Abstract：
:Bone is a peculiar tissue subjected to a continuous process of self-renewal essential to assure the integrity of the skeleton and to explicate the endocrine functions. The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great role played by osteocalcin in the endocrine functions of the skeleton. The ability of osteoclasts to regulate the decarboxylation of osteocalcin and to control glucose metabolism, male fertility, and cognitive functions was demonstrated by the use of animal models. In this review we described how diseases characterized by defective and increased bone resorption activity, as osteopetrosis and osteoporosis, were essential to understand the involvement of bone tissue in whole body physiology. To translate this knowledge into humans, recently published reports on patients were described, but further studies should be performed to confirm this complex hormonal regulation in humans.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Rossi M,Battafarano G,Pepe J,Minisola S,Del Fattore Adoi
10.3390/ijms20184502subject
Has Abstractpub_date
2019-09-11 00:00:00issue
18issn
1422-0067pii
ijms20184502journal_volume
20pub_type
杂志文章,评审abstract：:The aim of this work was to compare protective and anti-apoptotic effects of α-tocopherol at nanomolar and micromolar concentrations against 0.2 mM H(2)O(2)-induced toxicity in the PC12 neuronal cell line and to reveal protein kinases that contribute to α-tocopherol protective action. The protection by 100 nM α-tocoph...
journal_title：International journal of molecular sciences
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更新日期：2009-03-01 00:00:00
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更新日期：2020-03-26 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,多中心研究,随机对照试验
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