Evolution of Disease Defense Genes and Their Regulators in Plants.

Abstract:

:Biotic stresses do damage to the growth and development of plants, and yield losses for some crops. Confronted with microbial infections, plants have evolved multiple defense mechanisms, which play important roles in the never-ending molecular arms race of plant⁻pathogen interactions. The complicated defense systems include pathogen-associated molecular patterns (PAMP) triggered immunity (PTI), effector triggered immunity (ETI), and the exosome-mediated cross-kingdom RNA interference (CKRI) system. Furthermore, plants have evolved a classical regulation system mediated by miRNAs to regulate these defense genes. Most of the genes/small RNAs or their regulators that involve in the defense pathways can have very rapid evolutionary rates in the longitudinal and horizontal co-evolution with pathogens. According to these internal defense mechanisms, some strategies such as molecular switch for the disease resistance genes, host-induced gene silencing (HIGS), and the new generation of RNA-based fungicides, have been developed to control multiple plant diseases. These broadly applicable new strategies by transgene or spraying ds/sRNA may lead to reduced application of pesticides and improved crop yield.

journal_name

Int J Mol Sci

authors

Zhang R,Zheng F,Wei S,Zhang S,Li G,Cao P,Zhao S

doi

10.3390/ijms20020335

subject

Has Abstract

pub_date

2019-01-15 00:00:00

issue

2

issn

1422-0067

pii

ijms20020335

journal_volume

20

pub_type

杂志文章,评审
  • Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis.

    abstract::To uncover mechanisms and explore novel biomarkers of obesity, type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH)-associated hepatocarcinogenesis, cellular and molecular alterations in the liver, and hepatocellular carcinomas (HCCs) were investigated in NASH model 60-week-old Tsumura, Suzuki, Obese Diabeti...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21207746

    authors: Kakehashi A,Suzuki S,Ishii N,Okuno T,Kuwae Y,Fujioka M,Gi M,Stefanov V,Wanibuchi H

    更新日期:2020-10-20 00:00:00

  • A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation.

    abstract::Protein aggregation into insoluble amyloid fibrils is the hallmark of several neurodegenerative diseases, chief among them Alzheimer's and Parkinson's. Although caused by different proteins, these pathologies share some basic molecular mechanisms with familial amyloidotic polyneuropathy (FAP), a rare hereditary neurop...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17091428

    authors: Jesus CS,Almeida ZL,Vaz DC,Faria TQ,Brito RM

    更新日期:2016-08-31 00:00:00

  • Evaluation of the Potential Risk of Drugs to Induce Hepatotoxicity in Human-Relationships between Hepatic Steatosis Observed in Non-Clinical Toxicity Study and Hepatotoxicity in Humans.

    abstract::In the development of drugs, we sometimes encounter fatty change of the hepatocytes (steatosis) which is not accompanied by degenerative change in the liver in non-clinical toxicity studies. In this study, we investigated the relationships between fatty change of the hepatocytes noted in non-clinical toxicity studies ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18040810

    authors: Goda K,Kobayashi A,Takahashi A,Takahashi T,Saito K,Maekawa K,Saito Y,Sugai S

    更新日期:2017-04-12 00:00:00

  • Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

    abstract::The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms14047542

    authors: Daiber A,Daub S,Bachschmid M,Schildknecht S,Oelze M,Steven S,Schmidt P,Megner A,Wada M,Tanabe T,Münzel T,Bottari S,Ullrich V

    更新日期:2013-04-08 00:00:00

  • Brassinosteroid Signaling in Plant⁻Microbe Interactions.

    abstract::As sessile organisms, plants are frequently exposed to different stress conditions caused by either biotic or abiotic factors. Understanding the mechanisms that underlie plant interaction with the biotic and abiotic environments is fundamental to both plant biotechnology and sustainable agriculture. Brassinosteroids (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19124091

    authors: Yu MH,Zhao ZZ,He JX

    更新日期:2018-12-17 00:00:00

  • Transforming Growth Factor Beta 3-Loaded Decellularized Equine Tendon Matrix for Orthopedic Tissue Engineering.

    abstract::Transforming growth factor beta 3 (TGFβ3) promotes tenogenic differentiation and may enhance tendon regeneration in vivo. This study aimed to apply TGFβ3 absorbed in decellularized equine superficial digital flexor tendon scaffolds, and to investigate the bioactivity of scaffold-associated TGFβ3 in an in vitro model. ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20215474

    authors: Roth SP,Brehm W,Groß C,Scheibe P,Schubert S,Burk J

    更新日期:2019-11-03 00:00:00

  • Fractalkine/CX3CL1 in Neoplastic Processes.

    abstract::Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21103723

    authors: Korbecki J,Simińska D,Kojder K,Grochans S,Gutowska I,Chlubek D,Baranowska-Bosiacka I

    更新日期:2020-05-25 00:00:00

  • High-Dimensional descriptor selection and computational QSAR modeling for antitumor activity of ARC-111 analogues Based on Support Vector Regression (SVR).

    abstract::To design ARC-111 analogues with improved efficiency, we constructed the QSAR of 22 ARC-111 analogues with RPMI8402 tumor cells. First, the optimized support vector regression (SVR) model based on the literature descriptors and the worst descriptor elimination multi-roundly (WDEM) method had similar generalization as ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13011161

    authors: Zhou W,Dai Z,Chen Y,Wang H,Yuan Z

    更新日期:2012-01-01 00:00:00

  • Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis.

    abstract::Endometriosis is a chronic, inflammatory, hormone-dependent disease characterized by histological lesions produced by the presence of endometrial tissue outside the uterine cavity. Despite the fact that an estimated 176 million women are affected worldwide by this gynecological disorder, risk factors that cause endome...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21249397

    authors: García-Ibañez P,Yepes-Molina L,Ruiz-Alcaraz AJ,Martínez-Esparza M,Moreno DA,Carvajal M,García-Peñarrubia P

    更新日期:2020-12-10 00:00:00

  • Antimicrobial Resistance Profile of Planktonic and Biofilm Cells of Staphylococcus aureus and Coagulase-Negative Staphylococci.

    abstract::The objective of the present study was to determine the antimicrobial resistance profile of planktonic and biofilm cells of Staphylococcus aureus and coagulase-negative staphylococci (CoNS). Two hundred Staphylococcus spp. strains were studied, including 50 S. aureus and 150 CoNS strains (50 S. epidermidis, 20 S. haem...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17091423

    authors: de Oliveira A,Cataneli Pereira V,Pinheiro L,Moraes Riboli DF,Benini Martins K,Ribeiro de Souza da Cunha Mde L

    更新日期:2016-09-01 00:00:00

  • mTOR-Related Cell-Clearing Systems in Epileptic Seizures, an Update.

    abstract::Recent evidence suggests that autophagy impairment is implicated in the epileptogenic mechanisms downstream of mTOR hyperactivation. This holds true for a variety of genetic and acquired epileptic syndromes besides malformations of cortical development which are classically known as mTORopathies. Autophagy suppression...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21051642

    authors: Limanaqi F,Biagioni F,Busceti CL,Fabrizi C,Frati A,Fornai F

    更新日期:2020-02-28 00:00:00

  • Defect of Interferon γ Leads to Impaired Wound Healing through Prolonged Neutrophilic Inflammatory Response and Enhanced MMP-2 Activation.

    abstract::Interferon (IFN)-γ is mainly secreted by CD4+ T helper 1 (Th1), natural killer (NK) and NKT cells after skin injury. Although IFN-γ is well known regarding its inhibitory effects on collagen synthesis by fibroblasts in vitro, information is limited regarding its role in wound healing in vivo. In the present study, we ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20225657

    authors: Kanno E,Tanno H,Masaki A,Sasaki A,Sato N,Goto M,Shisai M,Yamaguchi K,Takagi N,Shoji M,Kitai Y,Sato K,Kasamatsu J,Ishii K,Miyasaka T,Kawakami K,Imai Y,Iwakura Y,Maruyama R,Tachi M,Kawakami K

    更新日期:2019-11-12 00:00:00

  • The between Now and Then of Lung Cancer Chemotherapy and Immunotherapy.

    abstract::Lung cancer is the most common cancer worldwide. Disappointingly, despite great effort in encouraging screening or, at least, a close surveillance of high-risk individuals, most of lung cancers are diagnosed when already surgically unresectable because of local advancement or metastasis. In these cases, the treatment ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18071374

    authors: Visconti R,Morra F,Guggino G,Celetti A

    更新日期:2017-06-27 00:00:00

  • Proteolytic Regulation of Parathyroid Hormone-Related Protein: Functional Implications for Skeletal Malignancy.

    abstract::Parathyroid hormone-related protein (PTHrP), with isoforms ranging from 139 to 173 amino acids, has long been implicated in the development and regulation of multiple tissues, including that of the skeleton, via paracrine and autocrine signaling. PTHrP is also known as a potent mediator of cancer-induced bone disease,...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20112814

    authors: Frieling JS,Lynch CC

    更新日期:2019-06-08 00:00:00

  • Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry.

    abstract::Evidence suggests that high-density lipoprotein (HDL) components distinct from cholesterol, such as sphingosine-1-phosphate (S1P), may account for the anti-atherothrombotic effects attributed to this lipoprotein. The current method for the determination of plasma levels of S1P as well as levels associated with HDL par...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18081800

    authors: Egom EE,Fitzgerald R,Canning R,Pharithi RB,Murphy C,Maher V

    更新日期:2017-08-18 00:00:00

  • Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases.

    abstract::Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these biological responses, GTPases activity is regulated by guanine nucleotide exchange factors (GEFs), GTP...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21176312

    authors: Arrazola Sastre A,Luque Montoro M,Gálvez-Martín P,Lacerda HM,Lucia AM,Llavero F,Zugaza JL

    更新日期:2020-08-31 00:00:00

  • CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis.

    abstract::Chromosomal rearrangements of the mixed lineage leukaemia (MLL, also known as KMT2A) gene on chromosome 11q23 are amongst the most common genetic abnormalities observed in human acute leukaemias. MLL rearrangements (MLLr) are the most common cytogenetic abnormalities in infant and childhood acute myeloid leukaemia (AM...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21124266

    authors: Sarrou E,Richmond L,Carmody RJ,Gibson B,Keeshan K

    更新日期:2020-06-15 00:00:00

  • Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma.

    abstract::Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a prognosis of 12-15 months and just 3-5% of survival over 5 years. This is mainly because most patients suffer recurrence after treatment that currently consists in maximal resection followed by radio- and chemotherapy with temozo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20112746

    authors: Fedele M,Cerchia L,Pegoraro S,Sgarra R,Manfioletti G

    更新日期:2019-06-04 00:00:00

  • The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model.

    abstract::Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation, migration, invasion, and angiogenesis processes. Depending on the type and malignancy grade of the tumor, Sema3C function remains controversial. In this study, we constr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20225672

    authors: Valiulytė I,Curkūnavičiūtė R,Ribokaitė L,Kazlauskas A,Vaitkevičiūtė M,Skauminas K,Valančiūtė A

    更新日期:2019-11-12 00:00:00

  • Pharmacogenetics of Type 2 Diabetes-Progress and Prospects.

    abstract::Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin resistance and progressively reduced insulin secretion, which leads to impaired glucose utilization, dyslipidemia and hyperinsulinemia and progressive pancreatic beta cell dysfunction. The incidence of type 2 diabetes mellitus is incr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21186842

    authors: Nasykhova YA,Tonyan ZN,Mikhailova AA,Danilova MM,Glotov AS

    更新日期:2020-09-18 00:00:00

  • Icariin protects rat cardiac H9c2 cells from apoptosis by inhibiting endoplasmic reticulum stress.

    abstract::Endoplasmic reticulum stress (ERS) is one of the mechanisms of apoptotic cell death. Inhibiting the apoptosis induced by ERS may be a novel therapeutic target in cardiovascular diseases. Icariin, a flavonoid isolated from Epimedium brevicornum Maxim, has been demonstrated to have cardiovascular protective effects, but...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms140917845

    authors: Zhang Q,Li H,Wang S,Liu M,Feng Y,Wang X

    更新日期:2013-08-30 00:00:00

  • Cytomegalovirus Infections after Hematopoietic Stem Cell Transplantation: Current Status and Future Immunotherapy.

    abstract::Cytomegalovirus (CMV) infection after hematopoietic stem cell transplantation (HSCT) is one of the critical infectious complications related to host immune recovery. The spectrum of CMV infection is quite extensive, from asymptomatic CMV reactivation presenting mainly as CMV DNAemia to fatal CMV diseases involving gut...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20112666

    authors: Cho SY,Lee DG,Kim HJ

    更新日期:2019-05-30 00:00:00

  • Unique Ca2+-Cycling Protein Abundance and Regulation Sustains Local Ca2+ Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells.

    abstract::Spontaneous beating of the heart pacemaker, the sinoatrial node, is generated by sinoatrial node cells (SANC) and caused by gradual change of the membrane potential called diastolic depolarization (DD). Submembrane local Ca2+ releases (LCR) from sarcoplasmic reticulum (SR) occur during late DD and activate an inward N...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19082173

    authors: Vinogradova TM,Tagirova Sirenko S,Lakatta EG

    更新日期:2018-07-25 00:00:00

  • Acid-denatured Green Fluorescent Protein (GFP) as model substrate to study the chaperone activity of protein disulfide isomerase.

    abstract::Green fluorescent protein (GFP) has been widely used in several molecular and cellular biology applications, since it is remarkably stable in vitro and in vivo. Interestingly, native GFP is resistant to the most common chemical denaturants; however, a low fluorescence signal has been observed after acid-induced denatu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms12074625

    authors: Mares RE,Meléndez-López SG,Ramos MA

    更新日期:2011-01-01 00:00:00

  • Hydroxyapatite Formation Coexists with Amyloid-like Self-Assembly of Human Amelogenin.

    abstract::Tooth enamel is formed in an extracellular environment. Amelogenin, the major component in the protein matrix of tooth enamel during the developing stage, could assemble into high molecular weight structures, regulating enamel formation. However, the molecular structure of amelogenin protein assembly at the functional...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21082946

    authors: Zhang J,Wang J,Ma C,Lu J

    更新日期:2020-04-22 00:00:00

  • Synergistic Interaction of Phytohormones in Determining Leaf Angle in Crops.

    abstract::Leaf angle (LA), defined as the angle between the plant stem and leaf adaxial side of the blade, generally shapes the plant architecture into a loosen or dense structure, and thus influences the light interception and competition between neighboring plants in natural settings, ultimately contributing to the crop yield...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21145052

    authors: Li X,Wu P,Lu Y,Guo S,Zhong Z,Shen R,Xie Q

    更新日期:2020-07-17 00:00:00

  • Gonadal, Not Maternal, Acquisition of Duplicated pax6 Orthologs in Megalobrama Amblycephala.

    abstract::: The highly conserved transcription factor Pax6 is involved in the development of the eyes, brain, and pancreas in vertebrates and invertebrates, whereas the additional expression pattern in other organs is still elusive. In this study, we cloned and characterized two pax6 homologs in blunt snout bream (Megalobrama a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20071710

    authors: Pan Q,Xue T,Xia B,Luo J,Wang Q,Jiang Y,Yu M,Chen T

    更新日期:2019-04-05 00:00:00

  • Metallothionein 3 Is a Hypoxia-Upregulated Oncogene Enhancing Cell Invasion and Tumorigenesis in Human Bladder Carcinoma Cells.

    abstract::Metallothioneins have been viewed as modulators in a number of biological regulations regarding cancerous development; however, the function of metallothionein 3 (MT3) in bladder cancer is unexplored. We determined the regulatory mechanisms and potential function of MT3 in bladder carcinoma cells. Real-Time Reverse Tr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20040980

    authors: Tsui KH,Hou CP,Chang KS,Lin YH,Feng TH,Chen CC,Shin YS,Juang HH

    更新日期:2019-02-23 00:00:00

  • Regulatory miRNAs in Colorectal Carcinogenesis and Metastasis.

    abstract::Colorectal cancer is one of the most common malignancies and is the second-leading cause of cancer-related death world-wide, which is linked to genetic mutations, epigenetic alterations, and oncogenic signaling activation. MicroRNAs, one of the categories of epigenetics, have been demonstrated significant roles in car...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18040890

    authors: Guo Y,Bao Y,Yang W

    更新日期:2017-04-22 00:00:00

  • Asymmetric introgression in the horticultural living fossil cycas sect. Asiorientales using a genome-wide scanning approach.

    abstract::The Asian cycads are mostly allopatric, distributed in small population sizes. Hybridization between allopatric species provides clues in determining the mechanism of species divergence. Horticultural introduction provides the chance of interspecific gene flow between allopatric species. Two allopatrically eastern Asi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms14048228

    authors: Chiang YC,Huang BH,Chang CW,Wan YT,Lai SJ,Huang S,Liao PC

    更新日期:2013-04-15 00:00:00