Abstract:
:Studies have shown that the type II pyridoxal phosphate-dependent decarboxylase (PLP_deC) genes produce secondary metabolites and flavor volatiles in plants, and TDC (tryptophan decarboxylase), a member of the PLP_deC family, plays an important role in the biosynthesis of terpenoid indole alkaloids (TIAs). In this study, we identified eight PLP_deC genes in Dendrobium officinale (D. officinale) and six in Phalaenopsis equestris (P. equestris), and their structures, physicochemical properties, response elements, evolutionary relationships, and expression patterns were preliminarily predicted and analyzed. The results showed that PLP_deC genes play important roles in D. officinale and respond to different exogenous hormone treatments; additionally, the results support the selection of appropriate candidates for further functional characterization of PLP_deC genes in D. officinale.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zhang L,Jiao C,Cao Y,Cheng X,Wang J,Jin Q,Cai Ydoi
10.3390/ijms21010054subject
Has Abstractpub_date
2019-12-20 00:00:00issue
1issn
1422-0067pii
ijms21010054journal_volume
21pub_type
杂志文章abstract::Treatment with 1-methylcyclopropylene (1-MCP) is an effective technique to preserve fruits, but inappropriate treatment with 1-MCP causes a ripening disorder (rubbery texture) in papaya fruit. In this study, a combined metabolomic and transcriptomic analysis was conducted to reveal the possible mechanism of the ripeni...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020916
更新日期:2021-01-18 00:00:00
abstract::Autism spectrum disorder (ASD) defines a group of neurodevelopmental disorders whose symptoms include impaired communication and social interaction with restricted or repetitive motor movements, frequently associated with general cognitive deficits. Although it is among the most severe chronic childhood disorders in t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18091916
更新日期:2017-09-07 00:00:00
abstract::The aim of this article is to review current knowledge related to the synthesis and characterization of sol gel-derived SBA-16 mesoporous silicas, as well as a review of the state of the art in this issue, to take stock of knowledge about current and future applications. The ease of the method of preparation, the orde...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms11093069
更新日期:2010-08-31 00:00:00
abstract::Wounds are a largely unrecognized, spiraling epidemic that affect millions of people world-wide [...]. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms20071724
更新日期:2019-04-08 00:00:00
abstract::The human gastrointestinal tract is inhabited by many types of microbiota, including bacteria, viruses, and fungi. Dysregulations of their microenvironment are associated with various health problems, not only limited to gastrointestinal disorders, such as inflammatory bowel disease, but to impacts beyond the intestin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20020387
更新日期:2019-01-17 00:00:00
abstract::Regulation of melanogenesis has been the focus of treatment for hyperpigmentary skin disorders. Although hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, its anti-melanogenic effect is not known. The present study aims to determine the anti-melanog...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160818384
更新日期:2015-08-07 00:00:00
abstract::Understanding disease pathology often does not require an overall proteomic analysis of clinical samples but rather the analysis of different, often rare, subpopulations of cells in a heterogeneous mixture of cell types. For the isolation of pre-specified cellular subtypes, fluorescence activated cell sorting (FACS) i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186557
更新日期:2020-09-08 00:00:00
abstract::Neonatal hypoxia-ischemia (HI) is a major cause of death and disability in neonates. HI leads to a dramatic rise in intracellular calcium levels, which was originally thought to be detrimental to the brain. However, it has been increasingly recognized that this calcium signaling may also play an important protective r...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092063
更新日期:2019-04-26 00:00:00
abstract::In the development of drugs, we sometimes encounter fatty change of the hepatocytes (steatosis) which is not accompanied by degenerative change in the liver in non-clinical toxicity studies. In this study, we investigated the relationships between fatty change of the hepatocytes noted in non-clinical toxicity studies ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18040810
更新日期:2017-04-12 00:00:00
abstract::The largest group of deubiquitinases-ubiquitin-specific proteases (UBPs)-perform extensive and significant roles in plants, including the regulation of development and stress responses. A comprehensive analysis of UBP genes has been performed in Arabidopsis thaliana, but no systematic study has been conducted in moso ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20174309
更新日期:2019-09-03 00:00:00
abstract::Zinc (Zn) and iron (Fe) are essential but are sometimes deficient in humans, while cadmium (Cd) is toxic if it accumulates in the liver and kidneys at high levels. All three are contained in the grains of rice, a staple cereal. Zn and Fe concentrations in rice grains harvested under different levels of soil/hydroponic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms160819111
更新日期:2015-08-13 00:00:00
abstract::Low temperature stress has a severe impact on the distribution, physiology, and survival of plants in their natural habitats. While numerous studies have focused on the physiological and molecular adjustments to low temperatures, this study provides evidence that cold induced physiological responses coincide with dist...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228753
更新日期:2020-11-19 00:00:00
abstract::Carvacrol is a natural compound known to be a highly effective antibacterial; however, it is a hydrophobic molecule, which is a limitation to its use within food packaging. Flaxseed gum (FG) films containing different contents of carvacrol (C) were produced by a film-casting method with sonication. The effects of sonic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051637
更新日期:2020-02-28 00:00:00
abstract::Scorpions of the genus Tityus are responsible for the majority of envenomation in Brazil, the Tityus serrulatus species being the most common and dangerous in South America. In this approach, we have investigated the ability of the aqueous extract from the leaves of Aspidosperma pyrifolium in reducing carrageenan-indu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18112248
更新日期:2017-11-11 00:00:00
abstract::With the development of new sensitive molecular techniques, circulating cell-free tumour DNA containing mutations can be identified in the plasma of cancer patients. The applications of this technology may result in significant changes to the care and management of cancer patients. Whilst, currently, these "liquid bio...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms160614122
更新日期:2015-06-19 00:00:00
abstract::Monocyte chemoattractant protein-1 (MCP-1) is a well-known chemokine critically involved in the pathophysiological progression of several inflammatory diseases including arthrosclerosis. N-caffeoyltryptamine is a phenolic amide with strong anti-inflammatory effects. Therefore, in this paper, the potential effect of N-...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18061148
更新日期:2017-05-27 00:00:00
abstract::Unfolded protein response (UPR) is a cytoprotective mechanism that alleviates the protein-folding burden in eukaryotic organisms. Moderate activation of UPR is required for maintaining endoplasmic reticulum (ER) homeostasis and profoundly contributes to tumorigenesis. Defects in UPR signaling are implicated in the att...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19071832
更新日期:2018-06-21 00:00:00
abstract::At present, studies on macrophage proteins mainly focus on biological stimuli, with less attention paid to the responses of macrophage proteins to physical stimuli, such as electric fields. Here, we exploited the electric field-sensitive hub proteins of macrophages. RAW 264.7 macrophages were treated with a direct cur...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124505
更新日期:2020-06-24 00:00:00
abstract::Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses-the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and dis...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21228565
更新日期:2020-11-13 00:00:00
abstract::Extracellular-signal regulated kinase (ERK) signaling is required for a multitude of physiological and patho-physiological processes. However, the identities of the proteins that ERK phosphorylates to elicit these responses are incompletely known. Using an affinity purification methodology of general utility, here we ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14023595
更新日期:2013-02-07 00:00:00
abstract::Hypertension is asymptomatic and a well-known "silent killer", which can cause various concomitant diseases in human population after years of adherence. Although there are varieties of synthetic antihypertensive drugs available in current market, their relatively low efficacies and major application in only single dr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19010120
更新日期:2018-01-02 00:00:00
abstract::One of the most common causes of mortality and morbidity in children is perinatal hypoxia-ischemia (HI). In spite of the advances in neonatology, its incidence is not diminishing, generating a pediatric population that will require an extended amount of chronic care throughout their lifetime. For this reason, new and ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms14059379
更新日期:2013-04-29 00:00:00
abstract::Osteoporosis is characterized by a reduction of the bone mineral density (BMD) and microarchitectural deterioration of the bone, which lead to bone fragility and susceptibility to fracture. Astaxanthin (AST) has a variety of biological activities, such as a protective effect against asthma or neuroinflammation, antiox...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19030912
更新日期:2018-03-19 00:00:00
abstract::A series of new 2-aminobenzamide derivatives (1-10) has been synthesized in good to excellent yields by adopting both conventional and/or a time-efficient microwave assisted methodologies starting from isatoic anhydride (ISA) and characterized on the basis of their physical, spectral and microanalytical data. Selected...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15035115
更新日期:2014-03-21 00:00:00
abstract::Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for example, the disruption of the plaque exposes endogenous agonists such as collagen, which activates platelets. Platelet hyper-activation and the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21010146
更新日期:2019-12-24 00:00:00
abstract::To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19041217
更新日期:2018-04-17 00:00:00
abstract::PCSK9 (Proprotein convertase subtilisin/kexin type 9) increases plasma cholesterol levels by promoting LDL receptor degradation. Current antibody inhibitors block the interaction between PCSK9 and LDL receptors, significantly decrease plasma cholesterol levels, and provide beneficial clinical outcomes. To reduce the a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19020640
更新日期:2018-02-24 00:00:00
abstract::Many studies have provided evidence suggesting that caspases not only contribute to the neurodegeneration associated with Alzheimer's disease (AD) but also play essential roles in promoting the underlying pathology of this disease. Studies regarding the caspase inhibition draw researchers' attention through time due t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20194850
更新日期:2019-09-29 00:00:00
abstract::Cardamom is a popular spice that has been commonly used in cuisines for flavor since ancient times. It has copious health benefits such as improving digestion, stimulating metabolism, and exhibits antioxidant and anti-inflammatory effects. The current study investigated the effect of cardamom on hemodynamic, biochemic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161126040
更新日期:2015-11-17 00:00:00
abstract::Advances in stem cell research have provided important understanding of the cell biology and offered great promise for developing new strategies for tissue regeneration. The beneficial effects of stem cell therapy depend also by the development of new approachs for the track of stem cells in living subjects over time ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms11031070
更新日期:2010-03-12 00:00:00