Abstract：
:Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functions. In the present study, we used heat-aggregated gamma globulin (HAGG) to simulate immune complexes and investigated their effects on GEC functions. Our results revealed that HAGG impaired different aspect of the GEC functions. HAGG changed cell morphology, upregulated the expression of active caspase-3, inhibited angiogenesis, and increased NO production in GECs. These results provide new clues for the mechanisms of renal damage and the pathology of LN.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wang L,Law HKWdoi
10.3390/ijms20215281subject
Has Abstractpub_date
2019-10-24 00:00:00issue
21issn
1422-0067pii
ijms20215281journal_volume
20pub_type
杂志文章abstract：:The bHLH-PAS (basic helix-loop-helix/ Period-ARNT-Single minded) proteins are a family of transcriptional regulators commonly occurring in living organisms. bHLH-PAS members act as intracellular and extracellular "signals" sensors, initiating response to endo- and exogenous signals, including toxins, redox potential, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2013-10-08 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-01-21 00:00:00
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更新日期：2010-04-26 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2009-08-04 00:00:00
