Impact of Sarcopenia as a Prognostic Biomarker of Bladder Cancer.


:Sarcopenia, the degenerative and systemic loss of skeletal muscle mass, indicates patient frailty and impaired physical function. Sarcopenia can be caused by multiple factors, including advanced age, lack of exercise, poor nutritional status, inflammatory diseases, endocrine diseases, and malignancies. In patients with cancer cachexia, anorexia, poor nutrition and systemic inflammation make the metabolic state more catabolic, resulting in sarcopenia. Thus, sarcopenia is considered as one of manifestations of cancer cachexia. Recently, growing evidence has indicated the importance of sarcopenia in the management of patients with various cancers. Sarcopenia is associated with not only higher rates of treatment-related complications but also worse prognosis in cancer-bearing patients. In this article, we summarized metabolic backgrounds of cancer cachexia and sarcopenia and definitions of sarcopenia based on computed tomography (CT) images. We conducted a systematic literature review regarding the significance of sarcopenia as a prognostic biomarker of bladder cancer. We also reviewed recent studies focusing on the prognostic role of changes in skeletal muscle mass during the course of treatment in bladder cancer patients. Lastly, we discussed the impact of nutritional support, medication, and exercise on sarcopenia in cancer-bearing patients.


Int J Mol Sci


Fukushima H,Takemura K,Suzuki H,Koga F




Has Abstract


2018-10-01 00:00:00










  • Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse.

    abstract::To evaluate whether chronic cocaine abuse will increase cardiac Fas-dependent and mitochondria-dependent apoptotic pathways, thirty-two male Wistar rats at 3-4 months of age were randomly divided into a vehicle-treated group (phosphate-buffered saline, PBS, 0.5 mL, SQ per day) and a cocaine-treated group (Cocaine, 10 ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Liou CM,Tsai SC,Kuo CH,Ting H,Lee SD

    更新日期:2014-04-09 00:00:00

  • Bone Regeneration Using Adipose-Derived Stem Cells in Injectable Thermo-Gelling Hydrogel Scaffold Containing Platelet-Rich Plasma and Biphasic Calcium Phosphate.

    abstract::For bone regeneration, a biocompatible thermo-gelling hydrogel, hyaluronic acid-g-chitosan-g-poly(N-isopropylacrylamide) (HA-CPN) was used as a three-dimensional organic gel matrix for entrapping rabbit adipose-derived stem cells (rASCs). Biphasic calcium phosphate (BCP) ceramic microparticles were embedded within the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Liao HT,Tsai MJ,Brahmayya M,Chen JP

    更新日期:2018-08-27 00:00:00

  • Annexins-Coordinators of Cholesterol Homeostasis in Endocytic Pathways.

    abstract::The spatiotemporal regulation of calcium (Ca2+) storage in late endosomes (LE) and lysosomes (Lys) is increasingly recognized to influence a variety of membrane trafficking events, including endocytosis, exocytosis, and autophagy. Alterations in Ca2+ homeostasis within the LE/Lys compartment are implicated in human di...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Rentero C,Blanco-Muñoz P,Meneses-Salas E,Grewal T,Enrich C

    更新日期:2018-05-12 00:00:00

  • Cytoprotective Effect of the UCP2-SIRT3 Signaling Pathway by Decreasing Mitochondrial Oxidative Stress on Cerebral Ischemia-Reperfusion Injury.

    abstract::Recovered blood supply after cerebral ischemia for a certain period of time fails to restore brain function, with more severe dysfunctional problems developing, called cerebral ischemia-reperfusion injury (CIR). CIR involves several extremely complex pathophysiological processes in which the interactions between key f...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Su J,Liu J,Yan XY,Zhang Y,Zhang JJ,Zhang LC,Sun LK

    更新日期:2017-07-24 00:00:00

  • miR-30-5p Regulates Muscle Differentiation and Alternative Splicing of Muscle-Related Genes by Targeting MBNL.

    abstract::MicroRNAs (miRNAs), a class of single stranded, small (~22 nucleotides), non-coding RNAs, play an important role in muscle development. We focused on the role of the miR-30-5p family during bovine muscle development from previous high-throughput sequencing results and analyzed their expression profiles. MHC and MyoG m...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang BW,Cai HF,Wei XF,Sun JJ,Lan XY,Lei CZ,Lin FP,Qi XL,Plath M,Chen H

    更新日期:2016-01-29 00:00:00

  • Molecular Regulation of Differentiation in Early B-Lymphocyte Development.

    abstract::B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isol...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Sigvardsson M

    更新日期:2018-06-30 00:00:00

  • The Role of ERα36 in Development and Tumor Malignancy.

    abstract::Estrogen nuclear receptors, represented by the canonical forms ERα66 and ERβ1, are the main mediators of the estrogen-dependent pathophysiology in mammals. However, numerous isoforms have been identified, stimulating unconventional estrogen response pathways leading to complex cellular and tissue responses. The estrog...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Thiebaut C,Konan HP,Guerquin MJ,Chesnel A,Livera G,Le Romancer M,Dumond H

    更新日期:2020-06-09 00:00:00

  • Effect of Pulsed Electric Field on Membrane Lipids and Oxidative Injury of Salmonella typhimurium.

    abstract::Salmonella typhimurium cells were subjected to pulsed electric field (PEF) treatment at 25 kV/cm for 0-4 ms to investigate the effect of PEF on the cytoplasmic membrane lipids and oxidative injury of cells. Results indicated that PEF treatment induced a decrease of membrane fluidity of Salmonella typhimurium (S. typhi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Yun O,Zeng XA,Brennan CS,Han Z

    更新日期:2016-08-22 00:00:00

  • The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis.

    abstract::Neoplastic growth and cellular differentiation are critical hallmarks of tumor development. It is well established that cell-to-cell communication between tumor cells and "normal" surrounding cells regulates tumor differentiation and proliferation, aggressiveness, and resistance to treatment. Nevertheless, the mechani...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Valdebenito S,Lou E,Baldoni J,Okafo G,Eugenin E

    更新日期:2018-04-24 00:00:00

  • Interactions between Host PPARs and Gut Microbiota in Health and Disease.

    abstract::The human gastrointestinal tract is inhabited by many types of microbiota, including bacteria, viruses, and fungi. Dysregulations of their microenvironment are associated with various health problems, not only limited to gastrointestinal disorders, such as inflammatory bowel disease, but to impacts beyond the intestin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Hasan AU,Rahman A,Kobori H

    更新日期:2019-01-17 00:00:00

  • Seed Germination in Oil Palm (Elaeis guineensis Jacq.): A Review of Metabolic Pathways and Control Mechanisms.

    abstract::Oil palm is an oil-producing crop of major importance at the global scale. Oil palm mesocarp lipids are used for myriads industrial applications, and market demand has been growing for decades. In addition, oil palm seeds are oleaginous, and the oil extracted therefrom can be used for several purposes, from food to co...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Cui J,Lamade E,Tcherkez G

    更新日期:2020-06-13 00:00:00

  • HER-2 Expression in Brain Metastases from Colorectal Cancer and Corresponding Primary Tumors: A Case Cohort Series.

    abstract::Brain metastases (BM) from colorectal cancer (CRC) are a rare but increasing event. Surgical resection of oligometastatic disease, including BM, may produce a survival benefit in selected patients. Previous studies described the HER-2 expression patterns in CRC patients, but its prognostic role still remains controver...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Aprile G,De Maglio G,Menis J,Casagrande M,Tuniz F,Pisa EF,Fontanella C,Skrap M,Beltrami AC,Fasola G,Pizzolitto S

    更新日期:2013-01-24 00:00:00

  • Estrogen Abolishes the Repression Role of gga-miR-221-5p Targeting ELOVL6 and SQLE to Promote Lipid Synthesis in Chicken Liver.

    abstract::Few studies have been conducted regarding the biological function and regulation role of gga-miR-221-5p in the liver. We compared the conservation of miR-221-5p among species and investigated the expression pattern of gga-miR-221-5p, validating the direct target genes of gga-miR-221-5p by dual luciferase reporter assa...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang DD,Wang DD,Wang Z,Wang YB,Li GX,Sun GR,Tian YD,Han RL,Li ZJ,Jiang RR,Liu XJ,Kang XT,Li H

    更新日期:2020-02-27 00:00:00

  • Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis.

    abstract::NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Haque E,Karim MR,Salam Teeli A,Śmiech M,Leszczynski P,Winiarczyk D,Parvanov ED,Atanasov AG,Taniguchi H

    更新日期:2020-07-29 00:00:00

  • Plant MicroRNAs in Cross-Kingdom Regulation of Gene Expression.

    abstract::MicroRNAs (miRNAs) are a class of noncoding small RNAs, which play a crucial role in post-transcriptional gene regulation. Recently, various reports revealed that miRNAs could be transmitted between species to mediate cross-kingdom regulation by integrating into a specific target gene-mediated regulatory pathway to ex...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Wang W,Liu D,Zhang X,Chen D,Cheng Y,Shen F

    更新日期:2018-07-10 00:00:00

  • Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner.

    abstract::Chronic inflammation in adipose tissue may contribute to depot-specific adipose tissue expansion, leading to obesity and insulin resistance. Dietary supplementation with quercetin or botanical extracts containing quercetin attenuates high fat diet (HFD)-induced obesity and insulin resistance and decreases inflammation...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Forney LA,Lenard NR,Stewart LK,Henagan TM

    更新日期:2018-03-17 00:00:00

  • Radiation-sensitising effects of antennapedia proteins (ANTP)-SmacN7 on tumour cells.

    abstract::The objective of this study was to investigate the underlying mechanisms behind the radiation-sensitising effects of the antennapedia proteins (ANTP)-smacN7 fusion protein on tumour cells. ANTP-SmacN7 fusion proteins were synthesised, and the ability of this fusion protein to penetrate cells was observed. Effects of r...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Du LQ,Wang Y,Xu C,Cao J,Wang Q,Zhao H,Fan FY,Wang B,Katsube T,Fan SJ,Liu Q

    更新日期:2013-12-11 00:00:00

  • Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression.

    abstract::The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: de-Freitas-Junior JCM,Andrade-da-Costa J,Silva MC,Pinho SS

    更新日期:2017-09-07 00:00:00

  • Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis.

    abstract::: The homing of Endothelial Progenitor Cells (EPCs) to tumor angiogenic sites has been described as a multistep process, involving adhesion, migration, incorporation and sprouting, for which the underlying molecular and cellular mechanisms are yet to be fully defined. Here, we studied the expression of Junctional Adhe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Czabanka M,Petrilli LL,Elvers-Hornung S,Bieback K,Albert Imhof B,Vajkoczy P,Vinci M

    更新日期:2020-02-11 00:00:00

  • Protective Effect of Colla corii asini against Lung Injuries Induced by Intratracheal Instillation of Artificial Fine Particles in Rats.

    abstract::Environmental issues pose huge threats to public health, particularly the damage caused by fine particulate matter (PM2.5). However, the mechanisms of injury require further investigation and medical materials that can protect the lungs from PM2.5 are needed. We have found that Colla corii asini, a traditional Chinese...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Liu T,Zhang P,Ling Y,Hu G,Gu J,Yang H,Wei J,Wang A,Jin H

    更新日期:2018-12-23 00:00:00

  • Lower Exposure to Busulfan Allows for Stable Engraftment of Donor Hematopoietic Stem Cells in Children with Mucopolysaccharidosis Type I: A Case Report of Four Patients.

    abstract::Busulfan is an alkylating agent routinely used in conditioning regimens prior to allogeneic hematopoietic cell transplantation (HCT) for various nonmalignant disorders, including inborn errors of metabolism. The combination of model-based dosing and therapeutic drug monitoring (TDM) of busulfan pharmacokinetics (PK) t...

    journal_title:International journal of molecular sciences



    authors: Shukla P,Dvorak CC,Long-Boyle J,Kharbanda S

    更新日期:2020-08-06 00:00:00

  • Verification of the Saccharina japonica Translocon Tic20 and its Localization in the Chloroplast Membrane in Diatoms.

    abstract::Tic20 is an important translocon protein that plays a role in protein transport in the chloroplast. The sequence of Tic20 was determined in the lower brown alga Saccharina japonica. Structural analysis of SjTic20 revealed a noncanonical structure consisting of an N-terminal non-cyanobacterium-originated EF-hand domain...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chen Z,Wang X,Li S,Yao J,Shao Z,Duan D

    更新日期:2019-08-16 00:00:00

  • A Current Overview of the Biological and Cellular Effects of Nanosilver.

    abstract::Nanosilver plays an important role in nanoscience and nanotechnology, and is becoming increasingly used for applications in nanomedicine. Nanosilver ranges from 1 to 100 nanometers in diameter. Smaller particles more readily enter cells and interact with the cellular components. The exposure dose, particle size, coati...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Cameron SJ,Hosseinian F,Willmore WG

    更新日期:2018-07-12 00:00:00

  • Potential Adverse Effects of Resveratrol: A Literature Review.

    abstract::Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including anti...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Shaito A,Posadino AM,Younes N,Hasan H,Halabi S,Alhababi D,Al-Mohannadi A,Abdel-Rahman WM,Eid AH,Nasrallah GK,Pintus G

    更新日期:2020-03-18 00:00:00

  • Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury.

    abstract::Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lima R,Monteiro S,Gomes ED,Vasconcelos NL,Assunção-Silva R,Morais M,Salgado AJ,Silva NA

    更新日期:2020-07-17 00:00:00

  • Oxymatrine Inhibits Influenza A Virus Replication and Inflammation via TLR4, p38 MAPK and NF-κB Pathways.

    abstract::Oxymatrine (OMT) is a strong immunosuppressive agent that has been used in the clinic for many years. In the present study, by using plaque inhibition, luciferase reporter plasmids, qRT-PCR, western blotting, and ELISA assays, we have investigated the effect and mechanism of OMT on influenza A virus (IAV) replication ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Dai JP,Wang QW,Su Y,Gu LM,Deng HX,Chen XX,Li WZ,Li KS

    更新日期:2018-03-23 00:00:00

  • A Confirmation for the Positive Electric Charge of Bio-Molecular Motors through Utilizing a Novel Nano-Technology Approach In Vitro.

    abstract::Molecular motors are microtubule-based proteins which contribute to many cell functions, such as intracellular transportation and cell division. The details of the nature of the mutual interactions between motors and microtubules still needs to be extensively explored. However, electrostatic interaction is known as on...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Feizabadi MS,Alejilat RS,Duffy AB,Breslin JC,Akintola II

    更新日期:2020-07-13 00:00:00

  • Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.

    abstract::Salivary gland dysfunction induces salivary flow reduction and a dry mouth, and commonly involves oral dysfunction, tooth structure deterioration, and infection through reduced salivation. This study aimed to investigate the impact of aging on the salivary gland by a metabolomics approach in an extensive aging mouse m...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Toan NK,Tai NC,Kim SA,Ahn SG

    更新日期:2021-01-02 00:00:00

  • Mechanisms of PKA-Dependent Potentiation of Kv7.5 Channel Activity in Human Airway Smooth Muscle Cells.

    abstract::β-adrenergic receptor (βAR) activation promotes relaxation of both vascular and airway smooth muscle cells (VSMCs and ASMCs, respectively), though the signaling mechanisms have not been fully elucidated. We previously found that the activity of Kv7.5 voltage-activated potassium channels in VSMCs is robustly enhanced b...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Brueggemann LI,Cribbs LL,Schwartz J,Wang M,Kouta A,Byron KL

    更新日期:2018-07-30 00:00:00

  • Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation.

    abstract::MicroRNAs (miRNAs) play important roles under multiple cellular conditions including endoplasmic reticulum (ER) stress. We found that miR-3648, a human specific microRNA, was induced under ER stress. Moreover, Adenomatous polyposis coli 2 (APC2), a tumor suppressor and a negative regulator of Wnt signaling, was found ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Rashid F,Awan HM,Shah A,Chen L,Shan G

    更新日期:2017-06-29 00:00:00