Abstract：
:An acylated flavonol glycoside, helichrysoside, at a dose of 10 mg/kg/day per os for 14 days, improved the glucose tolerance in mice without affecting the food intake, visceral fat weight, liver weight, and other plasma parameters. In this study, using hepatoblastoma-derived HepG2 cells, helichrysoside, trans-tiliroside, and kaempferol 3-O-β-D-glucopyranoside enhanced glucose consumption from the medium, but their aglycones and p-coumaric acid did not show this activity. In addition, several acylated flavonol glycosides were synthesized to clarify the structural requirements for lipid metabolism using HepG2 cells. The results showed that helichrysoside and related analogs significantly inhibited triglyceride (TG) accumulation in these cells. The inhibition by helichrysoside was more potent than that by other acylated flavonol glycosides, related flavonol glycosides, and organic acids. As for the TG metabolism-promoting activity in high glucose-pretreated HepG2 cells, helichrysoside, related analogs, and their aglycones were found to significantly reduce the TG contents in HepG2 cells. However, the desacyl flavonol glycosides and organic acids derived from the acyl groups did not exhibit an inhibitory impact on the TG contents in HepG2 cells. These results suggest that the existence of the acyl moiety at the 6'' position in the D-glucopyranosyl part is essential for glucose and lipid metabolism-promoting activities.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Morikawa T,Nagatomo A,Oka T,Miki Y,Taira N,Shibano-Kitahara M,Hori Y,Muraoka O,Ninomiya Kdoi
10.3390/ijms20246322subject
Has Abstractpub_date
2019-12-14 00:00:00issue
24issn
1422-0067pii
ijms20246322journal_volume
20pub_type
杂志文章abstract：:The red color of apples (Malus domestica) is an attractive trait for consumers. The green skinned "Granny Smith" cultivar develops red pigmentation after bagging treatment. DNA methylation plays an important role in various developmental processes in plants. To explore the possible functions of DNA methylation in the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103133
更新日期：2018-10-12 00:00:00
abstract：:Biliverdin reductase A is an enzyme, with serine/threonine/tyrosine kinase activation, converting biliverdin (BV) to bilirubin (BR) in heme degradation pathway. It has been reported to have anti-inflammatory and antioxidant effect in monocytes and human glioblastoma. However, the function of BVRA in polarized macropha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160922621
更新日期：2015-09-18 00:00:00
abstract：:Mast cells are pluripotent leukocytes that reside in the mucosa and connective tissue. Recent studies show an increased prevalence of cardiovascular disease among patients with mastocytosis, which is a hematological disease that is characterized by the accumulation of mast cells due to clonal proliferation. This assoc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20143395
更新日期：2019-07-10 00:00:00
abstract：:Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major cardiac dysfunction, revealing the importance in the regulation of excitability. In turn, some muta...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20020400
更新日期：2019-01-18 00:00:00
abstract：:Ataxia is a common clinical feature in inherited metabolic disorders. There are more than 150 inherited metabolic disorders in patients presenting with ataxia in addition to global developmental delay, encephalopathy episodes, a history of developmental regression, coarse facial features, seizures, and other types of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155519
更新日期：2020-08-01 00:00:00
abstract：:Angiogenesis is a complex biological process that plays a relevant role in sustaining the microenvironment, growth, and metastatic potential of several tumors, including non-small cell lung cancer (NSCLC). Bevacizumab was the first angiogenesis inhibitor approved for the treatment of patients with advanced NSCLC in co...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18102021
更新日期：2017-09-21 00:00:00
abstract：:Various strategies have been employed to speed tissue regeneration using bioactive molecules. Interestingly, platelet concentrates derived from a patient's own blood have been utilized as a regenerative strategy in recent years. In the present study, a novel liquid platelet formulation prepared without the use of anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020331
更新日期：2017-02-04 00:00:00
abstract：:With the avalanche of biological sequences generated in the postgenomic age, molecular science is facing an unprecedented challenge, i.e., how to timely utilize the huge amount of data to benefit human beings. Stimulated by such a challenge, a rapid development has taken place in molecular science, particularly in the...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms151120072
更新日期：2014-11-04 00:00:00
abstract：:Microglia constitute the resident immunocompetent cells of the central nervous system. Although much work has focused on their ability to mount an inflammatory response in reaction to pathology, recent studies have delved into their role in maintaining homeostasis in the healthy brain. It is important to note that the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18030561
更新日期：2017-03-04 00:00:00
abstract：:Presently, many studies have focused on exploring in silico approaches in the identification and development of alternative therapy for the treatment and management of cancer. Solute carrier family-2-member-4-gene (Slc2a4) which encodes glucose transporter 4 protein (GLUT4), has been identified as a promising therapeu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020386
更新日期：2018-01-28 00:00:00
abstract：:Docking-i.e., interaction of a small molecule (ligand) with a proteic structure (receptor)-represents the ground of drug action mechanism of the vast majority of bioactive chemicals. Ligand and receptor accommodate their geometry and energy, within this interaction, in the benefit of receptor-ligand complex. In an ind...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071377
更新日期：2017-06-27 00:00:00
abstract：:C-repeat binding factor/dehydration-responsive element (CBF/DRE) transcription factors (TFs) participate in a variety of adaptive mechanisms, and are involved in molecular signaling and abiotic stress tolerance in plants. In pear (Pyrus pyrifolia) and other rosaceous crops, the independent evolution of CBF subfamily m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092074
更新日期：2019-04-26 00:00:00
abstract：:The bromodomain and extra-terminal domain family inhibitors (BETi) are a promising new class of anticancer agents. Since numerous anticancer drugs have been correlated to cardiomyopathy, and since BETi can affect non-cancerous tissues, we aimed to investigate in healthy animals any ultrastructural BETi-induced alterat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071527
更新日期：2019-03-27 00:00:00
abstract：:Wallerian degeneration or nerve demyelination, arising from spinal nerve compression, is thought to bring on chronic neuropathic pain. The widely distributed metabotropic glutamate receptor subtype 5 (mGluR5) is involved in modulating nociceptive transmission. The purpose of this study was to investigate the potential...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16034642
更新日期：2015-03-02 00:00:00
abstract：:In order to understand the pyrolysis mechanism of β-O-4 type lignin dimers, a pyrolysis model is proposed which considers the effects of functional groups (hydroxyl, hydroxymethyl and methoxyl) on the alkyl side chain and aromatic ring. Furthermore, five specific β-O-4 type lignin dimer model compounds are selected to...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112364
更新日期：2017-11-09 00:00:00
abstract：:To investigate the effect of pollination on the fruit quality of 'Dangshan Su' pear, 'Dangshan Su' was fertilized by the pollen of 'Wonhwang' (Pyrus pyrifolia Nakai.) (DW) and 'Jingbaili' (Pyrus ussuriensis Maxim.) (DJ). The analysis of primary metabolites was achieved through untargeted metabolomics, and the quantita...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082273
更新日期：2018-08-02 00:00:00
abstract：:A combined theoretical and experimental study on the structure, infrared, UV-Vis and 1H NMR data of trans-2-(m-cyanostyryl)pyridine, trans-2-[3-methyl-(m-cyanostyryl)]pyridine and trans-4-(m-cyanostyryl)pyridine is presented. The synthesis was carried out with an efficient Knoevenagel condensation using green chemist...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14024005
更新日期：2013-02-18 00:00:00
abstract：:Chitin synthase synthesizes chitin, which is critical for the arthropod exoskeleton. In this study, we cloned the cDNA sequences of a chitin synthase 1 gene, PcCHS1, in the citrus red mite, Panonychus citri (McGregor), which is one of the most economically important pests of citrus worldwide. The full-length cDNA of P...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15033711
更新日期：2014-02-28 00:00:00
abstract：:Human cytochrome P450 1B1 (CYP1B1)-mediated biotransformation of endobiotics and xenobiotics plays an important role in the progression of human breast cancer. In this study, we investigated the effects of WY-14643, a peroxisome proliferator-activated receptor α (PPARα) agonist, on CYP1B1 expression and the related me...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235928
更新日期：2019-11-25 00:00:00
abstract：:Although poly(2-hydroxyethyl methacrylate) (pHEMA) and polyethylene glycol methacrylate (PEGMA) have been demonstrated to inhibit bacterial adhesion, no study has compared antibacterial adhesion when salivary pellicle is coated on polymethyl methacrylate (PMMA) grafted with pHEMA and on PMMA grafted with PEGMA. In thi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092764
更新日期：2018-09-14 00:00:00
abstract：:The presented studies focused on the specificity binding of particular casein fractions: αS1-, β- and κ-casein (αS1CN, βCN, κCN), with zinc ions. The binding mechanism was determined by kinetic modeling using results of batch sorption. For this goal, models of zero-order kinetics, pseudo-first-order, pseudo-second-ord...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218096
更新日期：2020-10-30 00:00:00
abstract：:The overexpressing ABCB1 transporter is one of the key factors leading to multidrug resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome ABCB1-mediated MDR. However, some inhibitors also work as a substrate of ABCB1, which indicates that in order to achieve an effective reversal dosage,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041387
更新日期：2020-02-19 00:00:00
abstract：:As the first crucial barrier in the midgut of insects, the peritrophic membrane (PM) plays an important role in preventing external invasion. PM proteins, as the major components of the PM, determine the structure and function of this membrane. A new PM protein, named LstiCBP, from the PM of Loxostege sticticalis larv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151019147
更新日期：2014-10-22 00:00:00
abstract：:The ubiquitous second messenger 3',5'-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19030801
更新日期：2018-03-10 00:00:00
abstract：:The turnover of the RNA molecules is determined by the rates of transcription and RNA degradation. Several methods have been developed to study RNA turnover since the beginnings of molecular biology. Here we summarize the main methods to measure RNA half-life: transcription inhibition, gene control, and metabolic labe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18122723
更新日期：2017-12-15 00:00:00
abstract：:The establishment of a proangiogenic phenotype and epithelial-to-mesenchymal transition (EMT) are considered as critical events that promote the induction of invasive growth in epithelial tumors, and stimulation of lymphangiogenesis is believed to confer the capacity for early dissemination to cancer cells. Recent res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186515
更新日期：2020-09-06 00:00:00
abstract：:Fat deposition, which influences pork production, meat quality and growth efficiency, is an economically important trait in pigs. Numerous studies have demonstrated that stearoyl-CoA desaturase (SCD), a key enzyme that catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, is associated wi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072446
更新日期：2020-04-01 00:00:00
abstract：:Copper is an essential microelement that plays an important role in a wide variety of biological processes. Copper concentration has to be finely regulated, as any imbalance in its homeostasis can induce abnormalities. In particular, excess copper plays an important role in the etiopathogenesis of the genetic disease ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21031069
更新日期：2020-02-06 00:00:00
abstract：:Endothelial cells (ECs) that line the lumen of blood vessels are important players in blood vessel formation, and EC migration is a key component of the angiogenic process. Thus, identification of genes that are specifically or preferentially expressed in vascular ECs and in-depth understanding of their biological fun...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13044920
更新日期：2012-01-01 00:00:00
abstract：:Porcine mammary fatty tissues represent an abundant source of natural biomaterial for generation of breast-specific extracellular matrix (ECM). Here we report the extraction of total ECM proteins from pig breast fatty tissues, the fabrication of hydrogel and porous scaffolds from the extracted ECM proteins, the struct...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19102912
更新日期：2018-09-25 00:00:00
