Abstract：
:Porcine mammary fatty tissues represent an abundant source of natural biomaterial for generation of breast-specific extracellular matrix (ECM). Here we report the extraction of total ECM proteins from pig breast fatty tissues, the fabrication of hydrogel and porous scaffolds from the extracted ECM proteins, the structural properties of the scaffolds (tissue matrix scaffold, TMS), and the applications of the hydrogel in human mammary epithelial cell spatial cultures for cell surface receptor expression, metabolomics characterization, acini formation, proliferation, migration between different scaffolding compartments, and in vivo tumor formation. This model system provides an additional option for studying human breast diseases such as breast cancer.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Rijal G,Wang J,Yu I,Gang DR,Chen RK,Li Wdoi
10.3390/ijms19102912subject
Has Abstractpub_date
2018-09-25 00:00:00issue
10issn
1422-0067pii
ijms19102912journal_volume
19pub_type
杂志文章abstract：:Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria, such as Shigella, Listeria, enteroinvasive E. coli and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithel...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms151018253
更新日期：2014-10-10 00:00:00
abstract：:Dysregulated human monocytes/macrophages can synthesize and secrete matrix metalloproteinases (MMPs), which play important roles in the progression of sepsis. In this study, we investigated the effects and mechanism of a novel histone deacetylase (HDAC8) inhibitor, (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide (W...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071394
更新日期：2017-06-29 00:00:00
abstract：:Forkhead box P1 (FOXP1) belongs to a family of winged-helix transcription factors that are involved in the processes of cellular proliferation, differentiation, metabolism, and longevity. FOXP1 can affect cell proliferation and migratory ability in hepatocellular carcinoma (HCC) in vitro. However, little is known abou...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17091501
更新日期：2016-09-08 00:00:00
abstract：:Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investiga...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140611816
更新日期：2013-06-03 00:00:00
abstract：:The aim of the present pilot study was the identification of micro-RNA changes over time during the development and progression of type 2 diabetes (T2D) in Zucker diabetic fatty rats (ZDF rats). T2D is a complex metabolic disorder that is characterized, inter alia, by progressive failure of pancreatic β cells to produ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17050665
更新日期：2016-05-03 00:00:00
abstract：:In the present study, we aim to identify the effect of restrain stress (RS) on the expression of miRNAs in mouse serum. We used three genotypes of animals (mice with knock-out of the gene-encoding norepinephrine transporter, NET-KO; C57BL/6J, and SWR/J) which had previously been shown to display different sensitivity ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249469
更新日期：2020-12-12 00:00:00
abstract：:Flooding negatively affects the growth of soybeans. Recently, omic approaches have been used to study abiotic stress responses in plants. To explore flood-tolerant genes in soybeans, an integrated approach of proteomics and computational genetic modification effectiveness analysis was applied to the soybean (Glycine m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051301
更新日期：2018-04-26 00:00:00
abstract：:Type 2 transglutaminase (TG2) is a ubiquitous enzyme able to modify gliadin peptides introduced into the organism through the diet. By means of its catalytic activity, TG2 seems to have an important pathogenetic role in celiac disease (CD), an inflammatory intestinal disease caused by the ingestion of gluten-containin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041231
更新日期：2020-02-12 00:00:00
abstract：:S-equol is a major bacterial metabolite of the soy isoflavone daidzein. It is known to be a phytoestrogen that acts by binding to the nuclear estrogen receptors (ERs) that are expressed in various brain regions, including the cerebellum. However, the effects of S-equol on cerebellar development and function have not y...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205178
更新日期：2019-10-18 00:00:00
abstract：:A field experiment was conducted using a 3 × 3 orthogonal regression design to explore the growth promotion of one-year-old Yunnan pine seedlings (Pinus yunnanensis Franch.) in response to foliar application of IAA (indole-3-acetic acid) at rates of 0, 200 and 400 mg·L(-1) and IBA (indole-3-butyric acid) at rates of 0...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13056507
更新日期：2012-01-01 00:00:00
abstract：:Peritoneal dialysis effluent (PDE) potentially carries an archive of peptides relevant to pathological processes in abdominal and surrounding tissues. Magnetic beads and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is one such approach that offers a unique tool for profiling of peptides...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15011162
更新日期：2014-01-16 00:00:00
abstract：:Alterations to the programmed cell death protein-1 (PD-1) pathway were previously shown to be involved in a poorer prognosis for patients with proliferative glomerulonephritis (PGN). Here, we investigated the association between several infectious agents and the expression of PD-1 and its ligand (PD-L1) on T and B lym...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218001
更新日期：2020-10-27 00:00:00
abstract：:The exposure of living organisms to environmental stress triggers defensive responses resulting in the activation of protective processes. Whenever the exposure occurs at low doses, defensive effects overwhelm the adverse effects of the exposure; this adaptive situation is referred to as "hormesis". Environmental, phy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197053
更新日期：2020-09-25 00:00:00
abstract：:To develop a biodegradable polymer possessing elasticity and flexibility, we synthesized MPEG-b-(PCL-co-PLA) copolymers (PC x L y A), which display specific rates of flexibility and elasticity. We synthesize the PC ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18030671
更新日期：2017-03-21 00:00:00
abstract：:Polyphenolic compounds contained in cherry extract (CE) are well known for their antioxidant and anti-inflammatory properties. Unfortunately, most of these natural compounds have low oral bioavailability, reducing their widespread use. Here, different concentrations of polyphenol-rich CE from Tuscany (Italy), encapsul...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071759
更新日期：2019-04-10 00:00:00
abstract：:The cause of inflammatory bowel disease (IBD) is still unknown, but there is growing evidence that environmental factors such as epigenetic changes can contribute to the disease etiology. The aim of this study was to identify newly hypermethylated genes in ulcerative colitis (UC) using a genome-wide DNA methylation ap...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17081291
更新日期：2016-08-09 00:00:00
abstract：:Due to a typesetting error during layout, several references were incorrectly listed in [...]. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,已发布勘误
doi：10.3390/ijms20112651
更新日期：2019-05-29 00:00:00
abstract：:Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071404
更新日期：2017-06-30 00:00:00
abstract：:TSPO is a receptor involved in the regulation of cellular proliferation, apoptosis and mitochondrial functions. Previous studies showed that the expression of TSPO protein correlated positively with tumour malignancy and negatively with patient survival. The aim of this study was to determine the transcription of Tspo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082176
更新日期：2018-07-25 00:00:00
abstract：:Aegista chejuensis and Aegista quelpartensis (Family-Bradybaenidae) are endemic to Korea, and are considered vulnerable due to declines in their population. The limited genetic resources for these species restricts the ability to prioritize conservation efforts. We sequenced the transcriptomes of these species using I...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030379
更新日期：2016-03-15 00:00:00
abstract：:Mass spectrometry-based metabolome profiling became the method of choice in systems biology approaches and aims to enhance biological understanding of complex biological systems. Genomics, transcriptomics, and proteomics are well established technologies and are commonly used by many scientists. In comparison, metabol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17050632
更新日期：2016-04-27 00:00:00
abstract：:Working memory deficit is the core neurocognitive disorder in schizophrenia patients. To identify the factors underlying working memory deficit in schizophrenia patients and to explore the implication of possible genes in the working memory using genome-wide association study (GWAS) of schizophrenia, computerized dela...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16012145
更新日期：2015-01-20 00:00:00
abstract：:Metastasis to the central nervous system remains difficult to treat, and such patients are faced with a dismal prognosis. The blood-brain barrier (BBB), despite being partially compromised within malignant lesions in the brain, still retains much of its barrier function and prevents most chemotherapeutic agents from e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17091463
更新日期：2016-09-02 00:00:00
abstract：:During plant-pathogen interactions, plants have to relocate their resources including energy to defend invading organisms; as a result, plant growth and development are usually reduced. Arabidopsis signal responsive1 (AtSR1) has been documented as a negative regulator of plant immune responses and could serve as a pos...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061764
更新日期：2018-06-14 00:00:00
abstract：:Spinal cord injury is a chronic and debilitating neurological condition that is currently being managed symptomatically with no real therapeutic strategies available. Even though there is no consensus on the best time to start interventions, the chronic phase is definitely the most stable target in order to determine ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19061776
更新日期：2018-06-15 00:00:00
abstract：:Under acidic conditions and at high ionic strength, the zinc cation is removed from its metal complex with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (TPPS4) thus leading to the diacid free porphyrin, that subsequently self-organize into J-aggregates. The kinetics of the demetallation step and the successive supr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21114001
更新日期：2020-06-03 00:00:00
abstract：:The emergence of antibiotic-resistant strains in facultative anaerobic Gram-positive coccal bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), is a global health issue. Typically, MRSA strains are found associated with institutions like hospitals but recent data suggest that they are becoming more p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047851
更新日期：2015-04-08 00:00:00
abstract：:Bacterial pathogens expose on the cell surface a variety of complex carbohydrate molecules. Gram-negative bacteria produce lipopolysaccharides, which are the main components of the outer membrane of bacterial envelopes and play a major role in host-pathogen interactions. B. pertussis, B. parapertussis, B. bronchisepti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031029
更新日期：2021-01-21 00:00:00
abstract：:Lymphoma, a group of widely prevalent hematological malignancies of lymphocyte origin, has become the focus of significant clinical research due to their high propensity for refractory/relapsed (R/R) disease, leading to poor prognostic outcomes. The complex molecular circuitry in lymphomas, especially in the aggressiv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030904
更新日期：2020-01-30 00:00:00
abstract：BACKGROUND:Growth failure and delayed puberty are well known features of children and adolescents with inflammatory bowel disease (IBD), in addition to the chronic course of the disease. Urinary metabonomics was applied in order to better understand metabolic changes between healthy and IBD children. METHODS:21 Pediat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17081310
更新日期：2016-08-11 00:00:00
