NECTIN4 Expression in Extramammary Paget's Disease: Implication of a New Therapeutic Target.

Abstract:

:Extramammary Paget's disease (EMPD) is a rare skin cancer arising in the anogenital area. Most EMPD tumors remain dormant as in situ lesions, but the outcomes of patients with metastatic EMPD are poor because of the lack of effective systemic therapies. Nectin cell adhesion molecule 4 (NECTIN4) has attracted attention as a potential therapeutic target for some cancers. Urothelial cancer is one such cancer, and clinical trials of enfortumab vedotin, a drug-conjugated anti-NECTIN4 antibody, are ongoing. However, little is known regarding the role of NECTIN4 in EMPD. In this study, we conducted immunohistochemical analysis of NECTIN4 expression in 110 clinical EMPD samples and normal skin tissue. In normal skin, positive signals were observed in epidermal keratinocytes (particularly in the lower part of the epidermis), eccrine and apocrine sweat glands, inner and outer root sheaths, and matrix of the hair follicles. The most EMPD lesions exhibited strong NECTIN4 expression, and high NECTIN4 expression was significantly associated with increased tumor thickness, advanced TNM stage, and worse disease-specific survival. These results support the potential use of NECTIN4-targeted therapy for EMPD. Our report contributes to the better understanding of the pathobiology of NECTIN4 in the skin and the skin-related adverse effects of NECTIN4-targeted therapy.

journal_name

Int J Mol Sci

authors

Murata M,Ito T,Tanaka Y,Kaku-Ito Y,Furue M

doi

10.3390/ijms21165891

subject

Has Abstract

pub_date

2020-08-16 00:00:00

issue

16

issn

1422-0067

pii

ijms21165891

journal_volume

21

pub_type

杂志文章
  • Different storage conditions influence biocompatibility and physicochemical properties of iron oxide nanoparticles.

    abstract::Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted increasing attention in many biomedical fields. In magnetic drug targeting SPIONs are injected into a tumour supplying artery and accumulated inside the tumour with a magnet. The effectiveness of this therapy is thus dependent on magnetic properties, s...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms16059368

    authors: Zaloga J,Janko C,Agarwal R,Nowak J,Müller R,Boccaccini AR,Lee G,Odenbach S,Lyer S,Alexiou C

    更新日期:2015-04-24 00:00:00

  • Statin, calcium channel blocker and Beta blocker therapy may decrease the incidence of tuberculosis infection in elderly Taiwanese patients with type 2 diabetes.

    abstract:BACKGROUND:It is well known that diabetes mellitus impairs immunity and therefore is an independent risk factor for tuberculosis. However, the influence of associated metabolic factors, such as hypertension, dyslipidemia and gout has yet to be confirmed. This study aimed to investigate whether the strong association be...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms160511369

    authors: Lee MY,Lin KD,Hsu WH,Chang HL,Yang YH,Hsiao PJ,Shin SJ

    更新日期:2015-05-18 00:00:00

  • Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases.

    abstract::Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19082208

    authors: Koh YC,Yang G,Lai CS,Weerawatanakorn M,Pan MH

    更新日期:2018-07-28 00:00:00

  • Self-Assembled Benznidazole-Loaded Cationic Nanoparticles Containing Cholesterol/Sialic Acid: Physicochemical Properties, In Vitro Drug Release and In Vitro Anticancer Efficacy.

    abstract::Cationic polymeric nanoparticles (NPs) have the ability to overcome biological membranes, leading to improved efficacy of anticancer drugs. The modulation of the particle-cell interaction is desired to control this effect and avoid toxicity to normal cells. In this study, we explored the surface functionalization of c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20092350

    authors: Dos Santos-Silva AM,de Caland LB,do Nascimento EG,Oliveira ALCSL,de Araújo-Júnior RF,Cornélio AM,Fernandes-Pedrosa MF,da Silva-Júnior AA

    更新日期:2019-05-11 00:00:00

  • Comprehensive analysis suggests overlapping expression of rice ONAC transcription factors in abiotic and biotic stress responses.

    abstract::NAC (NAM/ATAF/CUC) transcription factors comprise a large plant-specific gene family that contains more than 149 members in rice. Extensive studies have revealed that NAC transcription factors not only play important roles in plant growth and development, but also have functions in regulation of responses to biotic an...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms16024306

    authors: Sun L,Huang L,Hong Y,Zhang H,Song F,Li D

    更新日期:2015-02-17 00:00:00

  • In-Situ Investigation on Nanoscopic Biomechanics of Streptococcus mutans at Low pH Citric Acid Environments Using an AFM Fluid Cell.

    abstract::Streptococcus mutans (S. mutans) is widely regarded as the main cause of human dental caries via three main virulence factors: adhesion, acidogenicity, and aciduricity. Citric acid is one of the antibiotic agents that can inhibit the virulence capabilities of S. mutans. A full understanding of the acidic resistance me...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21249481

    authors: Nguyen LTP,Liu BH

    更新日期:2020-12-13 00:00:00

  • Hypoxia-Mediated Decrease of Ovarian Cancer Cells Reaction to Treatment: Significance for Chemo- and Immunotherapies.

    abstract::Hypoxia, a common factor ruling the microenvironment composition, leads to tumor progression. In this hypoxic context, cytokines and cells cooperate to favor cancer development and metastasis. Tumor hypoxia is heterogeneously distributed. Oxygen gradients depend on the vicinity, functionality of blood vessels, and oxy...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21249492

    authors: Klemba A,Bodnar L,Was H,Brodaczewska KK,Wcislo G,Szczylik CA,Kieda C

    更新日期:2020-12-14 00:00:00

  • Deep Learning Modeling of Androgen Receptor Responses to Prostate Cancer Therapies.

    abstract::Gain-of-function mutations in human androgen receptor (AR) are among the major causes of drug resistance in prostate cancer (PCa). Identifying mutations that cause resistant phenotype is of critical importance for guiding treatment protocols, as well as for designing drugs that do not elicit adverse responses. However...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21165847

    authors: Snow O,Lallous N,Ester M,Cherkasov A

    更新日期:2020-08-14 00:00:00

  • Optimizing PCR Detection of West Nile Virus from Body Fluid Specimens to Delineate Natural History in an Infected Human Cohort.

    abstract::West Nile virus (WNV), a mosquito-borne arbovirus, remains a major global health concern. In this study, we optimized PCR methods then assessed serially-collected whole blood (WB), urine (UR), saliva, and semen specimens from a large cohort of WNV-positive participants to evaluate the natural history of infection and ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20081934

    authors: Gorchakov R,Gulas-Wroblewski BE,Ronca SE,Ruff JC,Nolan MS,Berry R,Alvarado RE,Gunter SM,Murray KO

    更新日期:2019-04-19 00:00:00

  • Biofunctional constituents from Liriodendron tulipifera with antioxidants and anti-melanogenic properties.

    abstract::From the stems of Liriodendron tulipifera, seventeen known compounds have been extracted, isolated and purified. By using spectroscopic analysis, the structures of these pure constituents were determined as three lignans, four steroids and ten benzenoids. Identified compounds were screened for antioxidant abilities u...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms14011698

    authors: Li WJ,Lin YC,Wu PF,Wen ZH,Liu PL,Chen CY,Wang HM

    更新日期:2013-01-15 00:00:00

  • Carnosine as a Possible Drug for Zinc-Induced Neurotoxicity and Vascular Dementia.

    abstract::Increasing evidence suggests that the metal homeostasis is involved in the pathogenesis of various neurodegenerative diseases including senile type of dementia such as Alzheimer's disease, dementia with Lewy bodies, and vascular dementia. In particular, synaptic Zn2+ is known to play critical roles in the pathogenesis...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21072570

    authors: Kawahara M,Sadakane Y,Mizuno K,Kato-Negishi M,Tanaka KI

    更新日期:2020-04-07 00:00:00

  • In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats.

    abstract::Polyglutamine diseases, including Huntington's disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing polyglutamine expansions have long been thought to be pathogenic, but ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms160818741

    authors: Figura G,Koscianska E,Krzyzosiak WJ

    更新日期:2015-08-11 00:00:00

  • A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory.

    abstract::Lysophosphatidic acid (LPA) is a small lysophospholipid molecule that activates multiple cellular functions through pathways with G-protein-coupled receptors. So far, six LPA receptors (LPAR1 to LPAR6) have been discovered and each one of them can connect to the downstream cell message-transmitting network. A previous...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21082837

    authors: Lin YN,Audira G,Malhotra N,Ngoc Anh NT,Siregar P,Lu JH,Lee H,Hsiao CD

    更新日期:2020-04-18 00:00:00

  • Dietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer's Disease Pathology in 5xFAD Model Mice.

    abstract::Wheat amylase trypsin inhibitors (ATIs) represent a common dietary protein component of gluten-containing cereals (wheat, rye, and barley). They act as toll-like receptor 4 ligands, and are largely resistant to intestinal proteases, eliciting a mild inflammatory response within the intestine after oral ingestion. Impo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21176288

    authors: Dos Santos Guilherme M,Zevallos VF,Pesi A,Stoye NM,Nguyen VTT,Radyushkin K,Schwiertz A,Schmitt U,Schuppan D,Endres K

    更新日期:2020-08-31 00:00:00

  • Proteomic Differences in Feline Fibrosarcomas Grown Using Doxorubicin-Sensitive and -Resistant Cell Lines in the Chick Embryo Model.

    abstract::Proteomic analyses are rapid and powerful tools that are used to increase the understanding of cancer pathogenesis, discover cancer biomarkers and predictive markers, and select and monitor novel targets for cancer therapy. Feline injection-site sarcomas (FISS) are aggressive skin tumours with high recurrence rates, d...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19020576

    authors: Zabielska-Koczywąs K,Michalak K,Wojtalewicz A,Winiarczyk M,Adaszek Ł,Winiarczyk S,Lechowski R

    更新日期:2018-02-14 00:00:00

  • ROS Homeostasis in Abiotic Stress Tolerance in Plants.

    abstract::Climate change-induced abiotic stress results in crop yield and production losses. These stresses result in changes at the physiological and molecular level that affect the development and growth of the plant. Reactive oxygen species (ROS) is formed at high levels due to abiotic stress within different organelles, lea...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21155208

    authors: Nadarajah KK

    更新日期:2020-07-23 00:00:00

  • Divergent Evolution of Eukaryotic CC- and A-Adding Enzymes.

    abstract::Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seemed to be restricted to Bacteria, the first example of such split CCA-a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21020462

    authors: Erber L,Franz P,Betat H,Prohaska S,Mörl M

    更新日期:2020-01-10 00:00:00

  • Construction of a Lectin-Glycan Interaction Network from Enterohemorrhagic Escherichia coli Strains by Multi-omics Analysis.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) causes hemorrhagic colitis and hemolytic uremic syndrome. EHEC infection begins with bacterial adherence to the host intestine via lectin-like adhesins that bind to the intestinal wall. However, EHEC-related lectin-glycan interactions (LGIs) remain unknown. Here, we conducted ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21082681

    authors: Cho SH,Lee KM,Kim CH,Kim SS

    更新日期:2020-04-12 00:00:00

  • Effects of dietary conjugated linoleic acid and biopolymer encapsulation on lipid metabolism in mice.

    abstract::Forty mice were randomly divided into four groups on the basis of the diet to be fed as follows: 5% (low) fat diet (T1: LF); 20% (high) fat diet (T2: HF); 20% fat containing 1% conjugated linoleic acid (CLA) (T3: HFC); and 20% fat containing 1% CLA with 0.5% biopolymers (T4: HFCB). The high-fat with CLA diet groups (H...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms14046848

    authors: Hur SJ,Kim DH,Chun SC,Lee SK

    更新日期:2013-03-26 00:00:00

  • Preparation of lung-targeting, emodin-loaded polylactic acid microspheres and their properties.

    abstract::Emodin (1,3,8-trihydroxy-6-methylanthraquinone) has been identified to have the potential to improve lung fibrosis and lung cancer. To avoid the liver and kidney toxicities and the fast metabolism of emodin, emodin-loaded polylactic acid microspheres (ED-PLA-MS) were prepared and their characteristics were studied. ED...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms15046241

    authors: Chen X,Yang Z,Sun R,Mo Z,Jin G,Wei F,Hu J,Guan W,Zhong N

    更新日期:2014-04-11 00:00:00

  • Gene-Diet Interaction and Precision Nutrition in Obesity.

    abstract::The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18040787

    authors: Heianza Y,Qi L

    更新日期:2017-04-07 00:00:00

  • Evaluation of Seven Different RNA-Seq Alignment Tools Based on Experimental Data from the Model Plant Arabidopsis thaliana.

    abstract::Quantification of gene expression is crucial to connect genome sequences with phenotypic and physiological data. RNA-Sequencing (RNA-Seq) has taken a prominent role in the study of transcriptomic reactions of plants to various environmental and genetic perturbations. However, comparative tests of different tools for R...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21051720

    authors: Schaarschmidt S,Fischer A,Zuther E,Hincha DK

    更新日期:2020-03-03 00:00:00

  • Exploiting Gene Expression Profiles for the Automated Prediction of Connectivity between Brain Regions.

    abstract::The brain comprises a complex system of neurons interconnected by an intricate network of anatomical links. While recent studies demonstrated the correlation between anatomical connectivity patterns and gene expression of neurons, using transcriptomic information to automatically predict such patterns is still an open...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20082035

    authors: Roberti I,Lovino M,Di Cataldo S,Ficarra E,Urgese G

    更新日期:2019-04-25 00:00:00

  • Deciphering the molecular nature of ovarian cancer biomarker CA125.

    abstract::The ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confir...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms130810568

    authors: Weiland F,Martin K,Oehler MK,Hoffmann P

    更新日期:2012-01-01 00:00:00

  • Repellent and Antifeedant Activities of Citral-Derived Lactones against the Peach Potato Aphid.

    abstract::Citral is well known for its antimicrobial, antifungal, and insecticidal activities. Natural sesquiterpene α-methylenelactones also exhibit a broad spectrum of biological activities. The aim of the study was to explore the effect of structural changes to citral molecules on citral behavior-modifying activity towards M...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21218029

    authors: Dancewicz K,Szumny A,Wawrzeńczyk C,Gabryś B

    更新日期:2020-10-28 00:00:00

  • Optimization of a WGA-Free Molecular Tagging-Based NGS Protocol for CTCs Mutational Profiling.

    abstract::Molecular characterization of Circulating Tumor Cells (CTCs) is still challenging, despite attempts to minimize the drawbacks of Whole Genome Amplification (WGA). In this paper, we propose a Next-Generation Sequencing (NGS) optimized protocol based on molecular tagging technology, in order to detect CTCs mutations whi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21124364

    authors: De Luca G,Cardinali B,Del Mastro L,Lastraioli S,Carli F,Ferrarini M,Calin GA,Garuti A,Mazzitelli C,Zupo S,Dono M

    更新日期:2020-06-19 00:00:00

  • The effects of inhibiting hedgehog signaling pathways by using specific antagonist cyclopamine on the chondrogenic differentiation of mesenchymal stem cells.

    abstract::This study aimed to investigate the effects of cyclopamine, a specific inhibitor of Hedgehog signaling pathways, on the chondrogenic differentiation of mesenchymal stem cells (MSCs). During culture, the experimental groups were treated with cyclopamine and their cell proliferation status was assessed using the MTT tes...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms14035966

    authors: Wu X,Cai ZD,Lou LM,Chen ZR

    更新日期:2013-03-14 00:00:00

  • Rev-erbα Inhibits Proliferation and Promotes Apoptosis of Preadipocytes through the Agonist GSK4112.

    abstract::Proliferation and apoptosis are important physiological processes of preadipocytes. Rev-erbα is a circadian clock gene, and its activity contributes to several physiological processes in various cells. Previous studies demonstrated that Rev-erbα promotes preadipocyte differentiation, but a role of Rev-erbα on preadipo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20184524

    authors: Chu G,Zhou X,Hu Y,Shi S,Yang G

    更新日期:2019-09-12 00:00:00

  • Hold on or Cut? Integrin- and MMP-Mediated Cell-Matrix Interactions in the Tumor Microenvironment.

    abstract::The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication betwee...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms22010238

    authors: Niland S,Eble JA

    更新日期:2020-12-28 00:00:00

  • RNA Sequencing and Coexpression Analysis Reveal Key Genes Involved in α-Linolenic Acid Biosynthesis in Perilla frutescens Seed.

    abstract::Perillafrutescen is used as traditional food and medicine in East Asia. Its seeds contain high levels of α-linolenic acid (ALA), which is important for health, but is scarce in our daily meals. Previous reports on RNA-seq of perilla seed had identified fatty acid (FA) and triacylglycerol (TAG) synthesis genes, but the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18112433

    authors: Zhang T,Song C,Song L,Shang Z,Yang S,Zhang D,Sun W,Shen Q,Zhao D

    更新日期:2017-11-16 00:00:00