Abstract：
:Wounding is a serious environmental stress in plants. Oxylipins such as jasmonic acid play an important role in defense against wounding. Mechanisms to adapt to wounding have been investigated in vascular plants; however, those mechanisms in nonvascular plants remain elusive. To examine the response to wounding in Physcomitrella patens, a model moss, a proteomic analysis of wounded P. patens was conducted. Proteomic analysis showed that wounding increased the abundance of proteins related to protein synthesis, amino acid metabolism, protein folding, photosystem, glycolysis, and energy synthesis. 12-Oxo-phytodienoic acid (OPDA) was induced by wounding and inhibited growth. Therefore, OPDA is considered a signaling molecule in this plant. Proteomic analysis of a P. patens mutant in which the PpAOS1 and PpAOS2 genes, which are involved in OPDA biosynthesis, are disrupted showed accumulation of proteins involved in protein synthesis in response to wounding in a similar way to the wild-type plant. In contrast, the fold-changes of the proteins in the wild-type plant were significantly different from those in the aos mutant. This study suggests that PpAOS gene expression enhances photosynthesis and effective energy utilization in response to wounding in P. patens.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Luo W,Komatsu S,Abe T,Matsuura H,Takahashi Kdoi
10.3390/ijms21041417subject
Has Abstractpub_date
2020-02-19 00:00:00issue
4issn
1422-0067pii
ijms21041417journal_volume
21pub_type
杂志文章abstract：:The response and adaptation to drought remains poorly understood for Paulownia australis. To investigate this issue, transcriptome profiling of four P. australis accessions (two diploid and the other two autotetraploid) under water stress condition were studied using Illumina Genome Analyzer IIx analysis. The current ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15034583
更新日期：2014-03-17 00:00:00
abstract：:Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute and chronic infections in individuals with compromised immune systems. Its highly notorious persistence in clinical settings is attributed to its ability to form antibiotic-resistant biofilms. Biofilm is an architecture built mostly by...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-11-17 00:00:00
abstract：:Chitosan, a naturally occurring polysaccharide with abundant resources, has been extensively exploited for various biomedical applications, typically as wound dressings owing to its unique biocompatibility, good biodegradability and excellent antibacterial properties. In this work, composite nanofibrous membranes of c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11093529
更新日期：2010-09-21 00:00:00
abstract：:Antibacterial peptides (APMs) are a new type of antibacterial substance. The relationship between their structure and function remains indistinct; in particular, there is a lack of a definitive and fixed template for designing new antimicrobial peptides. Previous studies have shown that porcine Protegrin-1 (PG-1) exhi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20163954
更新日期：2019-08-14 00:00:00
abstract：:Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill the considerable requirements for suitable bioi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17121976
更新日期：2016-11-25 00:00:00
abstract：:The signaling function of the Na/K-ATPase has been established for 20 years and is widely accepted in the field, with many excellent reports and reviews not cited here. Even though there is debate about the underlying mechanism, the signaling function is unquestioned. This short review looks back at the evolution of N...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092600
更新日期：2018-09-01 00:00:00
abstract：:ortho-Quinones are produced in vivo through the oxidation of catecholic substrates by enzymes such as tyrosinase or by transition metal ions. Neuromelanin, a dark pigment present in the substantia nigra and locus coeruleus of the brain, is produced from dopamine (DA) and norepinephrine (NE) via an interaction with cys...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17020164
更新日期：2016-01-27 00:00:00
abstract：:The WRKY transcription factor superfamily is known to participate in plant growth and stress response. However, the role of this family in wheat (Triticum aestivum L.) is largely unknown. Here, a salt-induced gene TaWRKY13 was identified in an RNA-Seq data set from salt-treated wheat. The results of RT-qPCR analysis s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225712
更新日期：2019-11-14 00:00:00
abstract：:Cancer is known for its cellular changes contributing to tumour growth and cell proliferation. As part of these changes, metabolic rearrangements are identified in several cancers, including multiple myeloma (MM), which is a condition whereby malignant plasma cells accumulate in the bone marrow (BM). These metabolic c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19041200
更新日期：2018-04-14 00:00:00
abstract：:KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) has been reported to cause hepatic fat loss. However, the action mechanisms of KMUP-1 in obesity-induced steatohepatitis remains unclear. This study elucidated the steatohepatitis via matrix metallopeptidase 9 (MMP-9) and tumor necrosis factor α...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17081345
更新日期：2016-08-17 00:00:00
abstract：:Sarcopenia, the degenerative and systemic loss of skeletal muscle mass, indicates patient frailty and impaired physical function. Sarcopenia can be caused by multiple factors, including advanced age, lack of exercise, poor nutritional status, inflammatory diseases, endocrine diseases, and malignancies. In patients wit...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19102999
更新日期：2018-10-01 00:00:00
abstract：:Detection and recovery of heavy metals from environmental sources is a major task in environmental protection and governance. Based on previous research into cell-based visual detection and biological adsorption, we have developed a novel system combining these two functions by the BioBrick technique. The gold-specifi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123741
更新日期：2018-11-24 00:00:00
abstract：:Human bone marrow-derived mesenchymal stromal cells (MSCs) have been investigated in numerous disease settings involving impaired regeneration because of the crucial role they play in tissue maintenance and repair. Considering the number of comorbidities associated with type 2 diabetes mellitus (T2DM), the hypothesis ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072476
更新日期：2020-04-02 00:00:00
abstract：:Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析,评审
doi：10.3390/ijms19030711
更新日期：2018-03-02 00:00:00
abstract：:The consumption of polyphenols has frequently been associated with low incidence of degenerative diseases. Most of these natural antioxidants come from fruits, vegetables, spices, grains and herbs. For this reason, there has been increasing interest in identifying plant extract compounds. Polymeric tannins and monomer...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151120382
更新日期：2014-11-06 00:00:00
abstract：:Studies have shown that the type II pyridoxal phosphate-dependent decarboxylase (PLP_deC) genes produce secondary metabolites and flavor volatiles in plants, and TDC (tryptophan decarboxylase), a member of the PLP_deC family, plays an important role in the biosynthesis of terpenoid indole alkaloids (TIAs). In this stu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010054
更新日期：2019-12-20 00:00:00
abstract：:Colorectal cancer (CRC) remains a serious health problem worldwide. Approximately half of patients will develop distant metastasis after CRC resection, usually with very poor prognosis afterwards. Because patient performance after distant metastasis surgery remains very heterogeneous, ranging from death within 2 years...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155255
更新日期：2020-07-24 00:00:00
abstract：:In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of the metabolic syndrome (obesity, inflammation, hyperglycemia, or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This make...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030991
更新日期：2020-02-03 00:00:00
abstract：:Maintenance of genome integrity is a key process in all organisms. DNA polymerases (Pols) are central players in this process as they are in charge of the faithful reproduction of the genetic information, as well as of DNA repair. Interestingly, all eukaryotes possess a large repertoire of polymerases. Three protein c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20194814
更新日期：2019-09-27 00:00:00
abstract：:Kinase drug discovery represents an active area of therapeutic research, with previous pharmaceutical success improving patient outcomes across a wide variety of human diseases. In pancreatic ductal adenocarcinoma (PDAC), innovative pharmaceutical strategies such as kinase targeting have been unable to appreciably inc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228823
更新日期：2020-11-21 00:00:00
abstract：:The local anesthetic lidocaine, which has been used extensively during liposuction, has been reported to have cytotoxic effects and therefore would be unsuitable for use in autologous lipotransfer. We evaluated the effect of lidocaine on the distribution, number, and viability of adipose-derived stem cells (ASCs), pre...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082869
更新日期：2020-04-20 00:00:00
abstract：:Arterial wall remodeling underlies increased pulmonary vascular resistance and right heart failure in pulmonary arterial hypertension (PAH). None of the established vasodilator drug therapies for PAH prevents or reverse established arterial wall thickening, stiffening, and hypercontractility. Therefore, new approaches...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239222
更新日期：2020-12-03 00:00:00
abstract：:InPBi exhibits broad and strong photoluminescence at room temperature, and is a potential candidate for fabricating super-luminescence diodes applied in optical coherence tomography. In this paper, the strained InPBi quantum dot (QD) embedded in the AlGaAs barrier on a GaAs platform is proposed to enhance the light em...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20236001
更新日期：2019-11-28 00:00:00
abstract：:Uterine fibroids are the most common gynecologic benign tumors. Studies supporting a strong pregnancy-related growth of leiomyomas generally claimed a crucial role of sex steroid hormones. However, sex steroids are unlikely the unique actors involved as estrogen and progesterone achieve a pick serum concentration in t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18092014
更新日期：2017-09-20 00:00:00
abstract：:Carbonic anhydrase II (CAII) is a zinc-containing metalloenzyme whose aberrant activity is associated with various diseases such as glaucoma, osteoporosis, and different types of tumors; therefore, the development of CAII inhibitors, which can represent promising therapeutic agents for the treatment of these pathologi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071851
更新日期：2018-06-23 00:00:00
abstract：:An acylated flavonol glycoside, helichrysoside, at a dose of 10 mg/kg/day per os for 14 days, improved the glucose tolerance in mice without affecting the food intake, visceral fat weight, liver weight, and other plasma parameters. In this study, using hepatoblastoma-derived HepG2 cells, helichrysoside, trans-tilirosi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246322
更新日期：2019-12-14 00:00:00
abstract：:Milk fat is a key factor affecting milk quality and is also a major trait targeted in dairy cow breeding. To determine how the synthesis and the metabolism of lipids in bovine milk is regulated at the miRNA level, primary mammary epithelial cells (pMEC) derived from two Chinese Holstein dairy cows that produced extrem...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17020200
更新日期：2016-02-17 00:00:00
abstract：:Wounds are a largely unrecognized, spiraling epidemic that affect millions of people world-wide [...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms20071724
更新日期：2019-04-08 00:00:00
abstract：:Ostrinia furnacalis, is the major pest of maize causing significant yield losses. So far, many approaches have been used to increase the virulence of entomopathogenic fungal isolates. The current study is an attempt to estimate synergistic effect of Beauveria bassiana and Trichoderma asperellum in order to explore lar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218215
更新日期：2020-11-03 00:00:00
abstract：:Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used after transurethral res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071125
更新日期：2016-07-14 00:00:00
