Abstract：
:The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated cellular processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Moreover, a major goal of modern biotechnology is obtaining new potent pharmaceutical agents whose biological action is dependent on the binding of peptides to lipid-bilayers. Several issues need to be addressed such as secondary structure, orientation, oligomerization and localization inside the membrane. At the same time, the structural effects which the peptides cause on the lipid bilayer are important for the interactions and need to be elucidated. The structural characterization of membrane active peptides in membranes is a harsh experimental challenge. It is in fact accepted that no single experimental technique can give a complete structural picture of the interaction, but rather a combination of different techniques is necessary.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Galdiero S,Falanga A,Cantisani M,Vitiello M,Morelli G,Galdiero Mdoi
10.3390/ijms140918758subject
Has Abstractpub_date
2013-09-12 00:00:00pages
18758-89issue
9issn
1422-0067pii
ijms140918758journal_volume
14pub_type
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