Abstract：
:The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular and presents a robust mechanism of antigenic variation that allows the persistence of infection. There has been incredible progress in our understanding of how variable surface glycoproteins (VSGs) are organised and expressed, and how expression is switched, particularly through recombination. The objective of this manuscript is to create a reflection about the mechanisms of antigenic variation in T. brucei, more specifically, in the process of variable surface glycoprotein (VSG) release. We firstly explore the mechanism of VSG release as a potential pathway and target for the development of anti-T. brucei drugs.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Moreno CJG,Temporão A,Torres T,Sousa Silva Mdoi
10.3390/ijms20061484subject
Has Abstractpub_date
2019-03-25 00:00:00issue
6issn
1422-0067pii
ijms20061484journal_volume
20pub_type
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