Pseudomonas aeruginosa Biofilms.

abstract：:Fibroblast growth factor 21 (FGF-21) is known to be a biomarker for mitochondrial disorders. An upregulation of FGF-21 in serum and muscle of carnitine palmitoyltransferase I (CPT I) and carnitine palmitoyltransferase II (CPT II) knock-out mice has been reported. In human CPT II deficiency, enzyme activity and protein...

journal_title：International journal of molecular sciences

authors： Motlagh Scholle L,Lehmann D,Joshi PR,Zierz S

更新日期：2019-03-20 00:00:00

abstract：:Amyloidosis refers to aggregates of protein that accumulate and are deposited as amyloid fibrils into plaques. When these are detected in organs, they are the main hallmark of Alzheimer's disease, Parkinson's disease, and other related diseases. Recent medical advances have shown that many precursors and proteins can ...

journal_title：International journal of molecular sciences

authors： Lin X,Galaqin N,Tainaka R,Shimamori K,Kuragano M,Noguchi TQP,Tokuraku K

更新日期：2020-03-13 00:00:00

abstract：:The effects of various inhibitors on crude, commercial and partially purified commercial mushroom tyrosinase were examined by comparing IC(50) values. Kojic acid, salicylhydroxamic acid, tropolone, methimazole, and ammonium tetrathiomolybdate had relatively similar IC(50) values for the crude, commercial and partially...

journal_title：International journal of molecular sciences

authors： Neeley E,Fritch G,Fuller A,Wolfe J,Wright J,Flurkey W

更新日期：2009-09-02 00:00:00

abstract：:The FLOWERING LOCUS T (FT) gene plays crucial roles in regulating the transition from the vegetative to reproductive phase. To understand the molecular mechanism of reproduction, three homologous FT genes were isolated and characterized from Cymbidium sinense "Qi Jian Bai Mo", Cymbidium goeringii and Cymbidium ensifol...

journal_title：International journal of molecular sciences

authors： Huang W,Fang Z,Zeng S,Zhang J,Wu K,Chen Z,Teixeira da Silva JA,Duan J

更新日期：2012-01-01 00:00:00

abstract：:Transforming growth factor beta 3 (TGFβ3) promotes tenogenic differentiation and may enhance tendon regeneration in vivo. This study aimed to apply TGFβ3 absorbed in decellularized equine superficial digital flexor tendon scaffolds, and to investigate the bioactivity of scaffold-associated TGFβ3 in an in vitro model. ...

journal_title：International journal of molecular sciences

authors： Roth SP,Brehm W,Groß C,Scheibe P,Schubert S,Burk J

更新日期：2019-11-03 00:00:00

abstract：:HER2 (human epidermal growth factor receptor 2) activation is critical in breast cancer development. HER2 promotes cell proliferation, angiogenesis, survival, and metastasis by activation of PI3K/Akt, Ras/MEK/ERK, and JAK/STAT pathways. However, beyond these signaling molecules, the key proteins underlining HER2-media...

journal_title：International journal of molecular sciences

authors： Zeng P,Sun S,Li R,Xiao ZX,Chen H

更新日期：2019-05-06 00:00:00

abstract：:Autophagy primarily works to counteract nutrient deprivation that is strongly engaged during starvation and hypoxia, which happens in hypoperfusion. Nonetheless, autophagy is slightly active even in baseline conditions, when it is useful to remove aged proteins and organelles. This is critical when the mitochondria an...

journal_title：International journal of molecular sciences

authors： Ferrucci M,Biagioni F,Ryskalin L,Limanaqi F,Gambardella S,Frati A,Fornai F

更新日期：2018-09-13 00:00:00

abstract：:Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a-l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5] undecane-3,5-diones (6m-x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino] cycloalkanecarboxamides (3a-f) were prepared via adopting Strecker...

journal_title：International journal of molecular sciences

authors： Aboul-Enein MN,El-Azzouny AA,Attia MI,Maklad YA,Aboutabl ME,Ragab F,Abd El-Hamid WH

更新日期：2014-09-23 00:00:00

abstract：:Evidence from randomized controlled trials (RCTs) suggests that coenzyme Q10 (CoQ10) can regulate adipokine levels to impact inflammation and oxidative stress in conditions of metabolic syndrome. Here, prominent electronic databases such as MEDLINE, Cochrane Library, and EMBASE were searched for eligible RCTs reportin...

journal_title：International journal of molecular sciences

authors： Dludla PV,Orlando P,Silvestri S,Marcheggiani F,Cirilli I,Nyambuya TM,Mxinwa V,Mokgalaboni K,Nkambule BB,Johnson R,Mazibuko-Mbeje SE,Muller CJF,Louw J,Tiano L

更新日期：2020-05-04 00:00:00

abstract：:Phostensin is encoded by KIAA1949. 5'-RACEanalysis has been used to identify the translation start site of phostensin mRNA, indicating that it encodes 165 amino acids with an apparent molecular weight of 26 kDa on SDS-PAGE. This low-molecular-weight phostensin is present in human peripheral blood mononuclear cells and...

journal_title：International journal of molecular sciences

authors： Lin YS,Huang HL,Liu WT,Lin TH,Huang HB

更新日期：2014-01-15 00:00:00

abstract：:This study evaluated frequency-dependent effects of extremely low frequency electromagnetic fields (ELF-EMFs) on melanogenesis by melanocytes in vitro. Melanocytes were exposed to 2 mT EMFs at 30-75 Hz for 3 days before melanogenesis was examined. Exposure to ELF-EMFs at 50 and 60 Hz induced melanogenic maturation wit...

journal_title：International journal of molecular sciences

authors： Kim YM,Cho SE,Kim SC,Jang HJ,Seo YK

更新日期：2017-10-11 00:00:00

abstract：:Melanogenesis is a biological process resulting in the production of melanin pigment, which plays an important role in the prevention of sun-induced skin injury, and determines hair and skin color. So, a wide variety of approaches have been proposed to increase the synthesis of melanin. This study evaluated the effect...

journal_title：International journal of molecular sciences

authors： Kim YM,Lim HM,Ro HS,Ki GE,Seo YK

更新日期：2018-10-17 00:00:00

abstract：:A thorough characterization of the early time sub-100 fs relaxation dynamics of biologically relevant chromophores is of crucial importance for a complete understanding of the mechanisms regulating the ultrafast dynamics of the relaxation processes in more complex multichromophoric light-harvesting systems. While chlo...

journal_title：International journal of molecular sciences

authors： Fresch E,Collini E

更新日期：2020-04-18 00:00:00

abstract：:The quaternary transition between the relaxed (R) and tense (T) states of heme-binding proteins is a textbook example for the allosteric structural transition. Homodimeric hemoglobin (HbI) from Scapharca inaequivalvis is a useful model system for investigating the allosteric behavior because of the relatively simple q...

journal_title：International journal of molecular sciences

authors： Yang C,Choi M,Kim JG,Kim H,Muniyappan S,Nozawa S,Adachi SI,Henning R,Kosheleva I,Ihee H

更新日期：2018-11-18 00:00:00

abstract：:In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was...

journal_title：International journal of molecular sciences

authors： Sato K,Toriyama M

更新日期：2011-01-01 00:00:00

abstract：:The presence of abnormal ovarian ratios of myo-inositol (MI) to D-chiro-inositol (DCI) is a recurrent feature in PCOS. Available evidence suggests that MI and DCI may modulate steroid biosynthesis, likely in an opposite manner. Specifically, MI seems to induce estrogen production, while DCI has a role in the synthesis...

journal_title：International journal of molecular sciences

authors： Unfer V,Dinicola S,Laganà AS,Bizzarri M

更新日期：2020-09-28 00:00:00

abstract：:It is widely recognized that many chronic infections of the human body have a polymicrobial etiology. These include diabetic foot ulcer infections, lung infections in cystic fibrosis patients, periodontitis, otitis, urinary tract infections and even a proportion of systemic infections. The treatment of mixed infection...

journal_title：International journal of molecular sciences

authors： Batoni G,Maisetta G,Esin S

更新日期：2021-01-06 00:00:00

abstract：:The relationships among 55 wheat accessions (47 accessions collected from Iran and eight accessions provided by the Institute of Plant Biology of the University of Zurich, Switzerland) belonging to eight species carrying A genome (Triticum monococcum L., T. boeoticum Boiss., T. urartu Tumanian ex Gandilyan, T. durum D...

journal_title：International journal of molecular sciences

authors： Ehtemam MH,Rahiminejad MR,Saeidi H,Tabatabaei BE,Krattinger SG,Keller B

更新日期：2010-11-02 00:00:00

abstract：:Deficits in plasma membrane repair have been identified in dysferlinopathy and Duchenne Muscular Dystrophy, and contribute to progressive myopathy. Although Facioscapulohumeral Muscular Dystrophy (FSHD) shares clinicopathological features with these muscular dystrophies, it is unknown if FSHD is characterized by plasm...

journal_title：International journal of molecular sciences

authors： Bittel AJ,Sreetama SC,Bittel DC,Horn A,Novak JS,Yokota T,Zhang A,Maruyama R,Rowel Q Lim K,Jaiswal JK,Chen YW

更新日期：2020-08-04 00:00:00

abstract：:Cells have evolved balanced systems that ensure an appropriate response to stress. The systems elicit repair responses in temporary or moderate stress but eliminate irreparable cells via apoptosis in detrimental conditions of prolonged or severe stress. The tumor suppressor p53 is a central player in these stress resp...

journal_title：International journal of molecular sciences

authors： Kim E,Kim JY,Lee JY

更新日期：2019-10-18 00:00:00

abstract：:Aquaporins (AQPs) are among the best structural-characterized membrane proteins, fulfilling the role of allowing water flux across cellular membranes. Thus far, 34 single amino acid polymorphisms have been reported in HUMSAVAR for human aquaporins as disease-related. They affect AQP2, AQP5 and AQP8, where they are ass...

journal_title：International journal of molecular sciences

authors： Calvanese L,D'Auria G,Vangone A,Falcigno L,Oliva R

更新日期：2018-05-25 00:00:00

abstract：:Chemoradiation-based bladder preservation therapy (BPT) is currently a curative option for non-metastatic muscle-invasive bladder cancer (MIBC) patients at favorable risk or an alternative to radical cystectomy (RC) for those who are unfit for RC. In BPT, only patients who achieve complete response (CR) after chemorad...

journal_title：International journal of molecular sciences

authors： Koga F,Takemura K,Fukushima H

更新日期：2018-09-15 00:00:00

abstract：:This paper reports the rapid melt quenching technique preparation for the new family of bismuth-lead germanate glass (BPG) systems in the form of (GeO(2))(60)-(PbO)(40-) (x)-(½Bi(2)O(3))(x) where x = 0 to 40 mol%. Their densities with respect of Bi(2)O(3) concentration were determined using Archimedes' method with ace...

journal_title：International journal of molecular sciences

authors： Sidek HA,Bahari HR,Halimah MK,Yunus WM

更新日期：2012-01-01 00:00:00

abstract：:Besides being traditionally used to relieve hepatobiliary disorders, Cynara cardunculus L. has evidenced anticancer potential on triple-negative breast cancer (TNBC). This study highlights the antiproliferative effects of lipophilic extracts from C. cardunculus L. var. altilis (DC) leaves and florets, and of their maj...

journal_title：International journal of molecular sciences

authors： Ramos PA,Guerra ÂR,Guerreiro O,Santos SA,Oliveira H,Freire CS,Silvestre AJ,Duarte MF

更新日期：2016-12-29 00:00:00

abstract：:Syntenin is an adaptor-like molecule that has two adjacent tandem postsynaptic density protein 95/Discs large protein/Zonula occludens 1 (PDZ) domains. The PDZ domains of syntenin recognize multiple peptide motifs with low to moderate affinity. Many reports have indicated interactions between syntenin and a plethora o...

journal_title：International journal of molecular sciences

authors： Shimada T,Yasuda S,Sugiura H,Yamagata K

更新日期：2019-08-26 00:00:00

abstract：:Pre-mRNA splicing is an essential mechanism for ensuring integrity of the transcriptome in eukaryotes. Therefore, splicing deficiency might cause a decrease in functional proteins and the production of nonfunctional, aberrant proteins. To prevent the production of such aberrant proteins, eukaryotic cells have several ...

journal_title：International journal of molecular sciences

authors： Muraoka S,Fukumura K,Hayashi M,Kataoka N,Mayeda A,Kaida D

更新日期：2020-11-20 00:00:00

abstract：:Nanosilver plays an important role in nanoscience and nanotechnology, and is becoming increasingly used for applications in nanomedicine. Nanosilver ranges from 1 to 100 nanometers in diameter. Smaller particles more readily enter cells and interact with the cellular components. The exposure dose, particle size, coati...

journal_title：International journal of molecular sciences

authors： Cameron SJ,Hosseinian F,Willmore WG

更新日期：2018-07-12 00:00:00

abstract：:Alfalfa is an autotetraploid, allogamous and heterozygous forage legume, whose varieties are synthetic populations. Due to the complex nature of the species, information about genetic diversity of germplasm used in any alfalfa breeding program is most beneficial. The genetic diversity of five alfalfa varieties, involv...

journal_title：International journal of molecular sciences

authors： Nagl N,Taski-Ajdukovic K,Barac G,Baburski A,Seccareccia I,Milic D,Katic S

更新日期：2011-01-01 00:00:00

abstract：:The discovery of siRNAs as the mediators of RNA interference has led to an increasing interest in their therapeutic applications. Chemical modifications are introduced into siRNAs to optimize the potency, the stability and the pharmacokinetic properties in vivo. Here, we synthesize and test the effects of RNA-3'-PNA c...

journal_title：International journal of molecular sciences

authors： Potenza N,Moggio L,Milano G,Salvatore V,Di Blasio B,Russo A,Messere A

更新日期：2008-03-01 00:00:00

abstract：:SECONDARY WALL-ASSOCIATED NAC DOMAIN1 (SND1) is a master regulator of fibre secondary wall deposition in Arabidopsis thaliana (Arabidopsis), with homologs in other angiosperms and gymnosperms. However, it is poorly understood to what extent the fibre-specific regulation of the SND1 promoter, and that of its orthologs,...

journal_title：International journal of molecular sciences

authors： Tonfack LB,Hussey SG,Veale A,Myburg AA,Mizrachi E

更新日期：2019-09-18 00:00:00