Abstract：
:SDS-gradient mini-gel electrophoresis and immunoblotting of urine of rats given ochratoxin A (OTA), showed OTA binding to an alpha2u-globulin. Perceived potential internalised delivery of OTA to proximal tubule epithelia by the carrier, specific only to adult male rats and augmenting other uptake mechanisms, suggests that some experimental nephrotoxicological data may not be appropriate for human risk assessment. Reexamination of female rat renal tumour histopathology of the NTP high dose OTA study showed all carcinomas were solitary, unilateral, microscopic and clinically insignificant at the 2-year end-stage. The novel concept, when consolidated further from our archived material, may moderate current perceptions of the human risk of traces of dietary OTA.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Mantle PG,Nagy JMdoi
10.3390/ijms9050719subject
Has Abstractpub_date
2008-05-01 00:00:00pages
719-35issue
5issn
1422-0067journal_volume
9pub_type
杂志文章abstract：:The binding of epidermal growth factor (EGF) to EGF receptor (EGFR) stimulates cell mitogenesis and survival through various signalling cascades. EGF also stimulates rapid EGFR endocytosis and its eventual degradation in lysosomes. The immediate events induced by ligand binding include receptor dimerization, activatio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17081200
更新日期：2016-07-25 00:00:00
abstract：:The only curative treatment for hepatic failure is liver transplantation. Unfortunately, this treatment has several major limitations, as for example donor organ shortage. A previous report demonstrated that transplantation of induced pluripotent stem cells without reprogramming factor c-Myc (3-genes iPSCs) attenuates...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13033598
更新日期：2012-01-01 00:00:00
abstract：:Despite recent progresses in its treatment, malignant cutaneous melanoma remains a cancer with very poor prognosis. Emerging evidences suggest that the receptor for advance glycation end products (RAGE) plays a key role in melanoma progression through its activation in both cancer and stromal cells. In tumors, RAGE ac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21238989
更新日期：2020-11-26 00:00:00
abstract：:Type 2 innate lymphoid cells (ILC2s) and their adaptive counterpart type 2 T helper (TH2) cells respond to interleukin-33 (IL-33) by producing IL-5, which is a crucial cytokine for eosinophil development in the bone marrow. The aim of this study was to determine if bone marrow ILC2s, TH cells, and eosinophils are loca...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113751
更新日期：2020-05-26 00:00:00
abstract：:Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used after transurethral res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071125
更新日期：2016-07-14 00:00:00
abstract：:Diabetic nephropathy (DN) is the main cause of end-stage renal disease, which remains incurable. The progression of DN is associated with progressive and irreversible renal fibrosis and also high levels of adenosine. Our aim was to evaluate the effects of ADORA3 antagonism on renal injury in streptozotocin-induced dia...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184531
更新日期：2019-09-13 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Recently, many studies have focused on cellular and molecular mechanisms ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18091849
更新日期：2017-08-24 00:00:00
abstract：:High-density genetic linkage maps of crop species are particularly useful in detecting qualitative and quantitative trait loci for important agronomic traits and in improving the power of classical approaches to identify candidate genes. The aim of this study was to develop a high-density genetic linkage map in a duru...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061329
更新日期：2017-06-21 00:00:00
abstract：:Preterm birth (PTB) can be defined as the endpoint of a complex process that could be influenced by maternal and environmental factors. Epigenetics recently emerged as an interesting field of investigation since it represents an important mechanism of regulation. This study evaluates epigenetic impact of preterm birth...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145044
更新日期：2020-07-17 00:00:00
abstract：:The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160510324
更新日期：2015-05-06 00:00:00
abstract：:MicroRNAs have been identified as key regulators of gene expression and thus their potential in disease diagnostics, prognosis and therapy is being actively pursued. Deregulation of microRNAs in cerebral pathogenesis has been reported to a limited extent in both animal models and human. Due to the complexity of the pa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15011418
更新日期：2014-01-20 00:00:00
abstract：:KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) has been reported to cause hepatic fat loss. However, the action mechanisms of KMUP-1 in obesity-induced steatohepatitis remains unclear. This study elucidated the steatohepatitis via matrix metallopeptidase 9 (MMP-9) and tumor necrosis factor α...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17081345
更新日期：2016-08-17 00:00:00
abstract：:Wt% of aragonite, a CaCO(3) polymorph, increased with higher hydraulic activity ( degrees C) of limestone in precipitated calcium carbonate (PCC) from the lime-soda process (Ca(OH)(2)-NaOH-Na(2)CO(3)). Only calcite, the most stable polymorph, was crystallized at hydraulic activity under 10 degrees C, whereas aragonite...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10114954
更新日期：2009-11-11 00:00:00
abstract：:Liver fibrosis is a complex process associated to most types of chronic liver disease, which is characterized by a disturbance of hepatic tissue architecture and the excessive accumulation of extracellular matrix. Resolvin E1 (RvE1) is a representative member of the eicosapentaenoic omega-3 lipid derivatives, and is a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228827
更新日期：2020-11-22 00:00:00
abstract：:Parathyroid hormone-related protein (PTHrP), with isoforms ranging from 139 to 173 amino acids, has long been implicated in the development and regulation of multiple tissues, including that of the skeleton, via paracrine and autocrine signaling. PTHrP is also known as a potent mediator of cancer-induced bone disease,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112814
更新日期：2019-06-08 00:00:00
abstract：:Aphids are phloem feeders that cause large damage globally as pest insects. They induce a variety of responses in the host plant, but not much is known about which responses are promoting or inhibiting aphid performance. Here, we investigated whether one of the responses induced in barley by the cereal aphid, bird che...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061317
更新日期：2017-06-20 00:00:00
abstract：:Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11041930
更新日期：2010-04-26 00:00:00
abstract：:Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease (ESRD) and is therefore a major burden on the healthcare system. Patients with DKD are highly susceptible to developing cardiovascular disease, which contributes to increased morbidity and mortality rates. While progress has been made t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20143393
更新日期：2019-07-10 00:00:00
abstract：:Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a promising target for developing novel anticancer drugs. A combined molecular docking, structure-based pharmacophore modeling and three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12128713
更新日期：2011-01-01 00:00:00
abstract：:Checkpoint kinase 2 (CHK2) and cell division cycle 25C (CDC25C) are two proteins involved in the DNA damage response pathway, playing essential roles in maintaining genome integrity. As one of the major hallmarks of abnormal cellular division, genomic instability occurs in most cancers. In this study, we identified th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17111803
更新日期：2016-10-28 00:00:00
abstract：:Insulin-resistance is one of the main factors responsible for the onset and progression of Metabolic Syndrome (MetS). Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies. The aim of this review is to analyse th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20092061
更新日期：2019-04-26 00:00:00
abstract：:Placental homeostasis of tryptophan is essential for fetal development and programming. The two main metabolic pathways (serotonin and kynurenine) produce bioactive metabolites with immunosuppressive, neurotoxic, or neuroprotective properties and their concentrations in the fetoplacental unit must be tightly regulated...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207578
更新日期：2020-10-14 00:00:00
abstract：:Congenital dyserythropoietic anemia type II (CDA II) is a hypo-productive anemia defined by ineffective erythropoiesis through maturation arrest of erythroid precursors. CDA II is an autosomal recessive disorder due to loss-of-function mutations in SEC23B. Currently, management of patients with CDA II is based on tran...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155577
更新日期：2020-08-04 00:00:00
abstract：:Cell-to-cell communication mediates a plethora of cellular decisions and behaviors that are crucial for the correct and robust development of multicellular organisms. Many of these signals are encoded in secreted hormones or growth factors that bind to and activate cell surface receptors, to transmit the cue intracell...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21010188
更新日期：2019-12-26 00:00:00
abstract：:Metallothioneins (MTs) are a family of metal-binding proteins virtually expressed in all organisms including prokaryotes, lower eukaryotes, invertebrates and mammals. These proteins regulate homeostasis of zinc (Zn) and copper (Cu), mitigate heavy metal poisoning, and alleviate superoxide stress. In recent years, MTs ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18102197
更新日期：2017-10-23 00:00:00
abstract：:In excitable tissues, the endogenous dipeptide carnosine (CAR, β-Ala-l-His) sustains homeostatic responses to various challenges. By eliciting hypoglycemic effects via actions on the autonomic nervous system and protection of pancreatic beta-cells, CAR is also relevant in diabetes. We investigated the expression of ge...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061713
更新日期：2018-06-09 00:00:00
abstract：:Immune modulation is a very modern medical field for targeting viral infections. In the race to develop the best immune modulator against viruses, curcumin, as a natural product, is inexpensive, without side effects, and can stimulate very well certain areas of the human immune system. As a bright yellow component of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197150
更新日期：2020-09-28 00:00:00
abstract：:Skeletal muscle is constantly renewed in response to injury, exercise, or muscle diseases. Muscle stem cells, also known as satellite cells, are stimulated by local damage to proliferate extensively and form myoblasts that then migrate, differentiate, and fuse to form muscle fibers. The transmembrane heparan sulfate p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030823
更新日期：2020-01-27 00:00:00
abstract：:Stem cells for regenerative medicine purposes offer therapeutic benefits, but disadvantages are still ill defined. The benefit of stem cells may be attributed to their secretion of growth factors (GFs), cytokines (CKs), and extracellular vesicles (EVs), including exosomes. We present a novel cell-free stem cell-derive...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249364
更新日期：2020-12-09 00:00:00
abstract：:This review covers recent advances and work on the microstructure features, mechanical properties and cracking processes of conducting polymer film/coating- substrate structures under different testing conditions. An attempt is made to characterize and quantify the relationships between mechanical properties and micro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms10125257
更新日期：2009-12-08 00:00:00
