Abstract:
:Autism spectrum disorder (ASD) defines a group of neurodevelopmental disorders whose symptoms include impaired communication and social interaction with restricted or repetitive motor movements, frequently associated with general cognitive deficits. Although it is among the most severe chronic childhood disorders in terms of prevalence, morbidity, and impact to the society, no effective treatment for ASD is yet available, possibly because its neurobiological basis is not clearly understood hence specific drugs have not yet been developed. The endocannabinoid (EC) system represents a major neuromodulatory system involved in the regulation of emotional responses, behavioral reactivity to context, and social interaction. Furthermore, the EC system is also affected in conditions often present in subsets of patients diagnosed with ASD, such as seizures, anxiety, intellectual disabilities, and sleep pattern disturbances. Despite the indirect evidence suggestive of an involvement of the EC system in ASD, only a few studies have specifically addressed the role of the EC system in the context of ASD. This review describes the available data on the investigation of the presence of alterations of the EC system as well as the effects of its pharmacological manipulations in animal models of ASD-like behaviors.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zamberletti E,Gabaglio M,Parolaro Ddoi
10.3390/ijms18091916subject
Has Abstractpub_date
2017-09-07 00:00:00issue
9issn
1422-0067pii
ijms18091916journal_volume
18pub_type
杂志文章,评审abstract::Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms161025536
更新日期:2015-10-23 00:00:00
abstract::Buckwheat sprouts contain various bioactive compounds including rutin which have a number of biological activities. We have previously shown that buckwheat sprouts (TBWE) treated with methyl jasmonate (MeJA) significantly increased the amount of phenolics and the antioxidant activity. The aim of this study was to demo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14011428
更新日期:2013-01-11 00:00:00
abstract::Dietary supplementation with polyunsaturated fatty acids (PUFA) n-3 can affect cutaneous wound healing; however, recent findings demonstrate the variable extent of their influence on the quality of healing. Here, we compare the effect of several dietary oils, containing different levels of PUFA n-3 and PUFA n-6, on wo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21217911
更新日期:2020-10-24 00:00:00
abstract::Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays ha...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms11125165
更新日期:2010-01-01 00:00:00
abstract::The fish Vitellogenin (Vg) gene has been applied as a biomarker for exposure to estrogenic compounds in the aquatic environment. In this study, we cloned and characterized Vg cDNA from the Korean rose bitterling Rhodeus uyekii (Ru-Vg). The Ru-Vg cDNA encodes a 1424-amino-acid polypeptide that belongs to the VgAo1 fami...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151018804
更新日期:2014-10-17 00:00:00
abstract::The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141223654
更新日期:2013-12-04 00:00:00
abstract::The human gastrointestinal tract is inhabited by many types of microbiota, including bacteria, viruses, and fungi. Dysregulations of their microenvironment are associated with various health problems, not only limited to gastrointestinal disorders, such as inflammatory bowel disease, but to impacts beyond the intestin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20020387
更新日期:2019-01-17 00:00:00
abstract::Current outcome prediction markers for localized prostate cancer (PCa) are insufficient. The impact of the lipid-modifying Sphingomyelin Phosphodiesterase Acid Like 3B (SMPDL3B) in PCa is unknown. Two cohorts of patients with PCa who underwent radical prostatectomy (n = 40, n = 56) and benign prostate hyperplasia (BPH...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124373
更新日期:2020-06-19 00:00:00
abstract::Chenopodium quinoa Wild is a "pseudocereal" grain which attracts a lot of attention in the scientific community as it has a positive effect on health. Here, we investigate the presence of biologically active O-prenylated phenylpropanoids in the ethanol extract of commercially available quinoa seeds. We claim that 4'-G...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20133262
更新日期:2019-07-02 00:00:00
abstract::Inflammation is the body's response to injury or infection. As early as 2000 years ago, the Roman encyclopaedist Aulus Cornelius Celsus recognised four cardinal signs of this response-redness, heat, swelling and pain; a fifth sign is loss of function.[...]. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms18112415
更新日期:2017-11-14 00:00:00
abstract::Dysregulation of blood sphingolipids is an emerging topic in clinical science. The objective of this study was to determine preanalytical biases that typically occur in clinical and translational studies and that influence measured blood sphingolipid levels. Therefore, we collected blood samples from four healthy male...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051390
更新日期:2018-05-07 00:00:00
abstract::The consumption of polyphenols has frequently been associated with low incidence of degenerative diseases. Most of these natural antioxidants come from fruits, vegetables, spices, grains and herbs. For this reason, there has been increasing interest in identifying plant extract compounds. Polymeric tannins and monomer...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151120382
更新日期:2014-11-06 00:00:00
abstract::With the exception of a few Mendelian traits, almost all phenotypes (traits) in livestock science are quantitative or complex traits regulated by the expression of many genes. For most of the complex traits, differential expression of genes, rather than genomic variation in the gene coding sequences, is associated wit...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18020472
更新日期:2017-02-22 00:00:00
abstract::The p38α mitogen-activated protein kinase (MAPK) has become an attractive target for the treatment of many diseases such as rheumatoid arthritis, inflammatory bowel disease and Crohn's disease. In this paper, 3D-QSAR and molecular docking studies were performed on 59 p38α MAPK inhibitors. Comparative molecular field a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms11093357
更新日期:2010-09-17 00:00:00
abstract::Mitochondria-associated membranes (MAM) are a well-recognized contact link between the mitochondria and endoplasmic reticulum that affects mitochondrial biology and vascular smooth muscle cells (VSMCs) proliferation via the regulation of mitochondrial Ca2+(Ca2+m) influx. Nogo-B receptor (NgBR) plays a vital role in pr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092319
更新日期:2019-05-10 00:00:00
abstract::The retinoid X receptor (RXR) is a ligand-sensing transcription factor acting mainly as a universal heterodimer partner for other nuclear receptors. Despite presenting as a potential therapeutic target for cancer and neurodegeneration, adverse effects typically observed for RXR agonists, likely due to the lack of isof...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228457
更新日期:2020-11-11 00:00:00
abstract::In our study, poly(dl-lactide-co-glycolide) (PLGA) nanoparticles loaded with perphenazine (PPH) and chlorpromazine hydrochloride (CPZ-HCl) were formulated by emulsion solvent evaporation technique. The effect of various processing variables, including PLGA concentration, theoretical drug loading, poly(vinyl alcohol) (...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151223909
更新日期:2014-12-22 00:00:00
abstract::Nanotechnology has rapidly promoted the development of a new generation of industrial and commercial products; however, it has also raised some concerns about human health and safety. To evaluate the toxicity of the great diversity of nanomaterials (NMs) in the traditional manner, a tremendous number of safety assessm...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21072387
更新日期:2020-03-30 00:00:00
abstract::In advanced cirrhosis, the TNFα-mediated intestinal inflammation and bacteria dysbiosis are involved in the development of inflammation and vasoconstriction-related renal dysfunction. In colitis and acute kidney injury models, activation of SIRT1 attenuates the TNFα-mediated intestinal and renal abnormalities. This st...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031233
更新日期:2021-01-27 00:00:00
abstract::The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses the need to develop new therapeutic strategies. The notion of phage therapy against bacteria has been around for more than a century ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22020735
更新日期:2021-01-13 00:00:00
abstract::Oxidative stress and the resulting damage to DNA are inevitable consequence of endogenous physiological processes further amplified by cellular responses to environmental exposures. If left unrepaired, oxidative DNA lesions can block essential processes such as transcription and replication or can induce mutations. Em...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20020364
更新日期:2019-01-16 00:00:00
abstract::Winter turnip rape (Brassica rapa L.) is a large-scale winter-only oil crop cultivated in Northwest China. However, its cold-resistant molecular mechanism remains inadequate. Studying the cold adaptation mechanisms of winter turnip rape based on the proteomic technique of isobaric tags for relative and absolute quanti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113346
更新日期:2018-10-26 00:00:00
abstract::The Brassica genus contains abundant economically important vegetable and oilseed crops, which are under threat of diseases caused by fungal, bacterial and viral pathogens. Resistance gene analogues (RGAs) are associated with quantitative and qualitative disease resistance and the identification of candidate RGAs asso...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21238964
更新日期:2020-11-25 00:00:00
abstract::Traumatic brain injury (TBI) can cause biochemical and metabolomic alterations in the brain tissue and serum. These alterations can be used for diagnosis and prognosis of TBI. Here, the serum concentrations of seventeen amino acids (AA) were studied for their potential utility as biomarkers of TBI. Twenty-five female,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051786
更新日期:2020-03-05 00:00:00
abstract::Genomic actions of estrogens in vertebrates are exerted via two intracellular estrogen receptor (ER) subtypes, ERα and ERβ, which show cell- and tissue-specific expression profiles. Mammalian immune cells express ERs and are responsive to estrogens. More recently, evidence became available that ERs are also present in...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19040932
更新日期:2018-03-21 00:00:00
abstract::The Gram-negative Campylobacter jejuni is a major cause of foodborne gastroenteritis in humans worldwide. The cytotoxic effects of Campylobacter have been mainly ascribed to the actions of the cytolethal distending toxin (CDT): it is mandatory to put in evidence risk factors for sequela development, such as reactive a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21062207
更新日期:2020-03-23 00:00:00
abstract::As the worldwide application of nanomaterials in commercial products increases every year, various nanoparticles from industry might present possible risks to aquatic systems and human health. Presently, there are many unknowns about the toxic effects of nanomaterials, especially because the unique physicochemical pro...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082864
更新日期:2020-04-20 00:00:00
abstract::Endothelin-1 (ET-1) autocrine and paracrine signaling modulate cell proliferation of tumor cells by activating its receptors, endothelin A receptor (ETAR) and endothelin B receptor (ETBR). Dysregulation of ETAR activation promotes tumor development and progression. The potential of ETAR antagonists and the dual-ETAR a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17081244
更新日期:2016-08-02 00:00:00
abstract::A new anticancer ligustrazine derivative, 3β-hydroxyolea-12-en-28-oic acid- 3,5,6-trimethylpyrazin-2-methylester (T-OA, C38H58O3N2), was previously reported. It was synthesized via conjugating hepatoprotective and anticancer ingredients of traditional Chinese medicine. We found that T-OA exerted its anticancer activit...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160716401
更新日期:2015-07-17 00:00:00
abstract::Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,随机对照试验
doi:10.3390/ijms130912062
更新日期:2012-01-01 00:00:00