Overview of the Microenvironment of Vasculature in Vascular Tone Regulation.

Abstract:

:Hypertension is asymptomatic and a well-known "silent killer", which can cause various concomitant diseases in human population after years of adherence. Although there are varieties of synthetic antihypertensive drugs available in current market, their relatively low efficacies and major application in only single drug therapy, as well as the undesired chronic adverse effects associated, has drawn the attention of worldwide scientists. According to the trend of antihypertensive drug evolution, the antihypertensive drugs used as primary treatment often change from time-to-time with the purpose of achieving the targeted blood pressure range. One of the major concerns that need to be accounted for here is that the signaling mechanism pathways involved in the vasculature during the vascular tone regulation should be clearly understood during the pharmacological research of antihypertensive drugs, either in vitro or in vivo. There are plenty of articles that discussed the signaling mechanism pathways mediated in vascular tone in isolated fragments instead of a whole comprehensive image. Therefore, the present review aims to summarize previous published vasculature-related studies and provide an overall depiction of each pathway including endothelium-derived relaxing factors, G-protein-coupled, enzyme-linked, and channel-linked receptors that occurred in the microenvironment of vasculature with a full schematic diagram on the ways their signals interact. Furthermore, the crucial vasodilative receptors that should be included in the mechanisms of actions study on vasodilatory effects of test compounds were suggested in the present review as well.

journal_name

Int J Mol Sci

authors

Loh YC,Tan CS,Ch'ng YS,Yeap ZQ,Ng CH,Yam MF

doi

10.3390/ijms19010120

subject

Has Abstract

pub_date

2018-01-02 00:00:00

issue

1

issn

1422-0067

pii

ijms19010120

journal_volume

19

pub_type

杂志文章,评审
  • Hyaluronan synthase and hyaluronidase expression in serous ovarian carcinoma is related to anatomic site and chemotherapy exposure.

    abstract::The present study investigated the expression and clinical role of hyaluronan synthases (HAS1-3) and hyaluronidases (Hyal1-3) in serous ovarian carcinoma. HAS and HYAL mRNA expression was analyzed in 97 tumors (61 effusions, 27 primary carcinomas, 9 solid metastases) using PCR and further studied for association with ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms131012925

    authors: Weiss I,Trope CG,Reich R,Davidson B

    更新日期:2012-10-10 00:00:00

  • Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System.

    abstract::Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3390/ijms17071064

    authors: Montañez-Heredia E,Irízar S,Huertas PJ,Otero E,Del Valle M,Prat I,Díaz-Gallardo MS,Perán M,Marchal JA,Hernandez-Lamas Mdel C

    更新日期:2016-07-02 00:00:00

  • Decitabine and Melphalan Fail to Reactivate p73 in p53 Deficient Myeloma Cells.

    abstract::(1) Background: TP53 deficiency remains a major adverse event in Multiple Myeloma (MM) despite therapeutic progresses. As it is not possible to target TP53 deficiency with pharmacological agents, we explored the possibility of activating another p53 family member, p73, which has not been well studied in myeloma. (2) M...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19010040

    authors: Gillardin PS,Descamps G,Maiga S,Tessoulin B,Djamai H,Lucani B,Chiron D,Moreau P,Le Gouill S,Amiot M,Pellat-Deceunynck C,Moreau-Aubry A

    更新日期:2017-12-23 00:00:00

  • Isolation and characterization of microsatellite loci for Hibiscus aridicola (Malvaceae), an endangered plant endemic to the dry-hot valleys of Jinsha River in Southwest China.

    abstract::Hibiscus aridicola (Malvaceae) is an endangered ornamental shrub endemic to the dry-hot valleys of Jinsha River in southwest China. Only four natural populations of H. aridicola exist in the wild according to our field investigation. It can be inferred that H. aridicola is facing a very high risk of extinction in the ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms12095698

    authors: Zhang L,Sun W,Wang Z,Guan K,Yang J

    更新日期:2011-01-01 00:00:00

  • A Mechanism-Based Model for the Prediction of the Metabolic Sites of Steroids Mediated by Cytochrome P450 3A4.

    abstract::Early prediction of xenobiotic metabolism is essential for drug discovery and development. As the most important human drug-metabolizing enzyme, cytochrome P450 3A4 has a large active cavity and metabolizes a broad spectrum of substrates. The poor substrate specificity of CYP3A4 makes it a huge challenge to predict th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms160714677

    authors: Dai ZR,Ai CZ,Ge GB,He YQ,Wu JJ,Wang JY,Man HZ,Jia Y,Yang L

    更新日期:2015-06-30 00:00:00

  • Ultrasound tissue characterization of vulnerable atherosclerotic plaque.

    abstract::A thrombotic occlusion of the vessel fed by ruptured coronary atherosclerotic plaque may result in unstable angina, myocardial infarction or death, whereas embolization from a plaque in carotid arteries may result in transient ischemic attack or stroke. The atherosclerotic plaque prone to such clinical events is terme...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms160510121

    authors: Picano E,Paterni M

    更新日期:2015-05-05 00:00:00

  • Common Transcriptional Program of Liver Fibrosis in Mouse Genetic Models and Humans.

    abstract::Multifactorial metabolic diseases, such as non-alcoholic fatty liver disease, are a major burden to modern societies, and frequently present with no clearly defined molecular biomarkers. Herein we used system medicine approaches to decipher signatures of liver fibrosis in mouse models with malfunction in genes from un...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22020832

    authors: Blagotinšek Cokan K,Urlep Ž,Moškon M,Mraz M,Kong XY,Eskild W,Rozman D,Juvan P,Režen T

    更新日期:2021-01-15 00:00:00

  • PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates.

    abstract::Clinical applications of camptothecin (CPT) have been heavily hindered due to its non-targeted toxicity, active lactone ring instability, and poor water solubility. Targeted drug delivery systems may offer the possibility to overcome the above issues as reported. In this research, a series of prostate-specific membran...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19103251

    authors: Xu B,Zhou F,Yan MM,Cai DS,Guo WB,Yang YQ,Jia XH,Zhang WX,Li T,Ma T,Wang PL,Lei HM

    更新日期:2018-10-19 00:00:00

  • Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis.

    abstract::: The homing of Endothelial Progenitor Cells (EPCs) to tumor angiogenic sites has been described as a multistep process, involving adhesion, migration, incorporation and sprouting, for which the underlying molecular and cellular mechanisms are yet to be fully defined. Here, we studied the expression of Junctional Adhe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21041209

    authors: Czabanka M,Petrilli LL,Elvers-Hornung S,Bieback K,Albert Imhof B,Vajkoczy P,Vinci M

    更新日期:2020-02-11 00:00:00

  • miR-206-3p Inhibits 3T3-L1 Cell Adipogenesis via the c-Met/PI3K/Akt Pathway.

    abstract::MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an ap...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18071510

    authors: Tang R,Ma F,Li W,Ouyang S,Liu Z,Wu J

    更新日期:2017-07-14 00:00:00

  • Natural Bioactive Compounds: The Way Shown by Professor Maurizio Battino and His Group in an Italian Cutting-Edge Laboratory.

    abstract::Maurizio Battino, Ph.D., Associate Professor of Biochemistry in the Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche (Italy), is the Director of the Centre for Health and Nutrition, Universidad Europea del Atlantico (Santander, Spain) and Director of Nutrition and Health projec...

    journal_title:International journal of molecular sciences

    pub_type: 面试

    doi:10.3390/ijms17071038

    authors: Editorial Office International Journal Of Molecular Sciences.

    更新日期:2016-07-05 00:00:00

  • Synergistic Effect of Beauveria bassiana and Trichoderma asperellum to Induce Maize (Zea mays L.) Defense against the Asian Corn Borer, Ostrinia furnacalis (Lepidoptera, Crambidae) and Larval Immune Response.

    abstract::Ostrinia furnacalis, is the major pest of maize causing significant yield losses. So far, many approaches have been used to increase the virulence of entomopathogenic fungal isolates. The current study is an attempt to estimate synergistic effect of Beauveria bassiana and Trichoderma asperellum in order to explore lar...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21218215

    authors: Batool R,Umer MJ,Wang Y,He K,Zhang T,Bai S,Zhi Y,Chen J,Wang Z

    更新日期:2020-11-03 00:00:00

  • Design, synthesis and antiviral activity studies of schizonepetin derivatives.

    abstract::A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4,...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms140817193

    authors: Bao B,Meng Z,Li N,Meng Z,Zhang L,Cao Y,Yao W,Shan M,Ding A

    更新日期:2013-08-20 00:00:00

  • Plant regeneration and somatic embryogenesis from immature embryos derived through interspecific hybridization among different Carica species.

    abstract::Plant regeneration and somatic embryogenesis through interspecific hybridization among different Carica species were studied for the development of a papaya ringspot virus-resistant variety. The maximum fruit sets were recorded from the cross of the native variety C. papaya cv. Shahi with the wild species C. cauliflor...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms131217065

    authors: Azad MA,Rabbani MG,Amin L

    更新日期:2012-12-12 00:00:00

  • Reply to the Letter to the Editor by Li et al.: Bioinformatics Analysis in Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.

    abstract::n/a. ...

    journal_title:International journal of molecular sciences

    pub_type: 评论,杂志文章

    doi:10.3390/ijms18050994

    authors: Kobori M,Takahashi Y,Sakurai M,Ni Y,Chen G,Nagashimada M,Kaneko S,Ota T

    更新日期:2017-05-05 00:00:00

  • Kisspeptin and Testicular Function-Is it Necessary?

    abstract::The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigatin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21082958

    authors: Sharma A,Thaventhiran T,Minhas S,Dhillo WS,Jayasena CN

    更新日期:2020-04-22 00:00:00

  • Maize-Pathogen Interactions: An Ongoing Combat from a Proteomics Perspective.

    abstract::Maize (Zea mays L.) is a host to numerous pathogenic species that impose serious diseases to its ear and foliage, negatively affecting the yield and the quality of the maize crop. A considerable amount of research has been carried out to elucidate mechanisms of maize-pathogen interactions with a major goal to identify...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms161226106

    authors: Pechanova O,Pechan T

    更新日期:2015-11-30 00:00:00

  • mTOR and Aging: An Old Fashioned Dress.

    abstract::Aging is a physiologic/pathologic process characterized by a progressive impairment of cellular functions, supported by the alterations of several molecular pathways, leading to an increased cell susceptibility to injury. This deterioration is the primary risk factor for several major human pathologies. Numerous cellu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20112774

    authors: Stallone G,Infante B,Prisciandaro C,Grandaliano G

    更新日期:2019-06-06 00:00:00

  • Role of Autophagy in Zinc Oxide Nanoparticles-Induced Apoptosis of Mouse LEYDIG Cells.

    abstract::Zinc oxide nanoparticles (ZnO NPs) have shown adverse health impact on the human male reproductive system, with evidence of inducing apoptosis. However, whether or not ZnO NPs could promote autophagy, and the possible role of autophagy in the progress of apoptosis, remain unclear. In the current study, in vitro and in...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20164042

    authors: Shen J,Yang D,Zhou X,Wang Y,Tang S,Yin H,Wang J,Chen R,Chen J

    更新日期:2019-08-19 00:00:00

  • Tailored Biodegradable and Electroactive Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Based Morphologies for Tissue Engineering Applications.

    abstract::Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19082149

    authors: Amaro L,Correia DM,Marques-Almeida T,Martins PM,Pérez L,Vilas JL,Botelho G,Lanceros-Mendez S,Ribeiro C

    更新日期:2018-07-24 00:00:00

  • Establishing a Split Luciferase Assay for Proteinkinase G (PKG) Interaction Studies.

    abstract::Nitric oxide (NO/cyclic guanosine monophosphate (cGMP)-regulated cellular mechanisms are involved in a variety of (patho-) physiological processes. One of the main effector molecules in this system, proteinkinase G (PKG), serves as a molecular switch by phosphorylating different target proteins and thereby turning the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19041180

    authors: Schramm A,Mueller-Thuemen P,Littmann T,Harloff M,Ozawa T,Schlossmann J

    更新日期:2018-04-12 00:00:00

  • Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA Damage.

    abstract::NF-E2-related factor 2 (Nrf2) has been identified as a master regulatory factor in the protection of cells from oxidative and electrophilic stress. However, overexpression of Nrf2 in lung cancer may cause chemoresistance, as well as radioresistance. In this study, we examined the relationship between radioresistance a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17070997

    authors: Sun X,Wang Q,Wang Y,Du L,Xu C,Liu Q

    更新日期:2016-06-24 00:00:00

  • Methodologies and perspectives of proteomics applied to filamentous fungi: from sample preparation to secretome analysis.

    abstract::Filamentous fungi possess the extraordinary ability to digest complex biomasses and mineralize numerous xenobiotics, as consequence of their aptitude to sensing the environment and regulating their intra and extra cellular proteins, producing drastic changes in proteome and secretome composition. Recent advancement in...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms16035803

    authors: Bianco L,Perrotta G

    更新日期:2015-03-12 00:00:00

  • The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis.

    abstract::Spondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re-SpA), inflammatory bowel disease (IBD)-associated spondylitis, and unclassifiable spondylitis. These subsets share clinical phenot...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21176401

    authors: Tsukazaki H,Kaito T

    更新日期:2020-09-03 00:00:00

  • Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis.

    abstract::Kombucha tea (KT) has emerged as a substance that protects the liver from damage; however, its mechanisms of action on the fatty liver remain unclear. Therefore, we investigated the potential role of KT and its underlying mechanisms on nonalcoholic fatty liver disease (NAFLD). db/db mice that were fed methionine/choli...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20092369

    authors: Lee C,Kim J,Wang S,Sung S,Kim N,Lee HH,Seo YS,Jung Y

    更新日期:2019-05-13 00:00:00

  • Modeling the Effect of Hypoxia and DNA Repair Inhibition on Cell Survival After Photon Irradiation.

    abstract::Mechanistic approaches to modeling the effects of ionizing radiation on cells are on the rise, promising a better understanding of predictions and higher flexibility concerning conditions to be accounted for. In this work we modified and extended a previously published mechanistic model of cell survival after photon i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20236054

    authors: Liew H,Klein C,Zenke FT,Abdollahi A,Debus J,Dokic I,Mairani A

    更新日期:2019-11-30 00:00:00

  • Gadolinium Chloride Restores the Function of the Gap Junctional Intercellular Communication between Hepatocytes in a Liver Injury.

    abstract:BACKGROUND:Gadolinium chloride (GdCl3) has been reported to attenuate liver injury caused by a variety of toxicants. Gap junctional intercellular communication (GJIC) is thought to be essential in controlling liver homeostasis and pathology. Here we evaluate the effects of GdCl3 on functional GJIC and connexin expressi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20153748

    authors: Yang L,Dong C,Tian L,Ji X,Yang L,Li L

    更新日期:2019-07-31 00:00:00

  • Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice.

    abstract::Recombinant human fibroblast growth factor 10 (rhFGF-10) is frequently used to treat patients with skin injuries. It can also promote hair growth. However, the effective application of rhFGF-10 is limited because of its poor stability and transdermal absorption. In this study, polymerase chain reaction (PCR) and South...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18102177

    authors: Li W,Yang J,Cai J,Wang H,Tian H,Huang J,Qiang W,Zhang L,Li H,Li X,Jiang C

    更新日期:2017-10-18 00:00:00

  • EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma.

    abstract::For malignant pleural mesothelioma (MPM) novel therapeutic strategies are urgently needed. In a previous study, we identified 51 putative cancer genes over-expressed in MPM tissues and cell lines. Here, we deepened the study on nine of them (ASS1, EIF4G1, GALNT7, GLUT1, IGF2BP3 (IMP3), ITGA4, RAN, SOD1, and THBS2) to ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21144856

    authors: Dell'Anno I,Barbarino M,Barone E,Giordano A,Luzzi L,Bottaro M,Migliore L,Agostini S,Melani A,Melaiu O,Catalano C,Cipollini M,Silvestri R,Corrado A,Gemignani F,Landi S

    更新日期:2020-07-09 00:00:00

  • The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model.

    abstract::Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation, migration, invasion, and angiogenesis processes. Depending on the type and malignancy grade of the tumor, Sema3C function remains controversial. In this study, we constr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20225672

    authors: Valiulytė I,Curkūnavičiūtė R,Ribokaitė L,Kazlauskas A,Vaitkevičiūtė M,Skauminas K,Valančiūtė A

    更新日期:2019-11-12 00:00:00