Abstract：
:Parkinson's disease (PD) is the most common cause of movement disorders and is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. It is increasingly recognized as a complex group of disorders presenting widely heterogeneous symptoms and pathology. With the exception of the rare monogenic forms, the majority of PD cases result from an interaction between multiple genetic and environmental risk factors. The search for these risk factors and the development of preclinical animal models are in progress, aiming to provide mechanistic insights into the pathogenesis of PD. This review summarizes the studies that capitalize on modeling sporadic (i.e., nonfamilial) PD using Drosophilamelanogaster and discusses their methodologies, new findings, and future perspectives.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Nagoshi Edoi
10.3390/ijms19113343subject
Has Abstractpub_date
2018-10-26 00:00:00issue
11issn
1422-0067pii
ijms19113343journal_volume
19pub_type
杂志文章,评审abstract：:The juvenile hormone (JH) signalling and ecdysone signalling pathways are crucial endocrine signalling pathways that orchestrate the metamorphosis of insects. The metamorphic process, the morphological change from the immature to adult forms, is orchestrated by the dramatic reduction of JH and downstream transcription...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20102431
更新日期：2019-05-16 00:00:00
abstract：:Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with prognosis. Furthermore, Gal-9 directly induces apoptosis in various cancers; however, its mechanism of action and bioactivity has not been clarified. We evaluated Ga...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20112634
更新日期：2019-05-29 00:00:00
abstract：:Insulin resistance (IR) is one of the key contributing factors in the development of type 2 diabetes mellitus (T2DM). However, the molecular mechanisms leading to IR are still unclear. The implication of microRNAs (miRNAs) in the pathophysiology of multiple cardiometabolic pathologies, including obesity, atherosclerot...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228675
更新日期：2020-11-17 00:00:00
abstract：:Transcription control plays a crucial role in establishing a unique gene expression signature for each of the hundreds of mammalian cell types. Though gene expression data have been widely used to infer cellular regulatory networks, existing methods mainly infer correlations rather than causality. We developed statist...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113609
更新日期：2018-11-15 00:00:00
abstract：:The presence of lysine (Lys) or arginine (Arg) and tryptophan (Trp) are important for the antimicrobial effects of cationic peptides. Therefore, we designed and synthesized a series of antimicrobial peptides with various numbers of Lys (or Arg) and Trp repeats [(KW and RW)(n)-NH(2), where n equals 2, 3, 4, or 5]. Anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131115042
更新日期：2012-11-15 00:00:00
abstract：:Lung cancer is the most common cancer worldwide. Disappointingly, despite great effort in encouraging screening or, at least, a close surveillance of high-risk individuals, most of lung cancers are diagnosed when already surgically unresectable because of local advancement or metastasis. In these cases, the treatment ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071374
更新日期：2017-06-27 00:00:00
abstract：:Recent advances in the field of RNA research have provided compelling evidence implicating microRNA (miRNA) and long non-coding RNA molecules in many diverse and substantial biological processes, including transcriptional and post-transcriptional regulation of gene expression, genomic imprinting, and modulation of pro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms13010840
更新日期：2012-01-01 00:00:00
abstract：:Current outcome prediction markers for localized prostate cancer (PCa) are insufficient. The impact of the lipid-modifying Sphingomyelin Phosphodiesterase Acid Like 3B (SMPDL3B) in PCa is unknown. Two cohorts of patients with PCa who underwent radical prostatectomy (n = 40, n = 56) and benign prostate hyperplasia (BPH...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124373
更新日期：2020-06-19 00:00:00
abstract：:Genomic instability is a hallmark of human cancer and an enabling factor for the genetic alterations that drive cancer development. The processes involved in genomic instability resemble those of meiosis, where genetic material is interchanged between homologous chromosomes. In most types of human cancer, epigenetic c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060890
更新日期：2016-06-06 00:00:00
abstract：:Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow the design of in vitro aptamers that bind particularly to a target molecule with high affinity and selectivity. Theoretical methods...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228420
更新日期：2020-11-10 00:00:00
abstract：:Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms-NO-GC1 and NO-GC2-are known, represents a promising drug target to increase cGMP in the brain. Drug-like small molecules have been discovered that work synergistically with NO to s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082313
更新日期：2018-08-07 00:00:00
abstract：:Great progress has been made over the past decade with respect to the application of biotechnology to generate nutritionally improved food crops. Biofortified staple crops such as rice, maize and wheat harboring essential micronutrients to benefit the world's poor are under development as well as new varieties of crop...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16023895
更新日期：2015-02-11 00:00:00
abstract：:Larix olgensis Henry is an important coniferous species found in plantation forests in northeastern China, but it is vulnerable to pathogens. Nitric oxide (NO) is an important molecule involved in plant resistance to pathogens. To study the regulatory role of NO at the transcriptional level, we characterized the trans...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226117
更新日期：2015-12-02 00:00:00
abstract：:Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17020224
更新日期：2016-02-06 00:00:00
abstract：:Enhancer of zeste homolog 2 (EZH2) plays critical roles in a range of biological processes including organ development and homeostasis, epigenomic and transcriptomic regulation, gene repression and imprinting, and DNA damage repair. A widely known function of EZH2 is to serve as an enzymatic subunit of Polycomb repres...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21249501
更新日期：2020-12-14 00:00:00
abstract：:Members of the placenta-specific miRNA cluster C19MC, including miR-519d, are secreted by fetal trophoblast cells within extracellular vesicles (EVs). Trophoblast-derived EVs can be internalized by the autologous trophoblast and surrounding maternal immune cells, resulting in coordination of cellular responses. The st...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103458
更新日期：2020-05-14 00:00:00
abstract：:Melanin in the epidermis is known to ultimately regulate human skin pigmentation. Recently, we exploited a phenotypic-based screening system composed of ex vivo human skin cultures to search for effective materials to regulate skin pigmentation. Since a previous study reported the potent inhibitory effect of metformin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041451
更新日期：2020-02-20 00:00:00
abstract：:The mechanisms behind fatigue intensification during cancer therapy remain elusive. The interferon alpha-inducible protein 27 (IFI27) was the most up-regulated gene based on our previous microarray data in fatigued men with non-metastatic prostate cancer receiving localized external beam radiation therapy (EBRT). The ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140816943
更新日期：2013-08-16 00:00:00
abstract：:Patients with chronic hepatitis C virus (HCV) develop hepatocellular carcinoma (HCC) regardless of achieving a sustained viral response (SVR). Because advanced liver fibrosis is a powerful risk factor for HCC, we analyzed the association between autotaxin (ATX), a liver fibrosis marker, and post-SVR HCC development wi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124517
更新日期：2020-06-25 00:00:00
abstract：:This study investigated the interaction between eupatorin and bovine serum albumin (BSA) using ultraviolet-visible (UV-vis) absorption, fluorescence, synchronous fluorescence, circular dichroism (CD) spectroscopies, and molecular modeling at pH 7.4. Results of UV-vis and fluorescence spectroscopies illustrated that BS...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140714185
更新日期：2013-07-09 00:00:00
abstract：:The acetohydroxyacid synthase (AHAS) is an essential enzyme involved in branched amino acids. Several herbicides wither weeds via inhibiting AHAS activity, and the AHAS mutants show tolerance to these herbicides. However, most AHAS mutations are residue substitutions but not residue deletion. Here, residue deletion wa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041265
更新日期：2020-02-13 00:00:00
abstract：:One of the hallmarks of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a drastically reduced feed intake by an unknown mechanism. To further elucidate this wasting syndrome, we followed the effects of a single large dose (100 μg/kg) of TCDD on the serum levels of several energy balance-influencing...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150813938
更新日期：2014-08-12 00:00:00
abstract：:In a previous phylogenetic study of the family of pyruvate kinase, we found one cluster with Glu117 and another with Lys117. Those sequences with Glu117 have Thr113 and are K+-dependent, whereas those with Lys117 have Leu113 and are K+-independent. The carbonyl oxygen of Thr113 is one of the residues that coordinate K...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151222214
更新日期：2014-12-02 00:00:00
abstract：:Mango is affected by different decline disorders causing significant losses to mango growers. In the United Arab Emirates (UAE), the pathogen was isolated from all tissues sampled from diseased trees affected by Lasiodiplodia theobromae. Symptoms at early stages of the disease included general wilting appearance of ma...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102086
更新日期：2017-10-20 00:00:00
abstract：:Vitamin D deficiency is highly prevalent worldwide. It has been associated with heart failure (HF) given its immunoregulatory functions. In-vitro and animal models have shown protective roles through mechanisms involving procollagen-1, JNK2, calcineurin/NFAT, NF-κB, MAPK, Th1, Th2, Th17, cytokines, cholesterol-efflux,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225811
更新日期：2019-11-19 00:00:00
abstract：:Cytomegalovirus (CMV) infection after hematopoietic stem cell transplantation (HSCT) is one of the critical infectious complications related to host immune recovery. The spectrum of CMV infection is quite extensive, from asymptomatic CMV reactivation presenting mainly as CMV DNAemia to fatal CMV diseases involving gut...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112666
更新日期：2019-05-30 00:00:00
abstract：:Articular cartilage is compressed with joint-loading and weight-bearing stresses, followed by a bulging of the tissue during times of off-loading. This loading and off-loading causes changes in water content, and thus alterations in osmotic pressure. Another unique characteristic of articular cartilage is that it has ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051507
更新日期：2018-05-18 00:00:00
abstract：:Vascular cell adhesion molecule-1 (VCAM-1) is closely associated with tumor progression and metastasis. However, the relevance and role of VCAM-1 in lung cancer have not been clearly elucidated. In this study, we found that VCAM-1 was highly overexpressed in lung cancer tissue compared with that of normal lung tissue,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18030566
更新日期：2017-03-06 00:00:00
abstract：:The retinal pigment epithelium (RPE) is located between the neuroretina and the choroid, and plays a critical role in vision. RPE cells internalise outer segments (OS) from overlying photoreceptors in the daily photoreceptor renewal. Changes to RPE structure are linked with age and retinopathy, which has been describe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218408
更新日期：2020-11-09 00:00:00
abstract：:CXC motif chemokine ligand 10 (CXCL10) and its receptor CXC motif chemokine receptor 3 (CXCR3), play important roles in the motility of breast cancer cells. Alisma canaliculatum is a herb that has been used as a traditional medicine for thousands of years in Korea and China. Whether A. canaliculatum inhibits the motil...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092607
更新日期：2018-09-03 00:00:00
