Abstract:
:The HGF/c-MET pathway is active in the development of digestive system cancers, indicating that inhibition of HGF/c-MET signaling may have therapeutic potential. Various HGF/c-MET signaling inhibitors, mainly c-MET inhibitors, have been tested in clinical trials. The observed efficacy and adverse events of some c-MET inhibitors were not very suitable for treating digestive system cancers. The development of new HGF/c-MET inhibitors in preclinical studies may bring promising treatments and synergistic combination (traditional anticancer drugs and c-MET inhibitors) strategies provided anacceptable safety and tolerability. Insights into miRNA biology and miRNA therapeutics have made miRNAs attractive tools to inhibit HGF/c-MET signaling. Recent reports show that several microRNAs participate in inhibiting HGF/c-MET signaling networks through antagonizing c-MET or HGF in digestive system cancers, and the miRNAs-HGF/c-MET axis plays crucial and novel roles for cancer treatment. In the current review, we will discuss recent findings about inhibitors of HGF/c-MET signaling in treating digestive system cancers, and how miRNAs regulate digestive system cancers via mediating HGF/c-MET pathway.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zhang H,Feng Q,Chen WD,Wang YDdoi
10.3390/ijms19113295subject
Has Abstractpub_date
2018-10-23 00:00:00issue
11issn
1422-0067pii
ijms19113295journal_volume
19pub_type
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journal_title:International journal of molecular sciences
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更新日期:2018-12-09 00:00:00
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更新日期:2016-09-29 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2020-10-30 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051265
更新日期:2018-04-24 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-11-05 00:00:00