Abstract：
:Stem cell-derived hepatocytes represent promising models to study human liver biology and disease. This concise review discusses the recent progresses in the field, with a focus on human liver disease, drug metabolism and virus infection.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sun P,Zhou X,Farnworth SL,Patel AH,Hay DCdoi
10.3390/ijms141122011subject
Has Abstractpub_date
2013-11-06 00:00:00pages
22011-21issue
11issn
1422-0067pii
ijms141122011journal_volume
14pub_type
杂志文章,评审abstract：:Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082149
更新日期：2018-07-24 00:00:00
abstract：:We investigated the therapeutic potential and mechanism of chitosan oligosaccharides (COS) for experimental autoimmune uveoretinitis (EAU) in mice. EAU was induced in C57/BL6 mice by injection of human interphotoreceptor retinoid-binding protein (IRBP) peptides. At the same time, a high or low dose (20 or 10 mg/kg) of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218326
更新日期：2020-11-06 00:00:00
abstract：:Recent proteome analyses have reported that intrinsically disordered regions (IDRs) of proteins play important roles in biological processes. In higher plants whose genomes have been sequenced, the correlation between IDRs and post-translational modifications (PTMs) has been reported. The genomes of various eukaryotic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160819812
更新日期：2015-08-20 00:00:00
abstract：:We investigated the prevalence of reported deep-intronic variants in a French cohort of 70 patients with Stargardt disease harboring a monoallelic pathogenic variant on the exonic regions of ABCA4. Direct Sanger sequencing of selected intronic regions of ABCA4 was conducted. Complete phenotypic analysis and correlatio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205053
更新日期：2019-10-11 00:00:00
abstract：:The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020721
更新日期：2021-01-13 00:00:00
abstract：:Bone transplants are used to treat fractures and increase new tissue development in bone tissue engineering. Grafting of massive implantations showing slow curing rate and results in cell death for poor vascularization. The potentials of biocomposite scaffolds to mimic extracellular matrix (ECM) and including new biom...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17081222
更新日期：2016-07-28 00:00:00
abstract：:MnTE-2-PyP, a superoxide dismutase mimetic, inhibited OVA-induced airway inflammation in mice suggesting an effect on Th2 responsiveness. Thus, we hypothesized that MnTE-2-PyP may alter dendritic cell-Th2 interactions. Bone marrow derived dendritic cells (DC) and OVA(323-339)-specific Th2 cells were cultured separatel...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13089785
更新日期：2012-01-01 00:00:00
abstract：:Chaetomium globosum is frequently isolated in water-damaged buildings and produces two mycotoxins called chaetoglobosins A and C when cultured on building material. In this study, the influence of ambient pH on the growth of C. globosum was examined on an artificial medium. This fungus was capable of growth on potato ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9122357
更新日期：2008-12-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays an important role in multiple stress-related mental disorders. Although alterations in BDNF in multiple brain regions of individuals experiencing stress have been demonstrated in previous studies, it appears that a set of ele...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21041375
更新日期：2020-02-18 00:00:00
abstract：:While pancreatic cancer (PC) survival rates have recently shown modest improvement, the disease remains largely incurable. Early detection of pancreatic cancer may result in improved outcomes and therefore, methods for early detection of cancer, even premalignant lesions, may provide more favorable outcomes. Pancreati...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103722
更新日期：2020-05-25 00:00:00
abstract：:Nanoencapsulation of thiamine dilauryl sulfate (TDS), a vitamin B1 derivative, was proved to effectively inhibit the spore germination of Fusarium oxysporum f. sp. raphani (F. oxysporum), as well as mycelial growth. The average diameter of nanoparticles was measured as 136 nm by being encapsulated with an edible encap...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14024283
更新日期：2013-02-21 00:00:00
abstract：:The increase in antibiotic resistant bacteria demands the development of new antibiotics against preferably new targets. The common approach is to test compounds for their ability to kill bacteria or to design molecules that inhibit essential protein activities in vitro. In the first case, the mode of action of the dr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160817637
更新日期：2015-07-31 00:00:00
abstract：:Immune system deterioration in space represents a major risk, which has to be mitigated for exploration-class missions into the solar system. Altered gravitational forces have been shown to regulate adaptation processes in cells of the immune system, which are important for appropriate risk management, monitoring and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020436
更新日期：2019-01-20 00:00:00
abstract：:Antibodies are composed of structurally and functionally independent domains that can be used as building blocks to construct different types of chimeric protein-format molecules. However, the generally used genetic fusion and chemical approaches restrict the types of structures that can be formed and do not give an i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030711
更新日期：2020-01-21 00:00:00
abstract：:NW-G01, produced by Streptomyces alboflavus 313, is a novel cyclic hexapeptide antibiotic with many potential applications, including antimicrobial activity and antitumor agents. This study developed a system for optimizing medium components in order to enhance NW-G01 production. In this study, Plackett-Burman design ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13045230
更新日期：2012-01-01 00:00:00
abstract：:The mouse model of Alzheimer's disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their behavioral and amyloidosis phenotypes. In this study, we further characterize the role of MT-1 by crossing Mt1-overexpressing mice with Tg2576 mice (APPTgMT). ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020251
更新日期：2017-01-26 00:00:00
abstract：:Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge in the application of CS NPs was faced during their size-controlled s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246212
更新日期：2019-12-09 00:00:00
abstract：:Toll-like receptor (TLR) 9 is an endosomal receptor recognizing bacterial DNA/CpG-containing oligodeoxynucleotides (CpG ODN). Blocking CpG ODN/TLR9 activity represents a strategy for therapeutic prevention of immune system overactivation. Herein, we report that a synthetic peptide (SP) representing the leucine-rich re...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17020242
更新日期：2016-02-22 00:00:00
abstract：:Non-coding RNAs are dominant in the genomic output of the higher organisms being not simply occasional transcripts with idiosyncratic functions, but constituting an extensive regulatory network. Among all the species of non-coding RNAs, small non-coding RNAs (miRNAs, siRNAs and piRNAs) have been shown to be in the cor...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms130810268
更新日期：2012-01-01 00:00:00
abstract：:Various sulfonamide derivatives are intensively studied as anticancer agents owing to their inhibitory activity against human tumor-associated carbonic anhydrase isoforms. In this work, different synthetic procedures for the series of 1,3,5-triazinyl-aminobenzenesulfonamide conjugates with amino acids, possessing pola...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103661
更新日期：2020-05-22 00:00:00
abstract：:To investigate the potential for the utilization of cotton stalk, ammonia hydrothermal treatment was applied to fractionate the samples into aqueous ammonia-soluble and ammonia-insoluble portions. The ammonia-soluble portion was purified to yield lignin fractions. The lignin fractions obtained were characterized by we...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131115209
更新日期：2012-11-16 00:00:00
abstract：:Aflatoxin B(1) (AFB(1)) is commonly found in cereals and animal feeds and causes a significant threat to the food industry and animal production. Several microbial isolates with high AFB(1) transformation ability have been identified in our previous studies. The aim of this research was to characterize one of those is...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11104063
更新日期：2010-10-20 00:00:00
abstract：:The rice leaf roller (Cnaphalocrocis medinalis) is one of the most destructive agricultural pests. Due to its migratory behavior, it is difficult to control worldwide. To date, little is known about major genes of C. medinalis involved in chitin metabolism and insecticide detoxification. In order to obtain a comprehen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160921873
更新日期：2015-09-10 00:00:00
abstract：:Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a multimodal approac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123996
更新日期：2018-12-12 00:00:00
abstract：:The role of platelet-rich plasma (PRP) in promoting the healing of bone fractures has not yet been clearly stated. The aim of this prospective clinical study was to evaluate the effectiveness of plasma rich in growth factors (PRGF, a PRP derivate) in the treatment of naturally-occurring bone fractures in dogs. With th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051075
更新日期：2019-03-01 00:00:00
abstract：:Radiation-induced organizing pneumonia (RIOP) is an inflammatory lung disease that is occasionally observed after irradiation to the breast. It is a type of secondary organizing pneumonia that is characterized by infiltrates outside the irradiated volume that are sometimes migratory. Corticosteroids work acutely, but ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18020281
更新日期：2017-01-27 00:00:00
abstract：:Prion disease has displayed large infection host ranges among several species; however, dogs have not been reported to be infected and are considered prion disease-resistant animals. Case-controlled studies in several species, including humans and cattle, indicated a potent association of prion protein gene (PRNP) pol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20061404
更新日期：2019-03-20 00:00:00
abstract：:The application of autologous mesenchymal stem cells (MSC) for the treatment of bone defects requires two invasive procedures and several weeks of ex vivo cell expansion. To overcome these limitations, the administration of allogeneic MSC may be attractive, because they are anticipated to be immunoprivileged. Because ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092526
更新日期：2018-08-25 00:00:00
abstract：:Windup, a progressive increase in spinal response to repetitive stimulations of nociceptive peripheral fibers, is a useful model to study central sensitization to pain. Windup is expressed by neurons in both the dorsal and ventral horn of the spinal cord. In juvenile rats, it has been demonstrated both in vivo and in ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246146
更新日期：2019-12-05 00:00:00
abstract：:Most cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic, non-selective effects. These harmful side-effects drastically reduce the cancer patient's quality of life. Recently, researchers have focused their efforts on studying natural health products (NHP's) which have demonstrated the ab...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228480
更新日期：2020-11-11 00:00:00
