Abstract:
:Differentiation and variation in body color has been a growing limitation to the commercial value of red tilapia. Limited microRNA (miRNA) information is available on skin color differentiation and variation in fish so far. In this study, a high-throughput Illumina sequencing of sRNAs was conducted on three color varieties of red tilapia and 81,394,491 raw reads were generated. A total of 158 differentially expressed miRNAs (|log₂(fold change)| ≥ 1 and q-value ≤ 0.001) were identified. Target prediction and functional analysis of color-related miRNAs showed that a variety of putative target genes—including slc7a11, mc1r and asip—played potential roles in pigmentation. Moreover; the miRNA-mRNA regulatory network was illustrated to elucidate the pigmentation differentiation, in which miR-138-5p and miR-722 were predicted to play important roles in regulating the pigmentation process. These results advance our understanding of the molecular mechanisms of skin pigmentation differentiation in red tilapia.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wang L,Zhu W,Dong Z,Song F,Dong J,Fu Jdoi
10.3390/ijms19041209subject
Has Abstractpub_date
2018-04-16 00:00:00issue
4issn
1422-0067pii
ijms19041209journal_volume
19pub_type
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