large spectrum of their biological activities. Among others, anticancer and antiangiogenic effects account for the research interest of these substances. Because of an essential role in...

journal_title：International journal of molecular sciences

authors： Mirossay L,Varinská L,Mojžiš J

更新日期：2017-12-22 00:00:00

abstract：:We herein investigated the detection frequency and clinical relevance of circulating tumor cells (CTCs) in chemotherapy-naïve stage IIIB/IV non-small cell lung cancer (NSCLC), by using the CellSearch and real-time CEACAM5mRNA assays. Blood samples from 43 patients were obtained at different time points during first-li...

journal_title：International journal of molecular sciences

authors： Papadaki MA,Messaritakis I,Fiste O,Souglakos J,Politaki E,Kotsakis A,Georgoulias V,Mavroudis D,Agelaki S

更新日期：2021-01-18 00:00:00

abstract：:Grass carp reovirus (GCRV) causes huge economic loss to the grass carp cultivation industry but the mechanism remains largely unknown. In this study, we investigated the global and complement gene-specific DNA methylation in grass carp after GCRV infection aimed to uncover the mechanism underlying GCRV infection. The ...

journal_title：International journal of molecular sciences

authors： Xiong L,He L,Luo L,Li Y,Liao L,Huang R,Zhu Z,Wang Y

更新日期：2018-04-07 00:00:00

abstract：:Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, has five genotypes (I, II, III, IV, and V). JEV genotype I circulates widely in some Asian countries. However, current JEV vaccines based on genotype III strains show low neutralizing capacities against genotype I variants. In addition, JE has no specific...

journal_title：International journal of molecular sciences

authors： Huang SH,Lien JC,Chen CJ,Liu YC,Wang CY,Ping CF,Lin YF,Huang AC,Lin CW

更新日期：2016-08-24 00:00:00

abstract：:The aim of the study was to investigate the effect of using direct electric current (DC) of 0, 200, and 400 mA for five minutes on the physiochemical properties, cytotoxicity, antibacterial, and antioxidant activity of sodium alginate hydrosols with different sodium chloride concentrations. The pH, oxidation-reduction...

journal_title：International journal of molecular sciences

authors： Król Ż,Marycz K,Kulig D,Marędziak M,Jarmoluk A

更新日期：2017-03-22 00:00:00

abstract：:One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, w...

journal_title：International journal of molecular sciences

authors： Giannaccini M,Giannini M,Calatayud MP,Goya GF,Cuschieri A,Dente L,Raffa V

更新日期：2014-01-22 00:00:00